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1. 发明申请

WO2011158176A3 GOLD COMPLEXES FOR USE IN THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2011158176A3
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052572
申请日：2011-06-14
申请人： UNIVERSITY OF KWAZULU-NATAL , MUNRO, Orde, Quentin , AKERMAN, Kate, Julie , AKERMAN, Piers
发明人： MUNRO, Orde, Quentin , AKERMAN, Kate, Julie , AKERMAN, Piers
IPC分类号： A61K31/28 , A61P31/00 , C01G7/00 , C07C209/50 , C07D401/12 , C07F1/12
摘要： The invention provides compounds of the Formula (I), in which W is independently selected from W 1 , W 2 , W 3 , W 4 , W 5 , or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Z n -Z n bonds (n = 4-17; n' = n + 1 ) are optionally of any whole or partial bond order, Y is Y 1 or Y represents a pair of substituents independently selected from H, C- 1 -C 6 alkyl, Z 5 or Z 6 aryl, or Y is optionally a bridging structure that may comprise one or more C- 1 -C 6 amide, C- 1 -C 6 ether, or C- 1 -C 6 ester groups, R-R 39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C 5 -C 6 aryl, C 1 - C- 12 alkyl, amine, C- 1 -C 6 alkylamine, C- 1 -C 6 amide, nitro, cyano, carboxyl, C- 1 -C 6 ester, phosphane, thiol, C- 1 -C 6 thioether, OR 40 , and suitable pairs of adjacent R groups (R-R 39 ) may optionally together form part of a C 5 or C 6 aryl ring, a Z 5 or Z 6 ring, R 40 is independently selected from H, C- 1 -C 6 alkyl, Z 5 or Z 6 aryl, C- 1 -C 6 ester, poly(-C 2 O-), amine, and C- 1 -C 6 alkylamine, Z-Z 24 are independently selected from C, N, P, O, and S, and X - is a pharmaceutically acceptable anion, for the treatment of cancer.

2. 发明申请

WO2011064710A1 IN VITRO ANTI-SICKLING ACTIVITY OF BETULINIC ACID, OLEANOLIC ACID AND THEIR DERIVATIVES 审中-公开
标题翻译：口服酸，油酸及其衍生物的体外抗ING活性
公开(公告)号：WO2011064710A1
公开(公告)日：2011-06-03
申请号：PCT/IB2010/055327
申请日：2010-11-22
申请人： UNIVERSITY OF KWAZULU-NATAL , SHODE, Francis, Oluwole , KOORBANALLY, Neil , MPIANA, Pius, Tshimankinda , TSHIBANGU, Damien, Sha-Tshibey , OYEDEJI, Opeoluwa, Oyehan , HABILA, James, Dama
发明人： SHODE, Francis, Oluwole , KOORBANALLY, Neil , MPIANA, Pius, Tshimankinda , TSHIBANGU, Damien, Sha-Tshibey , OYEDEJI, Opeoluwa, Oyehan , HABILA, James, Dama
IPC分类号： A61K36/61 , A61K36/00 , A61K31/19
CPC分类号： A61K36/61 , A61K31/19
摘要： The invention provides triterpenoid compounds selected from betulinic acid, maslinic acid, oleanolic acid, esters thereof and mixtures of any two or more thereof for the treatment of sickle-cell anaemia.
摘要翻译：本发明提供三萜化合物，其选自桦木酸，马斯酸，齐墩果酸，其酯和其任何两种或多种的混合物，用于治疗镰状细胞性贫血。

3. 发明申请

WO2011039574A1 THE USE OF A HERBAL COMPOSITION FOR THE TREATMENT OF A PERSON INFECTED WITH HIV 审中-公开
标题翻译：用于治疗感染艾滋病毒的人的草本组合物的使用
公开(公告)号：WO2011039574A1
公开(公告)日：2011-04-07
申请号：PCT/IB2009/054320
申请日：2009-10-02
申请人： ALZANDANI, Abdul-Majeed, Bin, Aziz , VAN DER WALT, Louis, Stephanus
发明人： ALZANDANI, Abdul-Majeed, Bin, Aziz
IPC分类号： A61K36/285 , A61P31/18 , A61P31/12
CPC分类号： A61K36/285
摘要： The invention provides the use of a herbal composition in the preparation of a medicament for the treatment of a subject infected with HIV, the composition comprising an extract of the plant Aucklandia-(Costus Root).
摘要翻译：本发明提供草药组合物在制备用于治疗感染HIV的受试者的药物中的用途，所述组合物包含植物奥克兰（Costus Root）的提取物。

4. 发明申请

WO2010089691A1 A DEGRADABLE POLYMERIC MATERIAL 审中-公开
标题翻译：可降解的聚合材料
公开(公告)号：WO2010089691A1
公开(公告)日：2010-08-12
申请号：PCT/IB2010/050425
申请日：2010-02-01
申请人： EVERGREEN ENVIRONMENTAL (PTY) LTD , MAGAGULA, Bhekani, Douglas , NHLAPO, Nontete, Suzan , FOCKE, Walter, Wilhelm
发明人： MAGAGULA, Bhekani, Douglas , NHLAPO, Nontete, Suzan , FOCKE, Walter, Wilhelm
IPC分类号： C08K9/04 , C08K5/00 , C08L23/02
CPC分类号： C08K5/0033 , C08K5/005 , C08K5/09 , C08K9/04 , C08L23/02 , C08L23/06 , C08L2207/066 , C08L2310/00 , C08L2666/02
摘要： The invention provides a method of producing a degradable polymeric material by preparing an intercalated double hydroxide of the general formula (I) in which M II represents a single metal ion or more than one metal ion selected from V, Cr, Mn, Fe, Co, Ni, Cu, Zn and Sn and M III represents a single metal ion or more than one metal ion selected from Al, V, Cr, Mn, Fe, Co, Ni, Nb, Mo, In, W and Ce. A is selected from C8 to C24 straight or branched chain carboxylic acids and mixtures thereof and, optionally, at least one further component selected from an anionic surfactant, a straight or branched chain C 8 to C 24 amine, a straight or branched chain C 8 to C 24 alcohol and a straight or branched chain C 8 to C 24 aldehyde. The intercalated double hydroxide is combined with at least one polymeric substrate and, optionally, at least one additional component selected from anti-oxidants and degradation susceptible polymers to produce a mixture which is compounded to produce the degradable polymeric material.
摘要翻译：本发明提供一种通过制备通式（I）的插层双氢氧化物制备可降解聚合物材料的方法，其中MII代表单一金属离子或多于一种选自V，Cr，Mn，Fe，Co， Ni，Cu，Zn和Sn，MIII表示单一的金属离子或多于一种选自Al，V，Cr，Mn，Fe，Co，Ni，Nb，Mo，In，W和Ce的金属离子。 A选自C 8至C 24直链或支链羧酸及其混合物，以及任选地至少一种选自阴离子表面活性剂，直链或支链C 8至C 24胺，直链或支链C 8至C 24醇的其它组分和直链或支链C8至C24醛。插入的双氢氧化物与至少一种聚合物底物和任选地至少一种选自抗氧化剂和降解易感性聚合物的另外的组分组合以产生混合物以制备可降解聚合物材料。

5. 发明申请

WO2009104161A2 A COATING COMPOSITION FOR STRENGTHENING GLASS 审中-公开
标题翻译：用于加强玻璃的涂料组合物
公开(公告)号：WO2009104161A2
公开(公告)日：2009-08-27
申请号：PCT/IB2009/050704
申请日：2009-02-20
申请人： SABMILLER INTERNATIONAL BV , VAN DER WALT, Louis, Stephanus , WEN, Mei , HOPKINS, Thomas, R. , BROTZMAN, Jeffery, Richard , SILVERMAN, Gary, Stephen , CARSON, Stephen, William
发明人： WEN, Mei , HOPKINS, Thomas, R. , BROTZMAN, Jeffery, Richard , SILVERMAN, Gary, Stephen , CARSON, Stephen, William
IPC分类号： C09D175/04 , C08G18/76 , C08G18/28 , C08G18/48 , C08G18/32 , C03C17/32
CPC分类号： C03C17/005 , C03C17/30 , C03C17/322 , C08G18/289 , C08G18/4816 , C08G18/7664 , C09D175/04
摘要： The invention relates to a method of making a coating composition for strengthening glass in a one-coating procedure. The method includes the steps of combining a polyol component, an isocyanate component and a silane adhesion promoter. The silane adhesion promoter typically comprises less than about 15% of the composition.
摘要翻译：本发明涉及一种制备用于在一次涂覆程序中加强玻璃的涂料组合物的方法。该方法包括组合多元醇组分，异氰酸酯组分和硅烷粘合促进剂的步骤。硅烷粘合促进剂通常包含小于组合物的约15％。

6. 发明申请

WO2007093957A2 A CANNULA 审中-公开
标题翻译：一个肛门
公开(公告)号：WO2007093957A2
公开(公告)日：2007-08-23
申请号：PCT/IB2007/050464
申请日：2007-02-13
申请人： RÖSCH, Theodor, Gerhard
发明人： RÖSCH, Theodor, Gerhard
CPC分类号： A61B17/3421 , A61B17/3498 , A61B2017/3419 , A61B2017/3443 , A61B2017/349
摘要： A cannula for fixation within a portal to provide access to a surgical worksite by a surgical instrument, comprises an elongate tubular body defining a passage for receiving a surgical instrument, the tubular body having an upper end and a lower end, a sealing assembly located at the upper end for sealingly receiving a surgical instrument, and a generally cylindrical sleeve surrounding and extending along at least part of the tubular body. The sleeve has a lower end which is secured to the tubular body, an upper end and an external screw thread and is of a flexible material so that stretching the sleeve in the direction of the upper end of the tubular body by displacing the tubular body and sleeve relative to each other increases the pitch and reduces the depth of the thread and relative displacement in the opposite direction reduces the pitch and increases the depth of the thread.
摘要翻译：用于在入口内固定以通过外科器械进入手术工作场所的套管包括限定用于接收外科器械的通道的细长管状体，所述管状体具有上端和下端，密封组件位于用于密封地接收外科器械的上端，以及围绕并沿着管状体的至少一部分延伸的大致圆柱形套筒。套筒具有固定到管状体的下端，上端和外螺纹，并且是柔性材料，从而通过使管状体移位而沿着管状体的上端的方向拉伸套筒，相对于彼此的套筒增加了间距并减小了线的深度，并且相反方向上的相对位移减小了间距并增加了线的深度。

7. 发明申请

WO2006136982A2 AN ISOLATED RECOMBINANT VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN (HRVCP) POLYPEPTIDE 审中-公开
标题翻译：分离的重组疫苗疫苗补体控制蛋白（HRVCP）多肽
公开(公告)号：WO2006136982A2
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051918
申请日：2006-06-15
申请人： UNIVERSITY OF CAPE TOWN , KOTWAL, Girish, J. , GHEBREMARIAM, Yohannes, Tsegai
发明人： KOTWAL, Girish, J. , GHEBREMARIAM, Yohannes, Tsegai
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/24122
摘要： An isolated recombinant vaccinia virus complement control protein (hrVCP) polypeptide comprises a modified amino acid sequence comprising one or more amino acid substitutions to an amino acid sequence as set forth in SEQ ID NO: 2. The hrVCP polypeptide exhibits a complement activation regulatory activity greater than a complement activation regulatory activity of a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2. The one or more amino acid substitutions are selected from the group consisting of H98Y, E102K, E108K, E120K, and combinations thereof.
摘要翻译：分离的重组痘苗病毒补体对照蛋白（hrVCP）多肽包含修饰的氨基酸序列，其包含如SEQ ID NO：2所示的氨基酸序列的一个或多个氨基酸取代.hrVCP多肽表现出更大的补体活化调节活性比包含如SEQ ID NO：2所示的氨基酸序列的多肽的补体活化调节活性。一个或多个氨基酸取代选自H98Y，E102K，E108K，E120K及其组合。

8. 发明申请

WO2006061686A2 A CATHODIC DEVICE 审中-公开
标题翻译：阴极设备
公开(公告)号：WO2006061686A2
公开(公告)日：2006-06-15
申请号：PCT/IB2005/003668
申请日：2005-12-05
申请人： PRINS, Johan, Frans
发明人： PRINS, Johan, Frans
IPC分类号： H01J1/308 , H01J1/312 , H01J9/02
CPC分类号： B82Y10/00 , H01J1/308 , H01J1/312 , H01J9/022 , H01J2201/308
摘要： A method of forming a cathodic device includes the steps of forming a p-type layer and an n-type layer below a surface of a substrate. The material has a conduction band which is at an energy level no more than 0.5 electron-Volts (eV) below the lowest vacuum energy level. The layers are formed so that they are in contact, with the p-type layer located between the surface and the n-type layer, and so that they form a p-n junction. The thickness of the p-type layer is somewhat less than the average distance which an electron injected into the p-type layer travels by diffusion and the thickness of the negatively charged depletion layer in the p-type layer is such that the difference between the thickness of the p-type layer and the thickness of the negatively charged depletion layer in the p-type layer is substantially less than the said average distance.
摘要翻译：形成阴极器件的方法包括以下步骤：在衬底的表面下方形成p型层和n型层。该材料具有低于最低真空能级的能级不超过0.5电子伏特（eV）的导带。这些层被形成为使得它们接触，p型层位于表面和n型层之间，并且使得它们形成p-n结。 p型层的厚度稍微小于注入到p型层的电子通过扩散行进的平均距离，并且p型层中的带负电荷的耗尽层的厚度使得p型层之间的差异 p型层的厚度和p型层中的带负电荷的耗尽层的厚度基本上小于所述平均距离。

9. 发明申请

WO2013072855A2 DERMATOLOGICAL COMPOSITIONS 审中-公开
标题翻译：皮肤组成
公开(公告)号：WO2013072855A2
公开(公告)日：2013-05-23
申请号：PCT/IB2012/056406
申请日：2012-11-14
申请人： UNIVERSITY OF KWAZULU-NATAL
发明人： DLOVA, Ncoza, Cordelia
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/498
摘要： The invention provides a skin-lightening composition which includes at least one compound selected from morelloflavone, morelloflavone-7"-sulphate and sargaol.
摘要翻译：本发明提供一种皮肤增亮组合物，其包含至少一种选自更多的氟黄酮，更多的黄烷酮-7“ - 硫酸盐和沙尔醇的化合物。

10. 发明申请

WO2012123904A1 A FUNGICIDAL COMPOSITION 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO2012123904A1
公开(公告)日：2012-09-20
申请号：PCT/IB2012/051203
申请日：2012-03-14
申请人： ICA LABORATORIES CC , SCHREUDER, Wouter , ALBELDAS, Michael
发明人： SCHREUDER, Wouter , ALBELDAS, Michael
IPC分类号： A01N31/02 , A01N43/50 , A01N47/38 , A01N43/653 , A01P3/00 , A01N35/02 , A01N55/00 , A01N37/02 , A01N37/06
CPC分类号： A01N43/50 , A01N35/02 , A01N43/653 , A01N47/38 , A01N55/00 , A01N31/02 , A01N37/02 , A01N37/06 , A01N2300/00
摘要： The invention provides synergistic fungicidal compositions, for use in the treatment or control of plant diseases caused by or associated with phytopathogenic fungi. The compositions comprise at least one conazole fungicide and at least one fungicidal compound which is a fungicidal volatile oil. The conazole fungicides are selected from imazalil, prochloraz, propiconazole, tebuconazole, epoxiconazole, flusilazole and metal complexes thereof. The fungicidal volatile oils are selected from fungicidal C 6 -C 12 aldehydes, fungicidal C 6 -C 12 alcohols, fungicidal C 6 -C 12 carboxylic acids and fungicidal C 6 -C 12 esters. The preferred conazole fungicides are imazalil, prochloraz and the preferred fungicidal volatile oil is n-hexanal.
摘要翻译：本发明提供了协同杀真菌组合物，用于治疗或控制由植物病原真菌引起或与其相关的植物病害。组合物包含至少一种真菌杀真菌剂和至少一种杀真菌化合物，其是杀真菌挥发油。唑类杀真菌剂选自咪达唑仑，丙氯灵，丙环唑，戊唑醇，环氧唑，氟西拉唑及其金属配合物。杀真菌挥发油选自杀真菌C6-C12醛，杀真菌C6-C12醇，杀真菌C6-C12羧酸和杀真菌C6-C12酯。优选的唑类杀真菌剂是咪达唑仑，丙氯灵，优选的杀真菌挥发油是正己醛。

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