专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09112361B2 Combination and modified electrolyte to reduce risk of premature lithium ion battery failure, including in aircraft applications 有权
标题翻译：组合和改性电解质，以降低锂离子电池故障的风险，包括飞机应用
公开(公告)号：US09112361B2
公开(公告)日：2015-08-18
申请号：US14116156
申请日：2013-03-15
申请人： Brooke Schumm, Jr.
发明人： Brooke Schumm, Jr.
IPC分类号： H02J7/00
CPC分类号： H02J7/0026 , H02J7/007 , H02J2007/0037
摘要： A combined system reinforces the safety of lithium ion batteries by redesign of electrolyte and the charging current a) modifying the electrolyte to inhibit or prevent dendrite growth preferably by the addition of lithiated polyphenoxy polyethylene glycol and/or a second surface active compound chosen from the family of fluorosurfactants, and/or a modest amount of lithium or sodium borate, b) modifying the charging cycle by a so-called ripple current in order to inhibit or prevent dendrite growth (ripple current meaning oscillation in the amount of amperage or voltage in the charging cycle), c) programmable battery management systems with temperature and electrical limits integrated in order to eliminate from the circuit and bypass malfunctioning cells based on past performance of the charging cycle and voltage endpoints achieved, d) minimizing any transient currents and voltages into or out of the battery system and e) maintaining a cool atmosphere in the battery space.
摘要翻译：组合系统通过重新设计电解质和充电电流来加强锂离子电池的安全性a）优选通过加入锂化聚苯乙烯聚乙二醇和/或选自家族的第二表面活性化合物来改性电解质以抑制或防止枝晶生长的含氟表面活性剂和/或适量的硼酸锂或硼酸钠，b）通过所谓的纹波电流来改变充电周期，以便抑制或防止枝晶生长（纹波电流意味着电流或电压的振荡量充电周期），c）集成了温度和电气限制的可编程电池管理系统，以便根据过去的充电周期和电压端点的性能消除电路和旁路故障电池，d）最小化任何瞬态电流和电压进入或并且e）在电池空间内保持凉爽的气氛。

2. 发明授权

US08920300B2 Direct visualization robotic intra-operative radiation therapy device with radiation ablation capsule 有权
标题翻译：直接可视化机器人放射治疗装置与放射消融胶囊
公开(公告)号：US08920300B2
公开(公告)日：2014-12-30
申请号：US12886493
申请日：2010-09-20
申请人： Walter A. Roberts , Mason Gibbs , Thomas Cender , Brooke Schumm, III
发明人： Walter A. Roberts , Mason Gibbs , Thomas Cender , Brooke Schumm, III
IPC分类号： A61F5/00 , A61N5/10
CPC分类号： A61N5/1001 , A61N2005/1052 , A61N2005/1055 , A61N2005/1061
摘要： This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure. Control means would be added to identify and calculate margin and depth of tissue to be treated and the proper radiation source or radioactive isotope (which can be any particle emitter, including neutron, x-ray, alpha, beta or gamma emitter) to obtain the desired therapeutic effects. The invention enables stereotactical surgery and close confines radiation therapy adjacent to radiosensitive tissue.
摘要翻译：本发明提出一种机器人涂抹器装置，其内部部署到具有胶囊（也称为盒式磁带）的患者和具有通过孔径交替地封闭和暴露放射源的装置的孔。胶囊和孔将与外科手术机器人集成以创建如下面更充分描述的机器人IORT（手术中放射治疗）施用器装置。胶囊，辐射源和IORT施加器臂将被整合，以使医师，物理学家或技术人员以交互方式内部地观察和选择组织以暴露于足够数量的电离辐射以将治疗辐射剂量递送至组织。通过机器人操纵装置，医师和物理学家将远程地对不仅要暴露的组织施加辐射，而且还控制曝光时间的长短。将添加控制装置以识别和计算要处理的组织的边缘和深度，以及适当的辐射源或放射性同位素（其可以是任何颗粒发射体，包括中子，x射线，α，β或γ发射体），以获得所需治疗效果。本发明能够进行立体定向手术并且紧密地限制与放射敏感组织相邻的放射治疗。

3. 发明授权

US09252467B2 Fluid regulating microvalve assembly for fluid consuming cells with spring-like shape-retaining aperture cover 有权
标题翻译：用于流体消耗电池的流体调节微型阀组件，具有弹簧状保持孔盖
公开(公告)号：US09252467B2
公开(公告)日：2016-02-02
申请号：US13350727
申请日：2012-01-13
申请人： Brooke Schumm, Jr.
发明人： Brooke Schumm, Jr.
IPC分类号： H01M12/04 , H01M12/08 , H01M8/04 , H01M10/42 , H01M10/48 , H01M12/06 , F16K99/00
CPC分类号： H01M12/08 , F16K99/0005 , F16K99/0007 , F16K99/0015 , F16K99/0044 , H01M8/04089 , H01M8/04388 , H01M8/04395 , H01M8/04753 , H01M10/425 , H01M10/48 , H01M12/06 , Y02E60/128 , Y02E60/50
摘要： A fluid regulating microvalve assembly for use to control fluid flow to a fluid consuming electrode, such as an oxygen reduction electrode, in an electrochemical cell is proposed. The microvalve assembly includes a stationary valve body having an aperture and microactuators movable from a first closed aperture position to at least a second position where fluid is able to pass through the microvalve body aperture. These microactuators control the movement of spring-like shape-retaining interior aperture covers, which covers can be belleville springs or flat springs. The fluid regulating microvalve assembly can utilize cell potential or a separate source. The latter assembly can be located outside or inside the cell housing, for example between a fluid inlet aperture and the fluid consuming electrode. Using a printing process to deposit at least one of the layers is proposed for making the multilayer microvalve assembly for a fluid depolarized battery.
摘要翻译：提出了一种流体调节微型阀组件，用于在电化学电池中控制流体流向消耗电极，如氧还原电极。微型阀组件包括具有孔的固定阀体和可从第一闭合孔位置移动到至少第二位置的微致动器，其中流体能够通过微阀体孔。这些微型制动器控制弹簧状保持内孔的运动，盖子可以是百叶窗弹簧或扁平弹簧。流体调节微阀组件可以利用电池电位或单独的电源。后一组件可以位于电池壳体的外部或内部，例如位于流体入口孔口和流体消耗电极之间。提出了使用印刷方法沉积至少一层的方法来制造用于流体去极化电池的多层微型阀组件。

4. 发明授权

US09421238B2 Treatment of klebsiella pneumoniae with liposomally formulated glutathione 有权
标题翻译：用脂质体配制的谷胱甘肽治疗肺炎克雷伯杆菌
公开(公告)号：US09421238B2
公开(公告)日：2016-08-23
申请号：US14767985
申请日：2014-02-14
申请人： Emory University , YOUR ENERGY SYSTEMS, LLC , Children's Healthcare of Atlanta, Inc.
发明人： Lou Ann Brown , Frederick Timothy Guilford
IPC分类号： A61K9/127 , A61K38/06 , A61K9/00 , A61K9/48
CPC分类号： A61K38/063 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/006 , A61K9/0095 , A61K9/127 , A61K9/4858
摘要： The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as demonstrated by efficacy in reducing by large multiples the presence of cultures of Klebsiella in rats in animal tests. Further, because the liposomal glutathione bolsters body defenses as well as appearing to have direct killing action, the propensity to create more and more resistant strains to antibiotic treatment is downgraded.
摘要翻译：本发明的脂质体谷胱甘肽的组合物最近被证明具有在体外对抗肺炎克雷伯菌培养物具有抗生素作用的效用，并且在体内如通过大量倍数减少大鼠克雷伯杆菌培养物的效力所证明的动物试验。此外，由于脂质体谷胱甘肽抵抗身体防御以及似乎具有直接杀伤作用，因此降低对抗生素治疗产生越来越多抗性菌株的倾向。

5. 发明授权

US08679530B2 Liposomally encapsulated reduced glutathione, including with other pharmacologic preparation, capable of administration as an oral, topical, intraoral or transmucosal, prepartion, for reversal and prevention of oxidation of cholesterol and of low density lipoprotein 有权
标题翻译：脂质体包裹的还原型谷胱甘肽，包括与其他药理学制剂，能够作为口服，局部，口内或经粘膜的预处理，用于逆转和预防胆固醇和低密度脂蛋白的氧化
公开(公告)号：US08679530B2
公开(公告)日：2014-03-25
申请号：US12092628
申请日：2006-10-26
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/4808 , A61K31/122 , A61K31/198 , A61K31/366 , A61K33/04 , A61K38/00 , A61K38/05 , A61K38/063 , A61K45/06 , A61K2300/00
摘要： The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
摘要翻译：本发明提出在脂质体（脂质体还原型谷胱甘肽）中确保还原型谷胱甘肽以口服给药治疗有效量以改善血管疾病进展，包括动脉粥样硬化，糖尿病，高血压，导致血流减少的动脉狭窄，缺血性事件，血栓形成，血小板聚集异常和血栓形成事件，减少氧化胆固醇，氧化型HDL和氧化LDL的量和作用。本发明还提出将脂质体包封的谷胱甘肽与他汀类药物组合以改善不仅降低胆固醇而且降低氧化的胆固醇以及氧化的HDL和氧化的LDL的作用。本发明还提出将脂质体包封的谷胱甘肽与CoQ10组合作为血管疾病的治疗和他汀类药物治疗的副作用的管理。

6. 发明授权

US09089962B2 Anti-spalling combination on an impact tool with an improved holding system 有权
标题翻译：具有改进的保持系统的冲击工具上的防剥离组合
公开(公告)号：US09089962B2
公开(公告)日：2015-07-28
申请号：US10625149
申请日：2003-07-23
申请人： H. Downman McCarty, II , Brooke Schumm, III , Peter Popper
发明人： H. Downman McCarty, II , Brooke Schumm, III , Peter Popper
IPC分类号： B26B7/00 , B25G1/01 , B25D1/16 , B25D3/00
CPC分类号： B25G1/01 , B25D1/16 , B25D3/00 , Y10T83/04
摘要： The invention is a tool to be struck, or a striking tool, (collectively referred to as an “impact tool”), or alternatively, a cap, that will not suffer metal spall and the attendant dangers of spalling and flying or cutting metal slivers. The preferred mode is on a chisel (wood or cold) or repeated impact tool. The chisel would have a striking end cut square to the shaft. The striking end would be opposite the working end. Other tools such as impact wrenches, jackhammers, wedges, spikes, hammers, mallets or other tools being struck or striking forcibly benefit from the invention by use of a disk insert of polymeric material to alter ergonomic and noise characteristic.
摘要翻译：本发明是一种被打击的工具，或者一个醒目的工具（统称为“冲击工具”），或者是一个不会遭受金属剥落的帽子，以及剥落和飞行或切割金属条的附带危险。优选的模式是凿子（木头或冷）或反复冲击工具。凿子将有一个明显的切割方形的轴。惊人的结局将与工作端相反。通过使用聚合物材料的盘式插入件，冲击扳手，手提锤，楔形物，钉子，锤子，锤子或其他工具被击打或打击的其他工具强制地受益于本发明，以改变人体工程学和噪声特性。

7. 发明授权

US08147869B2 Liposome-encapsulated glutathione for oral administration 有权
标题翻译：用于口服给药的脂质体包封的谷胱甘肽
公开(公告)号：US08147869B2
公开(公告)日：2012-04-03
申请号：US13222254
申请日：2011-08-31
申请人： F. Timothy Guilford , Brian C. Keller
发明人： F. Timothy Guilford , Brian C. Keller
IPC分类号： A61K9/127 , A61K31/27 , A01N47/10
CPC分类号： A61K9/127 , A61K9/4808 , A61K31/122 , A61K31/198 , A61K31/366 , A61K33/04 , A61K38/00 , A61K38/05 , A61K38/063 , A61K45/06 , A61K2300/00
摘要： The invention is a composition administrable orally to provide systemic glutathione (reduced) and a method for providing systemic glutathione by oral administration of glutathione (reduced) in a liposome encapsulation. The administration of a therapeutically effective amount of oral liposomal glutathione (reduced) results in improvement of symptoms in disease states related to glutathione deficiency such as Parkinson's disease and cystic fibrosis. Compounds enhancing the effect of the liposomal glutathione are contemplated such as Selenium, EDTA, carbidopa, and levodopa.
摘要翻译：本发明是口服给药以提供全身性谷胱甘肽（还原）的组合物和通过在脂质体包封中口服施用谷胱甘肽（还原））来提供全身性谷胱甘肽的方法。治疗有效量的口服脂质体谷胱甘肽（还原）的施用导致与谷胱甘肽缺乏相关的疾病状态如帕金森病和囊性纤维化的症状改善。考虑了增加脂质体谷胱甘肽的作用的化合物，例如硒，EDTA，卡比多巴和左旋多巴。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式