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1. 发明申请

WO2008112514A1 HE4 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 审中-公开
标题翻译： HE4单克隆抗体及其使用方法
公开(公告)号：WO2008112514A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056132
申请日：2008-03-07
申请人： TRIPATH IMAGING, INC. , CHEEK, Robert, L. , FISCHER, Timothy, J. , GROELKE, John, W.
发明人： CHEEK, Robert, L. , FISCHER, Timothy, J. , GROELKE, John, W.
IPC分类号： C07K16/30 , C07K14/47 , C12N15/12 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3069 , C07K2317/34 , G01N33/57415 , G01N33/57449
摘要： Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal^ antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供了一种用于诊断患者卵巢癌和用于鉴定患卵巢癌可能性增加的患者的组合物和方法。组合物包括特异性结合HE4的单克隆抗体及其变体和片段。进一步提供具有本发明的HE4抗体的结合特性的单克隆抗体。产生本发明的HE4单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断方法以及用于鉴定具有增加卵巢癌可能性的患者的筛选方法。还提供了包含一种或多种所公开的HE4单克隆抗体和用于实施本发明的方法的试剂盒。包含HE4表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

2. 发明申请

WO2008079464A8 STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES 审中-公开
公开(公告)号：WO2008079464A8
公开(公告)日：2008-07-03
申请号：PCT/US2007/078076
申请日：2007-09-10
申请人： BECTON, DICKINSON AND COMPANY , SULLIVAN, Vincent, J , MIKSZTA, John, A. , ALARCON, Jason, B. , FERRITER, Matthew, S. , HUANG, Joanne , D'SOUZA, Ajit, M.
发明人： SULLIVAN, Vincent, J , MIKSZTA, John, A. , ALARCON, Jason, B. , FERRITER, Matthew, S. , HUANG, Joanne , D'SOUZA, Ajit, M.
IPC分类号： A61K9/14 , A61K9/19 , A61K39/07 , A61K39/08 , A61K39/085 , A61K39/29 , A61K47/02 , A61K39/02 , A61P31/04 , A61P31/12
摘要： The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum- adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided.

3. 发明申请

WO2007073411A1 MCM6 AND MCM7 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 审中-公开
标题翻译： MCM6和MCM7单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：WO2007073411A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/031136
申请日：2006-08-10
申请人： TRIPATH IMAGING, INC. , MALINOWSKI, Douglas, P. , FISCHER, Timothy, J. , TAYLOR, Adriann, J.
发明人： MALINOWSKI, Douglas, P. , FISCHER, Timothy, J. , TAYLOR, Adriann, J.
IPC分类号： C07K14/47 , C07K16/30 , G01N33/574
CPC分类号： C07K16/3069 , C07K14/4738 , C07K16/40 , C07K2317/34 , C12Q1/001 , G01N33/57411
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括特异性结合MCM6或MCM7的新单克隆抗体及其变体和片段。进一步提供具有本发明的MCM6或MCM7抗体的结合特征的单克隆抗体。产生本发明的MCM6或MCM7单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM6，MCM7或MCM6和MCM7两者的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM6或MCM7表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

4. 发明申请

WO2007061534A1 DEVICE AND METHOD FOR SCREENING A PLANT POPULATION FOR WIND DAMAGE RESISTANCE TRAITS 审中-公开
标题翻译：用于筛选植物人口用于风力耐受性旅行的装置和方法
公开(公告)号：WO2007061534A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/040351
申请日：2006-10-13
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , STEENHOEK, Loren , CARRIGAN, Lori , GHAFFARZADEH, Mohammadreza , HARTMAN, Michael, E. , BARREIRO, Roberto , GOLDMAN, Daniel, M. , JOHNSON David L.
发明人： STEENHOEK, Loren , CARRIGAN, Lori , GHAFFARZADEH, Mohammadreza , HARTMAN, Michael, E. , BARREIRO, Roberto , GOLDMAN, Daniel, M. , JOHNSON David L.
IPC分类号： A01G13/08 , A01G7/06
CPC分类号： A01G7/06 , A01G13/08
摘要： A device and method for applying a wind force to a plurality of plants in an agricultural environment is provided to screen for selected wind-resistance traits in the plurality of plants. In one embodiment of the present invention, a device is provided including a generating device for creating a moving fluid stream to provide the wind force, a directing device, such as a duct and/or movable vane, for precisely and selectively directing the wind force towards a portion of at least one plant, and a controller for adjusting one or more parameters of the fluid stream. The device and/or method embodiments of the present invention may thus be used to selectively apply the wind force to one or more plants (or portions thereof) such that the plants may be evaluated with respect to one or more wind-resistant physical characteristics.
摘要翻译：提供了一种用于在农业环境中向多个植物施加风力的装置和方法，用于筛选多个植物中选定的抗风性状。在本发明的一个实施例中，提供了一种装置，其包括用于产生移动流体流以提供风力的产生装置，诸如管道和/或可移动叶片的导向装置，用于精确地和选择性地引导风力朝向至少一个设备的一部分，以及用于调节流体流的一个或多个参数的控制器。因此，本发明的装置和/或方法实施例可以用于选择性地将风力施加到一个或多个植物（或其部分），使得可以关于一个或多个防风物理特性来评估植物。

5. 发明申请

WO2009105140A3 METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES 审中-公开
公开(公告)号：WO2009105140A3
公开(公告)日：2009-08-27
申请号：PCT/US2008/085370
申请日：2008-12-03
申请人： VIAMET PHARMACEUTICALS, INC. , SCHOTZINGER, Robert, J. , HOEKSTRA, William, J.
发明人： SCHOTZINGER, Robert, J. , HOEKSTRA, William, J.
IPC分类号： A61K31/10 , A61K31/122 , A61K31/35 , A61K31/37 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/404 , A61K31/431 , A61K31/437 , A61K31/44 , A61K31/55 , A61K31/5513
摘要： The presently disclosed subject matter is described to metalloenzyme inhibitors having metal binding moieties linked to a targeting moiety through a linking group or a direct bond, method of screening for metalloenzyme inhibitors, and methods for treating a metalloenzyme related disorder by administering a metalloenzyme inhibitor to a subject in need of treatment thereof.

6. 发明申请

WO2007094829A3 ISOLATED AND FIXED MICRO AND NANO STRUCTURES AND METHODS THEREOF 审中-公开
公开(公告)号：WO2007094829A3
公开(公告)日：2007-08-23
申请号：PCT/US2006/043305
申请日：2006-11-07
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , DESIMONE, Joseph, M. , ROTHROCK, Ginger, Denison
发明人： DESIMONE, Joseph, M. , ROTHROCK, Ginger, Denison
IPC分类号： A61F2/00 , A61N1/05
摘要： Discrete micro and nanoscale particles are formed in predetermined shapes and sizes and predetermined size dispersions. The particles can also be attached to a film to form arrays of particles on a film. The particles are formed from molding techniques that can include high throughput and continuous particle molding.

7. 发明申请

WO2007090076A2 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：识别患有卵巢癌的增加的可能性的患者的方法及其组合物
公开(公告)号：WO2007090076A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061205
申请日：2007-01-29
申请人： TRIPATH IMAGING, INC. , FISCHER, Timothy, J. , MALINOWSKI, Douglas, P. , HE, Qin , WHITEHEAD, Clark, M. , CHEEK, Robert, L. , GROELKE, John, W.
发明人： FISCHER, Timothy, J. , MALINOWSKI, Douglas, P. , HE, Qin , WHITEHEAD, Clark, M. , CHEEK, Robert, L. , GROELKE, John, W.
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供筛选方法用于鉴定患有卵巢癌可能性增加的患者。筛选方法涉及检测身体样品中多种生物标志物的表达，其中生物标志物的过度表达表示具有卵巢癌的可能性增加。筛选方法可以进一步包括两步分析。感兴趣的生物标志物包括例如涉及DNA复制/细胞周期控制，细胞生长和增殖中的缺陷，逃脱细胞凋亡，血管生成或淋巴生成，或癌细胞运动性和侵入机制的基因和蛋白质。在本发明的一些方面中，使用生物标志物特异性抗体在蛋白质水平检测生物标志物的表达或使用核酸杂交技术在核酸水平检测生物标志物的表达。本文进一步公开了检测患者卵巢癌的方法。进一步提供用于实践本发明方法的试剂盒。

8. 发明申请

WO2007050735A2 MARKERS FOR PRODUCTION TRAITS 审中-公开
标题翻译：生产特征标记
公开(公告)号：WO2007050735A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041745
申请日：2006-10-25
申请人： INNOVATIVE DAIRY PRODUCTS PTY LTD AS TRUSTEE FOR THE PARTICIPANTS OF THE COOPERATIVE RESEARCH CENTRE FOR INNOVATIVE DAIRY PRODUCTS , RAADSMA, Hermanus, Willem , CAVANAGH, Julie Anne, Louise , HAWKEN, Rachel, Jane , ZENGER, Kyall, Richard , CRUMP, Ronald, Edward , MCCLINTOCK, Sandy , TIER, Bruce , MCCLINTOCK, Sara , HOBBS, Matthew , BARIS, Wesley, Cole
发明人： RAADSMA, Hermanus, Willem , CAVANAGH, Julie Anne, Louise , HAWKEN, Rachel, Jane , ZENGER, Kyall, Richard , CRUMP, Ronald, Edward , MCCLINTOCK, Sandy , TIER, Bruce , MCCLINTOCK, Sara , HOBBS, Matthew , BARIS, Wesley, Cole
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , A01K2227/101 , A01K2267/01 , C12Q2600/124 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to a method for selecting an animal for milk protein yield using marker assisted selection, wherein said method comprises: (a) analyzing a nucleic acid sample from said animal for a polymorphism in at least one genetic marker selected from the group set out in Table 1 ; and (b) selecting the animal based on the presence or absence of the polymorphism in the at least one genetic marker, wherein the polymorphism is predictive of milk protein yield.
摘要翻译：本发明涉及使用标记辅助选择选择用于乳蛋白产量的动物的方法，其中所述方法包括：（a）至少分析来自所述动物的核酸样品中的多态性至少一个选自表1中列出的组的遗传标记; 和（b）基于所述至少一个遗传标记中存在或不存在多态性来选择动物，其中所述多态性预测乳蛋白产量。

9. 发明申请

WO2005106037A1 A METHOD FOR IDENTIFYING ACTIVATORS OF GENE TRANSCRIPTION 审中-公开
标题翻译：鉴定基因转录激活子的方法
公开(公告)号：WO2005106037A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/012286
申请日：2005-04-11
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , DUVICK, Jonathan, P. , FEDOROVA, Maria
发明人： DUVICK, Jonathan, P. , FEDOROVA, Maria
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12N15/1086
摘要： Methods and compositions for identifying a nucleotide sequence that encodes a polypeptide that directly or indirectly modulates the activity of a transcriptional regulatory region are provided. The methods permit the efficient screening of a large number of candidate nucleotide sequences for potential modulators of transcription. In particular, a population of polynucleotide constructs comprising a common transcriptional regulatory region operably linked to a candidate sequence is introduced into a population of host cells, and each candidate sequence is screened for modulation in its expression level, for example, using methods that employ hybridization to a complementary DNA microarray. The expression level of the candidate sequence correlates to the activity of the transcriptional regulatory region. Thus, alterations in the expression level of a candidate sequence indicate that the sequence encodes a polypeptide that modulates the activity of the transcriptional regulatory region. Compositions for practicing the invention are further provided.
摘要翻译：提供了用于鉴定编码直接或间接调节转录调节区活性的多肽的核苷酸序列的方法和组合物。该方法允许有效筛选潜在的转录调控因子的大量候选核苷酸序列。特别地，将包含可操作地连接到候选序列的常见转录调节区的多核苷酸构建体的群体引入宿主细胞群体中，并且筛选每个候选序列以其表达水平进行调节，例如使用采用杂交的方法到互补的DNA微阵列。候选序列的表达水平与转录调控区的活性相关。因此，候选序列的表达水平的改变表明序列编码调节转录调节区活性的多肽。进一步提供实施本发明的组合物。

10. 发明申请

WO2005066349A2 GENES ENCODING PROTEINS WITH PESTICIDAL ACTIVITY 审中-公开
标题翻译：编码具有杀虫活性的蛋白质的基因
公开(公告)号：WO2005066349A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/041530
申请日：2004-12-09
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E.I. DU PONT DE NEMOURS AND COMPANY , ABAD, André , DONG, Hua , HERRMANN, Rafael , LU, Albert , McCUTCHEN, Billy, F. , RICE, Janet, A. , SCHEPERS, Eric, J. , WONG, James, F.
发明人： ABAD, André , DONG, Hua , HERRMANN, Rafael , LU, Albert , McCUTCHEN, Billy, F. , RICE, Janet, A. , SCHEPERS, Eric, J. , WONG, James, F.
IPC分类号： C12N15/82
CPC分类号： C07K14/325 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for protecting a plant from an insect pest are provided. The invention provides mutagenized nucleic acids that have been engineered to encode pesticidal polypeptides having increased resistance to proteolytic degradation by a plant protease. In particular, nucleic acid sequences encoding pesticidal polypeptides modified to comprise a proteolytic protection site that confers resistance to degradation or proteolytic inactivation by a plant protease are provided. Particular embodiments of the invention provide pesticidal polypeptide compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds. These compositions find use in methods for controlling pests, especially plant pests. Novel plant proteases, sequences encoding these proteases, and methods for their use are also provided.
摘要翻译：提供了用于保护植物免受害虫侵害的组合物和方法。本发明提供了经过工程改造以编码对植物蛋白酶的蛋白水解降解具有增强的抗性的杀虫多肽的诱变核酸。具体而言，提供了编码杀有害生物多肽的核酸序列，其修饰成包含赋予对植物蛋白酶的降解或蛋白水解失活的抗性的蛋白水解保护位点。本发明的具体实施方案提供了杀有害生物多肽组合物和制剂，表达盒和转化植物，植物细胞和种子。这些组合物可用于防治害虫特别是植物害虫的方法中。还提供了新的植物蛋白酶，编码这些蛋白酶的序列及其使用方法。

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