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1. 发明申请

WO2022192703A1 COMPOUNDS HAVING TETRAHYDROINDOLIZINE-1-CARBOXAMIDE AS BCL-2 INHIBITORS 审中-公开
公开(公告)号：WO2022192703A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/019998
申请日：2022-03-11
申请人： EIL THERAPEUTICS, INC. , ABAGYAN, Ruben
发明人： KYSIL, Volodymyr , PARCHINSKY, Vladislav Zenonovich , PUSHECHNIKOV, Alexei , IVACHTCHENKO, Alexandre Vasilievich , ORRY, Andrew , LAM, Polo Chun-Hung , SAVCHUK, Nikolay
IPC分类号： A61K31/435 , A61K31/4353 , A61K31/437 , C07D471/00 , C07D471/02 , C07D471/08
摘要： The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):

2. 发明申请

WO2022192083A1 POLYMERS, METHODS OF MAKING POLYMERS, AND METHODS OF COUPLING OLIGONUCLEOTIDES TO POLYMERS 审中-公开
公开(公告)号：WO2022192083A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/018909
申请日：2022-03-04
申请人： ILLUMINA, INC.
发明人： MATHER, Brian , XI, Weixian
IPC分类号： C12Q1/6837 , C12Q1/6874 , C12Q1/68 , B01J19/00 , C09D149/00 , C08F8/00 , B82Y30/00 , C08F220/56 , C08F220/60
摘要： In some examples, a method of coupling oligonucleotides to a polymer is provided. Inactive moieties in a first region of a polymer may be selectively irradiated with light, while inactive moieties in a second region of the polymer are not irradiated, to generate first active moieties in the first region of the polymer. The first active moieties may be coupled to first oligonucleotides. The inactive moieties in the second region of the polymer may be irradiated with light to generate second active moieties in the second region of the polymer. The second active moieties may be coupled to second oligonucleotides.

3. 发明申请

WO2017200917A1 FEET OF SOLAR COLLECTOR SUPPORT STRUCTURES, JOINTS BETWEEN FEET OF SOLAR COLLECTOR SUPPORT STRUCTURES AND CONCRETE, AND METHODS OF FORMING THE SAME 审中-公开
标题翻译：太阳能收集器支撑结构的脚，太阳能收集器支撑结构的脚与混凝土之间的接合处，以及形成相同的方法
公开(公告)号：WO2017200917A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/032643
申请日：2017-05-15
申请人： ALION ENERGY, INC.
发明人： BAILEY, Sean , FRENCH, Adam , HOLLAND, Rodney, Hans , FRENCH, Tristan , CAISON, Christopher, C. , KINGSLEY, Mark
IPC分类号： H02S20/10 , F24J2/52 , F24J2/54 , H02S20/20 , H02S20/21 , H02S20/22
摘要： A method for installing a solar collector can include slip-forming a concrete track including a groove; curing the concrete track; placing a foot of a support structure of a solar collector in the groove; and applying adhesive between the foot and groove. Curing the concrete track optionally can include maintaining wetness of the concrete track for a sufficient period of time after slip-forming the concrete track. The foot optionally can include at least one of an aperture and a tab, and the adhesive flows through the aperture or around the tab. A foot of a support structure of a solar collector also is provided. The foot can be configured to be inserted into a groove and comprising a back wall, a first side wall including a first side tab, a second side wall including a second side tab, a third side wall, a fourth side wall, and a bottom wall.
摘要翻译：用于安装太阳能收集器的方法可包括：滑动成形包括凹槽的混凝土轨道; 固化混凝土轨道; 将太阳能收集器的支撑结构的脚放置在凹槽中; 并在脚和凹槽之间施加粘合剂。可选地固化混凝土轨道可以包括在滑动形成混凝土轨道之后将混凝土轨道的湿度保持足够的时间段。脚可选地可以包括孔和突片中的至少一个，并且粘合剂流过孔或围绕突片。还提供太阳能收集器的支撑结构的脚。该脚可以构造成插入到凹槽中并且包括后壁，包括第一侧翼片的第一侧壁，包括第二侧翼片的第二侧壁，第三侧壁，第四侧壁和底部壁。

4. 发明申请

WO2017147149A2 NESTED PACKAGING FOR PHARMACEUTICAL PRODUCTS, AND METHODS OF DISTRIBUTING PHARMACEUTICAL PRODUCTS USING SAME 审中-公开
标题翻译：用于制药产品的巢式包装和使用相同方式分销制药产品的方法
公开(公告)号：WO2017147149A2
公开(公告)日：2017-08-31
申请号：PCT/US2017/018871
申请日：2017-02-22
申请人： CELGENE CORPORATION
发明人： CORTES, Edy , ADATTE, Thierry
CPC分类号： B65D77/042 , A61J1/035 , A61K31/454 , B65B7/16 , B65B43/10 , B65B61/20 , B65B2220/16 , B65D5/02 , B65D5/4212 , B65D77/22 , G06Q30/00
摘要： A pharmaceutical product can be distributed to respective patients in a plurality of jurisdictions. First and second jurisdictions can have different labeling requirements than each other. A plurality of inner containers each store the pharmaceutical product, the pharmaceutical product being in a dosage form and in a package approved by each jurisdiction of the plurality. An inner container can be sealed within a first outer container including labeling required by the first jurisdiction and not required by the second jurisdiction. Another inner container can be sealed within a second outer container including labeling required by the second jurisdiction and not required by the first jurisdiction. The sealed first and second outer containers respectively can be distributed to the first and second jurisdictions.
摘要翻译：药品可以分配给多个辖区中的各个患者。第一和第二管辖区可以有不同的标签要求。多个内部容器各自储存药物产品，药物产品以剂型和由多个多个区域的每个辖区批准的包装中。内部容器可以密封在第一外部容器内，包括第一管辖区所要求的标签，而第二管辖区不需要。另一个内部容器可以密封在第二外部容器内，包括第二管辖区所要求的并且第一管辖区不需要的标签。密封的第一和第二外部容器分别可以分配到第一和第二辖区。

5. 发明申请

WO2015157161A1 FLEXIBLE LEAD FRAME FOR MULTI-LEG PACKAGE ASSEMBLY 审中-公开
标题翻译：用于多重包装组件的柔性引线框架
公开(公告)号：WO2015157161A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/024484
申请日：2015-04-06
申请人： ALPHABET ENERGY, INC.
发明人： LORIMER, Adam , CHASE, Jordan , CRANE, Douglas , BEERA, Sasi, Bhushan , ARORA, Hitesh , AGUIRRE, Mario
IPC分类号： H01L35/02 , H01L35/32 , H01L35/34
CPC分类号： H01L35/32 , H01L35/34
摘要： Thermoelectric structures include a flexible substrate; a plurality of conductive shunts; and a plurality of thermoelectric legs that are in thermal and electrical communication with the thermoelectric legs via thermal and electrical paths. In some embodiments, the paths are through apertures in the flexible substrate, and the flexible substrate can be substantially out of the thermal and electrical paths. Some embodiments include a circuit board coupled to the flexible substrate, and a bend in the flexible substrate can be disposed between the plurality of conductive shunts and the circuit board. In some embodiments, a plurality of perforations are defined through the flexible substrate and can be configured to rupture responsive to a temperature condition that otherwise would damage one or more of the thermal and electrical paths, said rupture inhibiting such damage. Other embodiments, and methods, are provided.
摘要翻译：热电结构包括柔性基板; 多个导电分流器; 以及多个热电腿，其通过热和电路与热电腿热电连通。在一些实施例中，路径穿过柔性基底中的孔，并且柔性基底可以基本上不在热和电路径之外。一些实施例包括耦合到柔性基板的电路板，并且柔性基板中的弯曲部可设置在多个导电分流器和电路板之间。在一些实施例中，通过柔性基底限定多个穿孔，并且可以被配置为响应于否则会损坏热路径和电路径中的一个或多个的温度条件而破裂，所述破裂抑制这种损伤。提供了其他实施例和方法。

6. 发明申请

WO2023034150A1 METHODS AND SYSTEMS OF GENERATING CAMERA MODELS FOR CAMERA CALIBRATION 审中-公开
公开(公告)号：WO2023034150A1
公开(公告)日：2023-03-09
申请号：PCT/US2022/041751
申请日：2022-08-26
申请人： QUARTUS ENGINEERING INCORPORATED
发明人： MELROSE, Jesse , PEARSON, Matthew , LISS, Jordan , WETHERILL, Julia , DUNNE, Brian
IPC分类号： G06T7/80
摘要： Methods of generating a camera model are provided. A robotic assembly is used to move a calibration assembly relative to a camera assembly through a series of poses. The calibration assembly comprises a calibration target and markers. The camera assembly comprises a mount, a camera having a field of view, and markers. The predetermined series of poses, together, cause the calibration target to pass through the field of view of the camera. The camera is used to generate a respective image of the calibration target. A tracker is used, to determine respective locations in space of the markers. A transformation function is generated that maps onto a three-dimensional space the stored coordinates and determined locations in space of the markers and features of the calibration target. The transformation functions are used to generate a model of parameters of the camera. Systems are also provided.

7. 发明申请

WO2023278744A1 DETECTING METHYLCYTOSINE USING A MODIFIED BASE OPPOSITE TO THE METHYLCYTOSINE 审中-公开
公开(公告)号：WO2023278744A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035786
申请日：2022-06-30
申请人： ILLUMINA, INC.
发明人： BROWN, Colin , SHULTZABERGER, Sarah , BRUSTAD, Eric
IPC分类号： C12Q1/6827
摘要： Examples provided herein are related to detecting methylcytosine using a modified base opposite to the methylcytosine. A methylcytosine in a first polynucleotide including a plurality of cytosines may be detected, using a method that includes hybridizing the first polynucleotide to a second polynucleotide. The second polynucleotide may include a modified base opposite to the methylcytosine. The methylcytosine may be detected using the modified base. For example, the modified base may include a fluorophore. The methylcytosine may be detected using fluorescence from the fluorophore responsive to excitation light.

8. 发明申请

WO2022211998A1 POLYPEPTIDE NANOPORES SYNTHETICALLY FUNCTIONALIZED WITH POSITIVELY CHARGED SPECIES, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2022211998A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/019802
申请日：2022-03-10
申请人： ILLUMINA, INC.
发明人： SAVAGIAN, Lisa , SIMPSON, Burton , PARK, Sang , BOYANOV, Boyan , MANDELL, Jeffrey, G. , MCDONALD, Seth, M.
IPC分类号： G01N33/487 , C12Q1/6869 , G01N27/414
摘要： Polypeptide nanopores synthetically functionalized with positively charged species, and methods of making and using the same, are provided herein. In some examples, a polypeptide nanopore includes a first side, a second side, a channel extending through the first and second sides, and a mutated amino acid residue. The mutated amino acid residue may be synthetically functionalized with a positively charged species that inhibits translocation of cations through the channel.

9. 发明申请

WO2022192191A1 ANALYZING EXPRESSION OF PROTEIN-CODING VARIANTS IN CELLS 审中-公开
公开(公告)号：WO2022192191A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/019258
申请日：2022-03-08
申请人： ILLUMINA, INC.
发明人： XU, Hongxia , LIU, Tong , XIAO, Shi, Min , CAO, Dan , QUIJANO, Victor , FARH, Kai-How , SUN, Mohan
IPC分类号： C12N15/10 , C12N15/86 , C12Q1/6806 , C12N15/102 , C12N15/1065 , C12N2310/20 , C12N2740/16043
摘要： Analyzing expression of protein-coding variants in cells is provided herein. A method may include replacing a protein coding-region of the DNA in a cell with a donor vector including a variant of the protein-coding region and a first barcode identifying that variant. The cell may generate mRNA including an expression of the variant and an expression of the first barcode. A second barcode corresponding to the cell may be coupled to the mRNA. The mRNA, having the second barcode coupled thereto, may be reverse transcribed into complementary cDNA. The cDNA may be sequenced. The donor vector or cDNA may be sequenced using amplicon sequencing. The donor vector sequence and the cDNA sequence may be correlated to identify the variant and the cell's expression of the variant.

10. 发明申请

WO2022140254A1 COMPOSITIONS AND METHODS FOR CAPTURING AND AMPLIFYING TARGET POLYNUCLEOTIDES USING MODIFIED CAPTURE PRIMERS 审中-公开
公开(公告)号：WO2022140254A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064342
申请日：2021-12-20
申请人： ILLUMINA, INC.
发明人： BLACK, Hayden , ARMIJO, Esteban , LESSARD-VIGER, Mathieu
IPC分类号： C12Q1/6837 , C12Q1/6832 , C12Q1/6853
摘要： A composition for capturing target polynucleotides at a surface of a substrate is provided. The composition may include a plurality of capture primers coupled to the surface of the substrate and including modified nucleic acids; and a plurality of orthogonal capture primers coupled to the surface of the substrate and including modified nucleic acids. The modified nucleic acids of the capture primers may include locked nucleic acid (LNA), peptide nucleic acid (PNA), or super T. The modified nucleic acids of the orthogonal capture primers may include locked nucleic acid (LNA), peptide nucleic acid (PNA), or super T.

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