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1. 发明申请

WO2013116175A3 REDUCED SUGAR SYRUPS AND METHODS OF MAKING REDUCED SUGAR SYRUPS 审中-公开
公开(公告)号：WO2013116175A3
公开(公告)日：2013-08-08
申请号：PCT/US2013/023530
申请日：2013-01-29
申请人： TATE & LYLE INGREDIENTS AMERICAS LLC , VERENIUM CORPORATION
发明人： MEDHEKAR, Rohit , HOFFMAN, Andrew, Joseph
IPC分类号： C12P19/14 , A23L2/60 , A23L1/236 , A61K8/60 , A61K47/26 , C13K1/06
摘要： A reduced sugar syrup having an advantageously low viscosity is prepared by hydrolysis of starch or starchy material using a particular type of alpha amylase enzyme which yields a saccharide distribution having a low DP1-2 and low DP11 + content. The DP4 content of the syrup may be favorably increased by using a maltotetragenic alpha amylase enzyme in combination with the aforementioned alpha amylase enzyme. The syrup is useful in the production of food, beverage, animal feed, animal health and nutrition, pharmaceutical, and cosmetic compositions and may be combined with a high intensity sweetener to provide a composition capable of being substituted for conventional corn syrups.

2. 发明申请

WO2009018449A1 TAILORED MULTI-SITE COMBINATORIAL ASSEMBLY 审中-公开
标题翻译：定制多地点组合装配
公开(公告)号：WO2009018449A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071771
申请日：2008-07-31
申请人： VERENIUM CORPORATION , TAN, Xuqiu
发明人： TAN, Xuqiu
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C12N15/102 , C12N15/1024
摘要： The present invention provides a novel method of producing a plurality of modified polynucleotides having different combinations of various mutations at multiple sites by a tailored multi-site combinatorial assembly, comprising adding at least two or at least three primers to a double stranded template polynucleotide in a single reaction mixture, wherein the primers are not overlapping, and wherein each of the primers comprise at least one mutation different from the other primers, wherein at least one primer is a forward primer that can anneal to a minus strand of the template and at least one primer is a reverse primer that can anneal to a plus strand of the template, and subjecting the reaction mixture to a polymerase extension reaction to yield a plurality of extended modified polynucleotides from the at least three primers. The method can be performed without employing a ligation step prior to transforming the extended modified polynucleotides into a cell. The plurality of extended modified polynucleotides can be treated with an enzyme for destroying the template polynucleotide prior to transforming in to the cell.
摘要翻译：本发明提供了一种通过定制的多位点组合组合产生多个具有多个位点的不同突变组合的多个修饰的多核苷酸的新方法，包括向双链模板多核苷酸中添加至少两个或至少三个引物单反应混合物，其中引物不重叠，并且其中每个引物包含与其它引物不同的至少一个突变，其中至少一个引物是可以与模板的负链退火的至少一个引物，并且至少一个引物是可以与模板的正链退火的反向引物，并且使反应混合物进行聚合酶延伸反应，以从至少三种引物产生多个延伸的修饰的多核苷酸。在将延伸的修饰的多核苷酸转化成细胞之前，可以不使用连接步骤进行该方法。多个延伸修饰的多核苷酸可以在用于在转化到细胞之前破坏模板多核苷酸的酶处理。

3. 发明申请

WO2008118176A2 LASE ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：编码酶的核酸，编码和制备和使用它们的方法
公开(公告)号：WO2008118176A2
公开(公告)日：2008-10-02
申请号：PCT/US2007/069877
申请日：2007-05-29
申请人： VERENIUM CORPORATION , WEINER, David , VARVAK, Alexander , RICHARDSON, Toby , PODAR, Mircea , BURKE, Ellen , HEALEY, Shaun
发明人： WEINER, David , VARVAK, Alexander , RICHARDSON, Toby , PODAR, Mircea , BURKE, Ellen , HEALEY, Shaun
IPC分类号： C12N9/88
CPC分类号： C12N9/88
摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.
摘要翻译：本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽可用于各种药物，农业和工业环境。

4. 发明申请

WO2008036863A3 PHOSPHOLIPASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2008036863A3
公开(公告)日：2008-03-27
申请号：PCT/US2007/079109
申请日：2007-09-21
申请人： VERENIUM CORPORATION , O'DONOGHUE, Eileen , BARTON, Nelson, R.
发明人： O'DONOGHUE, Eileen , BARTON, Nelson, R.
IPC分类号： C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
摘要： The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.

5. 发明专利

TW201441243A 編碼聚木糖酶含密碼子突變之基因审中-公开
简体标题：编码聚木糖酶含密码子突变之基因
公开(公告)号：TW201441243A
公开(公告)日：2014-11-01
申请号：TW103108201
申请日：2014-03-10
申请人：凡瑞寧恩公司 , VERENIUM CORPORATION
发明人：譚蘇奎 , TAN, XUQIU
IPC分类号： C07H21/04
CPC分类号： C12N9/2482 , A23L29/06 , C11D3/38636 , C12N9/248 , C12P7/06 , C12P19/14 , C12Y302/01008 , Y02E50/17
摘要：本發明提供編碼聚木糖酶之多核苷酸序列。更特定而言，本發明提供編碼聚木糖酶含密碼子突變之多核苷酸序列。
简体摘要：本发明提供编码聚木糖酶之多核苷酸串行。更特定而言，本发明提供编码聚木糖酶含密码子突变之多核苷酸串行。

6. 发明专利

TW201442641A 動物飼料酵素萃取审中-公开
简体标题：动物饲料酶萃取
公开(公告)号：TW201442641A
公开(公告)日：2014-11-16
申请号：TW103103282
申请日：2014-01-28
申请人：凡瑞寧恩公司 , VERENIUM CORPORATION
发明人：帕普克里斯汀娜 , POP, CRISTINA , 索巴克亞尼I 二世 , SOLBAK, ARNE I., JR. , 哈斯登戴文波特艾瑞安 , HUSTON DAVENPORT, ADRIENNE
IPC分类号： A23K1/165 , B01D11/04
CPC分类号： C12Q1/42 , C07K1/145 , C12Q1/25 , G01N33/573 , G01N2333/916
摘要：本發明提供一種用於自經高溫下處理之飼料球粒萃取酵素的飼用分析法及緩衝液。本發明之另一實施例為量測自動物飼料萃取之酵素添加劑的酵素活性、量測自動物飼料萃取之酵素的量，或量測該兩者。在一個實施例中，該酵素為動物飼料添加劑，諸如植酸酵素。
简体摘要：本发明提供一种用于自经高温下处理之饲料球粒萃取酶的饲用分析法及缓冲液。本发明之另一实施例为量测自动物饲料萃取之酶添加剂的酶活性、量测自动物饲料萃取之酶的量，或量测该两者。在一个实施例中，该酶为动物饲料添加剂，诸如植酸酶。

7. 发明专利

TW201512400A 植酸酶审中-公开
公开(公告)号：TW201512400A
公开(公告)日：2015-04-01
申请号：TW103108256
申请日：2014-03-10
申请人：凡瑞寧恩公司 , VERENIUM CORPORATION
发明人：譚蘇奎 , TAN, XUQIU , 索巴克亞尼I , SOLBAK, ARNE I.
IPC分类号： C12N9/16 , C12N15/55 , C12N15/78 , C12N15/81 , C12R1/39 , C12R1/84
CPC分类号： C12N9/16 , C12Y301/03008
摘要：本發明提供具有植酸酶活性之多肽及編碼該等植酸酶之多核苷酸序列。該基因以至少7g/L至40g/L之量表現該植酸酶。該等植酸酶具有較高比活性，在低pH保留活性且在高溫保留活性。該植酸酶可用於眾多組合物中，包含食品、飼料、醫藥及清潔。
简体摘要：本发明提供具有植酸酶活性之多肽及编码该等植酸酶之多核苷酸串行。该基因以至少7g/L至40g/L之量表现该植酸酶。该等植酸酶具有较高比活性，在低pH保留活性且在高温保留活性。该植酸酶可用于众多组合物中，包含食品、饲料、医药及清洁。

8. 发明申请

WO2014164458A1 GENES WITH CODON MUTATIONS ENCODING XYLANASE 审中-公开
标题翻译：具有编码XYLANASE的编码突变的基因
公开(公告)号：WO2014164458A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/022484
申请日：2014-03-10
申请人： VERENIUM CORPORATION
发明人： TAN, Xuqiu
IPC分类号： C12N15/55 , C12N15/56 , C12N9/24
CPC分类号： C12N9/2482 , A23L29/06 , C11D3/38636 , C12N9/248 , C12P7/06 , C12P19/14 , C12Y302/01008 , Y02E50/17
摘要： The present disclosure provides for a polynucleotide sequences encoding a xylanase. More specifically, the present disclosure provides for polynucleotide sequences with codon mutations encoding a xylanase.
摘要翻译：本公开提供了编码木聚糖酶的多核苷酸序列。更具体地，本公开提供了编码木聚糖酶的具有密码子突变的多核苷酸序列。

9. 发明申请

WO2014149985A1 CELLULASE AND PHYTASE INHIBITOR 审中-公开
标题翻译：纤维素酶和植物抑制剂
公开(公告)号：WO2014149985A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/021734
申请日：2014-03-07
申请人： VERENIUM CORPORATION
发明人： POP, Cristina , WU, Yi
IPC分类号： A61K38/47
CPC分类号： C12N9/96 , C08L2203/02 , C12N9/16 , C12N9/2437
摘要： At acidic and neutral pH, Pemulen 1622 inhibited Cellulase and Phytase from hydrolyze their substrates, beta-glucan and phytic acid, respectively, without interfering with the spectroscopic method of detection. Previously, the mechanism of inhibition has been unknown, but experiments suggested that Pemulen 1622 decreased the concentration of available substrate or it bound competitively to the enzyme active site.
摘要翻译：在酸性和中性pH下，Pemulen 1622分别抑制纤维素酶和植酸酶水解其底物β-葡聚糖和植酸，而不干扰光谱检测方法。以前，抑制机制是未知的，但是实验表明，Pemulen 1622降低了可利用底物的浓度，或者与酶活性位点竞争性地结合。

10. 发明申请

WO2011046812A1 PHOSPHOLIPASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：磷脂，核酸编码方法及其使用方法
公开(公告)号：WO2011046812A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/051903
申请日：2010-10-08
申请人： VERENIUM CORPORATION , BARTON, Nelson, R. , HITCHMAN, Tim, S. , LYON, Jonathan, D. , O'DONAGHUE, Eileen , WALL, Mark, A.
发明人： BARTON, Nelson, R. , HITCHMAN, Tim, S. , LYON, Jonathan, D. , O'DONAGHUE, Eileen , WALL, Mark, A.
IPC分类号： C07H21/00 , C07K14/45
CPC分类号： C12N9/16 , A61K38/465 , C07K16/40 , C10L1/02 , C11D3/38627 , C12Q1/44 , C12Y301/04011 , G01N33/573 , G01N2333/916 , G01N2500/04
摘要： Phosphatidyhnositol-specific phospholipase C (PI-PLC) enzymes, nucleic acids encoding them, antibodies that bind specifically to them, and methods for making and using them are disclosed lndustnal methods and products comprising use of these phosphohpases are also provided Further provided are methods for hydration of non hydratable phospholipids (NHPs) within a lipid matrix to enable migration of NHPs to an oil-water interface, thereby allowing the NHPs to be reacted and/or removed from the lipids Further provided is a method for removing NHPs, hydratable phospholipids, and lecithins from vegetable oils to produce a degummed oil or fat product that can be used for food production and/or non-food applications.
摘要翻译：公开了磷脂酰肌醇特异性磷脂酶C（PI-PLC）酶，编码它们的核酸，与它们特异性结合的抗体，以及制备和使用它们的方法，并且还提供了包含使用这些磷酸酶的产物。在脂质基质内水合非水合磷脂（NHP）以使NHP迁移到油 - 水界面，从而允许NHP从脂质中反应和/或去除。另外提供了一种除去NHP，可水合磷脂，和来自植物油的卵磷脂以产生可用于食品生产和/或非食品应用的脱胶油或脂肪产品。

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