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1. 发明授权

US10450571B2 Small interfering RNA (siRNA) for the therapy of type 2 (ADO2) autosomal dominant osteopetrosis caused by CLCN7 (ADO2 CLCN7-dependent) gene mutation 有权
公开(公告)号：US10450571B2
公开(公告)日：2019-10-22
申请号：US15313221
申请日：2015-05-21
申请人： Università degli Studi dell'Aquila
发明人： Anna Maria Teti , Nadia Rucci , Mattia Capulli , Antonio Maurizi
IPC分类号： C07H21/04 , C12N15/113
摘要： The present invention lies in the field of molecules known as “small interfering RNA” with therapeutic applications. siRNAs have the ability to reduce gene expression in an extremely specific way (1). These are small sequences of double-strand RNA, normally used in laboratory to modify cell function, which revolutionized cell biology by allowing previously precluded molecular manipulations.

2. 发明申请

WO2014020515A1 A PROCESS FOR THE SYNTHESIS OF CA (OH) 2 NANOPARTICLES BY MEANS OF IONIC EXCHANGE RESINS 审中-公开
标题翻译：通过离子交换树脂合成CA（OH）2纳米粒子的方法
公开(公告)号：WO2014020515A1
公开(公告)日：2014-02-06
申请号：PCT/IB2013/056195
申请日：2013-07-29
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： VOLPE, Roberto , TAGLIERI, Giuliana , DANIELE, Valeria , DEL RE, Giovanni
IPC分类号： C09C1/02 , C01F11/02 , C04B2/02
CPC分类号： C01F11/02 , B82Y30/00 , C01P2004/04 , C01P2004/64 , C04B2/02 , C04B2/06 , C09C1/02
摘要： The present invention relates to a process for the synthesis of Ca(OH)2 nanoparticles by means of ionic exchange resins, the obtained nanoparticles and the use thereof as consolidating and protective product in the preservation and consolidation of the calcareous architectural surfaces.
摘要翻译：本发明涉及一种通过离子交换树脂合成Ca（OH）2纳米颗粒的方法，所得到的纳米颗粒及其作为在钙质建筑表面的保存和固结中的固结和保护产品的用途。

3. 发明申请

WO2023002065A2 FUNGUS STRAIN AND USES THEREOF 审中-公开
公开(公告)号：WO2023002065A2
公开(公告)日：2023-01-26
申请号：PCT/EP2022/070846
申请日：2022-07-25
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： BENEDETTI, Manuel , MATTEI, Maria Benedetta , GIOVANNONI, Moira
IPC分类号： C12N1/14 , C12N9/14 , C12N9/88 , C12P21/00 , C07K14/385 , C12N1/145 , C12P2203/00 , C12R2001/80
摘要： The present invention refers to a Penicillium sumatraense (P. sumatraense) strain comprising in its genome: a) an RNA polymerase II second largest subunit (RPB2) gene sequence having 100%, 99%, or 98% sequence identity with the nucleic acid of SEQ ID NO: 1; b) β-tubulin (BenA) gene sequence having 100%, 99%, or 98% sequence identity with the nucleic acid of SEQ ID NO: 2; c) Calmodulin (CaM) gene sequence having 100%, 99%, or 98% sequence identity with the nucleic acid of SEQ ID NO: 3; and d) an Internal Transcribed Spacer (ITS) sequence having 100%, 99%, or 98% sequence identity with the nucleic acid of SEQ ID NO: 4 and further comprising in its genome, a gene comprising or consisting of a sequence having 100, 99, 98, 97, 96, 95, 94, 93, 92, 91, 90, 89, 88, 87, 86 or 85% sequence identity with SEQ ID NO:30 and/or wherein said strain produces an enzyme that comprises or consists of an amino acid sequence having 100, 99, 98, 97, 96, 95, 94, 93, 92, 91, 90, 89, 88 or 87% sequence identity with SEQ ID NO: 80 or functional fragments comprising the catalytic domain.

4. 发明申请

WO2014155215A1 METHOD AND APPARATUS FOR MONITORING THE PERSONAL EXPOSURE TO STATIC OR QUASI- STATIC MAGNETIC FIELDS 审中-公开
标题翻译：用于监测个人暴露于静态或准静态磁场的方法和装置
公开(公告)号：WO2014155215A1
公开(公告)日：2014-10-02
申请号：PCT/IB2014/059469
申请日：2014-03-05
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： GALANTE, Angelo , PLACIDI, Giuseppe
IPC分类号： A61N2/00
CPC分类号： A61N1/08 , G01R33/12 , G01R33/288
摘要： The present invention refers to an apparatus and a method for making an automatic "environmental" dosimeter, for environments characterized by the need for surveillance for purposes of protection of staff or visitors being admitted thereto, due to the presence of static or quasi-static magnetic fields.
摘要翻译：本发明涉及一种用于制造自动“环境”剂量计的装置和方法，其特征在于为了保护被允许的工作人员或访客的目的而需要监视的环境，由于存在静态或准静态磁领域。

5. 发明申请

WO2019229632A1 HYDROMETALLURGICAL METHOD FOR THE RECOVERY OF BASE METALS AND PRECIOUS METALS FROM A WASTE MATERIAL 审中-公开
公开(公告)号：WO2019229632A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/054381
申请日：2019-05-27
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： BIRLOAGA, Ionela , VEGLIO', Francesco
IPC分类号： C22B7/00 , C22B3/00
摘要： The present invention relates to a hydrometallurgical method for the recycling and recovery of base metals, such as copper, tin, lead and nickel, and precious metals, such as gold and silver, from electronic boards or printed circuits of electrical and electronic equipment. It also relates to the recovery of palladium and platinum from waste catalytic converters.

6. 发明申请

WO2019215583A1 HYDROMETALLURGICAL METHOD FOR THE TREATMENT OF PERMANENT MAGNETS 审中-公开
公开(公告)号：WO2019215583A1
公开(公告)日：2019-11-14
申请号：PCT/IB2019/053691
申请日：2019-05-06
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： BIRLOAGA, Ionela , VEGLIO', Francesco
IPC分类号： C22B3/16 , C22B1/248 , C22B3/38 , C22B3/22 , C22B7/00 , C22B59/00
摘要： The present invention describes a hydrometallurgical process which has the main aim of recovering the precious elements contained in waste permanent magnets. The method is applicable to waste neodymium (Nd) magnets.

7. 发明申请

WO2017060840A1 USE OF HTRA1 FOR EARLY DETECTION OF COLORECTAL CANCER 审中-公开
标题翻译：使用HTRA1早期检测彩色癌
公开(公告)号：WO2017060840A1
公开(公告)日：2017-04-13
申请号：PCT/IB2016/055979
申请日：2016-10-06
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： ALTOBELLI, Emma
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/96425
摘要： The invention relates to a novel test for the early diagnosis of colorectal cancer (CRC),. The test measures the expression decrease of HtrA1 protein in plasma samples. Its application implies either the use of HtrA1 alone or in combination with the immunochemical fecal occult blood test (iFOBT). The latter application is called "combined test". The new test offers the advantage of affording greater sensitivity than the most reliable available fecal occult blood test (FOBT). It may be hypothesized that the test could be used for routine population-based CRC screening, either alone or combined, before patients who are positive for fecal occult blood are referred for colonoscopy.
摘要翻译：本发明涉及一种用于结直肠癌（CRC）早期诊断的新型检测方法。该测试测量血浆样品中HtrA1蛋白的表达降低。其应用意味着单独使用HtrA1或与免疫化学粪便潜血试验（iFOBT）组合使用。后一种应用被称为“组合测试”。新测试提供了比最可靠的可靠的粪便潜血试验（FOBT）提供更大的灵敏度的优点。可以假设，在将粪便潜血阳性的患者称为结肠镜检查之前，该检测可以单独使用或组合用于常规基于人群的CRC筛查。

8. 发明申请

WO2015177743A1 SMALL INTERFERING RNA (SIRNA) FOR THE THERAPY OF TYPE 2 (ADO2) AUTOSOMAL DOMINANT OSTEOPETROSIS CAUSED BY CLCN7 (ADO2 CLCN7-DEPENDENT) GENE MUTATION 审中-公开
标题翻译：用于由CLCN7（ADO2 CLCN7依赖）基因突变引起的类型2（ADO2）自体主导性OSTEOPETROSIS治疗的小干扰RNA（SIRNA）
公开(公告)号：WO2015177743A1
公开(公告)日：2015-11-26
申请号：PCT/IB2015/053730
申请日：2015-05-21
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： TETI, Anna Maria , RUCCI, Nadia , CAPULLI, Mattia , MAURIZI, Antonio
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2320/34
摘要： The present invention lies in the field of molecules known as "small interfering RNA" with therapeutic applications. siRNAs have the ability to reduce gene expression in an extremely specific way (1). These are small sequences of double-strand RNA, normally used in laboratory to modify cell function, which revolutionized cell biology by allowing previously precluded molecular manipulations.
摘要翻译：本发明在于具有治疗应用的称为“小干扰RNA”的分子领域。 siRNA具有以非常特异的方式降低基因表达的能力（1）。这些是双链RNA的小序列，通常用于实验室来修饰细胞功能，其通过允许先前排除的分子操作来改变细胞生物学。

9. 发明申请

WO2017060840A4 USE OF HTRA1 FOR EARLY DETECTION OF COLORECTAL CANCER 审中-公开
标题翻译： HTRA1用于早期检测大肠癌
公开(公告)号：WO2017060840A4
公开(公告)日：2017-06-01
申请号：PCT/IB2016055979
申请日：2016-10-06
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA
发明人： ALTOBELLI EMMA
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/96425
摘要： The invention relates to a novel test for the early diagnosis of colorectal cancer (CRC),. The test measures the expression decrease of HtrA1 protein in plasma samples. Its application implies either the use of HtrA1 alone or in combination with the immunochemical fecal occult blood test (iFOBT). The latter application is called "combined test". The new test offers the advantage of affording greater sensitivity than the most reliable available fecal occult blood test (FOBT). It may be hypothesized that the test could be used for routine population-based CRC screening, either alone or combined, before patients who are positive for fecal occult blood are referred for colonoscopy.
摘要翻译：本发明涉及用于结肠直肠癌（CRC）早期诊断的新型测试。该测试测量血浆样品中HtrA1蛋白的表达降低。其应用意味着要么单独使用HtrA1，要么与免疫化学粪便隐血试验（iFOBT）联合使用。后者的应用被称为“组合测试”。新测试提供了比最可靠的大便隐血试验（FOBT）更高的灵敏度。可以假设该检验可用于常规基于群体的CRC筛查，无论是单独使用还是联合使用，在将粪便潜血阳性的患者转诊为结肠镜检查之前。

10. 发明申请

WO2017017628A1 SYNTHESIS OF TRIDIMENSIONAL GRAPHENE OXIDE BASED MATERIALS 审中-公开
标题翻译：三甲基氧化铁基材料的合成
公开(公告)号：WO2017017628A1
公开(公告)日：2017-02-02
申请号：PCT/IB2016/054502
申请日：2016-07-28
申请人： UNIVERSITÀ DEGLI STUDI DELL'AQUILA , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： IPPOLITI, Rodolfo , ANGELUCCI, Francesco , ARDINI, Matteo , OTTAVIANO, Luca , PERROZZI, Francesco , SANTUCCI, Sandro , MORANDI, Vittorio , ORTOLANI, Luca , PALERMO, Vincenzo
IPC分类号： C01B31/04
CPC分类号： C01B32/194 , C12N9/0006 , C12N11/14 , C12Y111/01015
摘要： The present invention relates to a three-dimensional structure made of graphene comprising at least two layers substantially constituted by graphene oxide therebetween one intermediate layer is interposed comprising protein rings or protein tubes of nanometric size as well as a process for implementing said structure. The present invention also relates to the use as adhesive, for implementing three-dimensional structures based upon hydrophilic materials, a protein capable of forming rings or tubes of nanometric dimensions having two surfaces with annular shape above and below a plane of the ring, not necessarily identical surfaces, at least partially hydrophobic and equipped with amino acids active from a redox point of view. Moreover, the present invention further relates to the manufacturing of 3D materials based upon graphene oxide functionalized with different metal species. The mineralisation of such materials is possible thanks to the engineering of the inner cavity of ring-like proteins with peptides equipped with amino acids capable of linking fixedly several metals.
摘要翻译：本发明涉及由石墨烯制成的三维结构，其包括基本上由氧化石墨烯构成的至少两层，其间插入包含蛋白质环或纳米尺寸的蛋白质管的中间层以及用于实施所述结构的方法。本发明还涉及作为粘合剂的用途，用于实现基于亲水材料的三维结构，能够形成具有在环的平面上方和下方具有环形形状的具有环形形状的环的纳米尺寸的管的蛋白质，不一定相同的表面，至少部分疏水并且配备有从氧化还原角度看活性的氨基酸。此外，本发明还涉及基于用不同金属物质官能化的氧化石墨烯的3D材料的制造。这种材料的矿化是可能的，这是由于具有装配有能够固定地连接几种金属的氨基酸的肽的环状蛋白质的内腔的工程化。

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