会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF BUPRENORPHINE WITH MINIMAL INITIAL BURST
    • 用最小初始爆炸物持续释放布可宁的可植入聚合物
    • WO2007139744A2
    • 2007-12-06
    • PCT/US2007/012046
    • 2007-05-18
    • TITAN PHARMACEUTICALS, INC.PATEL, Rajesh, A.BUCALO, Louis, R.
    • PATEL, Rajesh, A.BUCALO, Louis, R.
    • A61K9/06
    • A61K9/0024A61K9/1682
    • The present invention provides compositions, methods, and kits for treatment of pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time, and exhibits minimal initial burst upon subcutaneous implantation. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. Devices of the invention are washed with ethanol for greater than 30 minutes prior to subcutaneous implantation or have release characteristics of a device that has been washed with ethanol for greater than 30 minutes, such as a low peak to steady state plasma level ratio.
    • 本发明提供用于治疗疼痛的组合物,方法和试剂盒。 本发明提供了一种生物相容性非可矫治的聚合物装置,其通过线性释放动力学连续释放丁丙诺啡以延长时间,并且在皮下植入时表现出最小的初始爆发。 丁丙诺啡通过孔被释放,孔通过其被封装在其中的聚合物基质的表面。 该装置可以皮下给予需要用丁丙诺非连续治疗的个体。 在皮下植入之前,本发明的装置用乙醇洗涤超过30分钟,或者已经用乙醇洗涤超过30分钟的装置(例如低峰值 - 稳态血浆水平比)的释放特性。