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1. 发明专利

JP2004533699A Material of high-energy capacity to the nano-structure based 审中-公开
公开(公告)号：JP2004533699A
公开(公告)日：2004-11-04
申请号：JP2002510926
申请日：2001-06-11
申请人：ザユニバーシティオブノースカロライナ − チャペルヒルThe University Of North Carolina − Chapel Hill
发明人：ボガオ， , サロンシンハ， , オットー，ゼット．ゾウ，
IPC分类号： G01N27/30 , B32B3/00 , B82Y30/00 , C01B31/30 , D01F9/12 , G01N27/26 , G01N27/416 , H01L29/41 , H01L29/43 , H01M4/04 , H01M4/38 , H01M4/485 , H01M4/525 , H01M4/58 , H01M4/583 , H01M4/02 , H01M4/48
CPC分类号： H01M4/38 , H01M4/583 , Y10S977/70 , Y10S977/778 , Y10S977/835 , Y10S977/948 , Y10T428/24917
摘要： A nanostructure based material is capable of accepting-and reacting with an alkali metal such as lithium. The material exhibits a reversible capacity ranging from at least approximately 900 mAh/g-1,500 mAh/g. The high capacity of the material makes it attractive for a number of applications, such as a battery electrode material.

2. 发明专利

JP2004511884A x-ray generating mechanism that uses the electron field emission cathode 审中-公开
公开(公告)号：JP2004511884A
公开(公告)日：2004-04-15
申请号：JP2002535152
申请日：2001-09-27
申请人：ザユニバーシティオブノースカロライナ − チャペルヒルThe University Of North Carolina − Chapel Hill
发明人：ゾウ，　オットー，　ゼット． , ル，　ジアンピング
IPC分类号： G21K5/02 , A61B6/00 , A61B6/03 , G21K5/08 , H01J35/06 , H01J35/08 , H05G1/00 , H05G1/34
CPC分类号： H01J35/14 , A61B6/032 , A61B6/4021 , A61B6/4028 , A61B6/405 , A61B6/4488 , A61B6/482 , B82Y10/00 , H01J35/065 , H01J35/22 , H01J2201/30469 , H01J2235/064 , H01J2235/068 , H05G1/34 , Y10S977/939
摘要：Ｘ線発生装置は、少なくとも４Ａ／ｃｍ
２の放出電子流密度を有するナノ構造（１１１０）含有材料から少なくとも一部が形成されている電界放出カソードを含む。カソード（１１１０）と、ゲート又はアノード（１１３０）との間で冷カソード放出電子を集束することが容易であり、かつ異なるアノード材料（１１３０）で電子ビームを集束するために、高いエネルギー変換効率及びコンパクトな構造（１１００）が実現され、エネルギーの異なるパルスＸ線放射を１つの装置から発生させることが可能である。

3. 发明专利

JP2004534662A At least some of the aspects of e-how to create a nanotube-based material with improved field emission characteristics (Statement on research or development funded by the federal government) the present invention, the government under contract number n00014-98-1-05907 It was supported by. The government may have certain rights in this invention. 审中-公开
公开(公告)号：JP2004534662A
公开(公告)日：2004-11-18
申请号：JP2003505401
申请日：2002-06-18
申请人：ザユニバーシティオブノースカロライナ − チャペルヒルThe University Of North Carolina − Chapel Hill
发明人：オットー，ゼット．ゾウ，
IPC分类号： B82B3/00 , C01B21/082 , C01B31/02 , C01G31/00 , C01G39/06 , C01G41/00 , C30B33/00 , H01J1/304 , H01J9/02
CPC分类号： B82Y10/00 , C30B29/605 , C30B33/00 , H01J9/025 , H01J2201/30469 , Y10S977/742 , Y10S977/842
摘要：電子的な仕事関数を減少する方法、電子の電界放出に対する電界閾値を減少する方法、半導性の性質を金属の性質に変換する方法、フェルミ準位状態の電子密度を増加する方法、および電子の電界放出位置での密度を増加する方法であって、ナノチューブ含有材料中に開口を形成する工程と、その開口の少なくともいくつか中にアルカリ金属などの外来種を導入する工程と、その開口を閉じて、その外来種で満たされたカプセルを形成し、これらのカプセルを用いて電界放出カソードとフラットパネルディスプレイとを形成する工程とを含む方法。

4. 发明申请

WO2022076556A2 THERAPEUTIC ADENO-ASSOCIATED VIRUS DELIVERY OF FUKUTIN RELATED PROTEIN (FKRP) FOR TREATING DYSTROGLYCANOPATHY. DISORDERS INCLUDING LIMB GIRDLE 21 审中-公开
公开(公告)号：WO2022076556A2
公开(公告)日：2022-04-14
申请号：PCT/US2021/053768
申请日：2021-10-06
申请人： ASKLEPIOS BIOPHARMACEUTICAL, INC. , SYNPROMICS LTD , THE UNIVERSITY OF NORTH CAROLINA CHAPEL HILL , CHILDERS, Martin K. , YANEZ-CUNA, Jorge Omar , IGLESIAS GONZALEZ, Juan Manuel , COOPER, Sinclair , EVRIPIOTI, Antonia , ROBERTS, Michael L. , TRETIAKOVA, Anna , SUAREZ, Lester , NGUYEN, Anh , LOW, SiewHui , XIAO, Xiao
发明人： CHILDERS, Martin K. , YANEZ-CUNA, Jorge Omar , IGLESIAS GONZALEZ, Juan Manuel , COOPER, Sinclair , EVRIPIOTI, Antonia , ROBERTS, Michael L. , TRETIAKOVA, Anna , SUAREZ, Lester , NGUYEN, Anh , LOW, SiewHui , XIAO, Xiao
IPC分类号： A61K48/00 , C12N15/864 , A61K38/17 , C07K14/47
摘要： Disclosed herein are various optimized nucleic acids encoding the fukutin-related protein (FKRP). Recombinant vectors comprising the optimized nucleic acid (e.g. operatively linked to a muscle specific promoter), such as recombinant adeno-associated virus vectors, for expressing the protein (e.g. in skeletal and cardiac muscle), and therapeutic compositions contains the vectors are also disclosed. Therapeutic methods of administration of the vectors to a subject for the treatment of a subject with a dystroglycanopathy disorder (e.g., limb-girdle muscular dystrophy 2I) are also disclosed.

5. 发明申请

WO2004049901A2 METHODS OF TREATING CEREBRAL ISCHEMIA 审中-公开
标题翻译：方法治疗脑缺血
公开(公告)号：WO2004049901A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/036499
申请日：2003-11-14
申请人： THE UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL , KATZ, Laurence, M.
发明人： KATZ, Laurence, M.
IPC分类号： A61B
CPC分类号： A61K38/10
摘要： The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The hypothermia is induced by administering to the mammal an effective dose of a neurotensin analog that is capable of crossing the blood-brain barrier and the comprises neo-tryptophan.
摘要翻译：本发明提供治疗哺乳动物脑缺血的方法，其包括在哺乳动物脑缺血之前，期间或之后诱导哺乳动物体温降低。通过向哺乳动物施用能够穿过血脑屏障并且包含新色氨酸的有效剂量的神经降压素类似物来诱导低体温。

6. 发明申请

WO2005014889A2 DEPOSITION METHOD FOR NANOSTRUCTURE MATERIALS 审中-公开
标题翻译：用于纳米结构材料的沉积方法
公开(公告)号：WO2005014889A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/020150
申请日：2004-06-24
申请人： THE UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL? , OH, Soojin? , ZHOU, Otto, Z.?
发明人： OH, Soojin? , ZHOU, Otto, Z.?
IPC分类号： C25D
CPC分类号： C25D13/22 , B82Y10/00 , B82Y30/00 , C25D5/022 , C25D13/00 , C25D15/00
摘要： A method for depositing a patterned coating of a nanostructure material onto a substrate includes: (1) forming a solution or suspension of containing the nanostructure material; (2) masking at least a portion of at least one surface of the substrate (3) immersing electrodes in the solution, the substrate upon which the nanostructure material is to be deposited acting as one of the electrodes or is electrically connected to at least one electrode; (4) applying a direct and/or alternating current electrical field between the two electrodes for a certain period of time thereby causing the nanostructure materials in the solution to migrate toward and attach themselves to the substrate electrode; and (5) subsequent optional processing.
摘要翻译：将纳米结构材料的图案化涂层沉积到基材上的方法包括：（1）形成含有纳米结构材料的溶液或悬浮液; （2）掩蔽所述基板（3）的至少一个表面的至少一部分浸渍在所述溶液中，所述纳米结构材料将被沉积在其上的基板用作所述电极之一或者电连接到至少一个电极; （4）在两个电极之间施加直接和/或交流的电场一段时间，从而导致溶液中的纳米结构材料迁移并附着到衬底电极上; 和（5）随后的可选处理。

7. 发明申请

WO2003083128A3 METHOD FOR ASSEMBLING NANO OBJECTS 审中-公开
公开(公告)号：WO2003083128A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/006345
申请日：2003-03-03
申请人： THE UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL , ZHOU, Otto, Z. , SHIMODA, Hideo , OH, Soojin
发明人： ZHOU, Otto, Z. , SHIMODA, Hideo , OH, Soojin
IPC分类号： D01F9/12
摘要： A method for the self-assembly of a macroscopic structure with a pre-formed nano object is provided. The method includes processing a nano object to a desired aspect ratio and chemical functionality and mixing the processed nano object with a solvent to form a suspension. Upon formation of the suspension, a substrate (100) is inserted into the suspension. By either evaporation of the solvent, changing the pH value of the suspension, or changing the temperature of the suspension, the nano objects within the suspension deposit onto the substrate (100) in an orientational order. In addition, a seed crystal may be used in place of the substrate (100) thereby forming single-crystals and free-standing membranes of the nano-objects.

8. 发明申请

WO2003063195A1 LARGE-AREA INDIVIDUALLY ADDRESSABLE MULTI-BEAM X-RAY SYSTEM 审中-公开
标题翻译：大面积个别寻址多波束X射线系统
公开(公告)号：WO2003063195A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/000537
申请日：2003-01-09
申请人： THE UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL , ZHOU, Otto, Z. , LU, Jianping , QIU, Qi
发明人： ZHOU, Otto, Z. , LU, Jianping , QIU, Qi
IPC分类号： H01J35/00
CPC分类号： H01J35/14 , A61B6/032 , A61B6/4028 , B82Y10/00 , H01J35/065 , H01J35/22 , H01J2201/30469 , H01J2235/064 , H01J2235/068 , H05G1/34
摘要： A structure to generate x-rays has a plurality of stationary and individually electrically addressable field emissive electron sources (402) with a substrate composed of a field emissive material, such as carbon nanotubes. Electrically switching the field emissive electron sources at a predetermined frequency field emits electrons in a programmable sequence toward an incidence point on a target. The generated x-rays correspond in frequency and in position to that of the field emissive electron source. The large-area target (404) and array or matrix of emitters (402) can image objects (416) from different positions and/or angles without moving the object or the structure (400) and can produce a three dimensional image. The x-ray system is suitable for a variety of applications including industrial inspection/quality control. Analytical instruments, security systems such as airport security inspection systems and medical imaging, such as computed tomography.
摘要翻译：用于产生X射线的结构具有多个具有由诸如碳纳米管之类的场发射材料构成的衬底的固定和单独可电寻址的场发射电子源（402）。以预定频率电场电场切换场致发射电子源以可编程序列朝向目标上的入射点发射电子。产生的x射线的频率和位置与场发射电子源的频率和位置相对应。大面积目标（404）和发射器（402）的阵列或矩阵可以从不同位置和/或角度对物体（416）进行成像，而不移动物体或结构（400）并且可以产生三维图像。 x射线系统适用于各种应用，包括工业检测/质量控制。分析仪器，安全系统，如机场安全检查系统和医学成像，如计算机断层扫描。

9. 发明申请

WO2019104157A1 HIGHLY SPECIFIC ZIKA NEUTRALIZING HUMAN ANTIBODIES 审中-公开
公开(公告)号：WO2019104157A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/062233
申请日：2018-11-21
申请人： THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE , THE UNIVERSITY OF NORTH CAROLINA CHAPEL HILL
发明人： DIEHL, Sean , DE SILVA, Aravinda , COLLINS, Matthew , MCELVANY, Ben , TU, Huy
IPC分类号： A61K39/00 , A61K39/12 , A61K39/395 , A61K39/42 , A61P31/14 , C07K16/10
摘要： Provided herein, in some embodiments, are compositions of Zika- specific antibodies and antigen-binding fragments thereof and methods of using said antibodies and antigen-binding fragments.

10. 发明申请

WO2014144860A1 CORRECTORS ACTING THROUGH MSD1 OF CFTR PROTEIN 审中-公开
标题翻译：通过CFD蛋白质的MSD1进行校正
公开(公告)号：WO2014144860A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029449
申请日：2014-03-14
申请人： VERTEX PHARMACEUTICALS INCORPORATED , THE UNIVERSITY OF NORTH CAROLINA CHAPEL HILL
发明人： VAN GOOR, Fredrick, F. , HOFFMAN, Beth, Jennifer , DELA ROSA, Oxana, Adolfovna , CYR, Douglas
IPC分类号： A61P11/00 , C12Q1/00
CPC分类号： A61K31/443 , A61K31/407 , A61K31/47 , A61K31/69 , A61K45/06 , C12Q1/34 , G01N33/5023 , G01N33/5035 , G01N33/5041 , G01N33/6872 , G01N2333/914 , G01N2440/36 , G01N2500/02 , G01N2800/382 , A61K2300/00
摘要： The present disclosure provides methods for treating Cystic Fibrosis in a subject by administering to the subject a corrector agent capable of acting through MSD1 during the biosynthesis of CFTR protein. The disclosure also provides methods of screening for new corrector agents capable of acting through MSD1 during the biosynthesis of a CFTR protein.
摘要翻译：本公开提供了通过向受试者施用能够在CFTR蛋白质的生物合成过程中通过MSD1作用的校正剂来治疗受试者的囊性纤维化的方法。本公开还提供了在CFTR蛋白的生物合成过程中筛选能够通过MSD1作用的新校正剂的方法。

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