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1. 发明申请

WO1989004955A1 APPARATUS AND METHOD FOR COMBINED CLOSED AND OPEN TUBE SAMPLING 审中-公开
标题翻译：用于组合封闭和开放管采样的装置和方法
公开(公告)号：WO1989004955A1
公开(公告)日：1989-06-01
申请号：PCT/US1988003629
申请日：1988-10-21
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： TECHNICON INSTRUMENTS CORPORATION , UFFENHEIMER, Kenneth, F.
IPC分类号： G01N01/00
CPC分类号： G01N35/1097 , G01N35/1004
摘要： Sampler apparatus and method are provided and include both closed (12) and open (10) tube samplers, and selector valve (20) operable to select therebetween for sample supply to automated sample analysis apparatus (22). A shear valve (18) divides the samples into separate sample quantities for independent sample quantity analysis by multi-channel sample analysis apparatus. A pressure equilibration chamber (108) prevents vacuum build-up in the closed tube sampler to insure the supply of consistent sample quantities therefrom. A source of a pressurized rinse solution (102) is provided; and is operatively connected to the sampler apparatus in such manner as to insure the particularly thorough rinsing and cleansing of all relevant sample components to remove sample residue therefrom between sampling operations, thereby reducing sample carryover to levels below those of clinical significance.
摘要翻译：提供了采样装置和方法，包括封闭（12）和开放（10）管取样器，以及可操作以在其间选择供自动化样品分析装置（22）供样的选择阀（20）。剪切阀（18）通过多通道样品分析装置将样品分成单独的样品量用于独立样品量分析。压力平衡室（108）防止密封管取样器中的真空积聚，以确保从中提供一致的样品量。提供加压冲洗溶液（102）的来源; 并且以这样的方式可操作地连接到取样器装置，以便确保所有相关样品组分的特别彻底的漂洗和清洁以在取样操作之间从其中除去样品残余物，从而将样品携带量降低到低于临床意义的水平。

2. 发明申请

WO1990015333A1 APPARATUS AND METHOD FOR THE SELF-LEVELLING OF LIQUID IN A CONTAINER 审中-公开
标题翻译：用于容器中液体自动调节的装置和方法
公开(公告)号：WO1990015333A1
公开(公告)日：1990-12-13
申请号：PCT/US1989002345
申请日：1989-05-30
申请人： TECHNICON INSTRUMENTS CORPORATION , BOCK, Malcolm, G.
发明人： TECHNICON INSTRUMENTS CORPORATION
IPC分类号： G01N35/00
CPC分类号： G01F23/0053 , B01L3/0293 , B01L3/502 , B01L3/5027 , B01L2200/0605 , B01L2200/0642 , B01L2300/0832 , B01L2300/087 , B01L2400/0406
摘要： New and improved apparatus and method for the self-levelling of a liquid in a container (10) to a precisely predetermined level, with a concave meniscus, are provided and comprise a plurality of ribs (14, 16) defining with the container inner surface (28) one or more capillary pathways formed by the rib-container surface junctures (30, 32, 34, 36) operatively associated with the container (10) and operable upon contact therewith by the liquid within the container (10) to flow liquid out of the container (10) until the liquid has assumed the precisely predetermined level within the container (10) and to provide a concave liquid meniscus at that level. Central support of a predetermined volume of an immiscible isolation liquid on the concave meniscus of the liquid in the container (10) of the precisely determined liquid level is also disclosed.
摘要翻译：提供了用于将容器（10）中的液体自动调平到具有凹弯月面的精确预定水平的新的和改进的装置和方法，并且包括多个限定有容器内表面的肋（14,16）（28）由与所述容器（10）可操作地相关联的所述肋 - 容器表面接合部（30,32,34,36）形成的一个或多个毛细管路径，并且在与所述容器（10）内的液体接触时可操作以流动液体离开容器（10），直到液体已经在容器（10）内假定精确预定的水平并且在该水平面上提供凹的液体弯液面。还公开了在精确确定的液位的容器（10）中的液体的凹弯月面上的预定体积的不混溶隔离液体的中心支撑。

3. 发明申请

WO1988004052A1 METHOD AND APPARATUS FOR CONVEYING INFORMATION IN A LIQUID SAMPLE TRANSPORT SYSTEM 审中-公开
标题翻译：在液体样品运输系统中输送信息的方法和装置
公开(公告)号：WO1988004052A1
公开(公告)日：1988-06-02
申请号：PCT/US1987002772
申请日：1987-10-28
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： TECHNICON INSTRUMENTS CORPORATION , BURNS, Donald, A. , CASSADAY, Michael, M.
IPC分类号： G01N35/08
CPC分类号： G01N35/08
摘要： A transport system in which a liquid sample is conveyed in a flowing stream via a conduit from one location to another. An apparatus and method are further provided, whereby information with respect to the sample is conveyed in the stream. The method comprises: causing the liquid sample to flow through the conduit; incorporating with the sample or the stream a sequence of aliquots of a fluid immiscible with the sample or stream, the sequence or the aliquots having at least one parameter corresponding to the information; detecting the parameter at a location downstream from where the aliquots were introduced; and interpreting the detected parameter to provide the information.
摘要翻译：一种运输系统，其中液体样品在流动的流中经由导管从一个位置输送到另一个位置。还提供了一种装置和方法，由此在流中传送关于样品的信息。该方法包括：使液体样品流过导管; 将所述样品或所述物流与所述样品或物流不混溶的液体的等分试样序列，所述序列或等分试样具有对应于所述信息的至少一个参数; 在等分试样引入的下游位置检测参数; 并解释检测到的参数以提供信息。

4. 发明申请

WO1990008307A1 INTEGRATED SAMPLER FOR CLOSED AND OPEN SAMPLE CONTAINERS 审中-公开
标题翻译：用于封闭和开放样品容器的集成采样器
公开(公告)号：WO1990008307A1
公开(公告)日：1990-07-26
申请号：PCT/US1988004630
申请日：1988-12-29
申请人： TECHNICON INSTRUMENTS CORPORATION , UFFENHEIMER, Kenneth, F.
发明人： TECHNICON INSTRUMENTS CORPORATION
IPC分类号： G01N01/00
CPC分类号： G01N35/1079 , G01N35/1004 , G01N35/1095
摘要： Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers theron on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierceable stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe. Air segmented rinse liquid is provided for the sampling needle, transfer conduits, transfer valve, and dispensing well to minimize sample liquid carryover with regard to the sample liquids from the closed containers; and a surfactant is included with the rinse to lubricate the sampling needle to facilitate the piercing thereby of the closed sample liquid container stoppers and minimize the generation of sample liquid-contaminating stopper particles. For use with aqueous sampler rinse liquids, hydrophobic sample liquid transfer conduits, transfer valve, and dispensing well surfaces are provided; and an isolation liquid which selectively wets those surfaces to the substantial exclusion of the aqueous sample and rinse liquids, is utilized in conjunction with the rinse liquid to further minize sample liquid carryover. The open sample liquid containers and the dispensing well are supported at essentially the same level relative to the probe to maximize sampling accuracy thereby. A detector is provided to detect sample liquid identification as supported from the sample liquid container support component, and to differentiate between open and closed sample liquid containers for operation of the sample liquid analysis system probe in accordance therewith.
摘要翻译：提供了集成的取样器装置和方法，并且包括样品液体容器支撑部件，其可操作以随机地支撑封闭和打开的样品液体容器。来自开放的样品液体容器的样品液体直接存在于样品液体分析系统探针中以便进入; 而来自封闭的样品液体容器的样品液体，其采样样品液体容器的形式被样品可刺穿的塞子封闭，通过采样针组件和连接的样品液体传输导管和转移阀转移到样品液体分配良好的通过相同的样品液体分析系统探针的访问。为采样针，传输管道，转移阀和分配井提供空气分段冲洗液体，以使关于来自密闭容器的样品液体的样品液体残留最小化; 并且冲洗液中包含表面活性剂以润滑采样针以促进封闭的样品液体容器塞子的刺穿，并最小化样品液体污染塞子颗粒的产生。为了与含水取样器冲洗液体一起使用，提供疏水性样品液体输送管道，转移阀和分配井表面; 并且与冲洗液一起使用选择性润湿那些表面以将水性样品和冲洗液体基本排除的隔离液体，以进一步减少样品液体携带量。打开的样品液体容器和分配孔相对于探针基本上被支撑在相同的水平上，从而最大化采样精度。提供检测器以检测来自样品液体容器支撑部件的支撑物的样品液体鉴定，并且区分开和关的样品液体容器，以便根据样品液体分析系统探针操作。

5. 发明申请

WO1989000697A2 APPARATUS AND METHOD FOR SEPARATION AND/OR FORMATION OF IMMISCIBLE LIQUID STREAM 审中-公开
标题翻译：用于分离和/或形成不可混溶液体流的装置和方法
公开(公告)号：WO1989000697A2
公开(公告)日：1989-01-26
申请号：PCT/US1988002153
申请日：1988-06-21
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： TECHNICON INSTRUMENTS CORPORATION , CASSADAY, Michael, M. , CHRISTIANO, Vito, F. , VASUDEVA, Bachalli
IPC分类号： G01N35/00
CPC分类号： G01N35/08 , B01D17/0214 , B01D17/04 , B01D17/045 , Y10T436/118339
摘要： Apparatus and method are provided for the substantial separation on a continuous flow basis of immisicible liquids flowing as a common stream, with one of said liquids substantially encapsulating another of said liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit. Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immisicible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit. A liquid processing system including the conduit is provided wherein the liquid introduction apparatus are utilized to form the common liquids stream with one of the liquids being substantially encapsulated within the other of the liquids at a first location in the system; and the liquid separator apparatus are utilized to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream at a second location in the system which is downstream of the first location. As representatively configured in the herein disclosed preferred embodiments, the apparatus and method are applied to automated continuous flow sample liquid analysis systems wherein one of the liquids is an aqueous sample liquid, and the other of the liquids is an isolation liquid which selectively "wets" the hydrophobic inner surface of the flow conduit to the substantial exclusion of the aqueous sample liquids, and which functions to substantially encapsulate the aqueous sample liquids in the common liquids stream; and, for such application, the apparatus and method provide for significant increase in the accuracy of the sample liquid analysis results.
摘要翻译：用于在连续流动的基础上分离以共同物流形式流动的不混溶液体的装置和方法，这些液体中的一种在流动导管中含有另一种液体。导管包括内表面，其被一种液体选择性“润湿”而排除另一种液体。液体分离装置被布置在所述导管和分离出来的液体，或至少一种液体的一部分，公共电流液体同时与隔板接触的电流流过装置内的管道。还公开了一种用于将基于连续流的液体引入与第一液体不混溶且流入管道的另一液体的流动流中的设备和方法。导管包括内表面，该内表面可被液体中的一种选择性地“润湿”以排除这些液体中的另一种。引入装置中的流体被布置在所述管道与形成在管道中连续流动的一个共同的液体流，液体的一个被封装用这些液体中的一种，当液体混合到液体导入装置在管道中的高度。

6. 发明申请

WO1989000447A1 NEW AND IMPROVED APPARATUS AND METHOD FOR THE SEPARATION OF IMMISCIBLE LIQUIDS 审中-公开
标题翻译：用于分离易溶液体的新的改进的装置和方法
公开(公告)号：WO1989000447A1
公开(公告)日：1989-01-26
申请号：PCT/US1988002154
申请日：1988-06-21
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： TECHNICON INSTRUMENTS CORPORATION , BUHL, Steven, N. , AHMAD, Syed, I. , GRASSICK, Arden
IPC分类号： B01D17/022
CPC分类号： G01N1/34 , B01D17/0202 , B01D17/10 , G01N2001/4061 , Y10T436/117497 , Y10T436/118339
摘要： New and improved apparatus and method for the separation of immiscible liquids are provided, and comprise the use of separator means having a surface which is preferentially ''wettable'' by one of the liquids to the substantial exclusion of another of the liquids. In use, the liquids are flowed from a common liquids source onto said surface with the one liquid being sorbed thereby to the substantial exclusion of the other liquid to thus substantially separate the liquids. The separator means surface may be maintained essentially level to retain the substantially separated liquid thereon, or may be inclined to result in the flow of the same therefrom under the influence of the force of gravity. Alternatively, the separator means may be made of a liquid-permeable material to permit the flow of the substantially separated liquid therethrough and therefrom under the influence of the force of gravity. The apparatus and method are particularly adapted to the substantial separation of aqueous sample liquids from hydrophobic isolation liquids which encapsulate the same; and are readily combinable with a sample liquid reaction device to effectively combine the sample liquid separation and reaction operations. The material of the separator means may be inherently hydrophobic, or may be rendered super-hydrophobic by the surface coating thereof with a super-hydrophobic coating material.
摘要翻译：提供了用于分离不混溶液体的新的和改进的装置和方法，并且包括使用具有由其中一种液体优先“可润湿”的表面的分离器装置，从而基本排除另一种液体。在使用中，液体从普通液体源流出到所述表面上，其中一种液体被吸收，从而基本排除其它液体，从而基本上分离液体。分离器装置的表面可以保持基本上水平以将基本上分离的液体保持在其上，或者可以在重力的影响下倾斜以导致其相同的流动。或者，分离器装置可以由液体可渗透的材料制成，以允许基本分离的液体在重力的影响下通过其流过。该装置和方法特别适用于水性样品液体与其封装的疏水隔离液体的实质分离; 并且可以容易地与样品液体反应装置组合，以有效地组合样品液体分离和反应操作。分离器装置的材料可以是固有疏水性的，或者可以通过其超疏水涂层材料的表面涂层使其变得超疏水。

7. 发明专利

ES2029715T3 未知
公开(公告)号：ES2029715T3
公开(公告)日：1992-09-01
申请号：ES88305175
申请日：1988-06-07
申请人： TECHNICON INSTRUMENTS CORPORATION(A DELAWARE CORPORATION)
发明人： MAWHIRT, JAMES A. , DIFLORA, JOSEPH E. , MCCANDLESS, WILLIAM J. C. , WARD, GEORGE H.
IPC分类号： G01N35/04 , B01L9/06 , G01N35/02
摘要： A test tube holder includes an elongated tubular member (12) for receiving a test tube (18), which tubular member pivotably supports a pivot member (14), and co-operating latch members (58,80) are provided on the tubular member and pivot member whereby two or more such holders can be lined side-by-side via the latch members. The pivotal relationship between the tubular members and pivot members permits pivotal movement of one test tube holder with respect to the longitudinal axis of another test tube holder. A pivotal connection between the latch members of adjacent test tube holders also permits tilting of one test tube holder with respect to another test tube holder in the linkage. An adapter member (16) for holding the test tube (18) is insertable in the tubular member and pivot member assembly. The adapter member accommodates one size test tube and can be interchanged with another adapter member that accommodates another size test tube. Thus, the linkage of test tube holders can include test tubes of different size. The relative pivotal movement between test tube holders in the linkage can permit stacking of the linkage in a fan-fold arrangement.

8. 发明专利

CA2024166A1 COMPOUNDS AND REAGENT COMPOSITIONS AND THEIR USE IN THE QUANTITATIVE DETERMINATION OF RETICULOCYTES IN WHOLE BLOOD 未知
公开(公告)号：CA2024166A1
公开(公告)日：1991-06-02
申请号：CA2024166
申请日：1990-08-28
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： FAN, SOPHIE S. , FISCHER, GENA
IPC分类号： G01N21/64 , C07D219/08 , C09B15/00 , G01N15/14 , G01N33/48 , G01N33/80
摘要： Quaternized derivatives of acridine orange are used for quantitatively determining reticulocyte levels in whole blood by fluorescence flow cytometry techniques. The quaternized derivatives of acridine orange are of the general formula: wherein X is a benzyl group of formula wherein R1 is hydrogen or fluorine, and R2 is fluorine, trifluoromethyl or hydrogen; or X may be a hydroxyethylene group; and gamma is bromide or iodide.

9. 发明专利

ES2029478T3 未知
公开(公告)号：ES2029478T3
公开(公告)日：1992-08-16
申请号：ES87305748
申请日：1987-06-29
申请人： TECHNICON INSTRUMENTS CORPORATION(A DELAWARE CORPORATION)
发明人： RACZKOWSKI, JAN
IPC分类号： G01N35/08 , B29C35/04 , B29C35/06 , B29C35/16 , B29C55/30 , B29C71/00 , B29C71/02 , B29K27/18

10. 发明公开

EP0452308A4 INTEGRATED SAMPLER FOR CLOSED AND OPEN SAMPLE CONTAINERS 失效转让
标题翻译：集成采样器用于封闭和开放样品容器
公开(公告)号：EP0452308A4
公开(公告)日：1992-09-16
申请号：EP89903018
申请日：1988-12-29
申请人： TECHNICON INSTRUMENTS CORPORATION
发明人： UFFENHEIMER, KENNETH, F.
IPC分类号： G01N1/00 , G01N35/10
CPC分类号： G01N35/1079 , G01N35/1004 , G01N35/1095
摘要： Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers theron on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierceable stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe. Air segmented rinse liquid is provided for the sampling needle, transfer conduits, transfer valve, and dispensing well to minimize sample liquid carryover with regard to the sample liquids from the closed containers; and a surfactant is included with the rinse to lubricate the sampling needle to facilitate the piercing thereby of the closed sample liquid container stoppers and minimize the generation of sample liquid-contaminating stopper particles. For use with aqueous sampler rinse liquids, hydrophobic sample liquid transfer conduits, transfer valve, and dispensing well surfaces are provided; and an isolation liquid which selectively wets those surfaces to the substantial exclusion of the aqueous sample and rinse liquids, is utilized in conjunction with the rinse liquid to further minize sample liquid carryover. The open sample liquid containers and the dispensing well are supported at essentially the same level relative to the probe to maximize sampling accuracy thereby. A detector is provided to detect sample liquid identification as supported from the sample liquid container support component, and to differentiate between open and closed sample liquid containers for operation of the sample liquid analysis system probe in accordance therewith.

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