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5. 发明专利

TWI230610B 治療人類免疫不全病毒感染之藥劑套組及醫藥組合物 DOSAGE KITS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING HIV INTECTIONS 失效
简体标题：治疗人类免疫不全病毒感染之药剂套组及医药组合物 DOSAGE KITS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING HIV INTECTIONS
公开(公告)号：TWI230610B
公开(公告)日：2005-04-11
申请号：TW085105807
申请日：1996-05-16
申请人：韋爾克姆方台興有限公司 THE WELLCOME FOUNDATION LIMITED
发明人：大衛.瓦特.貝瑞 DAVID WALTER BARRY , 瑪莎.海德.聖.卡爾 MARTHA HEIDER ST. CLAIR
IPC分类号： A61K
摘要：本發明係關於具有抗-HIV活性之(1S,4R)-順式-4-[2-胺基-6-(環丙基胺基)-9H-嘌呤-9-基]-2-環戊烯-1-甲醇(1592U89)，3'-疊氮基-3'-疊氮胸(zidovudine)及(2R,順式)-4-胺基-1-(2-羥基甲基-1,3-氧硫伍圜-5-基)-(1H)-嘧啶-2-酮(3TC)(或者以(2R，順式)-4-胺基-5-氟-1-(2-羥基甲基-1,3-氧硫伍圜-5-基)-(1H)-嘧啶-2-酮(FTC替代3TC)之治療性組合。本發明亦關於包含該組合之醫藥組合物以及其在治療HIV感染上之用途，該感染包括帶有對核及/或非核抑制劑具抗藥性之HIV突變株之感染。
简体摘要：本发明系关于具有抗-HIV活性之(1S,4R)-顺式-4-[2-胺基-6-(环丙基胺基)-9H-嘌呤-9-基]-2-环戊烯-1-甲醇(1592U89)，3'-叠氮基-3'-叠氮胸(zidovudine)及(2R,顺式)-4-胺基-1-(2-羟基甲基-1,3-氧硫伍圜-5-基)-(1H)-嘧啶-2-酮(3TC)(或者以(2R，顺式)-4-胺基-5-氟-1-(2-羟基甲基-1,3-氧硫伍圜-5-基)-(1H)-嘧啶-2-酮(FTC替代3TC)之治疗性组合。本发明亦关于包含该组合之医药组合物以及其在治疗HIV感染上之用途，该感染包括带有对核及/或非核抑制剂具抗药性之HIV突变株之感染。

6. 发明专利

ES2038829T3 未知
公开(公告)号：ES2038829T3
公开(公告)日：1993-08-01
申请号：ES89310487
申请日：1989-10-12
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： NICHOLSON, RUSSELL
IPC分类号： C07D223/28 , A61K31/00 , A61K31/34 , A61K31/445 , A61K31/54 , A61K31/55 , A61K45/00 , A61P39/02 , C07D279/28 , C07D307/87
摘要： Antidotes to the rat poison flupropadine and substances acting in the same way include compounds which modulate (e.g. inhibit) aminergic systems in the gut or adrenal tissues. Such compounds include tricyclic anti-depressants (e.g. chlorpromazine) and many others.

7. 发明专利

AU2641192A THERAPEUTIC NUCLEOSIDES 未知
公开(公告)号：AU2641192A
公开(公告)日：1993-04-27
申请号：AU2641192
申请日：1992-09-23
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： WAYNE HOWARD MILLER , STANLEY DAWES CHAMBERLAIN , KAREN KATHLEEN BIRON
IPC分类号： C07C69/78 , C07D473/00 , C07F7/18 , C07F9/6561 , C07H9/04

8. 发明专利

AU1912592A CAP FOR A CONTAINER AND OPENING MEANS THEREFOR 未知
公开(公告)号：AU1912592A
公开(公告)日：1993-01-12
申请号：AU1912592
申请日：1992-06-05
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： BRIAN LESLIE OGDEN
IPC分类号： B65D41/34 , B65D50/04 , B65D55/02
摘要： A cap (1) having a top (2) and a depending skirt (3) which receives the neck of a container at its lower end, wherein the skirt (3) is provided at its outer and upper end portion with a first engaging means (6,7) for engaging an annular spanner located around the cap (1), and a seating means (8) at the base of the first engaging means (6,7) on which the annular spanner rests. Preferably the cap is for a medicine container and is circular; In a further enbodiment the cap is a two part child resistant cap designed to provide tamper evidence; There is further provided a medical implement adapted to engage over the cap and a kit comprising the cap and an annular spanner.

9. 发明专利

AU1655192A ANTIVIZAL DIBENZOTHIAZEPINONE DERIVATIVES 未知
公开(公告)号：AU1655192A
公开(公告)日：1992-12-21
申请号：AU1655192
申请日：1992-05-01
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： ROBIN HAMISH NICOL , MARTIN JOHN SLATER , SIMON TEANBY HODGSON
IPC分类号： A61K31/55 , A61K31/554 , A61P31/12 , C07D281/16
摘要： PCT No. PCT/GB92/00805 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19277 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6alkyl, C3-6cycloalkyl or C1-6alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); -NR4R5 where R4 and R5, which may be the same or different, each represent hydrogen or C1-6alkyl; -S(O)mR6, where m is 0, 1, 2 or 3 and R6 represents hydrogen, C1-6alkyl or C3-6cycloakyl; -SO2NR4R5 where R4 et R5 are each as defined above; phenyl, phenylC1-3alkoxy or phenylC1-3alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6alkyl, C1-6alkoxy, hydroxy, nitro, halogen and amino; and -CO2H or -COR7 where R7 is C1-6alkyl or C3-6cycloalkyl; R3 represents hydrogen or C1-4alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.

10. 发明专利

ES2031357T3 未知
公开(公告)号：ES2031357T3
公开(公告)日：1992-12-01
申请号：ES89306468
申请日：1989-06-26
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： BLUMENKOPF, TODD ANDREW , SPECTOR, THOMAS , AVERETT, DEVRON RANDOLPH , MORRISON, ROBERT WILLIAM, JR. , BIGHAM, ERIC CLEVELAND , STYLES, VIRGIL LEE
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/52 , A61K31/522 , C07D473/16 , A61K31/535 , A61K31/70 , A61K45/06 , A61P31/12 , C07D213/53 , C07D213/78 , C07D417/00 , C07D473/18 , C07D473/32
摘要： The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising of an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment or prophylaxis of virus infections, especially viruses of the herpes group.

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