专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

GB201616590D0 Method 未知
公开(公告)号：GB201616590D0
公开(公告)日：2016-11-16
申请号：GB201616590
申请日：2016-09-29
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
摘要： The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

2. 发明专利

GB201617886D0 Method 未知
公开(公告)号：GB201617886D0
公开(公告)日：2016-12-07
申请号：GB201617886
申请日：2016-10-21
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
摘要： A method for determining the presence, absence or amount of two or more target polynucleotides in a sample comprising additional components, the method comprising: (i) contacting the sample with a panel of two or more probes under conditions suitable for hybridisation of the target polynucleotides to the probes, wherein: (a) each probe comprises a non-hybridisation region and a hybridisation region that specifically hybridises to one of the target polynucleotides to form a hybridised probe; and (b) the hybridisation region of a probe of the panel comprises one or more non-natural nucleotides; (ii) contacting the sample prepared in step (i) with a transmembrane pore through which a single stranded polynucleotide but not a double stranded polynucleotide can pass and applying a potential difference to the transmembrane pore such that the hybridised probes in the sample interact with the pore; (iii) measuring current blockades having a duration within a defined window, wherein: (a) the one or more non-natural nucleotides present in the hybridisation region of the probe increase or decrease the duration of the current blockade due to the probe hybridised to its target polynucleotide such that the proportion of current blockades that occur within the window due to the interaction of the hybridised probes with the pore is increased compared to when the corresponding one or more natural nucleotides are present in the hybridisation region; and (b) each hybridised probe gives rise to a current blockade indicative of that probe; and (iv) correlating the measured current blockades with the probes, thereby determining the presence, absence or amount of the two or more target polynucleotides in the sample.

3. 发明申请

WO2021111133A2 MICROFLUIDIC DEVICE FOR PREPARING AND ANALYSING A TEST LIQUID 审中-公开
公开(公告)号：WO2021111133A2
公开(公告)日：2021-06-10
申请号：PCT/GB2020/053096
申请日：2020-12-03
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： BROWN, Clive Gavin , ORTIZ BAHAMON, Pedro Miguel , BOWEN, Rebecca Victoria
IPC分类号： B01L3/00 , B01L2200/0689 , B01L2200/16 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0829 , B01L2300/0864 , B01L2300/0883 , B01L2300/0896 , B01L2300/1805 , B01L2400/0424 , B01L2400/0427 , B01L2400/0481 , B01L2400/06 , B01L2400/0683 , B01L2400/086 , B01L3/502715 , B01L3/502761 , B01L3/502792
摘要： The invention resides in a microfluidic device for analysing a test liquid. The device has a preparation portion between an inlet and an upstream portion of the device, wherein said upstream portion is configured with a sensing chamber for housing a well array and for receiving via the inlet a test liquid to be sensed, and said preparation portion is configured having: a reagent port configured to receive a reagent for interacting with a test liquid to be sensed within the upstream portion; and/or an actuator, operably configured to induce a test liquid from the inlet towards the upstream portion. Between the inlet and respective outlet lies a sole channel. The channel can extend parallel to the substrate, preferably along its entire length. The preparation portion can be configured in a first part, and the upstream portion can be configured in a second part, wherein said first part and second part are connectable such that a sample received and processed in the first part can be passed to the second part for analysis.

4. 发明申请

WO2018100370A1 METHODS AND SYSTEMS FOR CHARACTERIZING ANALYTES USING NANOPORES 审中-公开
公开(公告)号：WO2018100370A1
公开(公告)日：2018-06-07
申请号：PCT/GB2017/053603
申请日：2017-11-29
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： CLARKE, James , WHITE, James , MUSCAT, Richard , KNOT, Jessica Mary May , NATHANI, Ramiz Iqbal , HERON, Andrew John , BRUCE, Mark John , JAYASINGHE, Lakmal Nishantha , CAPROTTI, Domenico , STODDART, David Jackson , BOWEN, Rebecca Victoria , WRIGHT, Christopher James , MOODY, Paul Richard
IPC分类号： C12Q1/6869
摘要： Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g ., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g ., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

5. 发明申请

WO2017149318A1 MUTANT PORES 审中-公开
标题翻译：突变体
公开(公告)号：WO2017149318A1
公开(公告)日：2017-09-08
申请号：PCT/GB2017/050571
申请日：2017-03-02
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： JAYASINGHE, Lakmal , WALLACE, Elizabeth Jayne
IPC分类号： C07K16/12 , C12Q1/68 , G01N33/483
摘要： The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
摘要翻译：本发明涉及CsgG的突变体形式。本发明还涉及使用CsgG的分析物检测和表征。

6. 发明申请

WO2016132124A1 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2016132124A1
公开(公告)日：2016-08-25
申请号：PCT/GB2016/050391
申请日：2016-02-17
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： JAYASINGHE, Lakmal , KILGOUR, John Joseph , WOOD, Neil Roger
IPC分类号： C12N15/00
CPC分类号： G01N33/48721 , B82B3/0047 , C12Q1/6869 , C12Q2565/631 , G06F19/22
摘要： The invention relates to a novel method of producing hetero-oligomeric pores. The invention also relates to hetero-oligomeric pores produced using the method and polynucleotide characterisation using the hetero-oligomeric pores.
摘要翻译：本发明涉及一种产生异低聚合孔的新方法。本发明还涉及使用使用异低聚物孔的方法和多核苷酸表征产生的异寡聚孔。

7. 发明申请

WO2016132123A1 HETERO-PORES 审中-公开
标题翻译：异质孔隙
公开(公告)号：WO2016132123A1
公开(公告)日：2016-08-25
申请号：PCT/GB2016/050390
申请日：2016-02-17
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： BROWN, Clive Gavin , CLARKE, James Anthony , HAMBLEY, Richard George , HERON, Andrew John , JAYASINGHE, Lakmal , MILTON, John , PUGH, Jonathan Bankes , WALLACE, Elizabeth Jayne
IPC分类号： C07K14/35 , C12Q1/68
CPC分类号： C12Q1/6869 , C07K14/35
摘要： The invention relates to hetero-oligomeric pores derived from Msp. The invention also relates to polynucleotide characterisation using the hetero-oligomeric pores.
摘要翻译：本发明涉及源自Msp的异低聚物孔。本发明还涉及使用异低聚物孔的多核苷酸表征。

8. 发明申请

WO2016059417A1 ELECTRICAL DEVICE WITH DETACHABLE COMPONENTS 审中-公开
标题翻译：具有可拆卸组件的电气设备
公开(公告)号：WO2016059417A1
公开(公告)日：2016-04-21
申请号：PCT/GB2015/053066
申请日：2015-10-15
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： BROWN, Clive Gavin , HYDE, Jason Robert , JACKSON, Mark David , MACKETT, Paul Raymond , MCKENDRY, Jonathan Edward , WILTSHIRE, Richard Kenneth John
IPC分类号： B01L3/00 , G01N33/487 , G01R31/28 , H01R3/08 , H01R13/02
CPC分类号： B01L3/502715 , B01L3/50857 , B01L2200/025 , B01L2200/04 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/161 , G01N33/48721 , G01R31/28 , G01R31/44 , H01R3/08 , H01R13/02
摘要： A detachable electrical device can be formed from a kit comprising a pair of component parts adapted for connection to each other, wherein the connected components of the device may be subsequently disconnected, comprising: an array of electrical connectors, each electrical connector comprising an electrically conductive liquid; and an array of electrodes; wherein the arrays can be brought into contact with each other so as to provide a plurality of electrical connections between the electrically conductive liquid of the array of electrical connectors and the electrodes of the array of electrodes, and wherein the electrical connections may be subsequently broken by detaching the electrically conductive liquid from the electrodes of the array.
摘要翻译：可拆卸电气装置可以由包括适于彼此连接的一对部件的套件形成，其中可以随后断开装置的连接部件，包括：一组电连接器，每个电连接器包括导电液体; 和一组电极; 其中阵列可以彼此接触，以便在电连接器阵列的导电液体和电极阵列的电极之间提供多个电连接，并且其中电连接可随后被从阵列的电极分离导电液体。

9. 发明申请

WO2015166276A1 METHOD OF IMPROVING THE MOVEMENT OF A TARGET POLYNUCLEOTIDE WITH RESPECT TO A TRANSMEMBRANE PORE 审中-公开
标题翻译：改进目标多核苷酸相对于透明质子核的运动的方法
公开(公告)号：WO2015166276A1
公开(公告)日：2015-11-05
申请号：PCT/GB2015/051291
申请日：2015-05-01
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： JAYASINGHE, Lakmal , WALLACE, Elizabeth Jayne , PUGH, Jonathan Bankes , HAMBLEY, Richard George , WOOD, Neil Roger , BROWN, Clive Gavin , WHITE, James
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C07K14/35 , C12Q2563/157 , C12Q2565/631
摘要： The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.
摘要翻译：本发明涉及当运动由多核苷酸结合蛋白控制时，改善靶多核苷酸相对于跨膜孔的运动。本发明还涉及改进的跨膜孔和多核苷酸结合蛋白。

10. 发明申请

WO2015166275A1 MUTANT PORES 审中-公开
公开(公告)号：WO2015166275A1
公开(公告)日：2015-11-05
申请号：PCT/GB2015/051290
申请日：2015-05-01
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： CLARKE, James Anthony , HERON, Andrew John , JAYASINGHE, Lakmal , WALLACE, Elizabeth Jayne
IPC分类号： C07K14/35 , C12Q1/68
CPC分类号： C12Q1/6869 , C07K14/35 , C12Q2563/157 , C12Q2565/631
摘要： The invention relates to mutant forms of Msp. The invention also relates to polynucleotide characterisation using Msp.
摘要翻译：本发明涉及Msp的突变形式。本发明还涉及使用Msp的多核苷酸表征。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式