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1. 发明申请

WO2011135440A1 METHODS AND APPARATUS FOR CALIBRATING RESPIRATORY EFFORT FROM PHOTOPLETHYSMOGRAPH SIGNALS 审中-公开
标题翻译：用于校准光电子信号信号的呼吸作用的方法和装置
公开(公告)号：WO2011135440A1
公开(公告)日：2011-11-03
申请号：PCT/IB2011/000906
申请日：2011-04-27
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, Nicholas
发明人： ADDISON, Paul, Stanley , WATSON, James, Nicholas
IPC分类号： A61B5/087 , A61B5/1455
CPC分类号： A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/14551 , A61B5/4818 , A61B5/726 , A61B2560/0223
摘要： Breathing effort of a patient, as determined (for example) from a photoplethysmograph ("PPG") signal from the patient, can be calibrated in relation to air pressure in the patient's respiratory system. This calibration can be done by subjecting the patient to varying amounts of breathing resistance; and for each such amount, concurrently measuring (1) air pressure in the respiratory system (e.g., in the oral/nasal cavity) and (2) breathing effort (from the PPG signal). Use can be made of this calibration, e.g., during a sleep study of the patient. During such a study, breathing effort, again determined from the PPG signal and occurring, for example, during an apneic event of the patient, can be used to infer air pressure in the respiratory system by using the above calibration.
摘要翻译：来自患者的光电容积描记器（“PPG”）信号确定（例如）患者的呼吸能力可以相对于患者呼吸系统中的空气压力进行校准。这种校准可以通过对患者进行不同量的呼吸阻力来进行; 并且对于每个这样的量，同时测量（1）呼吸系统中的空气压力（例如在口腔/鼻腔中）和（2）呼吸努力（来自PPG信号）。可以使用这种校准，例如在患者的睡眠研究期间。在这样的研究中，呼吸的努力再次从PPG信号确定并且例如在患者的呼吸暂停事件期间发生，可以通过使用上述校准来推断呼吸系统中的气压。

2. 发明申请

WO2011041090A1 SYSTEMS AND METHODS FOR NORMALIZING A PLETHYSMOGRAPH SIGNAL FOR IMPROVED FEATURE ANALYSIS 审中-公开
标题翻译：用于正常化用于改进特征分析的PLETHYSMOGRAPH信号的系统和方法
公开(公告)号：WO2011041090A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/048591
申请日：2010-09-13
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James , SETHI, Rakesh , STOUGHTON, Robert , ADDISON, Paul
发明人： WATSON, James , SETHI, Rakesh , STOUGHTON, Robert , ADDISON, Paul
IPC分类号： A61B5/00 , A61B5/021
CPC分类号： A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/14551 , A61B5/1495 , A61B5/72 , A61B5/7239 , A61B5/746
摘要： The present disclosure relates to systems and methods for analyzing and normalizing signals, such as PPG signals, for use in patient monitoring. The PPG signal may be detected using a continuous non- invasive blood pressure monitoring system and the normalized signals may be used to determine whether a recalibration of the system should be performed.
摘要翻译：本公开涉及用于分析和归一化信号的系统和方法，例如用于患者监测的PPG信号。可以使用连续无创血压监测系统来检测PPG信号，并且可以使用归一化信号来确定是否应该执行系统的重新校准。

3. 发明申请

WO2011001134A1 SYSTEMS AND METHODS FOR DETECTING EFFORT EVENTS 审中-公开
标题翻译：用于检测活动的系统和方法
公开(公告)号：WO2011001134A1
公开(公告)日：2011-01-06
申请号：PCT/GB2010/001194
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , CASSIDY, Andrew
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , CASSIDY, Andrew
IPC分类号： A61B5/00 , A61B5/08
CPC分类号： A61B5/14551 , A61B5/02028 , A61B5/08 , A61B5/4818 , A61B5/7239 , A61B5/726
摘要： A method and system for detecting effort events is disclosed. Effort may be determined through feature analysis of the signal as transformed by a continuous wavelet transform, which may be compared against a reference effort measure to trigger an effort event flag that signals the onset and/or severity of an effort event. For example, a respiratory effort measure may be determined based at least in part on a wavelet transform of a photoplethysmograph (PPG) signal and features of the transformed signal. A respiratory reference effort measure may be based at least in part on past values of the respiratory effort measure, and a threshold test may be used to trigger an effort event flag, which may indicate a marked change in respiratory effort exerted by a patient.
摘要翻译：公开了一种用于检测努力事件的方法和系统。可以通过由连续小波变换变换的信号的特征分析来确定努力，其可以与参考努力量度进行比较以触发用于表示努力事件的发作和/或严重性的努力事件标志。例如，可以至少部分地基于光电体积描记器（PPG）信号的小波变换和变换信号的特征来确定呼吸努力测量。呼吸参考努力测量可以至少部分地基于呼吸努力测量的过去值，并且可以使用阈值测试来触发努力事件标志，其可以指示由患者施加的呼吸力的显着变化。

4. 发明申请

WO2011001133A3 DETERMINING A CHARACTERISTIC BLOOD PRESSURE 审中-公开
公开(公告)号：WO2011001133A3
公开(公告)日：2011-01-06
申请号：PCT/GB2010/001186
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , SETHI, Rakesh
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , SETHI, Rakesh
IPC分类号： A61B5/02 , A61B5/08 , A61B5/1455 , A61B5/021
摘要： The present disclosure relates to monitoring a characteristic physiological parameter of a patient during a suitable time period that either precedes or follows a triggering event, such as a clinician/patient interaction, that may negatively impact the physiological parameter. In some embodiments, physiological parameter values falling between one or more pre-set thresholds (R1, R2) may be used to derive the characteristic physiological parameter. In some embodiments, tracking the physiological parameter may provide additional information about the patient's status. In some embodiments, confidence measures may be associated with, or may be used to analyze features of the patient signal to derive information about, the characteristic physiological parameter. The patient signal used to derive a patient's physiological parameter may be of an oscillatory nature or may include oscillatory features (455) that may be analyzed to derive a characteristic respiration rate.

5. 发明申请

WO2010146327A1 DETERMINING DISEASE STATE USING AN INDUCED LOAD 审中-公开
标题翻译：使用诱导负荷确定疾病状态
公开(公告)号：WO2010146327A1
公开(公告)日：2010-12-23
申请号：PCT/GB2010/000841
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/00 , A61B5/024
CPC分类号： A61B5/02007 , A61B5/02416 , A61B5/14551 , A61B5/4884 , A61B5/726
摘要： The present disclosure relates to determining a patient's disease state based at least in part on obtaining or determining certain underlying characteristics, such as vasotone, venous compliance, or ability of the vascular system to drain venous blood, of the patient's vascular system. The characteristics may be obtained by analyzing changes to a patient signal, such as the overall signal change, the rate of change, the shape of the change, changes in signal energy, or changes in the baseline and/or the amplitude of the signal, and/or the time period(s) over which the signal changes, that are caused by inducing a load on the vascular system. In some embodiments, the signal changes may be analyzed by transforming the signal using, for example, a continuous wavelet transform. The patient's health status or disease state may be determined using the one or more vascular system characteristics that influenced the signal change.
摘要翻译：本公开涉及至少部分地基于获得或确定患者血管系统的某些潜在特征（例如血管舒张，静脉顺应性或血管系统排出静脉血的能力）来确定患者的疾病状态。可以通过分析患者信号的变化（例如整体信号变化，变化率，变化的形状，信号能量的变化，或基线的变化和/或信号的幅度）来获得特征，和/或通过在血管系统上引起负载而引起的信号变化的时间段。在一些实施例中，可以使用例如连续小波变换来变换信号来分析信号变化。可以使用影响信号变化的一种或多种血管系统特征来确定患者的健康状况或疾病状态。

6. 发明申请

WO2010142936A1 SIGNAL PROCESSING TECHNIQUES FOR AIDING THE INTERPRETATION OF RESPIRATION SIGNALS 审中-公开
标题翻译：用于消除呼叫信号解释的信号处理技术
公开(公告)号：WO2010142936A1
公开(公告)日：2010-12-16
申请号：PCT/GB2010/000837
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , MCGONIGLE, Scott
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , MCGONIGLE, Scott
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/0002 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/7203 , A61B5/7207 , A61B5/726 , A61B5/7278 , A61B2562/08
摘要： The present disclosure is related to signal processing systems and methods for processing respiration signals. A respiration signal (505) is processed to normalize respiratory feature values in order to improve and/or simplify the interpretation and subsequent analysis of the signal. Data indicative of a signal is received at a sensor and is used to generate a respiration signal. Signal peaks (511, 512, 513, 514) in the respiration signal are identified and signal peak thresholds (510) are determined. The identified signal peaks are adjusted (511a, 512a, 513a, 514a) based on the signal peak threshold values to normalize the respiration signal.
摘要翻译：本公开涉及用于处理呼吸信号的信号处理系统和方法。处理呼吸信号（505）以使呼吸特征值归一化，以改善和/或简化信号的解释和随后的分析。在传感器处接收表示信号的数据，并用于产生呼吸信号。识别呼吸信号中的信号峰值（511,512,513,514），并确定信号峰值阈值（510）。基于信号峰值阈值来调整所识别的信号峰值（511a，512a，513a，514a）以归一化呼吸信号。

7. 发明申请

WO2010038119A2 DETECTING SLEEP EVENTS USING LOCALIZED BLOOD PRESSURE CHANGES 审中-公开
标题翻译：利用局部血压变化检测睡眠事件
公开(公告)号：WO2010038119A2
公开(公告)日：2010-04-08
申请号：PCT/IB2009/006895
申请日：2009-09-17
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James, Nicholas , ADDISON, Paul, Stanley , SETHI, Rakesh
发明人： WATSON, James, Nicholas , ADDISON, Paul, Stanley , SETHI, Rakesh
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/0059 , A61B5/02125 , A61B5/4809 , A61B5/4812 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838
摘要： Techniques for detecting sleep events are disclosed. In some embodiments, a continuous non-invasive blood pressure ("CNIBP") monitoring system may be used to obtain blood pressure values from a subject during a sleep study. Changes in the blood pressure over time may be determined and analyzed in order to identify a sleep event. The localized blood pressure changes may be interpreted in isolation or in combination with other signals collected from the subject.
摘要翻译：公开了用于检测睡眠事件的技术。在一些实施例中，连续无创血压（“CNIBP”）监测系统可用于在睡眠研究期间从受试者获得血压值。可以确定和分析血压随时间的变化以识别睡眠事件。局部血压变化可以单独解释或与从受试者收集的其他信号一起解释。

8. 发明申请

WO2010038118A1 SYSTEM AND METHOD FOR RECALIBRATING A NON- INVASIVE BLOOD PRESSURE MONITORING SYSTEM 审中-公开
标题翻译：用于记录非入血血压监测系统的系统和方法
公开(公告)号：WO2010038118A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/006893
申请日：2009-09-17
申请人： NELLCOR PURITAN BENNETT IRELAND , BAKER, Clark, R., Jr. , ADDISON, Paul, Stanley , WATSON, James, Nicholas
发明人： BAKER, Clark, R., Jr. , ADDISON, Paul, Stanley , WATSON, James, Nicholas
IPC分类号： A61B5/021 , A61B8/04
CPC分类号： A61B5/021 , A61B5/02125 , A61B5/022 , A61B5/02225 , A61B5/1455 , A61B5/7239 , A61B2560/0223 , G16H15/00 , G16H40/40 , G16H40/63
摘要： Techniques for non-invasive blood pressure monitoring are disclosed. Data corresponding to a patient may be received from a hospital information system. The data may include, for example, drug administration data, medical procedure data, medical equipment data, or a combination thereof. Whether a blood pressure monitoring system needs to be recalibrated may be determined, based at least in part on the received data. If it is determined that the blood pressure monitoring system needs to be recalibrated, the recalibration may be performed and at least one blood pressure measurement of the patient may be computed using the recalibrated blood pressure monitoring system.
摘要翻译：公开了用于非侵入性血压监测的技术。可以从医院信息系统接收对应于患者的数据。数据可以包括例如药物管理数据，医疗程序数据，医疗设备数据或其组合。至少部分地基于所接收的数据，可以确定是否需要重新校准血压监测系统。如果确定需要重新校准血压监测系统，则可以执行重新校准，并且可以使用重新校准的血压监测系统来计算患者的至少一个血压测量值。

9. 发明申请

WO2010038117A1 SYSTEMS AND METHODS FOR MAINTAINING BLOOD PRESSURE MONITOR CALIBRATION 审中-公开
标题翻译：用于维持血压监测仪校准的系统和方法
公开(公告)号：WO2010038117A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/006891
申请日：2009-09-17
申请人： NELLCOR PURITAN BENNETT IRELAND , SETHI, Rakesh , CAMPBELL, Shannon, E.
发明人： SETHI, Rakesh , CAMPBELL, Shannon, E.
IPC分类号： A61B5/021 , A61B5/024
CPC分类号： A61B5/021 , A61B5/02007 , A61B5/02108 , A61B5/02416 , A61B5/1455 , A61B5/7257
摘要： Systems and methods are disclosed herein for maintaining the calibration of non¬ invasive blood pressure monitoring devices. Phase components of pulse signals detected by the blood pressure monitoring device are compared to stored baseline phase component values. If the difference exceeds a threshold, the blood pressure monitoring device is recalibrated.
摘要翻译：本文公开了用于维持非侵入式血压监测装置的校准的系统和方法。将由血压监测装置检测的脉冲信号的相位分量与存储的基线相位分量值进行比较。如果差异超过阈值，则对血压监测装置进行重新校准。

10. 发明申请

WO2010007492A1 SYSTEMS AND METHODS USING INDUCED PERTURBATION TO DETERMINE PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：使用诱导性刺激来确定生理参数的系统和方法
公开(公告)号：WO2010007492A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/006217
申请日：2009-07-08
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James, Nicholas , ADDISON, Paul, Stanley , SETHI, Rakesh
发明人： WATSON, James, Nicholas , ADDISON, Paul, Stanley , SETHI, Rakesh
IPC分类号： A61B5/021 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/0051 , A61B5/0053 , A61B5/021 , A61B5/02108 , A61B5/7225 , A61B5/726 , A61B2560/0223
摘要： According to embodiments, systems and methods for non-invasive blood pressure monitoring are disclosed. An exciter may induce perturbations in a subject, and a sensor or probe may be used to obtain a detected signal from the subject. The detected signal may then be used to measure one or more physiological parameters of the patient. For example if the perturbations are based on a known signal, any differences between the known signal and the input signal may be attributable to the patient's physiological parameters. A phase drift between the perturbation signal and the detected signal may be determined from a comparison of the scalograms of the exciter location and the sensor or probe location. From the scalogram comparison, more accurate and reliable physiological parameters may be determined.
摘要翻译：根据实施例，公开了用于非侵入性血压监测的系统和方法。激励器可能引起受试者的扰动，并且可以使用传感器或探针来获得来自受试者的检测信号。然后可以使用检测到的信号来测量患者的一个或多个生理参数。例如，如果扰动基于已知信号，则已知信号和输入信号之间的任何差异可归因于患者的生理参数。扰动信号和检测信号之间的相位漂移可以根据激励器位置与传感器或探测器位置的缩放图的比较来确定。从标尺比较可以确定更准确可靠的生理参数。

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