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1. 发明专利

JP2013071936A Therapeutic agent for lung cancer containing anti-robo1 antibody as active ingredient 有权
标题翻译：含有作为活性成分的抗ROBO1抗体的肺癌治疗剂
公开(公告)号：JP2013071936A
公开(公告)日：2013-04-22
申请号：JP2011214803
申请日：2011-09-29
申请人： Molecular Dynamics For Antibody Drug Development , 分子動力学抗体創薬技術研究組合
发明人： MOMOSE TOSHIMITSU , FURUYAMA KEITARO , HAMAKUBO TAKAO , IWANARI HIROKO , HINO AKIHIRO , SAITO YASUTAKA
IPC分类号： A61K39/395 , A61K51/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a new therapeutic agent for lung cancer using an anti-ROBO1 antibody.SOLUTION: The therapeutic agent for lung cancer contains radioactively labeled anti-ROBO1 antibody as an active ingredient. The therapeutic agent for lung cancer is useful for small cell lung cancers.
摘要翻译：要解决的问题：使用抗ROBO1抗体提供新的肺癌治疗剂。解决方案：肺癌治疗剂含有放射性标记的抗ROBO1抗体作为活性成分。肺癌治疗剂可用于小细胞肺癌。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JPH0569210B2 失效
公开(公告)号：JPH0569210B2
公开(公告)日：1993-09-30
申请号：JP4946985
申请日：1985-03-14
申请人： MOLECULAR DYNAMICS
发明人： CARLSSON KJELL STURE , ASLUND NILS ROBERT
IPC分类号： H01J37/22 , G01N21/59 , G02B21/00 , G02B21/36 , G02B27/40 , G03B15/00 , G03B17/48

3. 发明申请

WO0157256A3 ROLLING CIRCLE AMPLIFICATION ASSAY FOR NUCLEIC ACID ANALYSIS 审中-公开
标题翻译：用于核酸分析的滚动圆放大测定
公开(公告)号：WO0157256A3
公开(公告)日：2002-07-25
申请号：PCT/US0103439
申请日：2001-02-02
申请人： MOLECULAR DYNAMICS INC , MAHTANI MELANIE M
发明人： MAHTANI MELANIE M
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6816 , C12Q1/6844 , C12Q2525/307 , C12Q2521/501 , C12Q2531/125 , C12Q2521/307 , C12Q2561/125 , C12Q2525/301 , C12Q2521/301
摘要： Method and reagents for analysis of nucleic acid sequences is disclosed. In this method a plurality of padlock probes is provided. Each padlock probe may hybridize to a locus on a target nucleic acid under hybridization conditions. If a targeted variant is present at the locus, the padlock probe may be ligated to form an amplification target circle. The amplification target circle acts as a template for production of tandem-sequence DNA. The tandem-sequence DNA may then be digested into non-tandem detection fragments which are subsequently separated and detected. The plurality of padlock probes are designed such that ligation of the probes, amplification of the target circle, and digestion of the tandem-sequence DNA subsequently produced, and detection may all be effected with the same set of reagents. Each probe targets a unique locus variant on the target nucleic acid sequence and produces a detection fragment that may be distinguished from detection fragments produced from other padlock probe in the plurality of padlock probes by using a fragment analysis detector.
摘要翻译：公开了分析核酸序列的方法和试剂。在该方法中，提供了多个挂锁探针。每个挂锁探针可以在杂交条件下与目标核酸上的位点杂交。如果在该位置处存在目标变体，则可以将挂锁探针连接以形成扩增目标圆。扩增目标圈作为串联序列DNA生产的模板。然后将串联序列DNA消化成非串联检测片段，随后分离和检测。多个挂锁探针被设计成使得探针的连接，目标循环的扩增和随后产生的串联序列DNA的消化以及检测都可以用同一组试剂进行。每个探针靶向靶核酸序列上的唯一基因座变体，并产生检测片段，其可以与通过使用片段分析检测器在多个挂锁探针中由其他挂锁探针产生的检测片段区分开。

4. 发明申请

WO2002063274A1 A SAMPLE CHAMBER FOR USE IN ANALYTICAL INSTRUMENTATION 审中-公开
标题翻译：用于分析仪器的样品室
公开(公告)号：WO2002063274A1
公开(公告)日：2002-08-15
申请号：PCT/US2001/050226
申请日：2001-12-20
申请人： MOLECULAR DYNAMICS, INC. , ARMSTRONG, Thomas, M. , LYTLE, John , BASHKIN, John, S.
发明人： ARMSTRONG, Thomas, M. , LYTLE, John , BASHKIN, John, S.
IPC分类号： G01N1/10
CPC分类号： G01N27/44721
摘要： A tube or chamber (30) comprising an optically tubular body (32) having an exterior surface (34) and an interior surface (36). The body wall (32) includes a first portion, through which incident radiation passes, having a non-uniform thickness about the sample passageway.
摘要翻译：包括具有外表面（34）和内表面（36）的光学管状体（32）的管或室（30）。主体壁（32）包括入射辐射通过的第一部分，在样品通道周围具有不均匀的厚度。

5. 发明申请

WO0157276A2 HUMAN GENOME-DERIVED SINGLE EXON NUCLEIC ACID PROBES USEFUL FOR ANALYSIS OF GENE EXPRESSION IN HUMAN BONE MARROW 审中-公开
标题翻译：人类基因组衍生的单个核酸探针有用于人骨骼基因表达分析
公开(公告)号：WO0157276A2
公开(公告)日：2001-08-09
申请号：PCT/US0100668
申请日：2001-01-30
申请人： MOLECULAR DYNAMICS INC , PENN SHARRON G , HANZEL DAVID K , CHEN WENSHENG , RANK DAVID R
发明人： PENN SHARRON G , HANZEL DAVID K , CHEN WENSHENG , RANK DAVID R
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/10 , C12N15/66 , C12Q1/68 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/26
CPC分类号： C12N15/1089 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/60 , C12N15/66 , C12Q1/6809 , C12Q1/6837 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/26 , C12Q2565/501 , C12Q2539/105
摘要： A single exon nucleic acid microarray comprising a plurality of single exon nucleic acid probes for measuring gene expression in a sample derived from human bone marrow is described. Also described are single exon nucleic acid probes expressed in the bone marrow and their use in methods for detecting gene expression.
摘要翻译：描述了包含用于测量源自人骨髓的样品中的基因表达的多个单个外显子核酸探针的单个外显子核酸微阵列。还描述了在骨髓中表达的单个外显子核酸探针及其在检测基因表达的方法中的用途。

6. 发明申请

WO1996018205A1 FLUORESCENCE IMAGING SYSTEM EMPLOYING A MACRO SCANNING OBJECTIVE 审中-公开
标题翻译：使用宏观扫描目标的荧光成像系统
公开(公告)号：WO1996018205A1
公开(公告)日：1996-06-13
申请号：PCT/US1995013531
申请日：1995-10-20
申请人： MOLECULAR DYNAMICS, INC.
发明人： MOLECULAR DYNAMICS, INC. , KAIN, Robert, C.
IPC分类号： H01J03/14
CPC分类号： G02B21/002 , G02B21/16
摘要： Fluorescence imaging system includes objective (21) which is achromatic and has an external entrance pupil (29), serves as a condenser for the system, and positioned above sample (23) in close proximity to one another. Laser (18) directs collimated light (19) to scan device (20) located at entrance pupil (29). Scan device (20) reflects, refracts, or diffracts light through objective (21) to illuminate a spot (22) on the sample's surface, and illuminates a line or an area on the sample surface by varying the angle of laser light into objective (21). Sample (23) emits fluorescent light (24) in response to the illumination. The fluorescent light (24) is collected by objective (21) and passes through the system along the path of the illumination light. Wavelength-discriminating dichroic filter (25), placed along the optical axis between laser (18) and objective (21), directs fluorescent light (24) onto photodetector (26) to produce a signal representing the sample surface emitting the fluorescent light. Display (37) displays the digitized data in a raster format.
摘要翻译：荧光成像系统包括不消色的物镜（21），并具有外部入射光瞳（29），用作系统的冷凝器，并且位于彼此靠近的样品（23）上方。激光器（18）将准直光（19）引导到位于入射光瞳（29）处的扫描装置（20）。扫描装置（20）通过物镜（21）反射，折射或衍射光以照射样品表面上的斑点（22），并且通过将激光的角度改变为目标来照射样品表面上的线或区域 21）。样品（23）响应于照明而发射荧光（24）。荧光灯（24）由物镜（21）收集并沿着照明光的路径通过系统。沿着激光（18）和物镜（21）之间的光轴放置的波长鉴别二向色滤光器（25）将荧光（24）引导到光电检测器（26）上，以产生表示发射荧光的样品表面的信号。显示（37）以光栅格式显示数字化数据。

7. 发明申请

WO1996002824A1 HIGH-SPEED FLUORESCENCE SCANNER 审中-公开
标题翻译：高速荧光扫描仪
公开(公告)号：WO1996002824A1
公开(公告)日：1996-02-01
申请号：PCT/US1995007834
申请日：1995-06-20
申请人： MOLECULAR DYNAMICS
发明人： MOLECULAR DYNAMICS , HUETON, Iain , VAN GELDER, Ezra
IPC分类号： G01N21/61
CPC分类号： G01N21/6452 , G01N27/44721 , G01N2021/6417 , G01N2201/101
摘要： A high-speed fluorescence scanner for scanning a sample at equal angles has most of its optical components, including a light beam source (11), a detector (19), filters (18), lenses (17), and reflectors (15-16), in a fixed position (24), removed from the scan head (22). The lightweight scan head contains a single reflector (13) and lens (12) combination which is reciprocated rapidly along one axis to lengthen and shorten a region of the path of a collimated excitation beam (30) and to form a scan line (25-26) on a sample. The fluorescence emission is gathered by the lens (12) of the scan head and directed back, generally along the optical path of the excitation beam, to a detector. Another embodiment places the light source (43), in miniature form, directly on the scan head. The sample may be translated in an axis orthogonal to the scan line to stimulate fluorescent emission from two-dimensional portion of the sample.
摘要翻译：用于以相等的角度扫描样品的高速荧光扫描器具有其大部分光学部件，包括光束源（11），检测器（19），滤光器（18），透镜（17）和反射器（15- 在固定位置（24）中，从扫描头（22）移除。轻型扫描头包含单个反射器（13）和透镜（12）组合，其沿着一个轴线快速往复运动，以延长和缩短准直激励光束（30）的路径的区域并形成扫描线（25- 26）。荧光发射由扫描头的透镜（12）聚集，并且通常沿着激发光束的光路向后指向检测器。另一实施例将光源（43）以微型形式放置在扫描头上。样品可以在与扫描线正交的轴上平移以刺激来自样品的二维部分的荧光发射。

8. 发明申请

WO2018029111A1 METHODS AND SYSTEMS FOR UTILIZING 3D SENSORS IN NUCLEAR MEDICINE 审中-公开
标题翻译：在核医学中利用3D传感器的方法和系统
公开(公告)号：WO2018029111A1
公开(公告)日：2018-02-15
申请号：PCT/EP2017/069832
申请日：2017-08-04
申请人： MOLECULAR DYNAMICS LIMITED , KENIG, Tal , GOLDBERG, Uri , STERN, Eli
发明人： KENIG, Tal , GOLDBERG, Uri , STERN, Eli
IPC分类号： A61B6/03 , A61B6/00 , A61B6/10 , A61B5/00 , A61B6/04
CPC分类号： A61B6/037 , A61B5/0064 , A61B5/0077 , A61B6/0407 , A61B6/102 , A61B6/4266 , A61B6/469 , A61B6/545 , A61B6/547
摘要： Described are methods and systems for scanning at least a portion of a patient with a gamma detector mounted on an arm extending towards the patient. One described method includes: obtaining data indicative of coordinates of points on the outer surface of the patient; determining a target position for the gamma detector based on the data indicative of the coordinates; and causing the gamma detector to detect gamma radiation from the patient when the gamma detector is at the target position.
摘要翻译：描述了用于利用安装在朝向患者延伸的臂上的伽马检测器来扫描患者的至少一部分的方法和系统。一种描述的方法包括：获得指示患者外表面上的点的坐标的数据; 基于指示坐标的数据确定伽马检测器的目标位置; 并在γ检测器位于目标位置时使γ检测器检测来自患者的γ辐射。

9. 发明申请

WO0186003A2 HUMAN GENOME-DERIVED SINGLE EXON NUCLEIC ACID PROBES USEFUL FOR ANALYSIS OF GENE EXPRESSION IN HUMAN LUNG 审中-公开
标题翻译：人类基因组衍生的单个核酸探针有用于人类肺癌基因表达分析
公开(公告)号：WO0186003A2
公开(公告)日：2001-11-15
申请号：PCT/US0100665
申请日：2001-01-30
申请人： MOLECULAR DYNAMICS INC , PENN SHARRON G , HANZEL DAVID K , CHEN WENSHENG , RANK DAVID R
发明人： PENN SHARRON G , HANZEL DAVID K , CHEN WENSHENG , RANK DAVID R
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/10 , C12N15/66 , C12Q1/68 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/26
CPC分类号： C12N15/1089 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/60 , C12N15/66 , C12Q1/6809 , C12Q1/6837 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/26 , C12Q2565/501 , C12Q2539/105
摘要： A single exon nucleic acid microarray comprising a plurality of single exon nucleic acid probes for measuring gene expression in a sample derived from human lung is described. Also described are single exon nucleic acid probes expressed in the lung and their use in methods for detecting gene expression.
摘要翻译：描述了包含用于测量源自人肺的样品中的基因表达的多个单个外显子核酸探针的单个外显子核酸微阵列。还描述了在肺中表达的单个外显子核酸探针及其在检测基因表达的方法中的用途。

10. 发明申请

WO1997046319A1 HIGH-SPEED LIQUID DEPOSITION DEVICE FOR BIOLOGICAL MOLECULE ARRAY FORMATION 审中-公开
标题翻译：用于生物分子阵列形成的高速液体沉积装置
公开(公告)号：WO1997046319A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009649
申请日：1997-06-03
申请人： MOLECULAR DYNAMICS, INC.
发明人： MOLECULAR DYNAMICS, INC. , ROACH, David, J. , JOHNSTON, Richard, F.
IPC分类号： B01L03/02
CPC分类号： B01L3/0262 , B01J2219/00387 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00639 , B01J2219/00659 , B01J2219/0072 , B01L3/0248 , B01L3/0255 , B01L2300/0838 , C40B60/14 , G01N2035/1037 , Y10T436/25 , Y10T436/2575
摘要： A microspot deposition system (12) featuring a hollow cylindrical wall (26) extending from a closed end (28), terminating in an open end (30) and including a longitudinal gap (34) extending from the open end (30) toward the closed end (28) to allow the rapid exhaustion of the atmosphere and efficient cleaning within the cylindrical wall (26). The cylindrical wall (26) defines a lumen (32) with both the lumen (32) and the gap (34) adapted to facilitate capillary action of liquid in fluid communication therewith to form a meniscus (46) proximate to the open end (30). To facilitate deposition of liquid contained within the lumen (32), the gap (34) may be tapered so that it is narrowest proximate to the open end (30). The narrowed portion of the gap (34) results in a meniscus (46) having a reduced area to ensure preferential fluid flow toward the open end (30), which facilitates deposition via capillary action between the liquid in the lumen (32) and a working surface (52).
摘要翻译：一种微孔沉积系统（12），其具有从封闭端（28）延伸的中空圆柱形壁（26），终止于开口端（30），并且包括从开口端（30）延伸的纵向间隙（34）闭合端（28）以允许气氛的快速耗尽并且在圆柱形壁（26）内进行有效的清洁。圆柱形壁（26）限定内腔（32），内腔（32）和间隙（34）都适于促进与其流体连通的液体的毛细作用，以形成靠近开口端（30）的弯月面（46））。为了便于包含在内腔（32）内的液体的沉积，间隙（34）可以是锥形的，使得其在开口端（30）附近最窄。间隙（34）的变窄的部分导致弯液面（46）具有减小的面积，以确保朝向开口端（30）的优先流体流动，这有利于通过管腔（32）中的液体和工作面（52）。

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