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1. 发明申请

US20040220564A1 Bendable cutting device 有权
标题翻译：弯曲切割装置
公开(公告)号：US20040220564A1
公开(公告)日：2004-11-04
申请号：US10783714
申请日：2004-02-20
申请人： MANOA MEDICAL, INC., A DELAWARE CORPORATION
发明人： Huddee Jacob Ho , Roberta Lee , Samuel E. Zuckswert , Stanley R. Conston , Ronald Yamamoto , Don Alden
IPC分类号： A61B018/14
CPC分类号： A61B10/02 , A61B8/12 , A61B10/0266 , A61B10/04 , A61B17/32 , A61B17/320016 , A61B17/32056 , A61B2017/00867 , A61B2018/00601 , A61B2018/1407 , A61B2018/144
摘要： Devices and methods for a minimally invasive procedure for cutting tissue are disclosed. The device generally includes a probe with a distal exit at an exit angle relative to the probe, a cutting loop with shape memory having a preconfigured shape, and a loop securing mechanism to secure the cutting loop in a penetrating configuration and to release the cutting loop into a cutting configuration. The cutting loop is generally within a profile of the probe in the penetrating configuration. In the cutting configuration, the cutting loop extends through the cutting loop exit and generally returns to the preconfigured shape at a cutting angle generally defined by the exit angle. The cutting loop securing mechanism may be, for example, a cover slidable over the probe, a slidable member extending from a distal tip of the probe, or a groove defined in the probe proximal to the cutting loop exit.
摘要翻译：公开了用于切割组织的微创程序的装置和方法。该装置通常包括具有相对于探针出射角度的远端出口的探针，具有预配置形状的形状记忆体的切割环以及将切割环固定在穿透构型中并释放切割环的环固定机构进入切割配置。切割环通常在探针的剖面中处于穿透构型。在切割配置中，切割环延伸穿过切割环出口并且通常以通常由出射角限定的切割角返回到预配置的形状。切割环固定机构可以是例如可以在探头上滑动的盖，从探头的远端延伸的可滑动构件或限定在探针中的靠近切割环出口的凹槽。

2. 发明申请

US20050222598A1 Tissue cutting device 审中-公开
标题翻译：组织切割装置
公开(公告)号：US20050222598A1
公开(公告)日：2005-10-06
申请号：US10819083
申请日：2004-04-05
申请人： Huddee Ho , Roberta Lee , Samuel Zuckswert
发明人： Huddee Ho , Roberta Lee , Samuel Zuckswert
IPC分类号： A61B17/32
CPC分类号： A61B17/3201 , A61B17/32 , A61B17/32002 , A61B17/32053 , A61B17/32056 , A61B17/3211 , A61B2017/32006 , A61B2017/320069 , A61B2017/32007 , A61B2017/320071
摘要： Devices for efficient severing or cutting of a material or substance such as soft tissue suitable for use in open surgical and/or minimally invasive procedures are disclosed. A cutting assembly generally includes a first and second cutting blades each having an inner surface and at least one set of cutting teeth, the first inner surface being in contact with the second inner surface so that the sets of cutting teeth of the first and second cutting blades are aligned with and configured to cooperate with each other when at least one of the cutting blades moves, e.g., rotates and/or oscillates, relative to the other. A tissue cutting device generally includes a probe and the cutting assembly configured to be in a storage configuration or in a cutting configuration. The cutting assembly may provide a coagulation mechanism.
摘要翻译：公开了用于有效切断或切割适合用于开放式外科手术和/或微创手术的软组织的材料或物质的装置。切割组件通常包括第一和第二切割刀片，每个切割刀片具有内表面和至少一组切割齿，第一内表面与第二内表面接触，使得第一和第二切割的切割齿组当至少一个切割刀片相对于另一个切割刀片移动例如旋转和/或振荡时，叶片对准并构造成彼此配合。组织切割装置通常包括探针和被配置为处于存储结构或切割构型的切割组件。切割组件可以提供凝结机构。

3. 发明申请

US20030105402A1 Ultrasound imaging of breast tissue using ultrasound contrast agent 有权
标题翻译：使用超声造影剂对乳腺组织进行超声成像
公开(公告)号：US20030105402A1
公开(公告)日：2003-06-05
申请号：US10167017
申请日：2002-06-11
申请人： MANOA MEDICAL, INC., A DELAWARE CORPORATION
发明人： Roberta Lee
IPC分类号： A61B008/14
CPC分类号： A61B17/32056 , A61B8/0825 , A61B8/481 , A61B18/14 , A61B2018/1407 , A61B2018/1467
摘要： A system and method for ultrasound imaging of breast tissue by injecting an ultrasound contrast agent into a duct lumen of a patient's breast to enhance the imaging of one or more ducts within a specified lobe of the breast to improve characterization of a lesion or lesions within the duct system of the specified lobe are disclosed. The ultrasound contrast agent used to improve breast imaging may be injected into the duct lumen through an orifice on the nipple and/or a duct wall into the duct lumen. The ultrasound contrast agent may be injected prior to and/or during ultrasound imaging. The ultrasound contrast agent may be an acoustically detectable gas such as a halogenated hydrocarbon, halogenated alkane gases, nitrogen, helium, argon and/or xenon. The halogenated alkane gas may be a perfluorinated hydrocarbon such as saturated perfluorocarbon, unsaturated perfluorocarbon, and/or cyclic perfluorocarbon. The acoustically detectable gas may alternatively be mixed in a liquid solution.
摘要翻译：一种用于通过将超声造影剂注射到患者乳房的管腔中以增强乳房特定瓣内的一个或多个管道的成像以改善乳房组织内的病变或病变的表征的用于乳腺组织的超声成像的系统和方法公开了指定叶片的管道系统。用于改善乳房成像的超声造影剂可以通过乳头上的孔口和/或管道壁注入管腔，进入管腔。可以在超声成像之前和/或超声成像期间注射超声造影剂。超声造影剂可以是可声学检测的气体，例如卤代烃，卤代烷烃气体，氮气，氦气，氩气和/或氙气。卤代烷烃气体可以是饱和全氟化碳，不饱和全氟化碳和/或环状全氟化碳等全氟化烃。可选地，声学可检测气体可以在液体溶液中混合。

4. 发明申请

US20070118033A1 Soft tissue orientation and imaging guide systems and methods 审中-公开
标题翻译：软组织取向和成像指导系统和方法
公开(公告)号：US20070118033A1
公开(公告)日：2007-05-24
申请号：US11637394
申请日：2006-12-12
申请人： Roberta Lee
发明人： Roberta Lee
IPC分类号： A61B5/05
CPC分类号： A61B8/0825 , A61B8/4209 , A61B8/4236 , A61B8/4472 , A61B8/488 , A61B2017/3413 , Y10S128/915
摘要： Systems and methods for the orientation of soft tissue such as breast tissue for enhanced accuracy of imaging and/or procedures such as a biopsy or excision are disclosed. The system for orientating and maintaining the orientation of soft tissue generally includes a frame defining an opening, the frame being configured to orient and immobilize an area of soft tissue positioned on one side of the opening, an attachment mechanism to secure the frame to an attachment region defined by the area of soft tissue or by a skin surface overlying the area of soft tissue, to facilitate orienting and immobilizing the area of soft tissue, and an imaging device to image the area of soft tissue. The opening may allow a probe of the imaging device or imaging energy transmitted by the imaging device to be movable therein for image scanning of the soft tissue. The probe, e.g., an ultrasound transducer can be rotated within the frame such that the probe scans at least either of two perpendicular directions within the frame. The frame may be adjustable in at least one dimension in order to adjust the size of the frame opening so as to facilitate the scanning and positioning of the probe within the frame opening. The frame may be attached and secured to the soft tissue with vacuum, adhesive, and/or clips or hooks. The soft tissue may be stretched into a desire orientation prior to attachment of the frame. An anchored lift member may be connected to the frame so as to slightly lift the frame and thus position and immobilize the soft tissue to which the frame is attached. Lifting of the soft tissue improves and enhances a tissue separation process using a tissue separation device. A connector may connect the imaging device to the tissue separation device to maintain a portion of the tissue separation device within the image plane of the probe to further improve and enhance the tissue separation process.
摘要翻译：公开了用于提高成像精度和/或诸如活组织检查或切除的程序的软组织如乳腺组织的取向的系统和方法。用于定向和保持软组织的取向的系统通常包括限定开口的框架，框架被配置为定位和固定位于开口的一侧上的软组织的区域，附接机构将框架固定到附件由软组织区域或覆盖软组织区域的皮肤表面限定的区域，以促进软组织区域的定向和固定，以及成像装置，以对软组织的区域进行成像。开口可以允许成像装置的探针或由成像装置传输的成像能量在其中可移动以进行软组织的图像扫描。探针，例如超声换能器可以在框架内旋转，使得探针扫描框架内的两个垂直方向中的至少一个。框架可以在至少一个维度上是可调节的，以便调节框架开口的尺寸，以便于探针在框架开口内的扫描和定位。框架可以用真空，粘合剂和/或夹子或钩子附接并固定到软组织。在连接框架之前，软组织可以被拉伸成期望的方向。锚定的提升构件可以连接到框架，以便稍微抬起框架，从而定位和固定框架所附着的软组织。软组织的提升使用组织分离装置改善和增强组织分离过程。连接器可以将成像装置连接到组织分离装置，以将组织分离装置的一部分保持在探针的图像平面内，以进一步改善和增强组织分离过程。

5. 发明申请

US20040162554A1 Systems and methods for cutting tissue 审中-公开
标题翻译：切割组织的系统和方法
公开(公告)号：US20040162554A1
公开(公告)日：2004-08-19
申请号：US10744462
申请日：2003-12-22
申请人： MANOA MEDICAL, INC., A DELAWARE CORPORATION
发明人： Roberta Lee , Samuel E. Zuckswert , Stanley R. Conston , Ronald Yamamoto , Huddee Jacob Ho
IPC分类号： A61B018/14
CPC分类号： A61B18/14 , A61B2018/00083 , A61B2018/00107 , A61B2018/00196 , A61B2018/00601 , A61B2018/1407 , A61B2018/1475
摘要： Devices and methods for cutting of soft tissue using radio frequency and suitable for use in minimally invasive procedures are disclosed. The device generally includes an electrode housed in a housing, the electrode being flexible and/or extendable out of and/or retractable into the housing, and an insulating layer partially surrounding the electrode to expose at least a portion of the electrode to define at least one cutting area so as to focus energy from the energy source to the cutting area to facilitate initiation of a cut with the cutting area in contact with tissue. The cutting area(s) may extend and/or be aligned in a direction along a length of the electrode and may include a sharpened and/or serrated edge. The tissue cutting device may include an automated electrode oscillator coupled to the electrode and configured to oscillate the electrode along an axis or plane generally defined by the electrode.
摘要翻译：公开了使用射频切割软组织并适用于微创程序的装置和方法。所述装置通常包括容纳在壳体中的电极，所述电极是柔性的和/或可延伸出外壳和/或伸缩到壳体中，以及绝缘层，其部分包围电极以暴露至少一部分电极至少限定一个切割区域，以将来自能量源的能量聚焦到切割区域，以便于与组织接触的切割区域开始切割。切割区域可以沿着电极长度的方向延伸和/或对齐，并且可以包括锐化和/或锯齿形边缘。组织切割装置可以包括耦合到电极并被配置为沿着通常由电极限定的轴线或平面振荡电极的自动电极振荡器。

6. 发明申请

US20070142852A1 Tissue cutting device 审中-公开
标题翻译：组织切割装置
公开(公告)号：US20070142852A1
公开(公告)日：2007-06-21
申请号：US11316600
申请日：2005-12-21
申请人： Roberta Lee , Huddee Ho , Samuel Zuckswert
发明人： Roberta Lee , Huddee Ho , Samuel Zuckswert
IPC分类号： A61B17/32
CPC分类号： A61B10/0266 , A61B2017/008
摘要： Devices and methods for efficient severing or cutting of a material or substance, such as soft tissue, suitable for use in open surgical and/or minimally invasive procedures, such as percutaneous procedures in breast tissue, are disclosed. A tissue cutting device may generally include a probe, a cutting assembly configured to be in a storage configuration or a preformed cutting configuration for cutting the specimen, a tissue fixator and a specimen retriever. When in the cutting configuration, the cutting assembly may be configured to move and cut the specimen relative to the tissue fixator along an axis of the probe. The tissue fixator may facilitate in stabilizing a region of tissue during cutting of the specimen. The region of tissue may be the specimen and/or tissue adjacent to and/or near the specimen. The specimen retriever may optionally be coupled to the cutting assembly and integrated as part of the tissue fixator.
摘要翻译：公开了用于有效切断或切割适合用于开放手术和/或微创手术（例如乳房组织中经皮手术）的材料或物质（例如软组织）的装置和方法。组织切割装置通常可以包括探针，被配置为处于存储结构的切割组件或用于切割样本的预成型切割构造，组织固定器和样本检索器。当处于切割配置时，切割组件可以被配置成沿着探针的轴线相对于组织固定器移动和切割样本。组织固定器可以有助于在切割样本期间稳定组织区域。组织区域可以是与样本相邻和/或附近的样本和/或组织。样本检索器可以可选地耦合到切割组件并且被集成为组织固定器的一部分。

7. 发明申请

US20050228403A1 Tissue cutting devices and methods 审中-公开
标题翻译：组织切割装置和方法
公开(公告)号：US20050228403A1
公开(公告)日：2005-10-13
申请号：US10815912
申请日：2004-03-31
申请人： Huddee Ho , Roberta Lee , Samuel Zuckswert
发明人： Huddee Ho , Roberta Lee , Samuel Zuckswert
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B18/14
CPC分类号： A61B10/0266 , A61B17/32056 , A61B2017/008 , A61B2017/32006 , A61B2018/1407
摘要： Minimally invasive devices and methods for cutting a volume of soft tissue such as a biopsy or a therapeutic excision of cancer are disclosed. The device generally includes a probe, a cutting loop with sufficient elasticity, shape memory or superelastic property such that the loop returns to a cutting configuration when released from a storage configuration, and a loop holder to hold and rotate the cutting loop about a loop holder axis when the cutting loop is in the cutting configuration so as to adjust a loop angle between the probe axis and the cutting loop. The method generally includes positioning the tissue cutting device adjacent the volume of tissue, releasing the cutting loop from the storage configuration to the cutting configuration, rotating the cutting loop to adjust the loop angle, and moving the tissue cutting device to cut the volume of tissue.
摘要翻译：公开了用于切割大量软组织的微创装置和方法，例如活检或癌症的治疗性切除。该装置通常包括探针，具有足够弹性的切割环，形状记忆或超弹性，使得当从储存构造释放时环路返回到切割构造，以及环保持器，用于保持和旋转切割环绕环支架当切割环处于切割配置时，以便调节探针轴和切割环之间的回转角度。该方法通常包括将组织切割装置定位成邻近组织体积，将切割环从存储配置释放到切割构造，旋转切割环以调节环形角度，以及移动组织切割装置以切割组织体积。

8. 发明申请

US20040199159A1 Devices and methods for tissue severing and removal 审中-公开
标题翻译：用于组织切断和去除的装置和方法
公开(公告)号：US20040199159A1
公开(公告)日：2004-10-07
申请号：US10825828
申请日：2004-04-16
申请人： MANOA MEDICAL, INC., A DELAWARE CORPORATION
发明人： Roberta Lee , Huddee Jacob Ho
IPC分类号： A61B018/14
CPC分类号： A61B10/0266 , A61B8/0825 , A61B8/481 , A61B17/32056 , A61B18/14 , A61B2018/1407 , A61B2018/1467
摘要： The present invention relates to devices and methods that enhance the accuracy of lesion excision, through severing, capturing and removal of a lesion within soft tissue. Furthermore, the present invention relates to devices and methods for the excision of breast tissue based on the internal anatomy of the breast gland. A tissue severing device generally comprises a guide having at least one lumen and a cutting tool contained within the lumen. The cutting tool is capable of extending from the lumen and forming an adjustable cutting loop. The cutting loop may be widened or narrowed and the angle between the loop extension axis and the guide axis may be varied. Optional tissue marker and tissue collector may additionally be provided. A method for excising a mass of tissue from a patient is also provided. The device and method are particularly useful for excising a lesion from a human breast, e.g., through the excision and removal of a part of a breast lobe, an entire breast lobe or a breast lobe plus surrounding adjacent tissue.
摘要翻译：本发明涉及通过切断，捕获和去除软组织内的损伤来增强病变切除的准确性的装置和方法。此外，本发明涉及基于乳腺的内部解剖学来切除乳腺组织的装置和方法。组织切断装置通常包括具有至少一个内腔的引导件和容纳在内腔内的切割工具。切割工具能够从内腔延伸并形成可调节的切割环。切割环可以变宽或变窄，并且环延伸轴线和引导轴线之间的角度可以变化。另外可以提供任选的组织标记物和组织收集器。还提供了从患者中切除组织块的方法。该装置和方法对于从人乳房切除病变特别有用，例如通过切除和去除一部分乳腺，整个乳腺或乳房加上周围的相邻组织。

9. 发明申请

US20040087851A1 Soft tissue orientation and imaging guide systems and methods 有权
标题翻译：软组织取向和成像指导系统和方法
公开(公告)号：US20040087851A1
公开(公告)日：2004-05-06
申请号：US10284990
申请日：2002-10-31
申请人： MANOA MEDICAL, INC. A DELAWARE CORPORATION
发明人： Roberta Lee
IPC分类号： A61B005/05
CPC分类号： A61B8/0825 , A61B8/4209 , A61B8/4236 , A61B8/4472 , A61B8/488 , A61B2017/3413 , Y10S128/915
摘要： Systems and methods for the orientation of soft tissue such as breast tissue for enhanced accuracy of imaging and/or procedures such as a biopsy or excision are disclosed. The system for orientating and maintaining the orientation of soft tissue generally includes a frame defining an opening, the frame being configured to orient and immobilize an area of soft tissue positioned on one side of the opening, an attachment mechanism to secure the frame to an attachment region defined by the area of soft tissue or by a skin surface overlying the area of soft tissue, to facilitate orienting and immobilizing the area of soft tissue, and an imaging device to image the area of soft tissue. The opening may allow a probe of the imaging device or imaging energy transmitted by the imaging device to be movable therein for image scanning of the soft tissue. The probe, e.g., an ultrasound transducer can be rotated within the frame such that the probe scans at least either of two perpendicular directions within the frame. The frame may be adjustable in at least one dimension in order to adjust the size of the frame opening so as to facilitate the scanning and positioning of the probe within the frame opening. The frame may be attached and secured to the soft tissue with vacuum, adhesive, and/or clips or hooks. The soft tissue may be stretched into a desire orientation prior to attachment of the frame. An anchored lift member may be connected to the frame so as to slightly lift the frame and thus position and immobilize the soft tissue to which the frame is attached. Lifting of the soft tissue improves and enhances a tissue separation process using a tissue separation device. A connector may connect the imaging device to the tissue separation device to maintain a portion of the tissue separation device within the image plane of the probe to further improve and enhance the tissue separation process.
摘要翻译：公开了用于提高成像精度和/或诸如活组织检查或切除的程序的软组织如乳腺组织的取向的系统和方法。用于定向和保持软组织的取向的系统通常包括限定开口的框架，框架被配置为定位和固定位于开口的一侧上的软组织的区域，附接机构将框架固定到附件由软组织区域或覆盖软组织区域的皮肤表面限定的区域，以促进软组织区域的定向和固定，以及成像装置，以对软组织的区域进行成像。开口可以允许成像装置的探针或由成像装置传输的成像能量在其中可移动以进行软组织的图像扫描。探针，例如超声换能器可以在框架内旋转，使得探针扫描框架内的两个垂直方向中的至少一个。框架可以在至少一个维度上是可调节的，以便调节框架开口的尺寸，以便于探针在框架开口内的扫描和定位。框架可以用真空，粘合剂和/或夹子或钩子附接并固定到软组织。在连接框架之前，软组织可以被拉伸成期望的方向。锚定的提升构件可以连接到框架，以便稍微抬起框架，从而定位和固定框架所附着的软组织。软组织的提升使用组织分离装置改善和增强组织分离过程。连接器可以将成像装置连接到组织分离装置，以将组织分离装置的一部分保持在探针的图像平面内，以进一步改善和增强组织分离过程。

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