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1. 发明专利

JP2013150605A Nucleotide and protein sequence of vertebrate serrate gene, and method based thereon 审中-公开
标题翻译： VERTEBRATE SERRATE基因的核苷酸和蛋白质序列及其基于方法
公开(公告)号：JP2013150605A
公开(公告)日：2013-08-08
申请号：JP2013023179
申请日：2013-02-08
申请人： Yale Univ , イェールユニバーシティーYale University , Imperial Cancer Research Technology Ltd , インペリアルキャンサーリサーチテクノロジーリミテッド
发明人： ISH-HOROWICZ DAVID , HENRIQUE DOMINGOS M P , LEWIS JULIAN H , MYAT ANNA M , ARTAVANIS-TSAKONAS SPYRIDON , MANN ROBERT S , GRAY GRACE E
IPC分类号： C12N15/09 , A61K31/70 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/16 , A61P17/02 , A61P17/06 , A61P17/14 , A61P25/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61P35/02 , C07K14/435 , C07K14/46 , C07K14/465 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577
CPC分类号： C07K14/465 , A61K38/00 , C07K14/43504 , C07K14/43581 , C07K14/46 , C07K14/463 , C07K14/705
摘要： PROBLEM TO BE SOLVED: To provide nucleotide sequences of vertebrate Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof.SOLUTION: There is provided a purified vertebrate Serrate protein. In one embodiment, the invention relates to vertebrate Serrate derivatives and analogs which are functionally active, i.e., they are capable of displaying one or more known functional activity associated with a full-length (wild-type) Serrate protein.
摘要翻译：要解决的问题：提供脊椎动物Serrate基因的核苷酸序列，及其编码的蛋白质的氨基酸序列，以及衍生物（例如片段）及其类似物。解决方案：提供纯化的脊椎动物Serrate蛋白质。在一个实施方案中，本发明涉及功能活性的脊椎动物Serrate衍生物和类似物，即它们能够显示与全长（野生型）Serrate蛋白相关的一种或多种已知功能活性。

2. 发明专利

JP2012070735A NUCLEOTIDE AND PROTEIN SEQUENCE OF VERTEBRATE Delta GENE AND METHOD BASED THEREON 审中-公开
标题翻译：基因的核苷酸和蛋白质序列及其基于方法
公开(公告)号：JP2012070735A
公开(公告)日：2012-04-12
申请号：JP2011220536
申请日：2011-10-04
申请人： Imperial Cancer Research Technology Ltd , Yale Univ , イェールユニバーシティーYale University , インペリアルキャンサーリサーチテクノロジーリミテッド
发明人： ISH-HOROWICZ DAVID , HENRIQUE DOMINGO M P , LEWIS JULIAN H , ARTAVANIS-TSAKONAS SPYRIDON , GRAY GRACE E
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07K14/46 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide nucleotide sequences of vertebrate Delta genes, and amino acid sequences of proteins encoded thereby, as well as derivatives (e.g., fragments) and analogs thereof.SOLUTION: A vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain in the amino-terminal side of the DSL domain, transmembrane region, or one or more EGF-like repeats domain, of a Delta protein, or any combination of these. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods for producing the Delta proteins, derivatives and analogs, e.g. by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.
摘要翻译：要解决的问题：提供脊椎动物Delta基因的核苷酸序列，以及由此编码的蛋白质的氨基酸序列，以及衍生物（例如片段）及其类似物。解决方案：脊椎动物Delta蛋白是一种人类蛋白质。本发明还涉及Delta的片段（及其衍生物和类似物），其包含Delta蛋白的一个或多个结构域，包括但不限于细胞外结构域，细胞外结构域，DSL结构域，氨基末端侧的结构域 DSL结构域，跨膜区或一个或多个EGF样重复结构域，或其任何组合。额外提供了抗体对Delta，其衍生物和类似物。用于产生Delta蛋白质，衍生物和类似物的方法，例如也提供了重组方法。提供了治疗和诊断方法和药物组合物。版权所有（C）2012，JPO＆INPIT

3. 发明申请

WO1995018856A1 VERTEBRATE EMBRYONIC PATTERN-INDUCING HEDGEHOG-LIKE PROTEINS 审中-公开
标题翻译： VERTEBRATE EMBRYONIC PATTERN-INDING HEDGEHOG-like蛋白质
公开(公告)号：WO1995018856A1
公开(公告)日：1995-07-13
申请号：PCT/US1994014992
申请日：1994-12-30
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD.
发明人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD. , INGHAM, Philip, W. , MCMAHON, Andrew, P. , TABIN, Clifford, J.
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/033 , A01K2207/05 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/46 , C07K2319/00
摘要： The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
摘要翻译：本发明涉及这样的发现：由脊椎动物家族（称为这些刺猬蛋白相关基因）编码的蛋白质包含由胚胎图案化中心产生的形态发生信号，并且涉及脊椎动物中分化组织的有序空间排列的形成。本发明提供可用于例如在体外和体内产生和/或维持不同脊椎动物组织阵列的组合物和方法。

4. 发明申请

WO1992000375A1 SEXE DETERMINING GENE 审中-公开
标题翻译：性别决定基因
公开(公告)号：WO1992000375A1
公开(公告)日：1992-01-09
申请号：PCT/GB1991001057
申请日：1991-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , GOODFELLOW, Peter, Neville , LOVELL-BADGE, Robin
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , A61K38/00 , C07K14/47 , C12Q1/6879 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides a DNA encoding a gene which controls the sex of the embryos of eutherian (Placental) mammals. Nucleic acid fragments, proteins, polypeptides, antibodies and related products and their use in medicine and agriculture are provided. The invention may be used in diagnosis or for controlling the sex of the progeny of commercially important animals.
摘要翻译：本发明提供了编码控制埃及（Placental）哺乳动物胚胎性别的基因的DNA。提供核酸片段，蛋白质，多肽，抗体及相关产品及其在医学和农业中的应用。本发明可用于诊断或控制商业上重要的动物后代的性别。

5. 发明申请

WO1991012272A1 PROTEIN FACTOR 审中-公开
标题翻译：蛋白因子
公开(公告)号：WO1991012272A1
公开(公告)日：1991-08-22
申请号：PCT/GB1991000245
申请日：1991-02-15
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , STOKER, Michael , GHERARDI, Ermanno
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K13/00
CPC分类号： C07K16/22 , A61K38/00 , C07K14/4753
摘要： A polypeptide or protein comprising at least five contiguous amino acid residues in a sequence corresponding to formula (I): VVNGIPTQTTVGX MVSLX YY wherein the internationally recognised 1-letter code is used to represent amino acid residues and X is any naturally occuring L-amino acid residue and X is any amino acid residue, but is preferably an L-leucine residue (L).
摘要翻译：包含对应于式（I）的序列中的至少五个连续氨基酸残基的多肽或蛋白质：VVNGIPTQTTVGX 1 MVSLX 2 YY其中国际公认的1个字母的代码用于表示氨基酸残基，X <1 >是任何天然存在的L-氨基酸残基，X 2是任何氨基酸残基，但优选L-亮氨酸残基（L）。

6. 发明申请

WO1991001364A1 SAMPLE MATERIAL TRANSFER DEVICE 审中-公开
标题翻译：样品转移装置
公开(公告)号：WO1991001364A1
公开(公告)日：1991-02-07
申请号：PCT/GB1990001137
申请日：1990-07-24
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , LEHRACH, Hans, Rudolf
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C12M01/32
CPC分类号： C12M33/02 , C12M23/04 , G01N35/0099 , G01N35/1065 , G01N2035/1037
摘要： The present invention provides a device for the replication of arrays of cell colonies comprising a plate with a large number of small projections projecting therefrom. The projections being formed by removing, preferably by machining, the material between the projections, thus enabling a high density of projections to be achieved.
摘要翻译：本发明提供了用于复制细胞集落阵列的装置，其包括具有从其突出的大量小突起的板。通过优选地通过机械移除突起之间的材料而形成突起，从而能够实现高密度的突起。

7. 发明申请

WO1989001481A1 CHROMOSOME-SPECIFIC NUCLEIC ACID PROBE FOR FAMILIAL POLYPOSIS COLI 审中-公开
标题翻译：用于家族聚脂病毒的染色体特异性核酸探针
公开(公告)号：WO1989001481A1
公开(公告)日：1989-02-23
申请号：PCT/GB1988000665
申请日：1988-08-11
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , BODMER, Walter, Fred , WILLIAMSON, Robert , MURDAY, Victoria, Alice , BAILEY, Carolyn, Jane
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： A nucleic acid fragment capable of selectively hybridising with the human chromosome 5 at the chromosomal region 5q20-q23.
摘要翻译：能够在染色体区5q20-q23处与人染色体5选择性杂交的核酸片段。

8. 发明申请

WO1990008160A1 GROWTH FACTOR RECEPTOR-LIKE PEPTIDES WITHOUT TYROSINE-KINASE ACTIVITY 审中-公开
标题翻译：不含酪氨酸激酶活性的生长因子受体样肽
公开(公告)号：WO1990008160A1
公开(公告)日：1990-07-26
申请号：PCT/GB1990000083
申请日：1990-01-19
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , STERNBERG, Michael, Joseph, Ezra , GULLICK, William, John , CHOTHIA, Cyrus
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K07/08
CPC分类号： C07K14/82 , A61K38/00 , C07K14/71
摘要： A peptide which lacks tyurosine kinase activity, having a binding portion of at least 8 contiguous amino acid residues adapted to form an intra-membrane alpha-helix and being capable of reducing tyrosine kinase activity in a target cell, the binding portion having a sequence identical to the sequence at positions P to P of a natural (wild type) or mutant growth factor receptor/tyrosine kinase portein having the motif set out below or having a sequence which differs at not more than 3 positions from the sequence at positions P to P of such a protein, wherein the motif comprises a sequence of 5 contiguous amino acid residues designated: P XXP P , wherein the residues X are the same or different and each is any naturally occurring L-amino acid residue, P is a residue selected from Ala, Gly, Ser, Thr, Pro, Val, Ile and leu, P is a residue selected from Ala, Gly, Met, Val, Ile and Leu and P is a residue selected from Ala, Gly, Thr, Pro and Val.
摘要翻译：缺乏酪氨酸激酶活性的肽，其具有适于形成膜内α-螺旋的至少8个连续氨基酸残基的结合部分，并且能够降低靶细胞中的酪氨酸激酶活性，所述结合部分具有相同的序列至具有以下所示基序的天然（野生型）或突变型生长因子受体/酪氨酸激酶蛋白的位置P 0至P 7的序列，或具有不超过3个位置的序列该蛋白质的位置P <0>至P <7>的序列，其中所述基序包含指定为：P P P P 4的5个连续氨基酸残基的序列，其中残基X为相同或不同，并且各自是任何天然存在的L-氨基酸残基，P 0是选自Ala，Gly，Ser，Thr，Pro，Val，Ile和leu的残基，P 3是选自Ala ，Gly，Met，Val，Ile和Leu，P 4是选自Ala，Gly，Thr，Pro和Val的残基。

9. 发明申请

WO1989004670A1 PROCESS FOR PRODUCING ANTIBODIES 审中-公开
标题翻译：生产抗体的方法
公开(公告)号：WO1989004670A1
公开(公告)日：1989-06-01
申请号：PCT/GB1988001030
申请日：1988-11-25
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD , CLARK, Bruce, Fletcher
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55505
摘要： An immunogenic material comprising a lipid immunogen and silica.
摘要翻译：包含脂质免疫原和二氧化硅的免疫原性物质。

10. 发明申请

WO1997001571A1 NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON 审中-公开
标题翻译： VERTEBRATE DELTA基因的核苷酸和蛋白质序列及其方法
公开(公告)号：WO1997001571A1
公开(公告)日：1997-01-16
申请号：PCT/US1996011178
申请日：1996-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD. , YALE UNIVERSITY , ISH-HOROWICZ, David , HENRIQUE, Domingo, M., P. , LEWIS, Julian, H. , ARTAVANIS-TSAKONAS, Spyridon , GRAY, Grace, E.
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD. , YALE UNIVERSITY
IPC分类号： C07H17/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00
摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antobidies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.
摘要翻译：本发明涉及脊椎动物Delta基因的核苷酸序列及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端，跨膜区域，或一种或多种Delta蛋白质的EGF样重复序列，或上述的任何组合。另外提供了对三角洲，其衍生物和类似物的安慰剂。还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。提供了治疗和诊断方法和药物组合物。在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

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