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1. 发明专利

JP2014054568A Variable current density single needle electroporation system and method 有权
标题翻译：可变电流密度单针电气系统及方法
公开(公告)号：JP2014054568A
公开(公告)日：2014-03-27
申请号：JP2013252684
申请日：2013-12-06
申请人： Genetronics Inc , ジェネトロニクス,インコーポレイティド
发明人： KJEKEN RUNE , KEMMERRER STEPHEN VINCENT , LIN FENG , DIETMAR RABUSSAY , KARDOS THOMAS JOSEPH
IPC分类号： A61M37/00
CPC分类号： A61N1/327 , A61N1/325 , C12M35/02 , C12N13/00 , C12N15/87
摘要： PROBLEM TO BE SOLVED: To provide an electroporation method, electrodes for electroporation, and an electroporation system that make it possible to quantitatively measure the volumetric capacity of the tissue to which electroporation is actually applied, and can bring the possibility of reducing the excitement of sensory cells during electroporation-assisted delivery of a therapeutic substance by enabling substantial reduction of the electrical energy sent into a tissue containing nerve sensory cells.SOLUTION: This invention comprises an improved electroporation electrode system including a single needle and a ring- or donut-shaped electrode. In this configuration, the difference in surface area of the electrodes leads to a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminating end portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
摘要翻译：要解决的问题：提供电穿孔方法，电穿孔用电极和电穿孔系统，其可以定量测量实际应用电穿孔的组织的体积容量，并且可以带来降低感觉兴奋的可能性通过使得能够发送到含有神经感觉细胞的组织的电能显着降低，在电穿孔辅助递送治疗物质期间的细胞。解决方案：本发明包括改进的电穿孔电极系统，其包括单针和环形或环状电极。在该结构中，电极表面积的差异导致处理组织表面附近的电流密度显着降低，并且仅在与单针电极的终止端部相邻的组织中足够电穿孔的浓度更大的电流密度。因此，本发明提供靶向用于电穿孔的特定组织，并且还应当提供减少处理组织中电流的感觉。

2. 发明专利

JP2002291910A METHOD AND APPARATUS USING ELECTROPORATION THERAPY METHOD FOR DELIVERY OF DRUG AND GENE 审中-公开
公开(公告)号：JP2002291910A
公开(公告)日：2002-10-08
申请号：JP2002057679
申请日：2002-03-04
申请人： GENETRONICS INC
发明人： HOFMANN GUNTER A , DEV SUKHENDU B , DIMMER STEVEN C , LEVATTER JEFFREY I , NANDA GURVINDER S
IPC分类号： A61B17/34 , A61B18/14 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/30 , A61N1/32
摘要： PROBLEM TO BE SOLVED: To provide a method and apparatus for in vivo electroporation therapy. SOLUTION: Using the electroporation therapy(EPT), tumors are treated by a combination of electroporation using the apparatus (100) and a chemotherapeutic agent to cause the regression of tumors in vivo. In one embodiment, a method of EPT utilizing low voltage and long pulse length for inducing cell death is provided. One embodiment includes a system for clinical electroporation that includes a needle array electrode (114) having a 'keying' element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. In another mode, a laparoscopic needle applicator is provided and this is preferably combined with an endoscope for minimally invasive EPT and used.

3. 发明申请

WO0002621A9 SKIN AND MUSCLE-TARGETED GENE THERAPY BY PULSED ELECTRICAL FIELD 审中-公开
标题翻译：皮肤和肌肉靶向基因治疗的脉冲电场
公开(公告)号：WO0002621A9
公开(公告)日：2000-03-23
申请号：PCT/US9915755
申请日：1999-07-13
申请人： GENETRONICS INC , DEV NAGENDU B , HOFMANN GUNTER A , NOLAN EDWARD , RABUSSAY DIETMAR , TONNESSEN ARNT , WIDERA GEORG , ZHANG LEI
发明人： DEV NAGENDU B , HOFMANN GUNTER A , NOLAN EDWARD , RABUSSAY DIETMAR , TONNESSEN ARNT , WIDERA GEORG , ZHANG LEI
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/0452 , A61N1/306 , A61N1/325
摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
摘要翻译：本发明描述了一种体内方法，其使用脉冲电场将治疗剂递送到皮肤和肌肉细胞中进行局部和全身治疗。具体而言，治疗剂包括裸露或配制的核酸，多肽和化学治疗剂。

4. 发明申请

WO1997007666A1 ELECTROPORATION-MEDIATED MOLECULAR TRANSFER IN INTACT PLANTS 审中-公开
标题翻译：电铸植物中的介电分子转移
公开(公告)号：WO1997007666A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013569
申请日：1996-08-22
申请人： GENETRONICS, INC.
发明人： GENETRONICS, INC. , DEV, S., B. , HAYAKAWA, Yasuhiko
IPC分类号： A01H05/00
CPC分类号： C12N15/8206
摘要： A method for producing a genetically modified plant by introducing a polynucleotide to an intact plant or plant cell(s) via electroporation, in the absence of cell wall-degrading enzymes. Genetically engineered plants produced by the method of the invention are also provided. The invention also provides a method for producing a polypeptide in an intact plant cell, including plant tissue or a whole plant by introducing a biologically active polypeptide directly into the plant.
摘要翻译：在不存在细胞壁降解酶的情况下通过电穿孔将多核苷酸引入完整植物或植物细胞来生产遗传修饰植物的方法。还提供了通过本发明的方法生产的基因工程植物。本发明还提供了通过将生物活性多肽直接引入植物中来在完整植物细胞中产生多肽的方法，包括植物组织或整个植物。

5. 发明申请

WO1996012520A1 ELECTROPORETIC GENE AND DRUG THERAPY BY INDUCED ELECTRIC FIELDS 审中-公开
标题翻译：电诱导基因和药物诱导电场治疗
公开(公告)号：WO1996012520A1
公开(公告)日：1996-05-02
申请号：PCT/US1995008138
申请日：1995-06-27
申请人： GENETRONICS, INC.
发明人： GENETRONICS, INC. , HOFMANN, Gunter, A.
IPC分类号： A61N01/32
CPC分类号： A61N1/306 , A61N1/325 , A61N1/40
摘要： A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into contact with the body of the patient for generating an electric field at a preselected location within a selected blood vessel. Preselected molecules are infused into the selected blood vessel. Simultaneously an electric signal is applied to the applied device to repeatedly subject a quantity of blood flowing within the selected blood vessel past the preselected location to electric fields of a predetermined amplitude and duration. The parameters of the electric fields are precisely controlled in order to make the walls of preselected cells in the blood transiently permeable to permit the molecules to enter said preselected cells without killing said cells. The device can include either an induction coil that placed into contact with the body over a blood vessel, or alternatively, an induction coil that surrounds the blood vessel. The electric signal is supplied by a power pack and the preselected molecules are infused with a supply pump.
摘要翻译：为了治疗目的，提供了一种方法和装置，用于将诸如基因和药物化合物的分子引入患者的活血细胞。将装置放置成与患者的身体接触，以在所选择的血管内的预选位置处产生电场。预先选择的分子被输入到所选择的血管中。同时，向所施加的装置施加电信号，以将在所选择的血管内流动的一定数量的血液重复地经过预选位置到预定的幅度和持续时间的电场。精确地控制电场的参数，以使血液中预选细胞的壁瞬时渗透以允许分子进入所述预选细胞而不杀死所述细胞。该装置可以包括放置在血管上与身体接触的感应线圈，或者包括围绕血管的感应线圈。电信号由电源组提供，并且预选的分子注入供应泵。

6. 发明申请

WO2008063555A3 METHODS OF ENHANCING IMMUNE RESPONSE USING ELECTROPORATION-ASSISTED VACCINATION AND BOOSTING 审中-公开
标题翻译：利用电子辅助接种和促进增强免疫反应的方法
公开(公告)号：WO2008063555A3
公开(公告)日：2008-11-06
申请号：PCT/US2007024051
申请日：2007-11-16
申请人： GENETRONICS INC , MATHIESEN IACOB , TJELLE ELISABETH TORUNN , KJEKEN RUNE , RABUSSAY DIETMAR , LIN FENG
发明人： MATHIESEN IACOB , TJELLE ELISABETH TORUNN , KJEKEN RUNE , RABUSSAY DIETMAR , LIN FENG
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K2039/545
摘要： Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.
摘要翻译：公开了增强免疫应答的方法。这些方法涉及将疫苗组合物给予不同的组织以引起增强的免疫应答。增强的反应来自两种分开的患者组织中的接种和加强给药途径，例如首先给予皮肤初免接种并随后在肌肉中施用加强免疫接种。在每种情况下，引发和加强，疫苗组合物的施用优选使用同时的电穿孔辅助递送抗原剂进行。

7. 发明申请

WO0034436A3 FACS ASSISTED METHODS FOR INTRODUCING INDIVIDUAL CHROMOSOMES INTO CELLS 审中-公开
标题翻译： FACS辅助方法将个体染色体引入细胞
公开(公告)号：WO0034436A3
公开(公告)日：2001-09-20
申请号：PCT/US9928715
申请日：1999-12-03
申请人： GENETRONICS INC , NOLAN EDWARD M , RABUSSAY DIETMAR P , HOFMANN GUNTER A
发明人： NOLAN EDWARD M , RABUSSAY DIETMAR P , HOFMANN GUNTER A
IPC分类号： C07K14/78 , C07K16/28 , C12N15/87 , G01N33/68 , C12N15/63 , A61K48/00 , C12M3/00
CPC分类号： C12N15/87 , C12M35/02 , G01N33/6887
摘要： The present invention provides methods and apparatus for the delivery of at least one chromosome into a cell. Invention methods and apparatus employ FACS or MACS technology for rapidly processing cells and for confirming the introduction of chromosome(s) into a cell. The introduction of the chromosome(s) into the cell is mediated by one or more of a laser, a linear accelerator or electrically induced fusion of a cell and encapsulated chromosome(s). Invention methods provide for the rapid and reliable processing associated with FACS and MACS technology to process thousands of cells a minute, thereby enabling large scale gene transfer.
摘要翻译：本发明提供了将至少一种染色体递送到细胞中的方法和装置。本发明的方法和装置采用FACS或MACS技术来快速处理细胞并确认染色体在细胞中的引入。将染色体引入细胞是通过激光，线性加速器或电诱导的细胞融合和包被的染色体中的一种或多种来介导的。本发明方法提供了与FACS和MACS技术相关的快速可靠的处理，每分钟处理数千个细胞，从而实现大规模的基因转移。

8. 发明申请

WO0034436A9 FACS ASSISTED METHODS FOR INTRODUCING INDIVIDUAL CHROMOSOMES INTO CELLS 审中-公开
标题翻译： FACS辅助方法引入个体染色体进入细胞
公开(公告)号：WO0034436A9
公开(公告)日：2001-03-29
申请号：PCT/US9928715
申请日：1999-12-03
申请人： GENETRONICS INC , NOLAN EDWARD M , RABUSSAY DIETMAR P , HOFMANN GUNTER A
发明人： NOLAN EDWARD M , RABUSSAY DIETMAR P , HOFMANN GUNTER A
IPC分类号： C07K14/78 , C07K16/28 , C12N15/87 , G01N33/68 , C12N
CPC分类号： C12N15/87 , C12M35/02 , G01N33/6887
摘要： The present invention provides methods and apparatus for the delivery of at least one chromosome into a cell. Invention methods and apparatus employ FACS or MACS technology for rapidly processing cells and for confirming the introduction of chromosome(s) into a cell. The introduction of the chromosome(s) into the cell is mediated by one or more of a laser, a linear accelerator or electrically induced fusion of a cell and encapsulated chromosome(s). Invention methods provide for the rapid and reliable processing associated with FACS and MACS technology to process thousands of cells a minute, thereby enabling large scale gene transfer.
摘要翻译：本发明提供了用于将至少一种染色体递送到细胞中的方法和设备。发明方法和装置使用FACS或MACS技术来快速处理细胞并确认将染色体引入细胞。将染色体引入细胞由一种或多种激光，直线加速器或电诱导的细胞融合和包封的染色体介导。发明方法提供与FACS和MACS技术相关的快速和可靠的处理，以每分钟处理数千个细胞，从而实现大规模基因转移。

9. 发明申请

WO1995019805A1 ELECTROPORATION AND IONTOPHORESIS APPARATUS AND METHOD FOR INSERTION OF DRUGS AND GENES INTO CELLS 审中-公开
标题翻译：电动和静电放电装置以及将药物和基因插入细胞的方法
公开(公告)号：WO1995019805A1
公开(公告)日：1995-07-27
申请号：PCT/US1995000799
申请日：1995-01-20
申请人： GENETRONICS, INC. , HOFMANN, Gunter, A. , CRANDELL, Lois, J.
发明人： GENETRONICS, INC.
IPC分类号： A61N01/30
CPC分类号： A61M29/02 , A61M31/00 , A61N1/306 , A61N1/325 , A61N1/327 , C12M35/02
摘要： A catheter device having a plurality of axially extending, circumferentially spaced electrodes carried thereby, infusion means for infusion of fluid medium for carrying genes and drugs, and expandable sealing means at each end of the electrodes for sealing off and confining the therapeutic medium to the area to be treated is inserted into a selected blood vessel of a patient and advanced to a preselected location within the blood vessel where cells on or near the wall of the vessel are to be treated. Once in place, the catheter device is expanded so that the plurality of axially extending, circumferentially spaced electrodes carried thereby are in contact with the inner wall of the blood vessel and seals at each end of the electrodes expand and seal the catheter device in the preselected location. A quantity of therapeutic genes or drugs is infused into the area of the electrodes via a tube and a conventional pump. A power pack connected to the electrodes is energized subjecting the cells to electric fields of predetermined amplitude and duration making the walls of the cells transiently permeable to enabling therapeutic genes or drugs carried by the fluid medium to enter the cells without killing them.
摘要翻译：导管装置，其具有多个沿轴向延伸的周向隔开的电极，由此输送用于输送用于携带基因和药物的流体介质的输注装置，以及用于密封和限制治疗介质至该区域的电极的每个端部处的可膨胀密封装置被处理的细胞被插入到患者的选定的血管中并且前进到血管内的预定位置，其中待处理血管壁上或其附近的细胞。一旦就位，导管装置被扩张，使得由其携带的多个沿轴向延伸的周向隔开的电极与血管的内壁接触，并且在电极的每个端部处的密封件将预先选定的导管装置膨胀和密封位置。一些治疗基因或药物通过管和常规泵注入电极区域。连接到电极的电源组通电使细胞进入具有预定振幅和持续时间的电场，使得细胞壁瞬时渗透，使得流体介质携带的治疗基因或药物进入细胞而不杀死细胞。

10. 发明申请

WO9958188A9 ELECTRICALLY INDUCED VESSEL VASODILATION 审中-公开
标题翻译：电动感应血管消化
公开(公告)号：WO9958188A9
公开(公告)日：2001-04-05
申请号：PCT/US9909975
申请日：1999-05-07
申请人： GENETRONICS INC
发明人： DEV NAGENDU B , DEV SUKHENDU B , HOFMANN GUNTER A
IPC分类号： A61N1/30 , A61N1/32 , A61N1/00
CPC分类号： A61N1/327 , A61N1/325 , Y10S977/883 , Y10S977/904 , Y10S977/905
摘要： The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double balloon catheter system (100) incorporating electroporation technology has been designed, and is used to apply the electrical impulse endoluminal.
摘要翻译：本发明提供诱导或增加血管的血管舒张的方法。本发明还提供了用于诱导或增加通过容器的流体流动的方法。为了诱导或增加血管血管舒张或诱导或增加通过血管的流体流动，向血管施加电脉冲。在一个具体实施例中，已经设计了一种结合电穿孔技术的新型双气囊导管系统（100），并且用于施加电脉冲腔内腔。

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