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1. 发明申请

WO1991018007A1 PHTHALOCYANATOPOLYETHYLENE GLYCOL, AND PHTHALOCYANATO SACCHARIDES AS FLUORESCENT DIGOXIN REAGENTS 审中-公开
标题翻译：作为荧光二氧化物试剂的羟基乙酰乙酸甘油酯和邻苯二甲酸盐
公开(公告)号：WO1991018007A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003426
申请日：1991-05-15
申请人： DIATRON CORPORATION
发明人： DIATRON CORPORATION , DANDLIKER, Walter, B. , HSU, Mao-Lin
IPC分类号： C07J43/00
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/60 , A61K49/0015 , A61K49/0054 , C07D487/22 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/045 , C09B47/24 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
摘要翻译：提供了没有聚集和血清结合的荧光染料。这些染料适用于荧光免疫测定，体内成像和体内肿瘤治疗。

2. 发明申请

WO1993019366A1 FLUORESCENCE IMMUNOASSAYS USING FLUORESCENT DYES FREE OF AGGREGATION AND SERUM BINDING 审中-公开
标题翻译：使用荧光染料免疫聚集和血清结合的荧光免疫
公开(公告)号：WO1993019366A1
公开(公告)日：1993-09-30
申请号：PCT/US1993002470
申请日：1993-03-23
申请人： DIATRON CORPORATION
发明人： DIATRON CORPORATION , DEVLIN, Robert, Francis , DANDLIKER, Walter, Beach , ARRHENIUS, Peter, Olof, Gustaf
IPC分类号： G01N33/533
CPC分类号： A61K49/0036 , A61K49/0052 , C07F7/0838 , G01N33/56983 , G01N33/582 , G01N33/94 , G01N2333/19
摘要： Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.
摘要翻译：提供荧光免疫测定方法，其使用不含聚集和血清结合的荧光染料。因此，这样的免疫测定方法对生物流体如血清，血浆，全血和尿液的测定特别有用。

3. 发明申请

WO1991018006A1 FLUORESCENT PORPHYRIN, AND FLUORESCENT PHTHALOCYANINE - POLYETHYLENE GLYCOL, POLYOL, AND SACCHARIDE DERIVATIVES AS FLUORESCENT PROBES 审中-公开
标题翻译：氟荧光素和荧光聚苯乙烯 - 聚乙烯甘油，聚异戊二烯和衍生物作为荧光探针
公开(公告)号：WO1991018006A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003424
申请日：1991-05-15
申请人： DIATRON CORPORATION
发明人： DIATRON CORPORATION , ARRHENIUS, Peter, Olof, Gustaf
IPC分类号： C07J43/00
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/60 , A61K49/0015 , A61K49/0054 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
摘要翻译：提供与水溶液相容的标记组分，显示出有利的荧光性质，并且在溶液中表现出降低的非特异性结合大分子。这些标记组分可用于荧光免疫测定，体内成像和体内肿瘤治疗等应用。

4. 发明申请

WO1993019358A1 FLUOROMETER DETECTION SYSTEM 审中-公开
标题翻译：荧光检测系统
公开(公告)号：WO1993019358A1
公开(公告)日：1993-09-30
申请号：PCT/US1993002540
申请日：1993-03-22
申请人： DIATRON CORPORATION
发明人： DIATRON CORPORATION , STUDHOLME, Robert, Marlin , BLAU, David, Arthur
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , G01N21/6456 , G01N2021/6463
摘要： An improved fluorescence detection system is provided which utilizes a relatively high powered, relatively high repetition rate light source (10) with high speed detection electronics to increase system sensitivity and accuracy. In the preferred embodiments, a laser diode (90) is the light source (10). In one embodiment, the position of a time window is varied to compile a decay profile of a fluorophore. In another embodiment, the time of detection of a photon is used to compile the decay profile. In one aspect of this invention, a histogram of the fluorescence decay is generated by determining a preliminary histogram of the shape and multiplying it by the ratio of the total number of events divided by the number of events comprising the preliminary histogram. In another aspect of this invention, the time of detection after excitation of the photon is started from a random time, such as after a preceding event is detected and the data stored.
摘要翻译：提供了一种改进的荧光检测系统，其利用具有高速检测电子装置的相对高功率，相对高的重复率光源（10）来提高系统灵敏度和精度。在优选实施例中，激光二极管（90）是光源（10）。在一个实施例中，改变时间窗的位置以编制荧光团的衰减曲线。在另一个实施例中，使用光子的检测时间来编译衰减曲线。在本发明的一个方面，通过确定形状的初步直方图并将其乘以总事件数除以包括初步直方图的事件数的比率来生成荧光衰减的直方图。在本发明的另一方面，光子激发后的检测时间是从随机时间开始的，例如在检测到先前事件并存储数据之后。

5. 发明授权

US5846703A Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding 失效
公开(公告)号：US5846703A
公开(公告)日：1998-12-08
申请号：US35633
申请日：1993-03-23
申请人： Robert F. Devlin , Walter B. Dandliker , Peter O. G. Arrhenius
发明人： Robert F. Devlin , Walter B. Dandliker , Peter O. G. Arrhenius
IPC分类号： A61K49/00 , G01N33/94 , G01N33/533
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0043 , A61K49/0058 , G01N33/9453 , G01N2333/19 , Y10S436/80 , Y10S436/815 , Y10S436/816 , Y10S436/817
摘要： Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.

6. 发明授权

US5707813A Nucleic acid probes and methods 失效
标题翻译：核酸探针和方法
公开(公告)号：US5707813A
公开(公告)日：1998-01-13
申请号：US709285
申请日：1996-09-06
申请人： Walter B. Dandliker , Robert F. Devlin
发明人： Walter B. Dandliker , Robert F. Devlin
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , C07D487/22 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/04 , C09B47/073 , C09B47/08 , C09B47/24 , C12Q1/68 , G01N33/533 , G01N33/58 , C12P19/34
CPC分类号： A61K49/0021 , A61K41/0057 , A61K41/0071 , A61K47/48092 , A61K47/48215 , A61K49/0015 , A61K49/0036 , A61K49/0054 , C07D487/22 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/045 , C09B47/073 , C09B47/08 , C09B47/24 , C12Q1/6813 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.
摘要翻译：本发明涉及包含连接到包含荧光团部分的可检测标记的标记组分的寡核苷酸的组合物，其包含与能够与两个轴向配体和两个聚氧化烃部分配位的中心原子配位的基本上平面的多齿大环配体，轴向配体到中心原子。本发明还涉及使用这种组合物的核酸杂交和扩增方法。

7. 发明授权

US5606045A Nucleic acid probes and methods 失效
标题翻译：核酸探针和方法
公开(公告)号：US5606045A
公开(公告)日：1997-02-25
申请号：US51446
申请日：1993-04-21
申请人： Walter B. Dandliker , Robert F. Devlin
发明人： Walter B. Dandliker , Robert F. Devlin
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , C07D487/22 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/04 , C09B47/073 , C09B47/08 , C09B47/24 , C12Q1/68 , G01N33/533 , G01N33/58 , C07H21/02 , C07H21/04
CPC分类号： A61K49/0021 , A61K41/0057 , A61K41/0071 , A61K47/48092 , A61K47/48215 , A61K49/0015 , A61K49/0036 , A61K49/0054 , C07D487/22 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/045 , C09B47/073 , C09B47/08 , C09B47/24 , C12Q1/6813 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.
摘要翻译：本发明涉及包含连接到包含荧光团部分的可检测标记的标记组分的寡核苷酸的组合物，其包含与能够与两个轴向配体和两个聚氧化烃部分配位的中心原子配位的基本上平面的多齿大环配体，轴向配体到中心原子。本发明还涉及使用这种组合物的核酸杂交和扩增方法。

8. 发明授权

US5403928A Fluorescent marker components and fluorescent probes 失效
标题翻译：荧光标记组分和荧光探针
公开(公告)号：US5403928A
公开(公告)日：1995-04-04
申请号：US701449
申请日：1991-05-15
申请人： Peter O. G. Arrhenuis
发明人： Peter O. G. Arrhenuis
IPC分类号： A61K31/695 , A61K41/00 , A61K47/48 , A61K49/00 , A61P35/00 , C07D487/22 , C07F7/10 , C07H15/26 , C07H17/00 , C07H23/00 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , C09K11/06 , G01N33/533 , G01N33/58 , C09B47/30
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/48215 , A61K49/0015 , A61K49/0054 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
摘要翻译：提供与水溶液相容的标记组分，显示出有利的荧光性质，并且在溶液中表现出降低的非特异性结合大分子。这些标记组分可用于荧光免疫测定，体内成像和体内肿瘤治疗等应用。

9. 发明授权

US4877965A Fluorometer 失效
标题翻译：荧光计
公开(公告)号：US4877965A
公开(公告)日：1989-10-31
申请号：US751746
申请日：1985-07-01
申请人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
发明人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
IPC分类号： G01N21/64 , G02B21/16
CPC分类号： G01N21/6408 , G02B21/16 , G01N21/6456 , G01N21/6458 , G01N2201/1087
摘要： A fluorometer for measuring a particular fluorescence emanating from a specimen and operating in accordance with the following method. Producing a burst of concentrated light energy and directing the concentrated light energy toward the specimen to produce a fluorescence from the specimen including the particular fluorescence. Preferably producing an image of the fluorescence. Detecting the fluorescence and producing a signal in accordance with the fluorescence. Controlling the passage of the image of the fluorescence for detecting within a particular time period so as to optimize the detection of the particular fluorescence. Timing the operation to sequence the detection of the fluorescence within the particular time period after the production of the burst of concentrated light energy. Scanning the fluorescence from the specimen for forming signals representative of the fluorescence from the specimen. Analyzing the signals to enhance the portion of the signal representing the particular fluorescence relative to the portion of the signal.
摘要翻译：一种荧光计，用于测量从样品发出的特定荧光并根据以下方法进行操作。产生集中的光能的突发，并将集中的光能引导到样品以从包括特定荧光的样品产生荧光。优选地产生荧光图像。根据荧光检测荧光并产生信号。控制在特定时间段内用于检测的荧光图像的通过，以便优化特定荧光的检测。计算在产生聚集的光能的突发之后的特定时间段内对荧光的检测进行排序的操作。扫描来自样品的荧光，以形成代表来自样品荧光的信号。分析信号以增强表示相对于信号部分的特定荧光的信号部分。

10. 发明授权

US5677199A Fluorescent marker components and fluorescent probes 失效
标题翻译：荧光标记组分和荧光探针
公开(公告)号：US5677199A
公开(公告)日：1997-10-14
申请号：US346098
申请日：1994-11-29
申请人： Peter Olof Gustaf Arrhenuis
发明人： Peter Olof Gustaf Arrhenuis
IPC分类号： A61K49/00 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , G01N33/533 , G01N33/58 , G01N33/53 , C07D487/22 , C09B47/30
CPC分类号： A61K49/0036 , A61K49/0021 , A61K49/0052 , A61K49/0054 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , G01N33/533 , G01N33/582 , G01N2333/19 , Y10S436/80
摘要： Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays and in vivo imaging.
摘要翻译：提供与水溶液相容的标记组分，显示出有利的荧光性质，并且在溶液中表现出降低的非特异性结合大分子。这些标记组分可用于荧光免疫测定和体内成像等应用。

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