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1. 发明申请

WO2009086521A3 SYSTEM, DEVICE, AND METHOD FOR LASER CAPTURE MICRODISSECTION 审中-公开
公开(公告)号：WO2009086521A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/088451
申请日：2008-12-29
申请人： CARL ZEISS MICROIMAGING AIS, INC. , BLOOM, Kenneth, J. , ZEINEH, Jack, A. , LESNIAK, Andrew, J.
发明人： BLOOM, Kenneth, J. , ZEINEH, Jack, A. , LESNIAK, Andrew, J.
IPC分类号： G02B21/36 , G01N21/00 , G01B9/04 , G01B11/00
摘要： A system, device, and method for obtaining samples from a laser capture microdissection system. A slide can be scanned to create a digital slide. The digital slide can then be annotated by a user. The coordinates of the annotations can then be subject to a transformation, such that the designated area is laser dissected out on a laser capture microdissection device.

2. 发明申请

WO2008085907A3 SYSTEM AND METHOD FOR ANALYZING TISSUE SLIDES FOR OBSERVABLE PATHOLOGIES 审中-公开
公开(公告)号：WO2008085907A3
公开(公告)日：2008-07-17
申请号：PCT/US2008/000145
申请日：2008-01-04
申请人： CARL ZEISS MICROIMAGING AIS, INC. , BLOOM, Kenneth, J. , ZEINEH, Jack, A.
发明人： BLOOM, Kenneth, J. , ZEINEH, Jack, A.
IPC分类号： G06K9/00
摘要： A system, device, and method for analyzing cellular specimen slides for observable pathologies, including presenting a first image of a first slide including a first portion of a cellular specimen, wherein the first portion is stained with a first stain, initiating an automated randomization sequence, wherein one or more regions of the first image are randomly selected and presented, and effecting analysis of the first image at each of the one or more regions to determine whether each of the one or more regions includes an area of interest.

3. 发明授权

US07421102B2 System and method for finding regions of interest for microscopic digital montage imaging 有权
公开(公告)号：US07421102B2
公开(公告)日：2008-09-02
申请号：US11221331
申请日：2005-09-06
申请人： Arthur W. Wetzel , John R. Gilbertson, II , Jeffrey A. Beckstead , Patricia A. Feineigle , Christopher R. Hauser , Frank A. Palmieri, Jr.
发明人： Arthur W. Wetzel , John R. Gilbertson, II , Jeffrey A. Beckstead , Patricia A. Feineigle , Christopher R. Hauser , Frank A. Palmieri, Jr.
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G06K9/00127 , G06K9/3233
摘要： A system for determining tissue locations on a slide.

4. 发明授权

US07457481B2 Apparatus and method for labeling rows and columns in an irregular array 失效
标题翻译：用于在不规则阵列中标记行和列的装置和方法
公开(公告)号：US07457481B2
公开(公告)日：2008-11-25
申请号：US11634747
申请日：2006-12-05
申请人： Jose de la Torre-Bueno , Peter Salamon
发明人： Jose de la Torre-Bueno , Peter Salamon
IPC分类号： G06K9/36
CPC分类号： G06F19/20 , B01J2219/00351 , B01J2219/00531 , B01J2219/00547 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , C40B60/14 , C40B70/00 , G06T7/66 , G06T7/75 , G06T2207/30072
摘要： The apparatus and method of the invention provide for assigning coordinates to samples in an array. The method is based on a hierarchical pattern matching to a local lattice structure that is used as a template. Starting from the best local match, the pattern is expanded hierarchically to encompass the entire array.
摘要翻译：本发明的装置和方法提供了将坐标分配给阵列中的样本。该方法基于与用作模板的局部晶格结构的分层模式匹配。从最好的本地匹配开始，模式分层扩展以包含整个数组。

5. 发明授权

US07428325B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物样本自动图像分析的方法和装置
公开(公告)号：US07428325B2
公开(公告)日：2008-09-23
申请号：US11685717
申请日：2007-03-13
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G01N15/1475 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06K9/20 , G06K9/342 , G06K9/4609 , G06K9/4652 , G06T5/002 , G06T5/005 , G06T5/30 , G06T7/136 , G06T2207/10024 , G06T2207/10056 , G06T2207/20012 , G06T2207/20016 , G06T2207/30024
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后过滤颜色空间转换的图像。候选兴趣像素被形态地处理并与斑点参数进行比较，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。

6. 发明授权

US07391894B2 System and method for remote navigation of a specimen 失效
标题翻译：用于样品远程导航的系统和方法
公开(公告)号：US07391894B2
公开(公告)日：2008-06-24
申请号：US11485478
申请日：2006-07-12
申请人： Jack A. Zeineh
发明人： Jack A. Zeineh
IPC分类号： G06K9/00
CPC分类号： G06T9/007
摘要： A system and method for remote navigation of a specimen.
摘要翻译：用于远程导航样本的系统和方法。

7. 发明授权

US07558415B2 Automated detection of objects in a biological sample 失效
标题翻译：自动检测生物样品中的物体
公开(公告)号：US07558415B2
公开(公告)日：2009-07-07
申请号：US11674652
申请日：2007-02-13
申请人： Gina McLaren , Robert Ellis , James W. Douglass , Thomas J. Riding , James E. Ring
发明人： Gina McLaren , Robert Ellis , James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K9/00
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.
摘要翻译：提供了用于自动光学显微镜检测与细胞增殖性疾病相关的蛋白质的方法，系统和装置。

8. 发明申请

US20090074284A1 SYSTEM AND METHOD FOR CREATING MAGNIFIED IMAGES OF A MICROSCOPE SLIDE 审中-公开
标题翻译：用于创建显微镜幻灯片放大图像的系统和方法
公开(公告)号：US20090074284A1
公开(公告)日：2009-03-19
申请号：US12277145
申请日：2008-11-24
申请人： Jack A. Zeineh , Rui-Tao Dong
发明人： Jack A. Zeineh , Rui-Tao Dong
IPC分类号： G06K9/00 , G02B27/64
CPC分类号： G02B21/365 , G02B21/367 , G02B27/0075 , G06T7/32 , G06T2200/32 , G06T2207/30004
摘要： A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.
摘要翻译：一种用于创建具有最佳图像质量特性的数字，虚拟幻灯片的方法和系统。识别物理幻灯片的多个区域以及至少两个焦点z位置z1和z2。在第一z位置扫描（成像）物理幻灯片的每个区域，以便产生每个限定区域的第一组数字图像。物理幻灯片的每个区域也在第二z位置被扫描（成像），以便产生每个限定区域的第二组数字图像。针对聚焦质量度量评估每组的每个图像，并且对于每个区域，选择对应于该区域的第一或第二图像，其呈现与期望焦点质量对应的焦点质量度量。然后将这些图像合并到数字虚拟幻灯片中。可以包括附加的焦点z位置，并且可以顺序，/或以重叠的方式扫描多个z位置。

9. 发明授权

US07505614B1 Remote interpretation of medical images 失效
标题翻译：远程解读医学图像
公开(公告)号：US07505614B1
公开(公告)日：2009-03-17
申请号：US09542091
申请日：2000-04-03
申请人： Jose De La Torre-Bueno
发明人： Jose De La Torre-Bueno
IPC分类号： G06K9/00 , G06K9/36 , G06K9/46
CPC分类号： G06F19/324 , G06F19/00 , G06F19/3418 , G06T7/0012 , G06T2207/10072 , G06T2207/10116 , H04N1/217 , H04N19/12 , H04N19/162 , H04N19/17 , H04N19/60 , H04N19/99
摘要： A remote view station is communicatively coupled to an image server and receives a compressed version of source medical images. The remote view station uncompresses and displays the received medical image. A medical professional, such as a pathologist, can select a region of the displayed medical image. Region information is transmitted back to the image server that applies image analysis operations on a region of the source medical image that corresponds to the selected region of the compressed medical image. In this manner, the data loss that occurs during image compression does not effect the image analysis operations. As such, the image analysis operations produce more accurate results than if the operations were applied by remote view station to the uncompressed image.
摘要翻译：远程观察站通信地耦合到图像服务器并且接收源医学图像的压缩版本。远程观察站解压缩并显示接收到的医学图像。诸如病理学家的医学专业人员可以选择所显示的医学图像的区域。区域信息被发送回到图像服务器，该图像服务器对与所压缩的医学图像的所选择的区域相对应的源医学图像的区域应用图像分析操作。以这种方式，在图像压缩期间发生的数据丢失不影响图像分析操作。因此，与远程观察站应用于未压缩图像的操作相比，图像分析操作产生更准确的结果。

10. 发明授权

US07456377B2 System and method for creating magnified images of a microscope slide 失效
标题翻译：用于创建显微镜幻灯片的放大图像的系统和方法
公开(公告)号：US07456377B2
公开(公告)日：2008-11-25
申请号：US11211405
申请日：2005-08-25
申请人： Jack A. Zeineh , Rui-Tao Dong
发明人： Jack A. Zeineh , Rui-Tao Dong
IPC分类号： G02B7/04
CPC分类号： G02B21/365 , G02B21/367 , G02B27/0075 , G06T7/32 , G06T2200/32 , G06T2207/30004
摘要： A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.
摘要翻译：一种用于创建具有最佳图像质量特性的数字，虚拟幻灯片的方法和系统。识别物理幻灯片的多个区域以及至少两个焦点z位置z 1和z 2。物理幻灯片的每个区域在第一z位置被扫描（成像），以便产生第一组每个定义区域的数字图像。物理幻灯片的每个区域也在第二z位置被扫描（成像），以便产生每个限定区域的第二组数字图像。针对聚焦质量度量评估每组的每个图像，并且对于每个区域，选择对应于该区域的第一或第二图像，其呈现与期望焦点质量对应的焦点质量度量。然后将这些图像合并到数字虚拟幻灯片中。可以包括附加的焦点z位置，并且可以顺序，/或以重叠的方式扫描多个z位置。

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