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1. 发明申请

WO2015013710A1 FLEXIBLE INTERFACE CRYOCAST WITH REMOTE COOLING 审中-公开
标题翻译：具有远程冷却功能的柔性接口
公开(公告)号：WO2015013710A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/048440
申请日：2014-07-28
申请人： BRUKER BIOSPIN CORPORATION
发明人： HEISS, Arthur H. , KHATRI, Ajay
IPC分类号： F16L9/19
CPC分类号： F17C9/00 , F16L9/19 , F17C2227/00 , F25B9/02 , F25B9/14 , F25B25/005 , F25B2309/021 , H01F6/04
摘要： A closed cycle cryocooler system for cooling a sample includes a cryocooler that receives helium gas and provides a cooled helium gas, a flexible interface that receives the cooled helium gas and provides the cooled helium gas to a rigid stinger assembly configured and arranged to provide the cooled helium gas to a cryostat. The flexible interface may include a first gas flow path that routes gas to the rigid stinger assembly, and a second gas flow path receives return gas from the rigid stinger. The first gas flow path may be radially interior with respect to the second gas flow path
摘要翻译：用于冷却样品的封闭循环低温冷却器系统包括接收氦气并提供冷却的氦气的低温冷却器系统，接收冷却的氦气的柔性界面，并将冷却的氦气提供给刚性施肥机组件，氦气到低温恒温器。柔性界面可以包括将气体输送到刚性施肥机组件的第一气体流动路径，并且第二气体流动路径接收来自刚性施肥管的返回气体。第一气体流动路径可以相对于第二气体流动路径在径向内部

2. 发明申请

WO2003079034A2 FLOW-THROUGH CRYOGENIC NMR PROBE 审中-公开
标题翻译：流通低温核磁共振探针
公开(公告)号：WO2003079034A2
公开(公告)日：2003-09-25
申请号：PCT/IB2003/002430
申请日：2003-03-13
申请人： BRUKER BIOSPIN CORPORATION
发明人： HOFMANN, Martin , SPRAUL, Manfred , NAST, Robert, Eric , HARRIS, Damon, Leslie
IPC分类号： G01R33/30
CPC分类号： G01R33/307 , G01R33/34023 , G01R33/34092
摘要： A nuclear magnetic resonance (NMR) spectroscopy probe has a sample cell into and out of which a room temperature liquid sample may be directed, The cell is surrounded by a radio frequency coil that is used to perform NMR measurements of the liquid sample, and which is maintained at cryogenic temperatures. The coil is separated from the sample cell by a thermally insulative boundary, such as a vacuum. The sample may enter the cell through an input path, and may exit through an output path. The input path, output path and sample cell may be surrounded by a sheath through which flows room temperature gas. The ends of the sample cell may be tapered to promote thorough flow through the cell, and flow diverters may be included in the sample cell adjacent to the input and output paths to force flow to the outer wall of the sample cell.
摘要翻译：核磁共振（NMR）光谱探针具有进入和离开室温液体样品的样品池，该池由射频线圈围绕，射频线圈用于进行NMR 液体样品的测量，并保持在低温下。线圈通过隔热边界（如真空）与样品池隔开。样本可以通过输入路径进入单元格，并可以通过输出路径退出。输入路径，输出路径和样品池可以被流经室温气体的鞘所包围。样品池的末端可以是锥形的以促进通过池的彻底流动，并且流动转向器可以包括在与输入和输出路径相邻的样品池中以强制流动到样品池的外壁。

3. 发明申请

WO2003079034A3 FLOW-THROUGH CRYOGENIC NMR PROBE 审中-公开
公开(公告)号：WO2003079034A3
公开(公告)日：2003-09-25
申请号：PCT/IB2003/002430
申请日：2003-03-13
申请人： BRUKER BIOSPIN CORPORATION
发明人： HOFMANN, Martin , SPRAUL, Manfred , NAST, Robert, Eric , HARRIS, Damon, Leslie
IPC分类号： G01R33/30
摘要： A nuclear magnetic resonance (NMR) spectroscopy probe has a sample cell into and out of which a room temperature liquid sample may be directed, The cell is surrounded by a radio frequency coil that is used to perform NMR measurements of the liquid sample, and which is maintained at cryogenic temperatures. The coil is separated from the sample cell by a thermally insulative boundary, such as a vacuum. The sample may enter the cell through an input path, and may exit through an output path. The input path, output path and sample cell may be surrounded by a sheath through which flows room temperature gas. The ends of the sample cell may be tapered to promote thorough flow through the cell, and flow diverters may be included in the sample cell adjacent to the input and output paths to force flow to the outer wall of the sample cell.

4. 发明申请

US20150102812A1 NMR REACTION MONITORING FLOW CELL 审中-公开
标题翻译： NMR反应监测流动池
公开(公告)号：US20150102812A1
公开(公告)日：2015-04-16
申请号：US14230832
申请日：2014-03-31
申请人： Bruker Biospin Corporation
发明人： Brian Marquez , Michael Fey , Kimberly L. Colson , Robert Krull , Eckhard Bez , Don Piroli , Werner E. Maas
IPC分类号： G01N24/08 , G01R33/46
CPC分类号： G01N24/08 , G01R33/307 , G01R33/31 , G01R33/46
摘要： A monitoring cell, used to perform a measurement in an NMR spectrometer of a reaction fluid produced by a reaction vessel, has a body having inlet and outlet transport coaxial capillaries for transporting the reaction fluid between the body and the reaction vessel. Cooling lines are also positioned coaxially with the transport capillaries to transport cooling liquid between the body and the reaction vessel. The cell further has a hollow sample probe for insertion into the NMR spectrometer and a coupler section that removably connects the sample probe to the body so that the inlet transport capillary extends through the body into the interior of the sample probe and the outlet transport capillary is sealed to the sample probe to allow reaction fluid that enters the sample probe via the inlet transport capillary to exit the sample probe via the outlet transport capillary.
摘要翻译：用于在由反应容器产生的反应流体的NMR光谱仪中进行测量的监测单元具有用于在体和反应容器之间输送反应流体的入口和出口输送同轴毛细管的主体。冷却管线也与运输毛细管同轴地定位，以在主体和反应容器之间输送冷却液体。细胞还具有用于插入NMR光谱仪的中空样品探针和可将样品探针可移除地连接到身体的耦合器部分，使得入口输送毛细管延伸穿过身体进入样品探针的内部，并且出口输送毛细管密封到样品探针，以允许经由入口输送毛细管进入样品探针的反应流体通过出口输送毛细管离开样品探针。

5. 发明申请

US20150061666A1 SAMPLE-PREPARATION METHOD TO MANIPULATE NUCLEAR SPIN-RELAXATION TIMES, INCLUDING TO FACILITATE ULTRALOW TEMPERATURE HYPERPOLARIZATION 有权
标题翻译：用于处理核心松弛时间的样品制备方法，包括加速超温度高效
公开(公告)号：US20150061666A1
公开(公告)日：2015-03-05
申请号：US14161172
申请日：2014-01-22
申请人： Millikelvin Technologies LLC , Buker Biospin Corporation
发明人： James G. Kempf , Neal Kalechofsky , Melanie Rosay
IPC分类号： G01R33/31 , G01R33/48
CPC分类号： G01R33/31 , G01R33/282
摘要： A method of providing a material sample in a state favorable to retaining spin polarization includes cooling a material sample from a temperature above a freezing point of the material sample down to a second temperature below the freezing point of the material sample; maintaining the sample at about the second temperature for a period of about several hours; and reducing temperature of the material sample to a third temperature lower than the second temperature to provide the material sample in a state favorable to retaining spin polarization, where the steps of cooling, maintaining and reducing are performed in the absence of an adulterant material. The method of providing a sample of pyruvic acid in a state favorable to retaining spin polarization may include cooling the sample of pyruvic acid in the absence of an adulterant material from a temperature above a freezing point of the sample of pyruvic acid down to less than about 200 Kelvin to provide the sample.
摘要翻译：以有利于保持自旋极化的状态提供材料样品的方法包括将材料样品从高于材料样品的凝固点的温度冷却至低于材料样品的凝固点的第二温度; 将样品保持在约第二温度约数小时; 并且将材料样品的温度降低到低于第二温度的第三温度，以提供有利于保持自旋极化的状态的材料样品，其中在没有掺杂材料的情况下进行冷却，保持和还原的步骤。以有利于保持自旋极化的状态提供丙酮酸样品的方法可包括在不存在掺杂材料的情况下将丙酮酸样品从高于丙酮酸样品的凝固点的温度冷却到小于约 200开尔文提供样品。

6. 发明申请

US20140176136A1 CRYOGEN-FREE COOLING SYSTEM FOR ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER 审中-公开
标题翻译：电子参比共振光谱仪的无冷冻冷却系统
公开(公告)号：US20140176136A1
公开(公告)日：2014-06-26
申请号：US14107587
申请日：2013-12-16
申请人： Bruker Biospin Corporation
发明人： Arthur H. Heiss , Ajay Khatri
IPC分类号： F25B9/02 , G01R33/38
CPC分类号： F25B9/02 , F25B25/00 , G01N24/10 , G01R33/31 , G01R33/38 , G01R33/3806 , G01R33/60
摘要： In an electron paramagnetic resonance spectrometer, a closed cycle cryocooler is used to cool gaseous helium, which is then circulated around a sample to cool the sample by direct convection. Since the sample is not mechanically connected to the refrigerator, no vibrations are transmitted from the refrigerator to the sample and the sample can be quickly removed and replaced. The cooled helium can be passed through a Joule-Thomson expansion device before circulating the cooled helium around the sample to further cool the helium. In addition, a vacuum pump can be connected to the helium outlet after circulating the cooled helium around the sample to increase the pressure differential across the Joule-Thomson expansion device and further cool the helium. In order to raise the temperature of the cooled helium, a heater can be placed about the cooled helium line upstream from the sample.
摘要翻译：在电子顺磁共振光谱仪中，使用封闭循环的低温冷却器来冷却气态氦气，然后将其循环在样品周围，通过直接对流冷却样品。由于样品没有机械地连接到冰箱，所以没有振动从冰箱传输到样品，并且可以快速地取出和更换样品。冷却的氦气可以通过焦耳 - 汤姆逊膨胀装置，然后将冷却的氦气循环到样品周围，以进一步冷却氦气。此外，在将冷却的氦气循环到样品周围之后，真空泵可以连接到氦出口，以增加焦耳 - 汤姆森膨胀装置的压差，并进一步冷却氦气。为了提高冷氦的温度，可以在样品上游的冷却氦管线周围放置加热器。

7. 发明申请

US20130271141A1 MULTIPLE RESONANCE SAMPLE COIL FOR MAGIC ANGLE SPINNING NMR PROBE 有权
标题翻译：用于魔术角旋转核磁共振探测器的多个共振样品盘
公开(公告)号：US20130271141A1
公开(公告)日：2013-10-17
申请号：US13447189
申请日：2012-04-14
申请人： Wurong Zhang , Michael Fey , Peter Gor'kov
发明人： Wurong Zhang , Michael Fey , Peter Gor'kov
IPC分类号： G01R33/34
CPC分类号： G01R33/34092 , G01R33/34053 , G01R33/34061 , G01R33/34076 , G01R33/3635
摘要： A multiple resonance sample coil for a magic angle spinning nuclear magnetic resonance probe is comprised of a solenoid coil that resonates at low frequencies and a resonator that resonates at high frequencies. The ends of the low frequency solenoid coil are electrically connected to the high frequency resonator to eliminate arcing and allow the solenoid coil to extend the full width of the resonator. In some embodiments, the high frequency resonator is constructed from the outermost turns of the solenoid coil in the form of a birdcage resonator. In another embodiment, the solenoid coil is electrically connected to one turn of the resonator and the other turn is used as part of a trap to shunt the resonator at low frequencies.
摘要翻译：用于魔角旋转核磁共振探测器的多重谐振采样线圈由在低频谐振的螺线管线圈和在高频下共振的谐振器构成。低频螺线管线圈的端部电连接到高频谐振器以消除电弧并允许螺线管线圈延伸谐振器的全部宽度。在一些实施例中，高频谐振器由鸟笼式谐振器形式的螺线管线圈的最外圈构成。在另一个实施例中，螺线管线圈电连接到谐振器的一匝，而另一匝用作陷波器的一部分以在低频下分流谐振器。

8. 发明授权

US08504140B2 Apparatus and method for fluorescence imaging and tomography using spatially structured illumination 有权
标题翻译：使用空间结构照明的荧光成像和断层摄影的装置和方法
公开(公告)号：US08504140B2
公开(公告)日：2013-08-06
申请号：US12411432
申请日：2009-03-26
申请人： Gilbert Feke , Laurie L. Voci
发明人： Gilbert Feke , Laurie L. Voci
IPC分类号： A61B6/02
CPC分类号： A61B5/0071 , A61B5/0077 , A61B2576/00 , G01N21/6456 , G01N2021/1782 , G01N2021/1787 , G01N2201/0635
摘要： An imaging system for imaging an object. More specifically, an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source wherein the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected to minimize excitation radiation from reaching the detection beam path.
摘要翻译：用于成像对象的成像系统。更具体地说，一种能够在诸如人或动物组织的混浊介质中进行深度分割荧光成像的成像系统基本上最小化到达检测光束路径的激发辐射。成像系统包括激发辐射源的布置，其中源的光轴相对于照相机的光轴倾斜，源的光学平面和物体的光学平面经受Scheimpflug条件，并且选择源的倾斜角度使得入射到物体上的激发辐射被反射以使得到达检测光束路径的激发辐射最小化。

9. 发明授权

US08445840B2 Imaging target for testing quality of multiple-magnification focus and image co-registration 有权
标题翻译：用于测试多重放大倍数焦点和图像共同注册质量的成像目标
公开(公告)号：US08445840B2
公开(公告)日：2013-05-21
申请号：US13235537
申请日：2011-09-19
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： G01D18/00
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/0059 , A61B6/5247 , A61B6/587 , A61B2562/17
摘要： An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system.
摘要翻译：适用于多模态成像系统的成像目标包括用于测试多重放大倍数和多模式成像系统的多种操作模式的聚焦质量和共同配准的测试模式。

10. 发明申请

US20050200359A1 Planar NMR coil with gyromagnetic arc suppression 有权
标题翻译：具有回旋磁阻抑制的平面NMR线圈
公开(公告)号：US20050200359A1
公开(公告)日：2005-09-15
申请号：US10796948
申请日：2004-03-10
申请人： Richard Withers
发明人： Richard Withers
IPC分类号： G01R33/34 , G01R33/341 , G01V3/00
CPC分类号： G01R33/34053 , G01R33/34007 , G01R33/34023 , G01R33/34092 , G01R33/341
摘要： A magnetic resonance RF coil comprises a conductive material deposited on a dielectric substrate. The conductive material includes magnetic field generating elements used to generate an RF magnetic field and interdigital capacitor elements. The capacitor elements are oriented parallel to the magnetic field generating elements and, therefore, to a main static magnetic field within which the coil is to be located. This orientation minimizes arcing resulted from emitted electrons and helps to prevent catastrophic breakdown of the coil.
摘要翻译：磁共振RF线圈包括沉积在电介质基片上的导电材料。导电材料包括用于产生RF磁场和叉指电容器元件的磁场产生元件。电容器元件平行于磁场产生元件定向，并且因此定向到其中线圈将要被定位的主静态磁场。该方向最小化由发射的电子产生的电弧，并有助于防止线圈的灾难性击穿。

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