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1. 发明专利

AU637356B2 NOVEL BENZIMIDAZOLE DERIVATIVES 未知
公开(公告)号：AU637356B2
公开(公告)日：1993-05-27
申请号：AU5162690
申请日：1990-02-23
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： MARK WHITTAKER , CHRISTOPHER DAVID FLOYD , JONATHAN PHILLIP DICKENS , ALAN HORNSBY DAVIDSON
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/675 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P37/00 , C07C211/52 , C07C309/65 , C07C309/66 , C07C309/72 , C07D235/02 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/18 , C07D235/26 , C07D235/28 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/04 , C07F9/6506
摘要： Compounds of general formula I: I wherein: each of R1-R8, k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.

2. 发明专利

AU2658692A SOLUBLE FORMS OF ELAM, USES AND DIAGNOSTICS 未知
公开(公告)号：AU2658692A
公开(公告)日：1993-05-03
申请号：AU2658692
申请日：1992-09-30
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： ANDREW JOHN HUBERT GEARING
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12

3. 发明专利

AU2312692A KETOPHOSPHANATE COUPLING PROCEDURE 未知
公开(公告)号：AU2312692A
公开(公告)日：1993-02-23
申请号：AU2312692
申请日：1992-07-15
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： ALAN HORNSBY DAVIDSON , CHRISTOPHER MARK BLACKWELL , CHRISTOPHER NORMAN LEWIS
IPC分类号： C07D309/30 , C07F7/18

4. 发明专利

AU1787392A SYNTHETIC PROCESS 未知
公开(公告)号：AU1787392A
公开(公告)日：1992-12-30
申请号：AU1787392
申请日：1992-05-21
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： RICHARD SIMON TODD , MAXWELL REEVE
IPC分类号： C07C69/013 , C07C69/732 , C07C69/757 , C07D309/30

5. 发明专利

AU631909B2 6-(HYDRONAPHTYL-1-ETHYL)-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H- PYRAN-2-ONES AND THE CORRESPONDING HYDROXY ACIDS 未知
公开(公告)号：AU631909B2
公开(公告)日：1992-12-10
申请号：AU6032290
申请日：1990-07-04
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： CHRISTOPHER NORMAN LEWIS , ALAN HORNSBY DAVIDSON , CHRISTOPHER DAVID FLOYD , JONATHAN PHILIP DICKENS
IPC分类号： A61K31/215 , A61K31/23 , A61K31/365 , A61K47/48 , A61P3/06 , A61P9/10 , C07C69/28 , C07C69/732 , C07C69/738 , C07D309/00 , C07D309/30
摘要： PCT No. PCT/GB90/01030 Sec. 371 Date Oct. 15, 1991 Sec. 102(e) Date Oct. 15, 1991 PCT Filed Jul. 4, 1990 PCT Pub. No. WO91/00280 PCT Pub. Date Jan. 10, 1991.Compounds of either of general formulae (I) and (II), wherein: R1 represents a C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-8)alkyl, C2-8 alkenyl, or C1-6 alkyl substituted phenyl group; R2 represents a C1-8 alkyl, C2-8 alkenyl, C2-8alkynyl group or a C1-5 alkyl, C2-5 alkenyl or C2-5 alkynyl group substituted with a substituted phenyl group; R3 represents a hydrogen atom or a substituent R4 or M; R4 represents a C1-5 alkyl group, or C1-5 alkyl group substituted with a group chosen from substituted phenyl, dimethylamino and acetylamino; R5 represents a hydrogen atom or a methyl or ethyl group except that when R2 is methyl then R5 is not methyl; M represents a cation capable of forming a pharmaceutically acceptable salt; Q represents C=O or CHOH; and each of a, b, c, and d, is independently a single or double bond except that when a and c are double bonds then b is a single bond; are inhibitors of the enzyme 24 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate limiting enzyme in the biosynthesis of cholesterol in mammals including man, and as such are useful in the treatment of hypercholesterolemia in general and arteriosclerosis, familiar hypercholesterolemia or hyperlipidemia in particular.

6. 发明专利

AU2883792A INTERMEDIATES AND PROCESS FOR THE PREPARATION OF MEVINIC ACIDS 未知
公开(公告)号：AU2883792A
公开(公告)日：1993-06-15
申请号：AU2883792
申请日：1992-11-02
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： CHRISTOPHER NORMAN LEWIS , RICHARD SIMON TODD , CHRISTOPHER MARK BLACKWELL
IPC分类号： C07D309/30 , C07F7/18

7. 发明专利

AU2786992A HEXAHYDROFURO(2,3-B)FURANS AS PAF ANTAGONISTS 未知
公开(公告)号：AU2786992A
公开(公告)日：1993-05-21
申请号：AU2786992
申请日：1992-10-21
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： MARK WHITTAKER
IPC分类号： C07D493/04 , C07D519/00
摘要： PCT No. PCT/GB92/01931 Sec. 371 Date Apr. 18, 1994 Sec. 102(e) Date Apr. 18, 1994 PCT Filed Oct. 21, 1992 PCT Pub. No. WO93/08194 PCT Pub. Date Apr. 29, 1993.The invention concerns compounds of the formula I: I wherein the variables are described in the specification which are antagonists of platelet activity factor.

8. 发明专利

AU634926B2 METHOD OF SYNTHESISING DOUBLE STRANDED DNA 未知
公开(公告)号：AU634926B2
公开(公告)日：1993-03-04
申请号：AU1052792
申请日：1992-01-28
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： RICHARD MARK EDWARDS , SALLY ELIZABETH ADAMS
IPC分类号： C12N15/09 , C07K14/16 , C12N15/10 , C12Q1/68 , C12Q1/686

9. 发明专利

AU1353692A EQUINE EPIDERMAL GROWTH FACTOR 未知
公开(公告)号：AU1353692A
公开(公告)日：1992-10-21
申请号：AU1353692
申请日：1992-03-09
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： RICHARD MARK EDWARDS , KEITH GRAHAM MCCULLAGH , CHRISTINE ANNA GREK POWER
IPC分类号： A61K38/00 , C07K14/485 , C12N15/16

10. 发明专利

AU1412192A 1-OXA-2,9-DIPHENYL-SPIRO(4,4)NONANE DERIVATIVES AS PAF ANTAGONISTS 未知
公开(公告)号：AU1412192A
公开(公告)日：1992-10-06
申请号：AU1412192
申请日：1992-03-04
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： ALAN HORNSBY DAVIDSON , MARK WHITTAKER , ZOE MARIE SPAVOLD
IPC分类号： C07D307/94 , C07D405/06
摘要： Compounds of general formula I; wherein: each of R , R , and R independently represents hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl; each of R and R independently represents hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COOH, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, -OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl or a -OC(=O)R group wherein R represents -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, -COC1-C6 alkyl, -COOC1-C6 alkyl, benzyl, benzoyl, -CF3, -CN or a V group wherein V represents a) a group wherein t is an integer from 0 to 3 and each of R , R and R is independently hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COOH, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, -OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl; b) a group -(CH2)s-Y wherein s is an integer from 0 to 5 and Y represents a 5- or 6-membered aromatic heterocyclic ring containing one or more sp2 nitrogen atoms in its ring, which heterocyclic ring may be optionally fused to a benzene ring or to a further 5- or 6-membered aromatic heterocyclic ring containing one or more nitrogen atoms, wherein at least one of the said heterocyclic rings may also contain an oxygen or sulphur atom, and wherein any of the rings may be optionally substituted with one or more substituents selected from -C1-C6 alkyl, -OC1-C6 alkyl, halo, -CF3 and -CN; or R together with R forms a =O, =N-OH, =NHR or =CHR group, wherein R is as defined above; each of R and R independently represents hydrogen, -C1-C6 alkyl, -COC1-C6 alkyl, benzyl, a group V as defined above or a -COV group wherein V is as defined above; or R together with R form a =CR R group wherein each of R and R independently represent a hydrogen atom, a C1-C18 alkyl, a -C2-C6 alkenyl, pyrrole or a group V as defined above; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or conditions mediated by PAF.

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