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1. 发明专利

TW201714669A 多孔性基材审中-公开
公开(公告)号：TW201714669A
公开(公告)日：2017-05-01
申请号：TW105104951
申请日：2016-02-19
申请人：阿斯頓大學 , ASTON UNIVERSITY
发明人：李亞當F , LEE, ADAM FRASER , 派雷特克里斯多弗M A , PARLETT, CHRISTOPHER MICHAEL ANDREW , 威爾森凱倫 , WILSON, KAREN
IPC分类号： B01J32/00 , B01J35/10
CPC分类号： B01J20/103 , B01J20/28092 , B01J20/28097 , B01J20/3057 , C01B33/12
摘要：本發明提供一種製造包含一多孔性網絡的一基材的方法。該方法包含形成含有一模板顆粒陣列的一基材前驅物；以及使用一處於低於室溫之溫度的溶劑從該基材前驅物移除該模板顆粒，以生成該基材。本發明亦提供一種製造一基材的方法，該基材包含一第一多孔性網絡與一第二多孔性網絡，該兩多孔性網絡係互連。該方法包含：形成含有一第一模板顆粒陣列與一第二模板顆粒陣列的一基材前驅物；從該基材前驅物選擇性地移除該第一模板顆粒，以形成該第一多孔性網絡；以及從該基材前驅物後續地移除該第二模板顆粒，以形成該第二多孔性網絡。
简体摘要：本发明提供一种制造包含一多孔性网络的一基材的方法。该方法包含形成含有一模板颗粒数组的一基材前驱物；以及使用一处于低于室温之温度的溶剂从该基材前驱物移除该模板颗粒，以生成该基材。本发明亦提供一种制造一基材的方法，该基材包含一第一多孔性网络与一第二多孔性网络，该两多孔性网络系互连。该方法包含：形成含有一第一模板颗粒数组与一第二模板颗粒数组的一基材前驱物；从该基材前驱物选择性地移除该第一模板颗粒，以形成该第一多孔性网络；以及从该基材前驱物后续地移除该第二模板颗粒，以形成该第二多孔性网络。

2. 发明专利

DE69819338T2 未知
公开(公告)号：DE69819338T2
公开(公告)日：2004-07-15
申请号：DE69819338
申请日：1998-08-24
申请人： ASTON UNIVERSITY BIRMINGHAM
发明人： TONGE RONALD , TIGHE JOHN
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K47/24 , A61K47/32 , A61P11/00 , A61P27/02
摘要： Lipid-containing compositions are disclosed which provide surfactants and solubilizing agents useful in medicine, biochemistry and other industries.

3. 发明专利

GB8314643D0 PYRIMIDINE DERIVATIVES 未知
公开(公告)号：GB8314643D0
公开(公告)日：1983-06-29
申请号：GB8314643
申请日：1983-05-26
申请人： WELLCOME FOUND , ASTON UNIVERSITY OF
IPC分类号： C07D239/48

4. 发明专利

DE69819338D1 未知
公开(公告)号：DE69819338D1
公开(公告)日：2003-12-04
申请号：DE69819338
申请日：1998-08-24
申请人： ASTON UNIVERSITY BIRMINGHAM
发明人： TONGE RONALD , TIGHE JOHN
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K47/24 , A61K47/32 , A61P11/00 , A61P27/02
摘要： Lipid-containing compositions are disclosed which provide surfactants and solubilizing agents useful in medicine, biochemistry and other industries.

5. 发明专利

GB201617139D0 Measuring fuel in a fuel tank 未知
公开(公告)号：GB201617139D0
公开(公告)日：2016-11-23
申请号：GB201617139
申请日：2016-10-10
申请人： AIRBUS OPERATIONS LIMITED AND ASTON UNIVERSITY
摘要： The present application relates to a method of measuring a height of a fuel in an aircraft fuel tank (21). The method includes illuminating the fuel in the aircraft fuel tank and detecting reflected light from the fuel. Optical coherence tomography is used to determine the height of a surface of fuel in the fuel tank. The present application also relates to apparatus (30) for measuring a height of a surface of fuel in an aircraft fuel tank, and an aircraft fuel tank system with a fuel tank and an apparatus for measuring a height of a surface of fuel in the aircraft fuel tank.

6. 发明申请

WO2021176199A1 ANTIBIOTICS 审中-公开
公开(公告)号：WO2021176199A1
公开(公告)日：2021-09-10
申请号：PCT/GB2021/050471
申请日：2021-02-24
申请人： ASTON UNIVERSITY
发明人： COX, Jonathan , BARRY, Nicolas , HARRISON, James , NOLAN, Victoria , PITTO-BARRY, Anaïs , SOLDEVILA-BARREDA, Joan
IPC分类号： C07F17/02 , A61K31/7135 , A61P31/04
摘要： The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt; wherein L is a substituted or non-substituted aromatic ligand; Z is a halogen or coordinating ligand; M is a group 8 or group 9 transition metal selected from; Fe, Ru, Os, Co, Rh and Os; A and B are independently selected from a substituted or non-substituted indole or pyridine, may be the same or different and coordinate to the transition metal M through the nitrogen atom of the indole or pyridine. The compounds have been shown to have use against antibiotic-resistant bacteria. A further aspect of the invention is directed towards treating or preventing bacterial infections.

7. 发明申请

WO2020260385A1 MESOPOROUS POLYMERIC PARTICULATE MATERIAL 审中-公开
公开(公告)号：WO2020260385A1
公开(公告)日：2020-12-30
申请号：PCT/EP2020/067686
申请日：2020-06-24
申请人： ASTON UNIVERSITY
发明人： AL-KHATTAWI, Ali , LE, Tuan-Tu
IPC分类号： A61K9/16 , A61K47/38 , A61K31/192 , A61K31/341 , A61K31/4422
摘要： A particulate material comprising porous polymeric particles is described. The porous polymeric particles have an average pore diameter of from 2 to 50 nm and a volume mean particle diameter D[4,3] of less than 100 μm. The material is obtained or obtainable by spray-drying a polymer solution. The particles find use as a solubility-enhancing carrier for active pharmaceutical compounds. Methods of manufacturing the particulate material and pharmaceutical compositions including the particulate material loaded with one or more active pharmaceutical compounds are also described.

8. 发明申请

WO2017089479A1 NON-INVASIVE HUMAN CONDITION MONITORING DEVICE 审中-公开
标题翻译：非侵入性人体状况监测装置
公开(公告)号：WO2017089479A1
公开(公告)日：2017-06-01
申请号：PCT/EP2016/078707
申请日：2016-11-24
申请人： ASTON UNIVERSITY
发明人： RAFAILOV, Edik , SOKOLOVSKY, Sergei , SIDOROV, Viktor Vasilyevich
IPC分类号： A61B5/026 , A61B5/00
CPC分类号： A61B5/0261 , A61B5/0071 , A61B5/418
摘要： A monitoring device capable of non-invasive simultaneous detection of flow properties of both red blood cells (RBC) and lymph contrast objects using Doppler flowmetry. Measure a combination of both blood microcirculation and lymph microcirculation is advantageous because can provide richer diagnostic information. The device comprises an infrared radiation source, a photodetector module for detecting a first and second signals that corresponding respectively to portions of an infrared pattern reflected from the biological tissue. The signals are analysed to determine Doppler shifts indicative of RBC flow velocity and lymph contrast object flow velocity. The device may also function as a fluorimeter, i.e. to excite and detect autofluorescent signals from biomarkers in irradiated tissue.
摘要翻译：
一种能够使用多普勒流量计非侵入式同时检测红血细胞（RBC）和淋巴造影对象的流动特性的监测装置。测量血液微循环和淋巴微循环的组合是有利的，因为可以提供更丰富的诊断信息。该设备包括红外辐射源，用于检测分别对应于从生物组织反射的红外图案的部分的第一和第二信号的光电检测器模块。分析信号以确定指示RBC流速和淋巴造影对象流速的多普勒偏移。该装置还可以用作荧光计，即激发和检测来自受辐射组织中生物标志物的自体荧光信号。

9. 发明申请

WO2016135489A1 POROUS HIERARCHICAL SUBSTRATE 审中-公开
标题翻译：多孔分层基板
公开(公告)号：WO2016135489A1
公开(公告)日：2016-09-01
申请号：PCT/GB2016/050477
申请日：2016-02-25
申请人： ASTON UNIVERSITY
发明人： LEE, Adam Fraser , PARLETT, Christopher Michael Andrew , WILSON, Karen
IPC分类号： B01J20/28 , C01B33/12 , B01J20/30 , B01J20/10
CPC分类号： B01J20/103 , B01J20/28092 , B01J20/28097 , B01J20/3057 , C01B33/12
摘要： The present invention provides a method of producing a substrate comprising a porous network. The method comprises forming a substrate precursor containing an array of template particles; and removing the template particles from the substrate precursor using a solvent at a temperature below room temperature to yield the substrate. The present invention also provides a method of producing a substrate comprising a first porous network and a second porous network, the two porous networks being interconnected. The method comprises: forming a substrate precursor containing an array of first template particles and an array of second template particles; selectively removing the first template particles from the substrate precursor to form the first porous network; and subsequently removing the second template particles from the substrate precursor to form the second porous network.
摘要翻译：本发明提供一种生产包括多孔网络的基底的方法。该方法包括形成含有模板颗粒阵列的底物前体; 并使用溶剂在低于室温的温度下从模板前体中除去模板颗粒，得到基材。本发明还提供一种生产包括第一多孔网络和第二多孔网络的基底的方法，所述两个多孔网络互连。该方法包括：形成含有第一模板颗粒阵列和第二模板颗粒阵列的衬底前体; 从所述衬底前体选择性地去除所述第一模板颗粒以形成所述第一多孔网络; 随后从衬底前体中除去第二模板颗粒以形成第二多孔网络。

10. 发明申请

WO2016132136A1 DIAGNOSTIC ASSAY AND TREATMENT FOR PREECLAMPSIA 审中-公开
标题翻译：诊断和治疗前列腺炎
公开(公告)号：WO2016132136A1
公开(公告)日：2016-08-25
申请号：PCT/GB2016/050408
申请日：2016-02-18
申请人： ASTON UNIVERSITY
发明人： AHMED, Asif , WANG, Keqing
IPC分类号： G01N33/68 , A61K31/198
CPC分类号： A61K31/198 , G01N33/689 , G01N2800/368 , A61K2300/00
摘要： The invention provides a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.
摘要翻译：本发明提供了一种在怀孕受试者中诊断或预后的先兆子痫的方法，包括提供来自怀孕受试者的样品并测量sFlt-1和PlGF之一或两者的量之间的比例，和（b）一或者样品中血红素的分解产物和精氨酸的分解产物两者。还描述了测定试剂盒和适用于该方法的计算机。还描述了治疗先兆子痫的方法，其包括施用药学有效量的L-精氨酸和/或瓜氨酸和精氨酸酶抑制剂或其药学上可接受的盐。还描述了一种治疗癌症的方法，包括用治疗有效量的抗VEGF化合物L-精氨酸和精氨酸酶抑制剂治疗受试者。

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