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1. 发明申请

WO1995029709A1 VESSEL USEFUL FOR MONITORING PLASMA STERILIZING PROCESSES 审中-公开
标题翻译：容器用于监测等离子体灭菌过程
公开(公告)号：WO1995029709A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005418
申请日：1995-05-01
申请人： ABTOX, INC.
发明人： ABTOX, INC. , MARTENS, Phillip, A. , CAPUTO, Ross, A.
IPC分类号： A61L02/26
CPC分类号： G01N31/226 , A61L2/14 , A61L2/28 , C12Q1/22 , Y10S422/906
摘要： A system for testing sterilization processes is provided by a vessel having a chamber, a plasma generator adapted to generate a plasma upstream of the chamber, a monitor associated with the chamber, and a biological or chemical indicator disposable within the chamber. The plasma generator generates upstream plasma that contains a plurality of atomic and/or molecular species, and the monitor is capable of determining a concentration of selected species in the plasma when flowing through the chamber.
摘要翻译：用于测试灭菌过程的系统由具有腔室的血管发生器，适于在腔室上游产生血浆的等离子体发生器，与腔室相关联的监测器以及在该腔室内一次性使用的生物或化学指示器提供。等离子体发生器产生包含多个原子和/或分子物质的上游等离子体，并且监测器能够在流过腔室时确定等离子体中选定物质的浓度。

2. 发明申请

WO1992004057A1 PLASMA CYCLING STERILIZING PROCESS 审中-公开
标题翻译：等离子体循环灭菌过程
公开(公告)号：WO1992004057A1
公开(公告)日：1992-03-19
申请号：PCT/US1991005678
申请日：1991-08-09
申请人： ABTOX, INC.
发明人： ABTOX, INC. , MOULTEN, Kern, A. , CAMPBELL, Bryant, A. , CAPUTO, Ross, A.
IPC分类号： A61L02/00
CPC分类号： H05H1/46 , A61L2/14 , Y10S422/906
摘要： A method for plasma sterilization within a controlled temperature range comprising exposing an article in a sterilizing chamber (4) to a gas plasma flowing from a plasma generating chamber (2) until the temperature in the sterilizing chamber (4) rises to a preselected maximum temperature. The flow of the plasma gas to the sterilizing chamber (4) is terminated until the temperature in the sterilizing chamber (4) falls to a temperature below the preselected maximum temperature. These steps are repeated until sterilization of the article is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3 DEG C below the preselected maximum temperature. The gas plasma can be generated from a mixture of gases consisting essentially of argon, helium, nitrogen or mixtures thereof. Preferably the pressure in the sterilizing chamber (4) rises to from 0.1 to 10 torr when the gas plasma is flowing into the chamber (4) and the pressure in the sterilizing chamber (4) falls to a lower pressure when the gas plasma flow into the sterilizing chamber (4) is terminated.
摘要翻译：一种用于在受控温度范围内等离子体灭菌的方法，包括将消毒室（4）中的物品暴露于从等离子体发生室（2）流出的气体等离子体直到灭菌室（4）中的温度升高至预选的最高温度。终止等离子体气体到灭菌室（4）的流动，直到灭菌室（4）中的温度降到低于预选的最高温度的温度。重复这些步骤直到制品的灭菌。当再次启动气体等离子体流时，低于预选最高温度的温度优选不超过预选最高温度3℃。气体等离子体可以由基本上由氩，氦，氮或其混合物组成的气体的混合物产生。当气体等离子体流入室（4）中时，当气体等离子体流入时，灭菌室（4）中的压力优选上升到0.1〜10乇灭菌室（4）终止。

3. 发明专利

DE69427958T2 未知
公开(公告)号：DE69427958T2
公开(公告)日：2002-04-11
申请号：DE69427958
申请日：1994-06-01
申请人： ABTOX INC
发明人： CAPUTO A , MARTENS A
IPC分类号： C12M1/34 , C12Q1/22 , C12R1/09 , G01N31/22
摘要： Biological indicators are provided for use in validating and routinely monitoring oxidizing gas sterilizations. The biological indicators are based on Bacillus circulans spores that are enclosed in packages with sufficient permeability to admit a sterilizing amount of vapor while being substantially bacteria impermeable.

4. 发明专利

CA2088995C PLASMA CYCLING STERILIZING PROCESS 未知
公开(公告)号：CA2088995C
公开(公告)日：2002-02-19
申请号：CA2088995
申请日：1991-08-09
申请人： ABTOX INC
发明人： MOULTON KERN A , CAMPBELL BRYANT A , CAPUTO ROSS A
IPC分类号： A61L2/14 , H05H1/46
摘要： A method for plasma sterilization within a controlled temperature range comprising exposing an article in a sterilizing chamber (4) to a gas plasma flowing from a plasma generating chamber (2) unt il the temperature in the sterilizing chamber (4) rises to a preselected maximum temperature. The flow of the plasma gas to th e sterilizing chamber (4) is terminated until the tem- perature in the sterilizing chamber (4) falls to a temperature below the preselected maximum temperature. These steps are repeat- ed until sterilization of the article is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3.degree.C below the preselected maximum temperature. The gas plasma can be generated from a mixture of gases consisting essentially of argon, helium, nitrogen or mixtures thereof. Preferably the pressure in the steri- lizing chamber (4) rises to from 0.1 to 10 torr when the gas plasma is flowi ng into the chamber (4) and the pressure in the steriliz- ing chamber (4) falls to a lower pressure whan the gas plasma flow into the sterilizing chamber (4) is terminated.

5. 发明专利

DK0387022T3 未知
公开(公告)号：DK0387022T3
公开(公告)日：1995-02-27
申请号：DK90302410
申请日：1990-03-07
申请人： ABTOX INC
发明人： CAMPBELL BRYANT A , MOULTON KERN A
IPC分类号： A61L2/14 , H05H1/46

6. 发明专利

CA2042284A1 STERILIZING WITH HYDROGEN PEROXIDE AND PLASMA 未知
公开(公告)号：CA2042284A1
公开(公告)日：1991-11-12
申请号：CA2042284
申请日：1991-05-10
申请人： ABTOX INC
发明人： CAMPBELL BRYANT A , MOULTON KERN A , CAPUTO ROSS A
IPC分类号： A61L2/14 , A61L2/18 , A61L2/20
摘要： A process for plasma sterilization comprising exposing an article to be sterilized to pretreatment with hydrogen peroxide, and optionally a peracid antimicrobial agent, and to a plasma generated from gases. The gases can be selected from the group consisting essentially of argon, helium, nitrogen, oxygen, hydrogen and mixtures thereof; and the exposure to the plasma can be carried out at a pressure of from 0.1 to 10 torr and a chamber temperature of less than 80.degree.C. The peracid antimicrobial agent can be a member selected from the group consisting of saturated and unsaturated peralkanoic acids having from 1 to 8 carbon atoms and halogenated derivatives thereof and is preferably peracetic acid. The article is preferably treated with plasma generated in a plasma generator separate from the sterilizing chamber.

7. 发明申请

WO1996039199A1 PLASMA WATER VAPOR STERILIZER AND METHOD 审中-公开
标题翻译：等离子体水蒸气灭菌器和方法
公开(公告)号：WO1996039199A1
公开(公告)日：1996-12-12
申请号：PCT/US1996009150
申请日：1996-06-05
申请人： ABTOX, INC.
发明人： ABTOX, INC. , MARTENS, Phillip, A. , RAINWATER, David, L.
IPC分类号： A61L02/14
CPC分类号： A61L2/14 , A61L2/06 , Y10S422/906
摘要： An apparatus for plasma sterilization of articles comprises a plasma generator, a sterilizing chamber, and a source of water vapor in fluid communication with the plasma generator, and may optionally include an autoclave. A method for plasma sterilization comprises exposing an article to be sterilized to a neutral active species of a plasma generated from water vapor. The exposure of the article to the plasma is carried out at reduced pressures and a chamber temperature of less than about 82 DEG C for a time period sufficient to effect sterilization.
摘要翻译：用于物品的等离子体灭菌的装置包括等离子体发生器，灭菌室和与等离子体发生器流体连通的水蒸气源，并且可任选地包括高压灭菌器。用于等离子体灭菌的方法包括将待消毒的物品暴露于由水蒸汽产生的等离子体的等离子体活性物质中。制品对等离子体的暴露在低于约82℃的低压和室温下进行足够长时间以进行灭菌。

8. 发明申请

WO1995026121A1 PLASMA GAS MIXTURE FOR STERILIZER AND METHOD 审中-公开
标题翻译：用于灭菌器和方法的等离子体气体混合物
公开(公告)号：WO1995026121A1
公开(公告)日：1995-09-28
申请号：PCT/US1995003603
申请日：1995-03-21
申请人： ABTOX, INC.
发明人： ABTOX, INC. , CAMPBELL, Bryant, A. +di , MOULTON, Kern, A. , FISHER, Jim
IPC分类号： H05H01/24
CPC分类号： A61L2/14 , H05H1/46
摘要： A method for plasma sterilization comprises exposing an article to be sterilized to a neutral active species of a plasma generated from a premixed gas mixture comprising oxygen, hydrogen, and a noble gas. The exposure of the article to the plasma is carried out at reduced pressures and a chamber temperature of less than 63 DEG C for a time period sufficient to effect sterilization. The apparatus for plasma sterilization of articles comprises a plasma generator (10, 12, 14), a sterilizing chamber (60), and a source of pressurized gas mixture in fluid communication with the plasma generator. The source of pressurized gas mixture has a noble gas and a substantially nonflammable mixture of hydrogen and oxygen, which is preferably between about 2.0 to 2.4 (v/v) percent hydrogen and between 2.6 to 3.0 (v/v) percent oxygen.
摘要翻译：用于等离子体灭菌的方法包括将待灭菌的物品暴露于由包含氧气，氢气和惰性气体的预混合气体混合物产生的等离子体活性物质。将物品暴露于等离子体在减压和小于63℃的室温下进行足够时间以进行灭菌。用于物品等离子体灭菌的装置包括等离子体发生器（10,12,14），灭菌室（60）以及与等离子体发生器流体连通的加压气体混合物源。加压气体混合物的来源具有惰性气体和基本上不可燃的氢气和氧气的混合物，其优选在约2.0至2.4（v / v）％的氢气和2.6至3.0（v / v）％的氧气之间。

9. 发明申请

WO1995024933A1 PACKAGING SYSTEMS FOR PERACID STERILIZATION PROCESSES 审中-公开
标题翻译：封闭灭菌过程的包装系统
公开(公告)号：WO1995024933A1
公开(公告)日：1995-09-21
申请号：PCT/US1995003241
申请日：1995-03-14
申请人： ABTOX, INC.
发明人： ABTOX, INC. , WENSKY, Afaf , MARTENS, Phillip, A. , CAPUTO, Ross, A.
IPC分类号： A61L02/26
CPC分类号： G01N31/226 , A61L2/28 , C12Q1/22
摘要： Devices useful to monitor whether or not an article has been exposed to sterilizing conditions are provided and comprise a package and an indicator associated with the package. The package is sufficiently permeable to admit sterilizing gas or vapor into the package. The indicator associated with the package changes color from a first color (indicating ambient conditions) to a second color (indicating exposure to acidic gas or vapor). Both the first and second colors of the indicator are stable and preferably subtantially maintain their colors under ambient conditions. Particularly, preferred embodiments are adapted for use with peracetic acid sterilization processes.
摘要翻译：提供了用于监测物品是否已经暴露于消毒条件的装置，并且包括与包装件相关联的包装和指示器。该包装具有足够的渗透性，以将消毒气体或蒸气引入包装中。与包装件相关联的指示器将颜色从第一种颜色（指示环境条件）改变为第二种颜色（指示暴露于酸性气体或蒸汽）。指示器的第一和第二颜色都是稳定的，并且优选地在环境条件下保持它们的颜色。特别地，优选的实施方案适用于过乙酸灭菌方法。

10. 发明申请

WO1995006134A1 BACILLUS CIRCULANS BASED BIOLOGICAL INDICATOR FOR GASEOUS STERILANTS 审中-公开
标题翻译：基于BACILUS CIRCULANS的生物学指标用于气道性休眠
公开(公告)号：WO1995006134A1
公开(公告)日：1995-03-02
申请号：PCT/US1994006158
申请日：1994-06-01
申请人： ABTOX, INC.
发明人： ABTOX, INC. , CAPUTO, Ross, A. , MARTENS, Phillip, A.
IPC分类号： C12Q01/22
CPC分类号： C12Q1/22 , G01N31/226 , Y10S435/832 , Y10S435/835
摘要： Biological indicators are provided for use in validating and routinely monitoring oxidizing gas sterilizations. The biological indicators are based on Bacillus circulans spores that are enclosed in packages with sufficient permeability to admit a sterilizing amount of vapor while being substantially bacteria impermeable.
摘要翻译：提供生物指标，用于验证和定期监测氧化气体灭菌。生物学指标是基于环状芽孢杆菌孢子，其包封在具有足够渗透性的包装中以允许消毒量的蒸气同时基本上不透细菌。

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