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1. 发明申请

WO2011064609A3 SYSTEM AND METHOD FOR DIGITIZING A MOVING SLIDE 审中-公开
公开(公告)号：WO2011064609A3
公开(公告)日：2011-06-03
申请号：PCT/HU2010/000130
申请日：2010-11-29
申请人： 3DHISTECH KFT. , MOLNÁR, Béla , VIRÁG, Tibor , VARGA, Viktor Sebestyén
发明人： MOLNÁR, Béla , VIRÁG, Tibor , VARGA, Viktor Sebestyén
IPC分类号： G06K9/00
摘要： The present invention relates to a system and a method of digitizing a moving slide (4). According to the invention, the slide (4) is displaced via stepper motors (6X, 6Y, 6Z) and the exposition of said slide (4) for imaging purposes is performed in synchronous with pre-set numbers of steppings (nx, nγ, nz) accomplished by said stepper motors (6X, 6Y, 6Z) by activating a light source (2) that is capable of emitting a luminous flux high enough. Said light source (2) is preferably controlled directly by the stepper motors (6X, 6Y, 6Z).

2. 发明申请

WO2007099382A1 AUTOMATED DIGITAL IMAGE RECORDING SYSTEM FOR AND METHOD OF DIGITIZING SLIDES 审中-公开
标题翻译：自动数字图像记录系统和数字滑块的方法
公开(公告)号：WO2007099382A1
公开(公告)日：2007-09-07
申请号：PCT/HU2007/000018
申请日：2007-03-05
申请人： 3DHISTECH KFT. , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
发明人： MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
IPC分类号： G01N21/84 , G01N15/14 , G06K9/00 , B01L3/00
CPC分类号： G01N21/84 , G02B21/365
摘要： The present invention relates to an automated digital image recording system (1) for digitizing slides (6). The image recording system (1) comprises a slide holding means (7, 17), a mechanism for actuating it, a first digital image recording means, a second digital image recording means of high magnification and a control unit (4) for a software-based control of the automated image recording. The image recording system (1) is adapted for digitizing a slide (6) having one or more regions with sample and at least one separate region that comprises a field of information. The first digital image recording means is adapted for reading out the at least one region comprising the field of information and comprises a digital preview camera (2) capturing a low resolution preview image of each of the one or more regions with sample separately. The control unit is provided with a routine for searching points of the low resolution preview images that belong to the sample.
摘要翻译：本发明涉及一种用于数字化幻灯片（6）的自动数字图像记录系统（1）。图像记录系统（1）包括滑动保持装置（7,17），用于致动它的机构，第一数字图像记录装置，高倍率的第二数字图像记录装置和用于软件的控制单元（4）的自动图像记录控制。图像记录系统（1）适于将具有一个或多个区域的幻灯片（6）数字化，其中包括样本和至少一个包括信息领域的分离区域。第一数字图像记录装置适于读出包括信息领域的至少一个区域，并且包括数字预览相机（2），分别用样本捕获一个或多个区域中的每一个的低分辨率预览图像。控制单元设置有用于搜索属于样本的低分辨率预览图像的点的例程。

3. 发明授权

US11428919B2 Objective changing and focusing apparatus for microscopes, and microscope having such objective changing and focusing apparatus 有权
公开(公告)号：US11428919B2
公开(公告)日：2022-08-30
申请号：US16764075
申请日：2018-11-09
申请人： 3DHISTECH KFT.
发明人： Bela Molnar , Viktor Sebestyen Varga , Janos Tibor Devenyi
IPC分类号： G02B21/24 , G02B7/02 , G02B7/14 , G02B21/02 , G02B27/64 , G02B21/00
摘要： The object of the invention relates to an objective changing and focussing apparatus (10) for microscopes (100) containing a plurality of objectives (12), and having an optical axis Z, the essence of which is that it contains—a first rail system (16a) having a first guide rail (17a) fixed to the microscope (100) and a first moving member (18a) guided by the first guide rail (17a), wherein the first rail system (16a) is arranged along an axis X perpendicular to the optical axis Z, —a first drive unit (20a) in drive connection with the first rail system (16a), —a plurality of objective interface elements (24), adapted for being connected to the objectives (12), arranged next to one another along the X axis and fixed to the first moving member (18a) movably along the Z axis, —a second rail system (16b) having a second guide rail (17b) fixed to the microscope (100) and a second moving member (18b) guided by the second guide rail (17b), wherein the second rail system (16b) is arranged parallel to the optical axis Z, and defines a starting position along the X axis, and—a second drive unit (20b) having a second drive connection with the second rail system (16b), and the second moving member (18b) is provided with a lifting element (26) providing a releasable connection with an objective interface (24) located in the starting position. The object of the invention also relates to a microscope containing such an objective changing and focusing apparatus (10).

4. 发明申请

US20090022419A1 Method for realistic stitching image blocks of an electronically recorded multipart image 有权
标题翻译：电子记录多部分图像的逼真拼接图像块的方法
公开(公告)号：US20090022419A1
公开(公告)日：2009-01-22
申请号：US11826752
申请日：2007-07-18
申请人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
发明人： Bela Molnar , Viktor Sebestyen Varga , Attila Tagscherer , Gabor Csendes
IPC分类号： G06T5/20
CPC分类号： G06T5/20 , G06T3/40 , G06T7/30
摘要： A method for realistic stitching and showing image blocks of an electronically recorded multipart image wherein relative positional offset values of the image blocks recorded with overlap are determined in a co-ordinate system in directions x and y and stored in matrix format, and the image blocks to be presented are stitched together on the basis of the stored values the method comprising: subdividing the overlaps of the individual image blocks into smaller regions with fixed relative positions; picking up at least one region most useful for the determination of the stitching; determining the offset goodness value based on the similarity of pattern of the image blocks; stitching the blocks of the image so that first the two image blocks characterised by the best offset goodness values are stitched together and the two image blocks characterised by the worst offset goodness values are stitched together last, whereas only the co-ordinates of the images figuring in a table are modified in the course of the stitching process; and distributing the errors produced by the stitching process over several image blocks.
摘要翻译：一种用于逼真拼接并示出电子记录的多部分图像的图像块的方法，其中在坐标系统中以x和y的方向确定以重叠记录的图像块的相对位置偏移值并以矩阵格式存储，并且图像块基于所存储的值将要呈现的方法包括：将各个图像块的重叠细分成具有固定相对位置的较小区域; 拾起至少一个区域最有用的确定缝合的区域; 基于图像块的图案的相似度来确定偏移良品值; 缝合图像的块，使得首先将由最佳偏移良品值表征的两个图像块缝合在一起，并且将最差偏移良品值表征的两个图像块最后拼接在一起，而仅图像的坐标在缝纫过程中修改了表格; 并且通过多个图像块分布由拼接处理产生的错误。

5. 发明授权

US11287631B2 Device for moving a microscope stage and microscope comprising such a device 有权
公开(公告)号：US11287631B2
公开(公告)日：2022-03-29
申请号：US16619266
申请日：2018-06-22
申请人： 3DHistech Kft.
发明人： David Istvan Szocs , Janos Tibor Devenyi , Viktor Sebestyen Varga , Bela Molnar
IPC分类号： G02B21/26
摘要： A microscope stage is movably mounted to a base and is movable relative to the base by two separate drive units on separate rail systems situated at an angle relative to one another. The drive units are mechanically isolated from one another and one of the drive units uses a belt drive.

6. 发明授权

US07663078B2 Focusing method for the high-speed digitalisation of microscope slides and slide displacing device, focusing optics, and optical rangefinder 失效
标题翻译：用于显微镜幻灯片和滑动位移装置，聚焦光学元件和光学测距仪的高速数字化的聚焦方法
公开(公告)号：US07663078B2
公开(公告)日：2010-02-16
申请号：US11661677
申请日：2005-01-27
申请人： Tibor Virág , Attila László , Béla Molnár , Attila Tagscherer , Viktor Sebestyén Varga
发明人： Tibor Virág , Attila László , Béla Molnár , Attila Tagscherer , Viktor Sebestyén Varga
IPC分类号： G02B7/04 , G01N21/86 , G01C3/08 , G01B9/00
CPC分类号： G02B21/245 , G02B21/242 , G02B21/26 , G02B21/34
摘要： A focusing method is provided for the high speed digitalization of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed. During rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device includes slide holding elements affixed to one side of a supporting member having two parallel sides, which are connected by stiffening elements defining at least two parallel planes.
摘要翻译：提供了一种使用成像装置对显微镜幻灯片进行高速数字化的聚焦方法，其中根据成像装置将幻灯片划分成视野并进行聚焦。在粗调聚焦期间，使用大的对焦步骤在对焦范围内捕获多个图像。在这组图像的基础上，确定最佳对比度的位置。通过根据已经为另一视场确定的对焦距离并通过精细对准进行对焦来调整对焦来执行精细对焦。提供了一种滑动位移装置，其使平行于光轴的滑块位移。滑动位移装置包括固定在具有两个平行侧面的支撑构件的一侧上的滑动保持元件，其通过限定至少两个平行平面的加强元件连接。

7. 发明申请

WO2017037486A3 CONFOCAL SLIDE-DIGITIZING APPARATUS 审中-公开
标题翻译： CONFOCAL滑动数字化设备
公开(公告)号：WO2017037486A3
公开(公告)日：2017-03-09
申请号：PCT/HU2016/050039
申请日：2016-08-31
申请人： 3DHISTECH KFT.
发明人： VARGA, Viktor Sebestyén , MOLNÁR, Béla , KOVÁCH, Gergely , LUCZI, Dániel
IPC分类号： G02B21/00 , G02B21/24 , G02B21/36 , G01N21/64 , G02B21/26
摘要： The object of the present invention is a confocal slide-digitizing apparatus (100), comprising a slide handling unit (20) and an imaging unit (10), wherein said slide handling unit (20) has a slide supplier unit (90) configured to handle slides (92), especially to store, supply and move slides (92) one after the other to and/or position in an imaging position, said slides (92) carrying a sample to be digitized; and said imaging unit (10) has a light source (40) to illuminate the sample to be digitized at the imaging position through an objective (18) arranged in a light path that enables confocal imaging of at least a region of the sample, and an image recording unit to receive light with information on at least an illuminated region of the sample through the objective (18) and generate a digital image of a section of a given thickness of said illuminated region. Moreover, said slide handling unit (20) and said imaging unit (10) are joined mechanically together in a tiltable manner relative to one another, thereby correcting the light path of said confocal imaging.
摘要翻译：本发明的目的是一种共焦滑动量化设备（100），其包括滑动处理单元（20）和成像单元（10），其中所述滑动处理单元（20）具有（92），特别是用于一个接一个地存储，供应和移动滑块（92）到成像位置和/或定位在成像位置的载玻片供应单元（90），所述载玻片（92）携带待测样品数字化; 并且所述成像单元（10）具有光源（40），以通过布置在光路径中的物镜（18）照射将在成像位置处被数字化的样品，所述光路能够实现样品的至少一个区域的共焦成像，并且图像记录单元，用于接收具有关于通过物镜（18）的样品的至少照射区域的信息的光并且生成所述照射区域的给定厚度的部分的数字图像。此外，所述滑动处理单元（20）和所述成像单元（10）以可倾斜的方式彼此机械地连接在一起，从而校正所述共焦成像的光路。

8. 发明申请

WO2008149169A1 SYSTEM FOR HANDLING SLIDES 审中-公开
标题翻译：处理滑块系统
公开(公告)号：WO2008149169A1
公开(公告)日：2008-12-11
申请号：PCT/HU2008/000065
申请日：2008-06-06
申请人： 3DHISTECH KFT. , VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
发明人： VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
IPC分类号： G01N35/00 , G01N35/04 , G02B21/34
CPC分类号： G02B21/34 , G01N2035/00138 , G01N2035/00376
摘要： The invention relates to a system for handling slides comprising a tray moving on a carriage provided with seats for the slides and with a tray moving mechanism; a slide loading arm; and a slide holding frame provided with a slide loading arm driving motor, wherein the slide holder (30) is provided with slide holding elements; there are outstretched Maltese crosses (13) on the lower side of the tray (6) of the slide feeder (1 ) and a crank (14) is arranged in the carriage (4), opposite to and parallel with the crosses (13), said crank being coupled to said crosses; said slide loading arm (9) is arranged movably and tillable above (30) and a supporting plate (11 ) is arranged movably and tiltable below the slide holder, said supporting plate cooperating with said slide loading arm. The slide holding frame (7) is provided with lifting means for tilting the slide loading arm (9) and the supporting plate (11 ), said lifting means being actuated by controlling means arranged on the disk (15) of the crank (14).
摘要翻译：本发明涉及一种用于处理滑块的系统，其包括在滑架上移动的托架，该托架设置有用于滑块的座和托盘移动机构; 滑动装载臂; 以及设置有滑动装载臂驱动电动机的滑动保持框架，其中，所述滑动架（30）设置有滑动保持元件; 在滑动进料器（1）的托盘（6）的下侧有伸出的马耳他十字架（13），并且在滑架（4）中布置有与十字架（13）相对并平行的曲柄（14）所述曲柄与所述十字架相连; 所述滑动装载臂（9）在上方（30）的上方可移动地放置，并且支撑板（11）可滑动地设置在滑动架的下方，所述支撑板与所述滑动装载臂配合。滑动保持框架（7）设置有用于使滑动装载臂（9）和支撑板（11）倾斜的提升装置，所述提升装置由设置在曲柄（14）的盘（15）上的控制装置致动，。

9. 发明申请

WO2007138369A1 METHOD AND SYSTEM FOR DIGITIZING A SPECIMEN WITH FLUORESCENT TARGET POINTS 审中-公开
标题翻译：用荧光目标点数字化的方法和系统
公开(公告)号：WO2007138369A1
公开(公告)日：2007-12-06
申请号：PCT/HU2007/000047
申请日：2007-05-25
申请人： 3DHISTECH KFT. , VARGA, Viktor, Sebestyén , MOLNÁR, Béla , KAMARÁS, Viktor, Imre
发明人： VARGA, Viktor, Sebestyén , MOLNÁR, Béla , KAMARÁS, Viktor, Imre
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/16
摘要： The present invention relates to a method and an automated fluorescent imaging system for digitizing a specimen with fluorescent target points on a microscope slide. The method uses the fluorescence microscope system for detecting and scanning said fluorescent target points. The method comprises the steps of marking the position of said specimen on said slide by visible marking means to define a specimen area containing said specimen and said fluorescent target points; capturing a bright field image of at least a portion of the slide at a first optical magnification, said portion(s) containing the specimen area and determining, from the visible marking means, a position of target fields falling within said specimen area; and scanning the target fields of the specimen area at a second optical magnification higher than said first optical magnification, said scanning including focusing on at least a part of said target fields.
摘要翻译：本发明涉及一种用于在显微镜载玻片上用荧光目标点数字化标本的方法和自动荧光成像系统。该方法使用荧光显微镜系统来检测和扫描所述荧光目标点。该方法包括以下步骤：通过可见标记装置将所述样品的位置标记在所述载玻片上，以限定包含所述样本和所述荧光目标点的样本区域; 以第一光学倍率捕获至少一部分幻灯片的亮场图像，所述部分包含样本区域，并且从可视标记装置确定落在所述标本区域内的目标场的位置; 并且以高于所述第一光学倍率的第二光学倍率扫描样本区域的目标场，所述扫描包括聚焦于所述目标场的至少一部分。

10. 发明公开

US20230350183A1 APPARATUS FOR POSITIONING A MICROSCOPE SLIDE 审中-公开
公开(公告)号：US20230350183A1
公开(公告)日：2023-11-02
申请号：US18221050
申请日：2023-07-12
申请人： 3DHISTECH KFT.
发明人： Béla MOLNÁR
IPC分类号： G02B21/34
CPC分类号： G02B21/34
摘要： Apparatus for positioning a microscope slide and comprising co-acting first and second clamping jaws attached to a robot arm and adapted to receive and carry a microscope slide.

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