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81. 发明授权

US06343225B1 Implantable glucose sensor 有权
标题翻译：植入式葡萄糖传感器
公开(公告)号：US06343225B1
公开(公告)日：2002-01-29
申请号：US09395466
申请日：1999-09-14
申请人： Leland C. Clark, Jr.
发明人： Leland C. Clark, Jr.
IPC分类号： A61B505
CPC分类号： A61B5/14865 , C12Q1/002 , C12Q1/006
摘要： The sensitivity of enzyme-based polarographic electrodes to oxygen concentration can be significantly reduced or eliminated by providing an oxygen-reservoir in intimate contact with the oxidative enzyme. This is achieved by making a stabilized emulsion between the enzyme and a compound in which oxygen is extremely soluble. An aqueous glucose oxidase solution is emulsified with a perfluorocarbon liquid, and the resulting emulsion is stabilized by chemically crosslinking the mixture to form a gel. Thin layers of the emulsion are fabricated by spreading a layer of the liquid emulsion before gelation occurs. Additional carrier proteins such as albumin may be added to the enzyne prior to crosslinking to protect enzymatic activity and enhance gel strength. Additional electron transport compounds may be added to further reduce sensitivity to oxygen concentration.
摘要翻译：通过提供与氧化酶紧密接触的氧气储存器，可以显着降低或消除基于酶的极谱法电极对氧浓度的敏感性。这是通过在酶和氧气极易溶解的化合物之间制备稳定的乳液来实现的。葡萄糖氧化酶水溶液用全氟化碳液体乳化，所得乳液通过化学交联混合物形成凝胶来稳定。通过在凝胶化发生之前铺展液体乳液层来制造乳液的薄层。可以在交联之前将额外的载体蛋白如白蛋白加入到炔，以保护酶活性并增强凝胶强度。可以加入另外的电子传输化合物以进一步降低对氧浓度的敏感性。

82. 发明授权

US06327494B1 Body-fat measuring apparatus equipped with body-height measuring device 失效
标题翻译：体脂测量装置配有体高测量装置
公开(公告)号：US06327494B1
公开(公告)日：2001-12-04
申请号：US09492268
申请日：2000-01-27
申请人： Nobuya Sakai
发明人： Nobuya Sakai
IPC分类号： A61B505
CPC分类号： A61B5/4869 , A61B5/0537 , A61B5/103 , A61B5/1072 , A61B5/4872
摘要： An improved body-fat measuring apparatus for measuring in-vivo impedance and computing body-fat quantity can obtain accurate and stable in-vivo impedance even if hand electrodes are used for the measurement. The apparatus includes a body-height measuring device having a footstool on which a examinee mounts, a measuring terminal to contact with the top of examinee's head, and a cursor movable in upward and downward direction with holding said measuring terminal, and also includes in-vivo impedance measuring electrodes integrated with said cursor, wherein said measuring electrodes are located at a height approximately corresponding to the examinee's shoulder as said measuring terminal of said body-height measuring device contacts with the top of examinee's head so that the angle between torso region and arm region of an examinee becomes approximately right angle when the examinee grasps said measuring electrodes.
摘要翻译：用于测量体内阻抗和计算身体脂肪量的改进的体脂测量装置即使使用手电极进行测量，也可以获得准确和稳定的体内阻抗。该装置包括：身高测量装置，其具有被检体安装的脚凳，与受检者头部的顶部接触的测量端子和保持所述测量端子的上下移动的光标，与所述光标集成的体内阻抗测量电极，其中所述测量电极位于与受检者的肩部大致相对应的高度处，因为所述体高测量装置的测量端子与受检者头部的顶部接触，使得躯干区域和当受检者掌握所述测量电极时，受检者的手臂区域变成大致直角。

83. 发明授权

US06314315B1 Ductal orifice identification by characteristic electrical signal 有权
标题翻译：通过特征电信号的导管孔识别
公开(公告)号：US06314315B1
公开(公告)日：2001-11-06
申请号：US09482145
申请日：2000-01-12
申请人： David Hung , Roger A Stern , Morton Grosser
发明人： David Hung , Roger A Stern , Morton Grosser
IPC分类号： A61B505
CPC分类号： A61B5/0531
摘要： The invention provides methods and kits relating to identification of ductal orifices on a mammalian breast nipple. The methods employ technology to measure characteristic electrical signals on a nipple surface to locate and image or map the ductal orifices on the nipple surface. Kits are also provided comprising materials for identifying a duct by characteristic electrical signal, and for additionally analyzing the signals, and accessing or marking the ducts once they have been identified by the characteristic electrical signal values.
摘要翻译：本发明提供了关于在哺乳动物乳房乳头上识别导管孔的方法和试剂盒。该方法采用技术来测量乳头表面上的特征性电信号，以便定位和成像或映射乳头表面上的导管孔。还提供了包括用于通过特征性电信号识别管道的材料的附件，并且用于另外分析信号，以及一旦它们被特征电信号值识别出来就可以访问或标记管道。

84. 发明授权

US06312392B1 Bipolar handheld nerve locator and evaluator 有权
标题翻译：双极手持神经定位器和评估器
公开(公告)号：US06312392B1
公开(公告)日：2001-11-06
申请号：US09544384
申请日：2000-04-06
申请人： Garrett D. Herzon
发明人： Garrett D. Herzon
IPC分类号： A61B505
CPC分类号： A61B5/4893 , A61B5/05 , A61B5/4041
摘要： A hand-held disposable combination surgical nerve evaluator and locator is provided. The device includes a housing that serves as a handpiece and that accommodates a printed circuit board, a DC voltage source and a compressed gas source. Two pre-programmed settings are provided by way of a nerve evaluation switch and a nerve location switch. By choosing a nerve evaluation switch, a pulsed current is sent down one electrical lead that extends outward from the housing. A return electrical lead is provided that also extends outward from the housing in a parallel, but spaced-apart relationship from the other electrical lead. Compressed gas is delivered to the distal ends of the first and second electrical leads by a cannula that is connected to the compressed gas source. It will also be noted that the return or the second electrical lead can also serve as a cannula for the delivery of compressed gas. A fiber optic light guide may also be provided to illuminate the area around the distal ends of the two electrical leads. In a nerve evaluation mode, when the nerve evaluation switch has been activated, a pulsed current is delivered to the first electrical lead. Similarly, in a nerve location mode, a pulsed current is also delivered to the first electrical lead. However, the frequency of the pulsed current in the nerve evaluation mode is less than the frequency of the current in the nerve location mode, the pulse duration in the nerve evaluation mode is less than the pulse duration in the nerve location mode and the amplitude of the current in the nerve evaluation mode is less than the amplitude of the current in the nerve location mode.
摘要翻译：提供手持一次性组合手术神经评估器和定位器。该装置包括用作手持件并容纳印刷电路板，直流电压源和压缩气体源的壳体。通过神经评估开关和神经定位开关提供两个预编程设置。通过选择神经评估开关，脉冲电流从一个从外壳向外延伸的电引线向下传送。还提供一个返回电引线，其也与另一个电引线以平行但间隔的关系从外壳向外延伸。压缩气体通过连接到压缩气体源的插管输送到第一和第二电引线的远端。还将注意到，返回或第二电引线也可以用作用于输送压缩气体的套管。还可以提供光纤光导以照亮两个电引线的远端周围的区域。在神经评估模式中，当神经评估开关被激活时，脉冲电流被传送到第一电引线。类似地，在神经定位模式中，脉冲电流也被传送到第一电引线。然而，神经评估模式中脉冲电流的频率小于神经定位模式下的电流频率，神经评估模式下的脉搏持续时间小于神经定位模式下的脉搏持续时间，振幅神经评估模式下的电流小于神经位置模式下电流的幅度。

85. 发明授权

US06304769B1 Magnetically directable remote guidance systems, and methods of use thereof 失效
标题翻译：易磁导向远程引导系统及其使用方法
公开(公告)号：US06304769B1
公开(公告)日：2001-10-16
申请号：US08951620
申请日：1997-10-16
申请人： Ronald L. Arenson , William V. Hassenzahl , Timothy Roberts
发明人： Ronald L. Arenson , William V. Hassenzahl , Timothy Roberts
IPC分类号： A61B505
CPC分类号： A61B5/06 , A61B1/00158 , A61B5/055 , A61B5/062 , A61B8/12 , A61B34/73 , A61B2034/732 , A61M25/0127 , G01R33/285
摘要： A magnetically directable guidance system useful in, for example, medical magnetic resonance imaging is provided, as well as methods of directing the traverse of a device directable by the remote guidance system to a remote destination. A directable device and methods of use thereof are also disclosed. In one embodiment, the device is a catheter directable using a magnetic resonance imaging system. In another embodiment, the method includes interventional radiological diagnostic and therapeutic procedures.
摘要翻译：提供了一种可用于例如医学磁共振成像的磁性可定向引导系统，以及将远程引导系统可指导的设备的横越引导到远程目的地的方法。还公开了一种可直接装置及其使用方法。在一个实施例中，该装置是使用磁共振成像系统可引导的导管。在另一个实施方案中，该方法包括介入放射学诊断和治疗程序。

86. 发明授权

US06298259B1 Combined magnetic resonance imaging and magnetic stereotaxis surgical apparatus and processes 有权
标题翻译：组合磁共振成像和磁立体定位手术设备及方法
公开(公告)号：US06298259B1
公开(公告)日：2001-10-02
申请号：US09174189
申请日：1998-10-16
申请人： John Kucharczyk , George T. Gillies
发明人： John Kucharczyk , George T. Gillies
IPC分类号： A61B505
CPC分类号： A61M25/0127 , A61B5/0555 , A61B90/10 , A61B2090/374 , A61M25/0105
摘要： A magnetic stereotaxis system (MSS) is functionally integrated with a magnetic resonance imaging (MRI) system to provide a non-invasive, radiation-free modality for integrated MRI/MMS tracking and guiding of an interventional medical device. Shielding is provided between regions where the patient is moved so that magnetic fields from one procedure do not interfere with the function or materials used in the other procedure. A process is described where a patient is moved on a track from one procedural field to another procedural field with the shield available between different zones provides for the procedures. A computer is associated with the system to supervise performance of a variety of functions and procedures within the surgical environment.
摘要翻译：磁性立体定位系统（MSS）在功能上与磁共振成像（MRI）系统集成，以提供用于综合MRI / MMS跟踪和引导介入医疗设备的非侵入性，无辐射模式。在患者移动的区域之间提供屏蔽，使得来自一个程序的磁场不会干扰其他过程中使用的功能或材料。描述了一个过程，其中患者在轨道上从一个程序领域移动到另一个程序领域，其中可用于不同区域之间的屏蔽提供了该过程。计算机与系统相关联，以监督手术环境中的各种功能和程序的性能。

87. 发明授权

US06298257B1 Cardiac methods and system 有权
标题翻译：心脏方法和系统
公开(公告)号：US06298257B1
公开(公告)日：2001-10-02
申请号：US09405314
申请日：1999-09-22
申请人： Andrew F. Hall , Roger N. Hastings , Walter M. Blume
发明人： Andrew F. Hall , Roger N. Hastings , Walter M. Blume
IPC分类号： A61B505
CPC分类号： A61B5/06 , A61B5/042 , A61B5/061 , A61B5/062 , G06F19/3481 , G16H50/50
摘要： A method of applying a magnetic medical device to the surface of an internal body structure, the medical device having a magnetically responsive element associated with its distal end, the method comprising applying a magnetic field to the distal end of the magnetic medical device to apply a measured and controlled force between the medical device and tissue to facilitate cardiac sensing, mapping, pacing, ablation, biopsying and other procedures. Contact is confirmed by the angle between the direction of the magnetic medical device and the applied magnetic field, and the contact force is controlled by controlling at least one of the magnetic field direction and the magnetic field strength.
摘要翻译：一种将磁性医疗装置应用于内部身体结构的表面的方法，所述医疗装置具有与其远端相关的磁性应答元件，所述方法包括向所述磁性医疗装置的远端施加磁场，在医疗设备和组织之间测量和控制力，以促进心脏感测，映射，起搏，消融，活检和其他程序。通过磁性医疗装置的方向与施加的磁场之间的角度来确认接触，并且通过控制磁场方向和磁场强度中的至少一个来控制接触力。

88. 发明授权

US06278890B1 Non-invasive turbulent blood flow imaging system 失效
标题翻译：非侵入性湍流血流成像系统
公开(公告)号：US06278890B1
公开(公告)日：2001-08-21
申请号：US09188510
申请日：1998-11-09
申请人： Charles E. Chassaing , Scott Donaldson Stearns , Mark Harold Van Horn , Carl Ashley Ryden
发明人： Charles E. Chassaing , Scott Donaldson Stearns , Mark Harold Van Horn , Carl Ashley Ryden
IPC分类号： A61B505
CPC分类号： A61B8/06 , A61B5/0402 , A61B5/08 , A61B7/00 , A61B8/4405 , A61B34/20 , A61B2034/2055 , A61B2034/2063 , A61B2090/3983 , G01S7/52036 , G01S7/5205 , G01S7/52073 , G01S7/52077 , G01S15/52 , G01S15/8906 , G01S15/8979 , G01S15/899 , G01S15/8993
摘要： A non-invasive methodology and instrumentation for the detection and localization of abnormal blood flow in a vessel of a patient is described. An array of sensors are positioned on an area of a patient's body above a volume in which blood flow may be abnormal. Signals detected by the sensor array are processed to display an image which may indicate the presence or absence of abnormal blood flow.
摘要翻译：描述了用于检测和定位患者血管中的异常血流的非侵入性方法和仪器。一组传感器位于患者体内的血流可能异常的体积上方。处理由传感器阵列检测到的信号以显示可以指示异常血流的存在或不存在的图像。

89. 发明授权

US06275719B1 Biomagnetic field measurement apparatus 有权
标题翻译：生物磁场测量装置
公开(公告)号：US06275719B1
公开(公告)日：2001-08-14
申请号：US09293885
申请日：1999-04-19
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Hitoshi Sasabuchi , Hiroyuki Suzuki
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Hitoshi Sasabuchi , Hiroyuki Suzuki
IPC分类号： A61B505
CPC分类号： A61B5/04007 , A61B5/02411
摘要： A biomagnetic field measurement apparatus comprises, a plurality of magnetometers each having a SQUID sensor and a detection coil and each detecting a magnetic field generated from a heart of a fetus in a mother; a processor processing magnetic field wave forms detected by the magnetometers; and a display displaying results obtained by the processor. The processor estimates a position of a current dipole from the magnetic field wave forms, and processes projecting the position of the current dipole on a first plane parallel to a plane on which one ends of the magnetometers are disposed on processes projecting the position of the current dipole on a second plane perpendicular to the plane on which the one ends of the magnetometers are disposed. The position of the current dipole projected on the first plane and the position of the current dipole projected on the second plane are displayed on the display.
摘要翻译：生物磁场测量装置包括：多个磁力计，每个磁力计具有SQUID传感器和检测线圈，并且各自检测从母体的胎儿的心脏产生的磁场; 由磁力计检测到的处理器处理磁场波形的处理器; 以及显示由处理器获得的结果的显示。处理器估计来自磁场波形的当前偶极子的位置，并且处理将电流偶极子的位置投影在平行于其上的磁力计的一端上的平面的第一平面上，该平面位于突出电流位置的过程偶极子在垂直于其上放置磁力计的一端的平面的第二平面上。投影在第一平面上的当前偶极子的位置和投影在第二平面上的当前偶极子的位置显示在显示器上。

90. 发明授权

US06272370B1 MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging 有权
标题翻译：使用非线性磁立体定位的神经系统干预的MR可见医疗装置和方法成像
公开(公告)号：US06272370B1
公开(公告)日：2001-08-07
申请号：US09131031
申请日：1998-08-07
申请人： George T. Gillies , John Kucharczyk , William C. Broaddus , Richard Latchaw
发明人： George T. Gillies , John Kucharczyk , William C. Broaddus , Richard Latchaw
IPC分类号： A61B505
CPC分类号： A61M25/0105 , A61B2090/3954 , A61M25/0127
摘要： The present invention comprises a device and method for targeted drug delivery, and especially intracranial inflsion or retroperfusion drug delivery using nonlinear magnetic stereotaxis in combination with magnetic resonance (MR) imaging and/or X-ray visualization. An MR-visible and/or X-ray visible drug delivery device is positioned by non-linear magnetic stereotaxis at a site such as an intracranial target site, its location is verified via MR imaging, and it is then used to deliver a biologically active material such as a diagnostic or therapeutic drug solution into that site (such as the brain) at constant or variable rates. The spatial distribution kinetics of the injected or infised drug agent may be monitored quantitatively and non-invasively using real-time MR-imaging such as water proton directional diffusion MR imaging, to establish the efficacy of targeted drug delivery.
摘要翻译：本发明包括用于靶向药物递送的装置和方法，特别是使用非线性磁立体定位与磁共振（MR）成像和/或X射线可视化相结合的颅内灌注或后灌注药物递送。通过非线性磁立体定位在诸如颅内靶位点的位置定位MR可见和/或X射线可见药物递送装置，其位置通过MR成像验证，然后用于递送生物活性材料，例如以恒定或可变速率进入该部位（例如脑）的诊断或治疗药物溶液。可以使用实时MR成像（例如水质子定向扩散MR成像）定量和非侵入性地监测注射或致死药物的空间分布动力学，以确定靶向药物递送的功效。

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