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81. 发明授权

US5686248A Fungal stress proteins 失效
标题翻译：真菌应激蛋白
公开(公告)号：US5686248A
公开(公告)日：1997-11-11
申请号：US672514
申请日：1996-06-28
申请人： James Peter Burnie , Ruth Christine Matthews
发明人： James Peter Burnie , Ruth Christine Matthews
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/40 , C07K14/00 , C07K14/37 , C07K14/40 , C07K14/41 , C07K16/00 , C07K16/14 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/725 , C12R1/91 , G01N33/577 , C12Q1/68 , C07H21/04 , C12N1/00 , C12P19/34
CPC分类号： C07K16/14 , C07K14/40 , A61K38/00 , C07K2317/34 , Y10S435/921 , Y10S435/922 , Y10S435/924 , Y10S436/815 , Y10S530/806 , Y10S530/823
摘要： A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Saccharomyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.
摘要翻译：描述了来自白色念珠菌的多肽序列，其与来自其他生物体的已知应激蛋白具有显着的序列同源性，特别是酿酒酵母的热休克蛋白hsp90。还描述了相应的DNA序列，连同针对序列片段产生的抗体。多肽和DNA序列和抗体提供用于诊断和/或治疗真菌，特别是假丝酵母属感染的分开的手段。

82. 发明授权

US4960695A Fermentation process to produce 2-keto-L-gluonic acid 失效
标题翻译：发酵工艺生产2-酮-L-葡糖酸
公开(公告)号：US4960695A
公开(公告)日：1990-10-02
申请号：US412758
申请日：1989-09-26
申请人： Tatsuo Hoshino , Setsuko Nomura , Teruhide Sugisawa
发明人： Tatsuo Hoshino , Setsuko Nomura , Teruhide Sugisawa
IPC分类号： C12P7/60 , C12P39/00 , C12R1/01 , C12R1/645 , C12R1/72 , C12R1/74 , C12R1/78 , C12R1/84 , C12R1/85 , C12R1/86 , C12R1/865 , C12R1/88
CPC分类号： C12P7/60 , C12P39/00 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/924 , Y10S435/93 , Y10S435/941 , Y10S435/942 , Y10S435/944
摘要： A process of producing 2-keto-L-gulonic acid by fermentative conversion of L-sorbose utilizing a fermentation system composed of component produced from a microorganism having the identifying characteristics of strain DSM No. 4025 and a yeast component.

83. 发明授权

US4827030A 3-hydroxydicarboxylic acids and process for their production 失效
标题翻译： 3-羟基二羧酸及其制备方法
公开(公告)号：US4827030A
公开(公告)日：1989-05-02
申请号：US855035
申请日：1986-04-23
申请人： Frank F. Hill
发明人： Frank F. Hill
IPC分类号： C07C59/01 , C07C51/00 , C07C59/245 , C07C67/00 , C12P7/44 , C12R1/72 , C12R1/74
CPC分类号： C07C59/245 , C12P7/44 , Y10S435/924
摘要： 3-hydroxydicarboxylic acids of 12-18 carbon atoms are produced microbiologically from n-alkanes employing the yeast mutant Candida tropicalis DSM 3152.
摘要翻译： 12-18个碳原子的3-羟基二羧酸由采用酵母突变型热带假丝酵母DSM 3152的正烷烃微生物产生。

84. 发明授权

US4559305A Microbial culture system 失效
公开(公告)号：US4559305A
公开(公告)日：1985-12-17
申请号：US270013
申请日：1981-06-03
申请人： James E. Zajic , Martha A. Hill , Donald F. Manchester , Karel Muzika
发明人： James E. Zajic , Martha A. Hill , Donald F. Manchester , Karel Muzika
IPC分类号： C02F1/24 , C02F3/34 , C12N1/00
CPC分类号： C02F1/24 , C02F3/34 , Y10S435/911 , Y10S435/924
摘要： The specification discloses making a mixed fungal (yeast and yeast-like) system culture adapted to biodegradation of spent sulfite liquor (SSL) comprising the steps of exposing a mixed culture system (being a sludge from a sewage treatment plant) to increasing concentration of SSL until the fungus becomes acclimatized to SSL of the desired concentration. The resulting biotic population comprises a fungal mixture, of yeast and yeast-like cultures. It was based on an autolytic culture system: Phialophora jeanselmei, Phialophora richardsiae, Hyalodendron lignicola, Trichosporon infestans and Candida tropicalis. A method and apparatus are disclosed for biodegrading both the soluble substrates in a spent sulfite liquor and the biological solids produced therefrom by a potentially autolytic culture system. The method comprises the steps of adding a nutrient medium, adjusting the pH to mildly acid or neutral condition, feeding the mixture to a fungal culture inoculated fermentor with agitation and with aeration, resulting in foaming of the mixture, said foam carrying with it the fungi and sludge resulting from the fermentation, the suspended solids content of the foam when collapsed being generally not more than half the suspended solids content of the fermentor broth, said foam being processed so as to separate the components into a sludge and a clarified effluent, said sludge being recycled to the fermentor vessel and the clarified effluent prepared for discharge or additional processing. The recycling of sludge to the fermentor vessel is controlled where necessary to maintain the suspended solids in the fermentor vessel at not greater than 60,000 parts per million. The degree of recycling and retention time are held at a level at which autolysis of the suspended solids may be maintained. The process differs from other extended aeration processes in the high MLSS level in the reactor (.about.30,000-55,000 ppm); low sludge return rate (.about.43% of fresh feed rate); high BOD loading (1400 lb BOD/1000 cu. ft.); long mean cell residence time (up to 95 days). The system may be maintained at full sludge recycle thus obviating the need for an external sludge handling and disposal system. Under optimum operating conditions as much as 85 to 90% BOD removal from spent sulfite liquor is accomplished.

85. 发明授权

US4474882A Microbiological process for the preparation of unsaturated dicarboxylic acids 失效
标题翻译：用于制备不饱和二羧酸的微生物过程
公开(公告)号：US4474882A
公开(公告)日：1984-10-02
申请号：US304284
申请日：1981-09-21
申请人： Etsumi Kunishige , Tsuyoshi Morinaga
发明人： Etsumi Kunishige , Tsuyoshi Morinaga
IPC分类号： C12P7/46 , C12P7/44 , C12R1/74 , C12P7/64
CPC分类号： C12P7/44 , Y10S435/924
摘要： A process for the preparation of an unsaturated dicarboxylic acid which comprises cultivating under aerobic conditions a yeast belonging to Candida tropicalis which is capable of producing an unsaturated dicarboxylic acid from an unsaturated fatty acid or its ester, such as Candida tropicalis 104-04 strain, in a medium containing an unsaturated fatty acid having 14 to 22 carbon atoms or its ester, to produce an unsaturated dicarboxylic acid having 14 to 22 carbon atoms; or effecting oxidation of said fatty acid or its ester in the presence of microorganisms of said yeast produced in advance by cultivation in an assimilable carbon source to produce an unsaturated dicarboxylic acid having 14 to 22 carbon atoms; and then recovering the thus-produced unsaturated dicarboxylic acid.
摘要翻译：一种制备不饱和二羧酸的方法，其包括在好氧条件下培养属于热带假丝酵母的酵母，其能够从不饱和脂肪酸或其酯生产不饱和二羧酸，例如热带假丝酵母104-04菌株，含有14-22个碳原子的不饱和脂肪酸或其酯的介质，以制备具有14-22个碳原子的不饱和二羧酸; 或者在可同化碳源中预先通过培养生成的所述酵母的微生物存在下进行所述脂肪酸或其酯的氧化，生成具有14-22个碳原子的不饱和二羧酸; 然后回收由此产生的不饱和二羧酸。

86. 发明授权

US4411998A Suppressing method of iso-citric acid formation in producing citric acid from hydrocarbons by fermentation 失效
标题翻译：通过发酵从碳氢化合物生产柠檬酸中抑制异柠檬酸形成的方法
公开(公告)号：US4411998A
公开(公告)日：1983-10-25
申请号：US359773
申请日：1982-03-19
申请人： Takao Matsumoto , Atsushi Fujimaki , Takeo Nagata
发明人： Takao Matsumoto , Atsushi Fujimaki , Takeo Nagata
IPC分类号： C12P7/48
CPC分类号： C12P7/48 , Y10S435/923 , Y10S435/924
摘要： The present invention relates to a suppressing method of iso-citric acid formation in producing citric acid from hydrocarbons by fermentation.This process is carried out by culturing the microorganisms selected from the group belonging to Candida tropicalis, Candida lipolytica, Candida intermedia and Candida brumptii and their mutants and variants in the culture medium containing paraffinic and olefinic hydrocarbons and their mixture as carbon source under aerobic conditions, wherein specific non-ionic surface active agent is added to said culture medium.The specific non-ionic surface active agent added to said culture medium is selected from the group of sorbitan fatty acid esters and polyoxy-ethylene sorbitan fatty acid esters. The amount of specific surface active agent added to said culture medium is enough from 0.005 to 0.5 percent by weight, preferably from 0.02 to 0.2 percent on the weight basis of said culture medium.
摘要翻译：本发明涉及通过发酵从烃生产柠檬酸中异柠檬酸形成的抑制方法。该方法通过在需氧条件下培养选自属于热带假丝酵母，解脂假丝酵母，中间假丝酵母和布氏假丝酵母的组的微生物及其在含有链烷烃和烯烃的培养基及其混合物中的突变体和变体，其中将特定的非离子表面活性剂加入到所述培养基中。添加到所述培养基中的特定非离子表面活性剂选自脱水山梨糖醇脂肪酸酯和聚氧乙烯脱水山梨糖醇脂肪酸酯。添加到所述培养基中的比表面积活性剂的量足以按所述培养基的重量计0.005至0.5重量％，优选0.02至0.2重量％。

87. 发明授权

US4301244A Quantitative analysis of free fatty acid and reagent composition therefor 失效
标题翻译：游离脂肪酸及其试剂组成的定量分析
公开(公告)号：US4301244A
公开(公告)日：1981-11-17
申请号：US121166
申请日：1980-02-13
申请人： Toshiro Kikuchi , Makoto Ando
发明人： Toshiro Kikuchi , Makoto Ando
IPC分类号： G01N33/50 , C12Q1/25 , C12Q1/26 , C12Q1/44 , C12Q1/00
CPC分类号： C12Q1/25 , C12Q1/26 , Y10S435/81 , Y10S435/923 , Y10S435/924
摘要： There is provided a method for the quantitative analysis of a free fatty acid which comprises (1) the first step of treating a sample containing the free fatty acid with acyl-coenzyme A synthetase in the presence of adenosine triphosphate and coenzyme A to form acyl-coenzyme A, (2) the second step of oxidizing said acyl-coenzyme A, in the presence of oxygen, with acyl-coenzyme A oxidase produced by a microorganism of the genus Candida to form enoyl-coenzyme A and hydrogen peroxide, and (3) the third step of (a) measuring the amount of the formed enoyl-coenzyme A or hydrogen peroxide or (b) measuring the amount of oxygen consumed in said oxidation reaction, to thereby determine the amount of free fatty acid in said sample.
摘要翻译：提供了一种游离脂肪酸的定量分析方法，其包括（1）在三磷酸腺苷和辅酶A存在下用酰基辅酶A合成酶处理含有游离脂肪酸的样品的第一步骤，形成酰基辅酶A，辅酶A，（2）在氧的存在下氧化所述酰基辅酶A与由念珠菌属的微生物产生的酰基辅酶A氧化酶形成乙酰辅酶A和过氧化氢的第二步，和（3 ）第三步：（a）测量形成的烯酰辅酶A或过氧化氢的量，或（b）测量所述氧化反应中消耗的氧量，从而确定所述样品中游离脂肪酸的量。

88. 发明授权

US3907645A Cholesterol assay 失效
标题翻译：胆固醇测定
公开(公告)号：US3907645A
公开(公告)日：1975-09-23
申请号：US43589274
申请日：1974-01-23
申请人： NAT RES DEV
发明人： RICHMOND WILLIAM
IPC分类号： C12N9/04 , C12Q1/26 , C12Q1/60 , G01N31/14
CPC分类号： C12N9/0006 , C12Q1/26 , C12Q1/60 , Y10S210/922 , Y10S435/815 , Y10S435/866 , Y10S435/872 , Y10S435/911 , Y10S435/913 , Y10S435/923 , Y10S435/924 , Y10S435/942
摘要： Enzyme preparations which will convert cholesterol to Delta 4cholestenone and hydrogen peroxide are obtained from certain Nocardia species belonging to the Mycobacterium rhodocrous group. The preparations have a cholesterol oxidase specific activity of at least 1 unit per 5 mg of protein nitrogen and, when in liquid form, a potency of at least 10 2 units/ml. They are prepared by growing the organism and recovering the enzyme preparation, preferably by extracting the harvested cells with a surface active agent such as Triton X-100. The enzyme preparations are used to assay for cholesterol by measuring the amount in which one of the products of the cholesterol oxidase reaction, preferably hydrogen peroxide, is formed or the quantity in which oxygen is used.
摘要翻译：将胆固醇转化为DELTA4-胆甾烯酮和过氧化氢的酶制剂从属于分枝杆菌属的诺卡氏菌属获得。该制剂具有每5mg蛋白质氮至少1单位的胆固醇氧化酶比活性，并且当以液体形式时，其效力为至少10 -3单位/ ml。它们通过生长生物体并回收酶制剂，优选通过用表面活性剂如Triton X-100萃取收获的细胞来制备。酶制剂用于通过测量胆固醇氧化酶反应的产物之一，优选过氧化氢的形成量或使用氧气的量来测定胆固醇。

89. 发明授权

US3870599A Microbial degradation of petroleum 失效
标题翻译：石油微生物降解
公开(公告)号：US3870599A
公开(公告)日：1975-03-11
申请号：US33370673
申请日：1973-02-20
申请人： BIOTEKNIKA INTERNATIONAL
发明人： AZAROWICZ EDWARD N
IPC分类号： C02F1/68 , C12B1/00
CPC分类号： C02F1/681 , Y10S435/921 , Y10S435/924
摘要： A process for the microbial degradation of petroleum or oily waste materials which comprises treating the petroleum or oily waste with a strain of Candida parapsilosis, Candida tropicalis or Candida utilis for a sufficient time until degradation has been achieved. The microorganism strains employed have a broad spectrum of degradation capability and are capable of degrading crude petroleum as well as a variety of organic molecules, including aliphatic, aromatic and heterocyclic compounds.
摘要翻译：一种用于石油或油性废物的微生物降解的方法，其包括将具有假丝酵母（Candida parapsilosis），热带假丝酵母或产朊假丝酵母菌株的石油或油性废物处理足够的时间，直到达到降解。所用的微生物菌株具有广谱的降解能力，并且能够降解原油以及各种有机分子，包括脂族，芳族和杂环化合物。

90. 发明授权

US3767534A Recycle type, continuous process for fermentation based on application of mixed culturing principle 失效
标题翻译：基于混合文化原理应用的循环型连续发酵工艺
公开(公告)号：US3767534A
公开(公告)日：1973-10-23
申请号：US3767534D
申请日：1971-10-21
申请人： MIURA Y
发明人： MIURA Y
IPC分类号： C12P7/40 , C12N1/00 , C12N1/14 , C12N1/20 , C12P13/04 , C12P13/14 , C12P17/18 , C12P39/00 , C12B1/00 , C12B1/20
CPC分类号： C12N1/00 , Y10S435/813 , Y10S435/843 , Y10S435/866 , Y10S435/869 , Y10S435/875 , Y10S435/923 , Y10S435/924 , Y10S435/944
摘要： A continuous process for fermentation of mixed cultures of microorganisms includes inoculating at least two fermentation tanks with different types of microorganisms and recycling the culture liquors between the tanks. Fermentation products are recovered at intermediate stations in the recycling system.
摘要翻译：用于发酵微生物混合培养物的连续方法包括用不同类型的微生物接种至少两个发酵罐，并在罐之间循环培养液。发酵产品在回收系统的中间站回收。

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