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81. 发明申请

WO2012085668A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2012085668A2
公开(公告)日：2012-06-28
申请号：PCT/IB2011003244
申请日：2011-12-23
申请人： NOVARTIS AG , COSTANTINO PAOLO , ADAMO ROBERTO , ROMANO MARIA ROSARIA , DANIEL ELISA , BERTI FRANCESCO , CAPPELLITTI EMILIA , LAY LUIGI
发明人： COSTANTINO PAOLO , ADAMO ROBERTO , ROMANO MARIA ROSARIA , DANIEL ELISA , BERTI FRANCESCO , CAPPELLITTI EMILIA , LAY LUIGI
CPC分类号： A61K39/08 , A61K47/6415 , A61K47/646 , C07H15/04 , C07H15/18 , C08B37/0003 , C08B37/0006 , C08B37/006 , C12P19/04 , C12Y302/00
摘要： The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.
摘要翻译：本发明提供了一种合成艰难梭菌PS-II细胞壁糖。本发明还提供了从艰难梭菌细菌细胞中纯化艰难梭菌PS-II糖的方法，导致污染减少。糖类可以用于疫苗，特别是与载体蛋白质的缀合物。

82. 发明申请

WO2006119217A2 GRAIN WET MILLING PROCESS FOR PRODUCING DEXTROSE 审中-公开
标题翻译：用于生产甜味剂的谷物湿法生产工艺
公开(公告)号：WO2006119217A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016679
申请日：2006-05-02
申请人： TATE & LYLE INGREDIENTS , JANSEN ROBERT , KERR JOHN , FARLEY EDWARD , WALKER GORDON , CAMBORIEUX SEBASTEIN
发明人： JANSEN ROBERT , KERR JOHN , FARLEY EDWARD , WALKER GORDON , CAMBORIEUX SEBASTEIN
IPC分类号： A23J1/12 , A23J3/18 , A23J3/34 , A23K1/14 , C13B20/14 , C13K1/08
CPC分类号： C12Y302/00 , A23J1/125 , A23J3/18 , A23K10/30 , A23K20/179 , A23K50/80 , A23L7/104 , A23L29/35 , C13B20/142 , C13K1/08 , Y02A40/818
摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain or at least partially dehulled grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 5O°C, producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 5O°C, producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and wheat germ. The process also includes the steps of (f) further saccharifying the screened material by contacting it with amyloglucosidase at a temperature of at least about 5O°C, producing a second saccharified material, (g) membrane filtering the second saccharified material, producing a permeate that comprises primarily dextrose and other soluble components and a retentate that comprises insoluble protein, and (h) purifying the permeate by chromatographic separation, producing a purified dextrose stream. The chromatographic separation can also produce a raffinate, and the process can further include the steps of (i) combining the retentate from the membrane filtration and the raffinate from the chromatographic separation to form a fermentation medium, (j) fermenting the fermentation medium aerobically with a microorganism, (k) separating a protein product that comprises insoluble protein and microorganism from the medium, and (1) drying the protein product.
摘要翻译：可以通过（a）在水性液体中浸渍颗粒或至少部分脱壳的颗粒以产生软化的颗粒，（b）研磨软化的颗粒以产生（例如，小麦，大麦，黑麦和/或米）磨碎的谷物，（c）通过使其与淀粉酶接触并将其加热至至少约50℃的温度来液化碾磨的谷粒，产生液化物质，（d）至少部分地使液化物质与淀粉葡糖苷酶接触，至少约50℃的温度，产生第一糖化物质，和（e）从第一糖化物质分离纤维和胚芽，产生基本上不含纤维和小麦胚芽的筛选材料。该方法还包括以下步骤：（f）通过使筛选的材料与淀粉葡糖苷酶在至少约50℃的温度下接触进一步糖化，产生第二糖化物质，（g）膜过滤第二糖化物质，产生渗透物其主要包括葡萄糖和其他可溶性组分以及包含不溶性蛋白质的渗余物，和（h）通过色谱分离纯化渗透物，产生纯化的葡萄糖流。色谱分离还可以产生萃余液，并且该方法还可以包括以下步骤：（i）将来自膜过滤的残留物和来自色谱分离的萃余液组合以形成发酵培养基，（j）有氧地发酵发酵培养基，微生物，（k）从培养基中分离含有不溶性蛋白质和微生物的蛋白质产物，（1）干燥蛋白质产物。

83. 发明申请

WO2002082923A1 MODIFIED PECTIC SUBSTANCE 审中-公开
标题翻译：改良的化学物质
公开(公告)号：WO2002082923A1
公开(公告)日：2002-10-24
申请号：PCT/DK2002/000240
申请日：2002-04-10
申请人： CP KELCO APS , BASF HEALTH & NUTRITION A/S , STRARUP, Annette , HANSEN, Karin, Meyer , PEDERSEN, Anders, Vagnø , HANSEN, Morten, Mohr , MADSEN, Susanne, Lund , JENSEN, Nina, Musaeus , HANSEN, Carsten, Lynggaard
发明人： STRARUP, Annette , HANSEN, Karin, Meyer , PEDERSEN, Anders, Vagnø , HANSEN, Morten, Mohr , MADSEN, Susanne, Lund , JENSEN, Nina, Musaeus , HANSEN, Carsten, Lynggaard
IPC分类号： A23L1/0524
CPC分类号： C12Y301/00 , A23L2/56 , A23L27/80 , A23L29/231 , A23V2002/00 , C12P19/26 , C12Y302/00 , A23V2200/222 , A23V2250/5072 , A23V2250/712 , A23V2200/224
摘要： Modified pectic substance having emulsifying, microencapsulating, foam stabilizing and/or film forming properties and obtainable by treating a pectic substance with one or more enzymes selected from the group consisting of esterases (E.C.3.1.), glucosidases (E.C.3.2.) and lyases (E.C.4.) and products consisting of or containing such modified substance.
摘要翻译：通过用选自酯酶（EC3.1。），葡糖苷酶（EC3.2。）和裂解酶（EC3.2。）的一种或多种酶处理果胶物质可获得具有乳化，微胶囊化，泡沫稳定和/或成膜性能的改性果胶物质， EC4。）和由这些改性物质组成或含有的产品。

84. 发明申请

WO98045453A1 LIPASE AND USE OF SAME FOR IMPROVING DOUGHS AND BAKED PRODUCTS 审中-公开
标题翻译：用于改进DOUGHS和烘焙产品的使用和使用
公开(公告)号：WO98045453A1
公开(公告)日：1998-10-15
申请号：PCT/DK1998/000137
申请日：1998-04-03
IPC分类号： A21D2/16 , A21D2/26 , A21D8/04 , A23L7/104 , A23L7/109 , C12N1/15 , C12N9/20 , C12N9/80 , C12N15/55 , C07K19/00 , C12N15/80
CPC分类号： C12Y101/03005 , A21D2/16 , A21D2/26 , A21D8/042 , A23L7/107 , C07K2319/00 , C12N9/20 , C12N9/80 , C12Y301/01003 , C12Y301/01004 , C12Y301/01026 , C12Y302/00
摘要： A polypeptide having lipase activity that retains at least 80 % activity after 4 days at 20 DEG C at a pH in the range of 3.5-8, retains at least 60 % of its activity after 1 hour at 60 DEG C in acetate buffer at pH 5.0, and has an isoelectric point in the range of 3.5-4.5. The polypeptide is useful as a dough and bread quality improving agent and it reduces crumb pore diameter, increases crumb pore homogeneity and improves the gluten index in doughs. The polypeptide is derived from fungi, yeast, bacteria, plant cells or animal cells and is produced in transformed host cells including filamentous fungi, e.g. Aspergillus tubigensis.
摘要翻译：具有脂肪酶活性的多肽在20℃下在3.5-8之间的pH下在4天后保持至少80％的活性，在pH为1的乙酸缓冲液中，在60℃下保持其活性至少60％ 5.0，等电点在3.5-4.5的范围内。该多肽可用作面团和面包质量改良剂，并且减少碎屑孔径，增加碎屑孔均匀性并改善面团中的面筋指数。多肽衍生自真菌，酵母，细菌，植物细胞或动物细胞，并且在转化的宿主细胞中产生，包括丝状真菌，例如丝状真菌。曲霉菌

85. 发明公开

EP3102940A4 ANTI-METALLOPROTEASE ANTIBODY FOR DIAGNOSIS AND TREATMENT OF CANCERS 有权
标题翻译： ANTI-METALLOPROTEASE-ANTIKÖRPERZUR DIAGNOSE UND BEHANDLUNG VON KREBS
公开(公告)号：EP3102940A4
公开(公告)日：2017-08-23
申请号：EP15746777
申请日：2015-02-04
申请人： UNIV MONASH , MEMORIAL SLOAN KETTERING CANCER CENTER , LUDWIG INST FOR CANCER RES LTD
发明人： LACKMANN MARTIN , JANES PETER W , MUDIYANSELAGE LAKMALI ATAPATTU , SCOTT ANDREW M , NIKOLOV DIMITAR B , SAHA NAYANENDU
IPC分类号： G01N33/53 , C07K16/28 , C07K16/40
CPC分类号： C07K16/40 , A61K31/4745 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K2299/00 , C07K2317/34 , C07K2317/54 , C07K2317/565 , C07K2317/76 , C12Y302/00 , G01N33/573 , G01N33/574 , G01N33/57484 , G01N33/57492 , G01N2333/96486 , A61K2300/00
摘要： Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumor cells that also express the putative tumor stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumor cells and also as a therapeutic agent for treating cancers, tumors and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumor, renal tumor, prostate cancer, sarcoma and/or melanoma.
摘要翻译：蛋白水解活性的高分子量ADAM蛋白酶的表达在也表达推定的肿瘤干细胞标记CD133的肿瘤细胞中相对增加。抗体或抗体片段如8C7单克隆抗体可以用于选择性结合蛋白水解活性的高分子量ADAM10蛋白酶，从而检测肿瘤细胞，并且还可以用作治疗癌症，肿瘤和其他恶性肿瘤包括白血病，淋巴瘤，肺癌，结肠癌，腺瘤，神经母细胞瘤，脑肿瘤，肾肿瘤，前列腺癌，肉瘤和/或黑素瘤。

86. 发明公开

EP3124612A1 METHODS AND COMPOSITIONS USING FGF23 FUSION POLYPEPTIDES 审中-公开
标题翻译： VFAFAHREN UND ZUSAMMENSETZUNGEN MIT FGF23-FUSIONSPOLYPEPTIDEN
公开(公告)号：EP3124612A1
公开(公告)日：2017-02-01
申请号：EP16184724.9
申请日：2011-01-27
申请人： NOVARTIS AG
发明人： GLASS, David , HU, Shou-Ih
IPC分类号： C12N15/62 , G01N33/574 , G01N33/68
CPC分类号： C07K14/50 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C12N9/2445 , C12N9/93 , C12Y302/00 , C12Y302/01021 , C12Y602/01003
摘要： The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The fusion polypeptides of the disclosure include FGF23 or an active fragment thereof. In one embodiment, the fusion polypeptide comprises (a) a polypeptide comprising fibroblast growth factor 23 (FGF23), or a functionally active variant or derivative thereof, wherein FGF23 has a mutation at one or more of the positions Q 156, C206 and C244; and (b) either a modified Fc fragment having decreased affinity for Fc-gamma-receptor and/or increased serum half-life, or a polypeptide comprising at least one extracellular subdomain of a Klotho protein, or a functionally active variant or derivative thereof; and, optionally (c) a linker. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23), or a functionally active variant or derivative thereof; and a modified Fc fragment, or a functionally active variant or derivative thereof. In various embodiments of the fusion polypeptides, FGF23 has mutations which decrease aggregation and protease-mediated cleavage.
摘要翻译：本公开涉及用于预防或治疗年龄相关病症或代谢紊乱的方法，试剂盒和组合物。本公开的融合多肽包括FGF23或其活性片段。在一个实施方案中，融合多肽包含（a）包含成纤维细胞生长因子23（FGF23）或其功能活性变体或衍生物的多肽，其中FGF23在一个或多个位置Q 156，C206和C244处具有突变; 或（b）具有降低的对Fc-γ受体的亲和性和/或增加的血清半衰期的修饰的Fc片段或包含至少一个Klotho蛋白的胞外亚结构域的多肽或其功能活性变体或衍生物; 和（c）连接体。 Klotho融合蛋白可用于治疗和预防各种年龄相关病症和代谢紊乱。在另一个实施方案中，融合多肽包含FGF（如FGF23）或其功能活性变体或衍生物; 和修饰的Fc片段或其功能活性变体或衍生物。在融合多肽的各种实施方案中，FGF23具有降低聚集和蛋白酶介导的切割的突变。

87. 发明授权

EP1721527B1 Lipase and use of same for improving doughs and baked products 失效
标题翻译：脂肪酶及其用于面团和烘焙食品的改善
公开(公告)号：EP1721527B1
公开(公告)日：2010-06-09
申请号：EP06017416.6
申请日：1998-04-03
申请人： DANISCO A/S
发明人： Poulson, Charlotte Horsmans , Søe, Jørn Borch , Rasmussen, Preben , Madrid, Susan Mampusti , Zargahi, Masound R.
IPC分类号： A21D8/04 , A23L1/16
CPC分类号： C12Y101/03005 , A21D2/16 , A21D2/26 , A21D8/042 , A23L7/107 , C07K2319/00 , C12N9/20 , C12N9/80 , C12Y301/01003 , C12Y301/01004 , C12Y301/01026 , C12Y302/00

88. 发明公开

EP1883313A2 GRAIN WET MILLING PROCESS FOR PRODUCING DEXTROSE 审中-公开
标题翻译：用于生产DEXTROSE的谷物湿磨工艺
公开(公告)号：EP1883313A2
公开(公告)日：2008-02-06
申请号：EP06758871.5
申请日：2006-05-02
申请人： Tate & Lyle Ingredients Americas, Inc.
发明人： JANSEN, Robert , KERR, John , FARLEY, Edward , WALKER, Gordon , CAMBORIEUX, Sebastien
IPC分类号： A23J1/12 , A23J3/18 , A23J3/34 , A23K1/14 , A23K1/16 , A23L1/105 , C13K1/08 , C13D3/14
CPC分类号： C12Y302/00 , A23J1/125 , A23J3/18 , A23K10/30 , A23K20/179 , A23K50/80 , A23L7/104 , A23L29/35 , C13B20/142 , C13K1/08 , Y02A40/818
摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain or at least partially dehulled grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and wheat germ. The process also includes the steps of (f) further saccharifying the screened material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a second saccharified material, (g) membrane filtering the second saccharified material, producing a permeate that comprises primarily dextrose and other soluble components and a retentate that comprises insoluble protein, and (h) purifying the permeate by chromatographic separation, producing a purified dextrose stream. The chromatographic separation can also produce a raffinate, and the process can further include the steps of (i) combining the retentate from the membrane filtration and the raffinate from the chromatographic separation to form a fermentation medium, (j) fermenting the fermentation medium aerobically with a microorganism, (k) separating a protein product that comprises insoluble protein and microorganism from the medium, and (l) drying the protein product.
摘要翻译：（a）将谷物或至少部分脱谷的谷粒浸渍在水性液体中以产生软化的谷物，（b）将软化的谷物碾磨以产生（c）通过使磨碎的谷物与淀粉酶接触并将其加热至至少约50℃的温度而液化所述磨碎的谷物，从而产生液化的物质，（d）通过使液化的物质与玉米淀粉葡糖苷酶接触至少部分糖化至少约50℃的温度，产生第一糖化材料，和（e）从第一糖化材料分离纤维和胚芽，产生基本上不含纤维和小麦胚芽的筛选材料。该方法还包括以下步骤：（f）通过在至少约50℃的温度下使其与淀粉葡糖苷酶接触进一步糖化筛分的材料，产生第二糖化材料，（g）膜过滤第二糖化材料，产生渗透物其主要包含右旋糖和其他可溶性组分以及包含不溶性蛋白质的渗余物，和（h）通过色谱分离纯化渗透物，产生纯化的右旋糖流。色谱分离也可以产生提余液，并且该方法可以进一步包括以下步骤：（i）将来自膜过滤的渗余物和来自色谱分离的提余液组合以形成发酵培养基，（j）用（a）有氧地发酵发酵培养基（k）从培养基中分离含有不溶性蛋白质和微生物的蛋白质产物，和（1）干燥蛋白质产物。

89. 发明授权

EP0977869B1 LIPASE AND USE OF SAME FOR IMPROVING DOUGHS AND BAKED PRODUCTS 失效
标题翻译：脂肪酶和它们的用途升级和面包店改进
公开(公告)号：EP0977869B1
公开(公告)日：2004-07-28
申请号：EP98913539.7
申请日：1998-04-03
申请人： DANISCO A/S
发明人： POULSEN, Charlotte, Horsmans , SOE, Jorn, Borch , RASMUSSEN, Preben , MADRID, Susan, Mampusti , ZARGAHI, Masoud, R.
IPC分类号： C12N9/20 , C07K19/00 , C12N15/80 , A21D8/04
CPC分类号： C12Y101/03005 , A21D2/16 , A21D2/26 , A21D8/042 , A23L7/107 , C07K2319/00 , C12N9/20 , C12N9/80 , C12Y301/01003 , C12Y301/01004 , C12Y301/01026 , C12Y302/00

90. 发明公开

EP1433852A1 Lipase and use of same for improving doughs and baked products 失效
标题翻译：脂肪酶及其用于改善面团和烘焙产品的用途
公开(公告)号：EP1433852A1
公开(公告)日：2004-06-30
申请号：EP04075818.7
申请日：1998-04-03
申请人： DANISCO A/S
发明人： Poulsen, Charlotte Horsmans , Soe, Jorn Borch , Rasmussen, Preben , Madrid, Susan Mampusti , Zargahi, Masoud R.
IPC分类号： C12N15/55 , C12N9/20 , C07K19/00 , C12N15/80 , C12N1/15 , A21D8/04
CPC分类号： C12Y101/03005 , A21D2/16 , A21D2/26 , A21D8/042 , A23L7/107 , C07K2319/00 , C12N9/20 , C12N9/80 , C12Y301/01003 , C12Y301/01004 , C12Y301/01026 , C12Y302/00
摘要： A polypeptide having lipase activity that retains at least 80% activity after 4 days at 20°C at a pH in the range of 3.5-8, retains at least 60% of its activity after 1 hour at 60°C in acetate buffer at pH 5.0, and has an isoelectric point in the range of 3.5-4.5. The polypeptide is useful as a dough and bread quality improving agent and it reduces crumb pore diameter, increases crumb pore homogeneity and improves the gluten index in doughs. The polypeptide is derived from fungi, yeast, bacteria, plant cells or animal cells and is produced in transformed host cells including filamentous fungi, e.g. Aspergillus tubigensis.
摘要翻译：具有脂肪酶活性的多肽在20℃下4天后在3.5-8的pH下保持至少80％的活性，在60℃下在乙酸盐缓冲液中1小时后在pH下保留其活性的至少60％ 5.0，等电点在3.5-4.5的范围内。该多肽作为面团和面包品质改良剂是有用的，并且它减少了面包屑孔径，增加了面包屑孔隙均匀性并且改善了面团中的面筋指数。多肽源自真菌，酵母，细菌，植物细胞或动物细胞，并且在转化的宿主细胞中产生，所述宿主细胞包括丝状真菌，例如丝状真菌。曲霉菌（Aspergillus tubigensis）。

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