会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 90. 发明公开
    • 확장에 의한 고성능 핵산 서열분석
    • 通过扩增测序的高通量核酸
    • KR1020100044790A
    • 2010-04-30
    • KR1020107001274
    • 2008-06-19
    • 스트라토스 지노믹스 인코포레이티드
    • 코코리스,마크,스타마티오스맥루어,로버트,엔
    • C12Q1/68C12N15/11C07H21/00G06F19/20
    • C12Q1/6897C12Q1/68C12Q1/6869C12Q1/6876C12Q2565/631C12Q2525/197C12Q2525/131G06F19/20
    • Nucleic acid sequencing methods and related products are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of the target nucleic acid, wherein the individual subunits comprise a tether, at least one probe or nucleobase residue, and at least one selectively cleavable bond. The selectively cleavable bond(s) is/are cleaved to yield an Xpandomer of a length longer than the plurality of the subunits of the daughter strand, the Xpandomer comprising the tethers and reporter elements for parsing genetic information in a sequence corresponding to the contiguous nucleotide sequence of all or a portion of the target nucleic acid. Reporter elements of the Xpandomer are then detected. Corresponding products, including Xpandomers and oligomeric and monomeric substrate constructs are also disclosed.
    • 公开了核酸测序方法和相关产品。 用于对靶核酸进行测序的方法包括提供通过模板指导的合成产生的子链,所述子链包含以对应于靶核酸的全部或部分的连续核苷酸序列的序列偶联的多个亚基,其中 单个亚基包含系链,至少一个探针或核碱基残基,以及至少一个选择性可切割键。 切割可选择性切割键以产生长于子链多个亚基的长度的Xpandomer,Xpandomer包含用于在对应于连续核苷酸的序列中解析遗传信息的系链和报道元件 靶核酸的全部或部分序列。 然后检测Xpandomer的记录元素。 还公开了相应的产物,包括Xpandomer和低聚单体底物构建体。