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81. 发明授权

US09737734B2 Charged particle translation slide control apparatus and method of use thereof 有权
公开(公告)号：US09737734B2
公开(公告)日：2017-08-22
申请号：US15073471
申请日：2016-03-17
申请人： Susan L. Michaud , Stephen L. Spotts
发明人： Susan L. Michaud , Stephen L. Spotts
IPC分类号： H01J27/00 , A61N5/10 , G21K1/08 , G21K1/10 , G21K5/04 , H01J35/14
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , G21K1/08 , G21K1/10 , G21K5/04 , H01J35/14
摘要： The invention comprises a system for patient specific control of charged particles in a charged particle beam path using one or more trays inserted into the charged particle beam path, such as at the exit port of a gantry nozzle in close proximity to a tumor of a patient. Each tray holds an insert, such as a patient specific insert for controlling the energy, focus depth, and/or shape of the charged particle beam. Examples of inserts include a range shifter, a compensator, an aperture, a ridge filter, and a blank. Trays in a tray assembly are optionally retracted into an output nozzle of a charged particle cancer treatment system. Optionally and preferably, each tray communicates a held and positioned insert to a main controller of the charged particle cancer therapy system.

82. 发明申请

US20160339265A1 IMPLANTABLE SPACER 审中-公开
标题翻译：可植入间距
公开(公告)号：US20160339265A1
公开(公告)日：2016-11-24
申请号：US15108352
申请日：2014-12-25
申请人： NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Takayuki Asao
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1094 , A61N2005/1096
摘要： Provided is an implantable spacer that can be placed in a body and can be easily removed after placement. The implantable spacer includes a tube which is folded or bent at one or a plurality of positions to form partial sections adjacent to each other; fixing threads which are disposed along a direction transverse to the partial sections in order to maintain the shape of the tube; and a trigger thread for catching the fixing threads being in a releasable state.
摘要翻译：提供了可植入的间隔物，其可以放置在身体中并且可以在放置之后容易地移除。可植入间隔件包括一个管，该管在一个或多个位置处被折叠或弯曲以形成彼此相邻的部分部分; 固定螺纹，其沿着横向于部分部分的方向设置，以便保持管的形状; 以及用于捕获固定螺纹处于可释放状态的触发螺纹。

83. 发明申请

US20160206395A1 ADJUSTABLE IMMOBILIZER APPARATUS AND METHOD FOR IMMOBILIZING A PATIENT 审中-公开
标题翻译：可调节的固定器装置和用于使患者固定的方法
公开(公告)号：US20160206395A1
公开(公告)日：2016-07-21
申请号：US14913760
申请日：2015-02-02
申请人： QFIX SYSTEMS, LLC
发明人： Daniel D. Coppens , David M. Rabeno , Stephen J. Reiser
IPC分类号： A61B90/18
CPC分类号： A61B90/18 , A61B6/0421 , A61B90/14 , A61F5/05841 , A61F5/05858 , A61F5/3707 , A61N2005/1096 , A61N2005/1097
摘要： Systems for immobilizing a patient are disclosed. The system includes at least one preform formed from a low melting temperature thermoplastic, the preform being configured to be formed to the anatomy of the patient, at least one frame coupled to the at least one preform, and at least one support configured to support the anatomy of the patient. The system also includes at least one lock mechanism coupled to at least one of the frame and the support and configured to couple the at least one frame to the at least one support, and at least one adjuster mechanism coupled to at least one of the at least one frame and the at least one support and configured to selectively adjust a distance between the at least one frame and the at least one support while the at least one frame is coupled to the at least one support.
摘要翻译：公开了用于固定患者的系统。所述系统包括由低熔点温度的热塑性塑料形成的至少一个预型件，所述预成型件构造成形成于患者的解剖结构，至少一个框架与所述至少一个预成型件相连接，以及至少一个支撑件，患者的解剖结构。该系统还包括耦合到框架和支撑件中的至少一个的至少一个锁定机构，并且被配置为将至少一个框架耦合到至少一个支撑件，并且至少一个调节器机构联接到至少一个框架至少一个框架和所述至少一个支撑件，并且被配置为当所述至少一个框架联接到所述至少一个支撑件时，选择性地调整所述至少一个框架和所述至少一个支撑件之间的距离。

84. 发明申请

US20160199670A1 CHARGED PARTICLE TRANSLATION SLIDE CONTROL APPARATUS AND METHOD OF USE THEREOF 审中-公开
标题翻译：充电粒子翻译幻灯片控制装置及其使用方法
公开(公告)号：US20160199670A1
公开(公告)日：2016-07-14
申请号：US15073471
申请日：2016-03-17
申请人： Susan L. Michaud , Stephen L. Spotts
发明人： Susan L. Michaud , Stephen L. Spotts
IPC分类号： A61N5/10 , H01J27/20
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , G21K1/08 , G21K1/10 , G21K5/04 , H01J35/14
摘要： The invention comprises a system for patient specific control of charged particles in a charged particle beam path using one or more trays inserted into the charged particle beam path, such as at the exit port of a gantry nozzle in close proximity to a tumor of a patient. Each tray holds an insert, such as a patient specific insert for controlling the energy, focus depth, and/or shape of the charged particle beam. Examples of inserts include a range shifter, a compensator, an aperture, a ridge filter, and a blank. Trays in a tray assembly are optionally retracted into an output nozzle of a charged particle cancer treatment system. Optionally and preferably, each tray communicates a held and positioned insert to a main controller of the charged particle cancer therapy system.
摘要翻译：本发明包括用于利用插入带电粒子束路径中的一个或多个托盘（例如在靠近患者肿瘤的台架喷嘴的出口处）对带电粒子束路径中的带电粒子进行患者特异性控制的系统。每个托盘保持插入件，例如用于控制带电粒子束的能量，聚焦深度和/或形状的患者特定插入物。刀片的例子包括范围移位器，补偿器，孔，脊过滤器和空白。托盘组件中的托盘可选地缩回到带电粒子癌症治疗系统的输出喷嘴中。可选地，优选地，每个托盘将保持和定位的插入物连通到带电粒子癌症治疗系统的主控制器。

85. 发明申请

US20140270076A1 Rodent Ionizing Radiation Treatment Device 审中-公开
标题翻译：啮齿动物电离辐射治疗装置
公开(公告)号：US20140270076A1
公开(公告)日：2014-09-18
申请号：US13834025
申请日：2013-03-15
申请人： THE OHIO STATE UNIVERSITY
发明人： Christopher E. Pelloski , James L. Sommerfeld , Kathryn Bondra , Lanchun Lu
IPC分类号： A61N5/10
CPC分类号： A61N5/1079 , A61N2005/1094 , A61N2005/1096 , A61N2005/1097
摘要： The present application relates to rodent radiation device that enables simultaneous radiation treatment of a plurality of small animals such as mice with localized radiation therapy. The device can provide clinically-relevant homogeneous radiation dosing and scheduling to a plurality of small animals or other in vivo cancer models simultaneously. Specifically, the multi station/unit design of the device allows for rapid loading of anesthetized small animals into radiation shield chambers that absorbs over 95% of the delivered dose and protects the remainder of the untreated animal, allowing for more clinically accurate recapitulation of radiotherapy regimens. In one embodiment, a total of 40-50 Gy is delivered in 20-25 fractions to small animals with more than 95% survival rates.
摘要翻译：本发明涉及能够通过局部放射治疗同时对多个小动物如小鼠进行放射治疗的啮齿动物辐射装置。该装置可以同时向多个小动物或其他体内癌症模型提供与临床相关的均匀辐射计量和调度。具体来说，设备的多站/单元设计允许将麻醉的小动物快速装载到辐射屏蔽室中，其吸收超过95％的递送剂量并保护未处理动物的其余部分，从而允许更准确地概括放射治疗方案。在一个实施方案中，总共40-50Gy以20-25个分数递送至具有超过95％存活率的小动物。

86. 发明授权

US08724775B2 Applicator means for x-ray radiation therapy, fastening means as well as radiation therapy device 有权
标题翻译：施放器用于X线放射治疗，紧固装置以及放射治疗装置
公开(公告)号：US08724775B2
公开(公告)日：2014-05-13
申请号：US12928793
申请日：2010-12-17
申请人： Timo Kleinwaechter , Frank Weigand , Frederik Wenz
发明人： Timo Kleinwaechter , Frank Weigand , Frederik Wenz
IPC分类号： A61N5/10 , G21K1/00
CPC分类号： A61N5/1028 , A61N5/1014 , A61N2005/1096
摘要： Among other things, an applicator means (20) for x-ray radiation therapy for the irradiation of surfaces, as well as a radiation therapy device are described, having an applicator element (21) for taking up a probe tip or a radiation source element of a radiation source means (11). In order to further develop applicator means (20) in such a way that it is especially suitable also for the irradiation of surfaces, it is provided that applicator element (21) for adjusting different beam characteristics has at least one element (27) for influencing the beam, in particular a lens element, which is disposed in an exchangeable manner at/in applicator element (21). In addition, an advantageous fastening means is described, by means of which applicator means (20) can be attached and fixed on the surface to be treated.
摘要翻译：其中，描述了一种用于照射表面的X射线辐射治疗的施用装置（20）以及放射治疗装置，其具有用于吸收探针尖端或辐射源元件的施加器元件（21）的辐射源装置（11）。为了进一步开发施用装置（20），使得其特别适用于表面的照射，提供用于调节不同光束特性的施加器元件（21）具有用于影响的至少一个元件（27）光束，特别是透镜元件，其以可更换的方式设置在施加器元件（21）的/处。此外，描述了有利的紧固装置，通过该紧固装置可以将施用装置（20）附接并固定在待处理的表面上。

87. 发明授权

US08704201B2 Flexible energy filter for ion beam therapy 有权
标题翻译：用于离子束治疗的柔性能量过滤器
公开(公告)号：US08704201B2
公开(公告)日：2014-04-22
申请号：US13512670
申请日：2010-11-16
申请人： Jacobus Maarten Schippers
发明人： Jacobus Maarten Schippers
IPC分类号： H01J29/52
CPC分类号： A61N5/1077 , A61N5/10 , A61N5/1078 , A61N5/1081 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , G21K1/043 , G21K1/10
摘要： An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient.
摘要翻译：能量滤波器特别是在较低的波束能量下允许确定的光束能量的扩展，以便保留光束边缘并且在每个单独的光束能量下扩展布拉格峰。能量滤波器的行为类似于脊滤波器，并展开低能量质子束（70-100MeV）的布拉格峰值，使得能够以5毫米的步长在一整个范围内完成束的能量调制 235-70 MeV。由于其机械灵活性，能量过滤器可以放置在患者的皮肤上，由于在柔性软塑料片内的多个金属颗粒层之后的短距离到皮肤的距离，从而使过滤器中散射的影响最小化的病人。

88. 发明申请

US20130087721A1 CHARGED PARTICLE DOSE SIMULATION DEVICE, CHARGED PARTICLE BEAM IRRADIATION DEVICE, CHARGED PARTICLE DOSE SIMULATION METHOD, AND CHARGED PARTICLE BEAM IRRADIATION METHOD 有权
标题翻译：充电颗粒剂量模拟装置，充电颗粒光束辐射装置，充电颗粒剂量模拟方法和带电颗粒光束辐照方法
公开(公告)号：US20130087721A1
公开(公告)日：2013-04-11
申请号：US13267510
申请日：2011-10-06
申请人： Teiji NISHIO , Yuusuke EGASHIRA , Manabu YAMADA
发明人： Teiji NISHIO , Yuusuke EGASHIRA , Manabu YAMADA
IPC分类号： G21K5/00 , G06F17/50
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096
摘要： A simulation device includes an input unit which receives an input of simulation data including material information of the irradiation target and irradiation information of a charged particle beam, and an arithmetic unit which calculates the dose distribution of the charged particle beam in the irradiation target on the basis of simulation data received by the input unit and the dose distribution kernel. The arithmetic unit segments the charged particle beam spread to a predetermined range at an intermediate portion in the traveling direction of the charged particle beam, hypothesizes a plurality of virtual shapes having conical spread with a segmented position as a start point, and calculates the dose distribution of the charged particle beam in the irradiation target on the basis of simulation data received by the input unit and a plurality of virtual shapes of the charged particle beam.
摘要翻译：模拟装置包括：输入单元，其接收包括照射目标的材料信息和带电粒子束的照射信息的模拟数据的输入;以及运算单元，其计算照射对象中的带电粒子束的剂量分布由输入单元和剂量分布核心接收的模拟数据的基础。算术单元将带电粒子束分散到带电粒子束的行进方向的中间部分的预定范围，假设以分段位置为起始点的具有锥形扩展的多个虚拟形状，并计算剂量分布基于由输入单元接收的模拟数据和多个虚拟形状的带电粒子束的照射目标中的带电粒子束。

89. 发明申请

US20130043408A1 Shielding Device For An Irradiation Unit And Irradiation Method 有权
标题翻译：一种照射装置的屏蔽装置和照射方法
公开(公告)号：US20130043408A1
公开(公告)日：2013-02-21
申请号：US13492100
申请日：2012-06-08
申请人： Yves Claereboudt , Thomas Colmant , Michel Closset
发明人： Yves Claereboudt , Thomas Colmant , Michel Closset
IPC分类号： G21F3/00 , B26D3/00 , G21K5/00
CPC分类号： G21K1/10 , A61N5/1042 , A61N5/1077 , A61N2005/1087 , A61N2005/109 , A61N2005/1094 , A61N2005/1095 , A61N2005/1096 , G21K1/02 , Y10T83/0524
摘要： The present invention relates to a method for obtaining a shielding element for minimizing the penumbra of a beam of hadrons outside a target area, the hadron beam being guided in a longitudinal direction by an irradiation unit, and the beam having a width (σ). The method includes: (i) defining a closed or open contour of said target area; (ii) providing a block having a longitudinal thickness capable of blocking the passage of said beam and having a lateral surface perpendicular to said longitudinal thickness; (iii) forming an aperture of a shape similar to said contour and crossing said longitudinal thickness of said block for letting through said beam, said aperture forming a longitudinal internal surface; and (iv) trimming said block so as to form a longitudinal external surface around said longitudinal internals surface, said longitudinal internal and longitudinal external surfaces delimiting a side wall.
摘要翻译：本发明涉及一种用于获得屏蔽元件的方法，用于使目标区域之外的强子束的半暗最小化，强子束通过照射单元在纵向方向上被引导，并且具有宽度（＆。该方法包括：（i）限定所述目标区域的封闭或打开的轮廓; （ii）提供具有能够阻挡所述梁的通过并具有垂直于所述纵向厚度的侧表面的纵向厚度的块; （iii）形成类似于所述轮廓的形状的孔，并且穿过所述块的所述纵向厚度以穿过所述梁，所述孔形成纵向内表面; 以及（iv）修剪所述块，以形成围绕所述纵向内部表面的纵向外表面，所述纵向内部和纵向外表面限定侧壁。

90. 发明授权

US08263954B2 Bolus, bolus manufacturing method, particle beam therapy system, and treatment planning apparatus 有权
标题翻译：螺栓，弹丸制造方法，粒子束治疗系统和治疗计划装置
公开(公告)号：US08263954B2
公开(公告)日：2012-09-11
申请号：US13126235
申请日：2010-11-16
申请人： Takaaki Iwata
发明人： Takaaki Iwata
IPC分类号： G21K5/04
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1096 , G21K1/10 , Y10T29/49
摘要： The objective is to obtain a bolus, with which there can be formed an irradiation field that is accurately suited to the depth-direction shape of an irradiation subject, and a particle beam therapy system. An irradiation orbit of a particle beam is defined by a first slant with respect to a first axis that starts from a first reference point, that is perpendicular to a beam axis, and that includes the first reference point and by a second slant with respect to a second axis that is perpendicular to the beam axis and the first axis; the shape of a bolus is set in such a way that the path length, of a particle beam, within the bolus in each of the irradiation orbits defined for combinations within a predetermined range among combinations of the first slant and the second slant, compensates the path length from a body surface to a to-be-irradiated portion.
摘要翻译：目的是获得一种可以形成准确地适合照射对象的深度方向形状的照射场和粒子束治疗系统的推注。颗粒束的照射轨道由相对于从第一参考点开始的第一倾斜度定义，第一轴垂直于梁轴，并且包括第一参考点和第二倾斜相对于垂直于光束轴线和第一轴线的第二轴线; 弹丸的形状被设置为使得在第一倾斜和第二倾斜的组合之间的预定范围内为组合定义的每个照射轨道内的弹丸内的粒子束的路径长度补偿从身体表面到被照射部分的路径长度。

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