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81. 发明申请

WO02009510A2 SELECTION AND CLONING METHODS 审中-公开
标题翻译：选择和克隆方法
公开(公告)号：WO02009510A2
公开(公告)日：2002-02-07
申请号：PCT/US2001/041561
申请日：2001-08-01
IPC分类号： A01K67/027 , C12N15/85 , C12N15/873
CPC分类号： C12N15/873 , A01K67/0273 , A01K2217/05 , A01K2217/20 , A01K2227/101 , A01K2267/02 , C12N15/8509
摘要： Selection and cloning methods are disclosed that are effective for the selective multiplication of desired animals, for instance livestock animals. These methods can be used to expand populations of animals, and are particularly useful for duplicating animals selected based on traits that are measured after the animal is deceased. Certain embodiments include techniques useful for selecting a desirable bovine animal (e.g., desirable steer) based at least in part on a measurable carcass trait. Also described are specific cloning techniques that involve repetitive (for instance, two) cycles of cloning, such as nuclear transfer cloning. In specific embodiments, a two-step cloning system is described, in which the nuclear donor of the first cloning cycle is an adult fibroblast cell and the nuclear donor of the second cloning cycle is a fetal fibroblast harvested from a fetus that arose from the fist cloning cycle.
摘要翻译：公开了选择和克隆方法，其对于所需动物例如牲畜的选择性增殖是有效的。这些方法可用于扩大动物群体，并且特别可用于基于在动物死亡后测量的性状选择的重复动物。某些实施方案包括至少部分地基于可测量的胴体特征来选择期望的牛动物（例如期望的转向）的技术。还描述了涉及克隆的重复（例如，两个）循环的特异性克隆技术，例如核转移克隆。在具体实施方案中，描述了两步克隆系统，其中第一克隆周期的核供体是成体成纤维细胞，第二克隆周期的核供体是从第一次产生的胎儿收获的胎儿成纤维细胞克隆周期。

82. 发明申请

WO01084920A1 THE PRODUCTION OF AGRICULTURAL ANIMALS FROM EMBRYONIC STEM (ES) CELLS 审中-公开
标题翻译：从胚胎干细胞（ES）细胞生产农业动物
公开(公告)号：WO01084920A1
公开(公告)日：2001-11-15
申请号：PCT/US2001/015075
申请日：2001-05-10
IPC分类号： A01K67/027 , C12N15/873 , C12N15/877 , A01K67/00 , C12N15/00
CPC分类号： C12N15/873 , A01K67/0273 , A01K2217/05 , A01K2227/101 , C12N15/8771
摘要： This invention describes a novel method of agricultural animal production that provides animals with optimum growth characteristics in a reliable and cost-effective manner. The invention utilizes a novel combination of Nuclear Transfer (NT) and Embryonic Stem (ES) cell technologies that improves the efficiency of delivering optimized animals and facilitates the introduction of genetic modifications into farm animals.
摘要翻译：本发明描述了一种以可靠和具有成本效益的方式为动物提供最佳生长特性的新型农业动物生产方法。本发明利用核转移（NT）和胚胎干细胞（ES）细胞技术的新型组合，其提高了递送优化动物的效率，并有助于将遗传修饰引入农场动物。

83. 发明公开

EP3359661A1 MULTIPLEXED GENOME EDITING 审中-公开
公开(公告)号：EP3359661A1
公开(公告)日：2018-08-15
申请号：EP16854392.4
申请日：2016-10-07
申请人： President and Fellows of Harvard College
发明人： CHURCH, George M. , YANG, Luhan , GUELL, Marc
IPC分类号： C12N9/22 , C12N15/10 , C12N15/113 , C12N15/63 , C12N15/90
CPC分类号： A01K67/0275 , A01K67/0273 , A01K2227/108 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/1132 , C12N15/63 , C12N15/907 , C12N2310/20 , C12N2740/10062 , C12N2800/80
摘要： A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.

84. 发明公开

EP2982744A1 HIGHLY EFFICIENT METHODS FOR REPROGRAMMING DIFFERENTIATED CELLS AND FOR GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM REPROGRAMMED CELLS 审中-公开
标题翻译：重编程分化的细胞和产生动物和胚胎干细胞来自非洲高效的方法重新编程的细胞
公开(公告)号：EP2982744A1
公开(公告)日：2016-02-10
申请号：EP15164113.1
申请日：2008-02-22
申请人： Advanced Cell Technology, Inc.
发明人： Lanza, Robert , Chung, Young
IPC分类号： C12N5/00 , C12N5/02 , C12N15/00 , A01K67/027 , C07K14/435 , C12N5/0735 , C12N5/073
CPC分类号： C12N5/0606 , A01K67/0273 , A01K67/0275 , A01K2227/105 , A01K2267/0393 , C07K14/43595 , C12N5/0603 , C12N5/0604 , C12N5/0619 , C12N5/0621 , C12N5/0634 , C12N5/0657 , C12N2501/235 , C12N2501/998 , C12N2502/02 , C12N2506/02 , C12N2517/04 , C12N2533/52
摘要： The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.
摘要翻译：本发明涉及基因集会体细胞核转移（SCNT）的领域，并且创造克隆动物和细胞。本发明涉及克隆哺乳动物，获得多能性细胞的方法：如胚胎干细胞，或者用于重新编程使用在卵母细胞和哺乳动物细胞中受精胚胎。

85. 发明授权

EP2042594B1 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates 有权
标题翻译：异种（人）免疫球蛋白的克隆转基因有蹄类动物的表达
公开(公告)号：EP2042594B1
公开(公告)日：2011-03-23
申请号：EP08016978.2
申请日：2001-11-16
申请人： Kyowa Hakko Kirin Co., Ltd.
发明人： Robl, James M. , Kuroiwa, Yoshimi , Tomizuka, Kazuma , Ishida, Isao
IPC分类号： C12N15/00 , C12P21/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/01 , C12N9/1051 , C12N2800/30

86. 发明授权

EP1343880B1 EXPRESSION OF XENOGENOUS (HUMAN) IMMUNOGLOBULINS IN CLONED, TRANSGENIC BOVINE 有权
标题翻译：在克隆，转基因牛表达异种（人）免疫球蛋白
公开(公告)号：EP1343880B1
公开(公告)日：2009-05-27
申请号：EP01273248.3
申请日：2001-11-16
申请人： Kyowa Hakko Kirin Co., Ltd.
发明人： ROBL, James, M. , GOLDSBY, Richard, A. , FERGUSON, Stacy, E. , KUROIWA, Yoshimi , TOMIZUKA, Kazuma , ISHIDA, Isao , OSBORNE, Barbara A.
IPC分类号： C12N15/00 , C12P21/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/01 , C12N9/1051 , C12N2800/30
摘要： The present invention relates to the production of a trangenic bovine which comprises a genetic modification that resulrs in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.

87. 发明公开

EP2042594A1 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates 有权
标题翻译：表达von xenogenen（人类）在klonierten，transgenen Huftieren的Immunglobulinen
公开(公告)号：EP2042594A1
公开(公告)日：2009-04-01
申请号：EP08016978.2
申请日：2001-11-16
申请人： Kirin Pharma Kabushiki Kaisha
发明人： Robl, James M. , Kuroiwa, Yoshimi , Tomizuka, Kazuma , Ishida, Isao
IPC分类号： C12N15/00 , C12P21/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/01 , C12N9/1051 , C12N2800/30
摘要： The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.
摘要翻译：本发明涉及转基因牛的生产，其包含导致其内源性抗体失活和丧失表达的遗传修饰，以及异源抗体（优选人抗体）的表达。这通过IgM重链表达的失活和任选地通过Ig轻链表达的失活以及进一步引入导致非牛抗体（优选人抗体）表达的人造染色体来实现。

88. 发明公开

EP1749102A4 TRANSGENIC ANIMALS AND USES THEREOF 审中-公开
标题翻译： VERWENDUNGEN DAVON的TRANSGENE TIERE
公开(公告)号：EP1749102A4
公开(公告)日：2009-02-25
申请号：EP05738421
申请日：2005-04-21
申请人： KIRIN PHARMA KK
发明人： ROBL JAMES , KUROIWA YOSHIMI , KASINATHAN POOTHAPPILLAI , ISHIDA ISAO , TOMIZUKA KAZUMA
IPC分类号： C12P21/00 , A01K67/027 , C07K16/00 , C12N15/00 , C12N15/85 , C12N15/877
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and method of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
摘要翻译：通常，本发明的特征在于遗传修饰的非人哺乳动物（例如牛和其他有蹄类动物）以及制备这些哺乳动物的方法。特别地，本发明具有具有降低的内源性IgM重链和/或朊病毒蛋白水平的转基因有蹄类动物。

89. 发明授权

EP1313849B8 METHODS OF ENUCLEATING A CELL 有权
标题翻译：用于生产克隆BIRDS
公开(公告)号：EP1313849B8
公开(公告)日：2007-03-07
申请号：EP01968166.7
申请日：2001-08-27
申请人： Avigenics, Inc.
发明人： CHRISTMANN, Leandro , PRATT, Scott, L. , RAPP, Jeffrey, C.
IPC分类号： C12N15/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0273 , A01K2217/05 , A01K2217/075 , A01K2227/30 , A01K2267/01 , A01K2267/02 , C07K14/005 , C12N2770/24222
摘要： Methods for producing cloned non-human animals by nuclear transfer and by combinations of nuclear transfer and ovum transfer, employing near-infrared visualization of the recipient cell nucleus are described herein. Transgenic, knock-out, and knock-in avians are provided. Method for producing eggs which contain exogenous proteins are encompassed by the present invention. Thus, the instant invention satisfies the need for an effective route to the generation of cloned avians.

90. 发明公开

EP1749102A2 TRANSGENIC ANIMALS AND USES THEREOF 审中-公开
标题翻译：转基因动物和其用途
公开(公告)号：EP1749102A2
公开(公告)日：2007-02-07
申请号：EP05738421.6
申请日：2005-04-21
申请人： KIRIN BEER KABUSHIKI KAISHA
发明人： ROBL, James , KUROIWA, Yoshimi , KASINATHAN, Poothappillai , ISHIDA, Isao , TOMIZUKA, Kazuma
IPC分类号： C12P21/00 , A01K67/027 , C12N15/00 , C07K16/00
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and method of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

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