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1. 发明申请

WO2009111086A1 TRANSGENIC NON-HUMAN MAMMALS WITH KAPPA LIGHT CHAIN OF XENOGENOUS IMMUNOGLOBULIN 审中-公开
标题翻译：具有KAPPA轻链免疫球蛋白轻链的转基因非人类哺乳动物
公开(公告)号：WO2009111086A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001501
申请日：2009-03-09
申请人： KIRIN PHARMA KABUSHIKI KAISHA , KUROIWA, Yoshimi , TOMIZUKA, Kazuma , ROBL, James, M.
发明人： KUROIWA, Yoshimi , TOMIZUKA, Kazuma , ROBL, James, M.
IPC分类号： C12P21/00
CPC分类号： C07K16/00 , A01K67/0273 , A01K67/0278 , A01K2217/052 , A01K2217/15 , A01K2227/101 , A01K2267/01 , C07K16/1278 , C07K16/18 , C07K2317/21 , C07K2317/41 , C07K2317/50 , C12N15/8509 , C12N2800/30
摘要： Genetically modified non-human mammals (e.g., bovines, porcines, and other ungulates) and cells containing a nucleic acid encoding all or part of a xenogenous kappa immunoglobulin gene capable of undergoing rearrangement and expressing a xenogenous kappa immunoglobulin are described. Antibodies produced from these non-human mammals and cells are described. Methods of making these mammals and cells are presented. In addition, methods of producing xenogenous (e.g., human) antibodies from the genetically modified non-human mammals and cells are described.
摘要翻译：描述了遗传修饰的非人哺乳动物（例如牛，猪和其他有蹄类动物）和含有编码全部或部分能够进行重排和表达异种κ免疫球蛋白的异源κ免疫球蛋白基因的核酸的细胞。描述了从这些非人哺乳动物和细胞产生的抗体。提出制作这些哺乳动物和细胞的方法。此外，描述了从遗传修饰的非人哺乳动物和细胞产生异种（例如，人）抗体的方法。

2. 发明申请

WO2008018904A3 SYSTEMS AND METHODS FOR PROCESSING SAMPLES IN A CLOSED CONTAINER, AND RELATED DEVICES 审中-公开
公开(公告)号：WO2008018904A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/001170
申请日：2007-01-17
申请人： ARGOS THERAPEUTICS, INC. , KIRIN PHARMA KABUSHIKI KAISHA , SPENCE, Simon Jonathon , GRANT, Richard Alexander , PEELE, Timothy Doyle , HUNTER, William Samuel , ABDELMOTELEB, Ashraf F. , KNEEN, David Thomas , NEIL, Robert Alister , HARRIS, Simon
发明人： SPENCE, Simon Jonathon , GRANT, Richard Alexander , PEELE, Timothy Doyle , HUNTER, William Samuel , ABDELMOTELEB, Ashraf F. , KNEEN, David Thomas , NEIL, Robert Alister , HARRIS, Simon
IPC分类号： B25J3/00 , F16K31/00
摘要： A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device. The barrier can be flexible, and allow the robotic arm to move the pipette head throughout the work area of the tray. All samples, reagents, pipette tips and other tools or devices for processing nucleic acid samples may remain within the closed compartment provided by the container during processing.

3. 发明申请

WO2009017743A3 IMPROVED PRIMERS AND PROBES FOR THE AMPLIFICATION AND DETECTION OF HIV GAG, REV AND NEF POLYNUCLEOTIDES 审中-公开
公开(公告)号：WO2009017743A3
公开(公告)日：2009-02-05
申请号：PCT/US2008/009185
申请日：2008-07-30
申请人： ARGOS THERAPEUTICS, INC. , KIRIN PHARMA KABUSHIKI KAISHA , TCHEREPANOVA, Irina , STARR, Aijing , LACKFORD, Brad
发明人： TCHEREPANOVA, Irina , STARR, Aijing , LACKFORD, Brad
IPC分类号： C07H21/04 , C12Q1/20
摘要： Methods and compositions for the nucleic acid amplification of one or multiple variants (strains) of Human Immunodeficiency Virus (HIV) present in a sample from a pathogen infected individual are disclosed. Primers, methods and kits for the amplification of one or more species of HIV Rev, Gag and Nef nucleic acids are provided. The amplified HIV nucleic acid can be used to identify and/or quantitate HIV variants present in a sample. Nucleic acids produced by the amplification reaction or the proteins encoded thereby can also be used directly as vaccines or to transfect/load antigen presenting cells. The loaded antigen presenting cells can be used as a vaccine for the treatment or prevention of HIV infection.

4. 发明申请

WO2008088524A2 THROMBOSPONDIN-DOMAIN-DEFICIENT R-SPONDIN 1 PROTEIN AS GASTROINTESTINAL TRACT EPITHELIAL PROLIFERATION FACTOR 审中-公开
标题翻译：血栓形成蛋白缺失型R-SPONDIN 1蛋白作为胃肠道上皮上皮增殖因子
公开(公告)号：WO2008088524A2
公开(公告)日：2008-07-24
申请号：PCT/US2007/025219
申请日：2007-12-10
申请人： NUVELO, INC. , KIRIN PHARMA KABUSHIKI KAISHA , TOMIZUKA, Kazuma , KAKITANI, Makoto , OSHIMA, Takeshi
发明人： TOMIZUKA, Kazuma , KAKITANI, Makoto , OSHIMA, Takeshi
IPC分类号： A61K38/17 , G01N33/53 , C12Q1/68 , A61K49/00 , A61P1/04
CPC分类号： A61K38/1709 , C07K14/47
摘要： The present invention relates to an agent for promoting epithelial proliferation and a method for promoting epithelial proliferation, particularly to an agent for promoting gastrointestinal tract-epithelial proliferation and a method for promoting gastrointestinal tract-epithelial proliferation. The present invention further relates to an agent for treatment or prevention of gastrointestinal tract-epithelium-associated diseases or disorders, and to a method for treating or preventing gastrointestinal tract-epithelium- associated diseases or disorders. The present invention further relates to the use of an R-spondin 1 variant protein, which lacks the thrombospondin type 1 repeat, or the nucleic acid encoding the same.
摘要翻译：本发明涉及促进上皮增殖的药剂和促进上皮细胞增殖的方法，特别涉及促进胃肠道 - 上皮增生的药物和促进胃肠道 - 上皮增生的方法。本发明还涉及治疗或预防胃肠道上皮相关疾病或病症的药剂，以及治疗或预防胃肠道上皮相关疾病或病症的方法。本发明还涉及不含血小板反应蛋白1型重复的R-杆菌素1变体蛋白或其编码的核酸的用途。

5. 发明申请

WO2009048769A2 VACCINIA VIRUS H3L AND B5R SPECIFIC MONOCLONAL ANTIBODIES AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2009048769A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/078316
申请日：2008-09-30
申请人： KIRIN PHARMA KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KATO, Shinichiro , GRANGER, Steve , CROTTY, Shane , RICKERT, Sandra
发明人： KATO, Shinichiro , GRANGER, Steve , CROTTY, Shane , RICKERT, Sandra
IPC分类号： C07K16/08 , A61K39/42 , A61P31/20 , C07K16/00
CPC分类号： C07K16/081 , A61K2039/507 , C07K2317/565 , C07K2317/734
摘要： The invention relates to antibodies and subsequences thereof that specifically bind to poxvirus B5R envelope protein, antibodies and subsequences thereof that specifically bind to poxvirus H3L envelope protein, and combinations thereof.

6. 发明申请

WO2008027338A2 ANTAGONISTIC HUMAN LIGHT-SPECIFIC HUMAN MONOCLONAL ANTIBODIES 审中-公开
标题翻译：拮抗性人类光特异性人单克隆抗体
公开(公告)号：WO2008027338A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018832
申请日：2007-08-24
申请人： KIRIN PHARMA KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , GRANGER, Steven, W. , KATO, Shinichiro , WARE, Carl, F.
发明人： GRANGER, Steven, W. , KATO, Shinichiro , WARE, Carl, F.
IPC分类号： C07K16/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies, such as fully human antibodies, that immunospecifically bind to an hLIGHT polypeptide. Also provided are isolated nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Further provided are vectors and host cells comprising nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided are methods of making antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided herein is a method of treating a hLIGHT- mediated disease in a subject comprising administering to the subject an antibody, such as a fully human antibody, that immunospecifically binds to a hLIGHT polypeptide. In preferred embodiments, that anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo ( e.g. , the hLIGHT- mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。还提供了编码免疫特异性结合hLIGHT多肽的抗体例如完全人抗体的分离的核酸。进一步提供了包含免疫特异性结合hLIGHT多肽的编码抗体的核酸（如完全人抗体）的载体和宿主细胞。还提供了制备免疫特异性结合hLIGHT多肽的抗体如完全人抗体的方法。本文还提供了治疗受试者中hLIGHT介导的疾病的方法，其包括向受试者施用免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。在优选的实施方案中，本文提供的抗hLIGHT抗体将改善，中和或以其他方式抑制hLIGHT体内生物学活性（例如，hLIGHT介导的CCL20的产生或分泌， IL-8或来自表达hLIGHT受体的细胞的RANTES）。本文还提供了用于检测样品中hLIGHT的方法以及用于改善，中和或以其他方式抑制hLIGHT活性的方法，例如在患有hLIGHT活性是有害的病症的人类受试者中的方法。

7. 发明专利

TW200902549A 抗FGF23抗體及含有其之醫藥組合物审中-公开
简体标题：抗FGF23抗体及含有其之医药组合物
公开(公告)号：TW200902549A
公开(公告)日：2009-01-16
申请号：TW097105234
申请日：2008-02-14
申请人：麒麟醫藥股份有限公司 KIRIN PHARMA KABUSHIKI KAISHA
发明人：山崎雄司 YAMAZAKI, YUJI , 浦川到 URAKAWA, ITARU , 吉田均 YOSHIDA, HITOSHI , 青野友紀子 AONO, YUKIKO , 山下武美 YAMASHITA, TAKEYOSHI , 島田孝志 SHIMADA, TAKASHI , 長谷川尚 HASEGAWA, HISASHI
IPC分类号： C07K , A61K , C12P , C12N , A61P
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要：本發明提供一種抗FGF23之抗體、以及藉由使用該抗體來抑制FGF23的作用而可預防或治療疾病之預防或治療劑等之醫藥組合物。本發明亦提供一種由融合瘤C10(寄存號碼FERM BP-10772)所產生之抗人類FGF23之抗體或其功能性片段。
简体摘要：本发明提供一种抗FGF23之抗体、以及借由使用该抗体来抑制FGF23的作用而可预防或治疗疾病之预防或治疗剂等之医药组合物。本发明亦提供一种由融合瘤C10(寄存号码FERM BP-10772)所产生之抗人类FGF23之抗体或其功能性片段。

8. 发明专利

TW200817512A 人類人工染色體(HAC)載體及含有人類人工染色體(HAC)載體之人類細胞醫藥审中-公开
简体标题：人类人工染色体(HAC)载体及含有人类人工染色体(HAC)载体之人类细胞医药
公开(公告)号：TW200817512A
公开(公告)日：2008-04-16
申请号：TW096124839
申请日：2007-07-06
申请人：麒麟醫藥股份有限公司 KIRIN PHARMA KABUSHIKI KAISHA
发明人：掛田實 KAKEDA, MINORU , 富塚一磨 TOMIZUKA, KAZUMA , 押村光雄 OSHIMURA, MITSUO , 香月康宏 KAZUKI, YASUHIRO
IPC分类号： C12N
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2217/206 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K48/00 , C12N2510/00 , C12N2800/208 , C12N2800/30
摘要：本發明係關於一種保有來自人類染色體之著絲點以及亞端粒序列及端粒序列之人類人工染色體(HAC)載體、含有該HAC載體之人類細胞醫藥或人類細胞、該HAC載體及人類細胞之製作方法、以及使用該HAC載體之治療用蛋白質製造方法。
简体摘要：本发明系关于一种保有来自人类染色体之着丝点以及亚端粒串行及端粒串行之人类人工染色体(HAC)载体、含有该HAC载体之人类细胞医药或人类细胞、该HAC载体及人类细胞之制作方法、以及使用该HAC载体之治疗用蛋白质制造方法。

9. 发明专利

TWI313299B 用於製造人類抗體之轉殖基因轉殖染色體齧齒動物 TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES 有权
简体标题：用于制造人类抗体之转殖基因转殖染色体啮齿动物 TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES
公开(公告)号：TWI313299B
公开(公告)日：2009-08-11
申请号：TW090129658
申请日：2001-11-30
申请人：美達瑞克斯公司 MEDAREX INC. , 麒麟醫藥股份有限公司 KIRIN PHARMA KABUSHIKI KAISHA
发明人：尼爾斯隆伯格 NILS LONBERG , 艾德豪克 ED HALK , 富塚一磨 KAZUMA TOMIZUKA , 石田功 ISAO ISHIDA
IPC分类号： C12N , A01K , C07K
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要：本發明提出可產生人類序列抗體之新穎的轉殖基因非人類哺乳動物,以及產製及使用此類抗體之方法。
简体摘要：本发明提出可产生人类串行抗体之新颖的转殖基因非人类哺乳动物,以及产制及使用此类抗体之方法。

10. 发明专利

TW200911837A 抗CD40單株抗體 ANTI-CD40 MONOCLONAL ANTIBODY 审中-公开
简体标题：抗CD40单株抗体 ANTI-CD40 MONOCLONAL ANTIBODY
公开(公告)号：TW200911837A
公开(公告)日：2009-03-16
申请号：TW097138439
申请日：2002-04-26
申请人：麒麟醫藥股份有限公司 KIRIN PHARMA KABUSHIKI KAISHA
发明人：三箇山俊文 MIKAYAMA, TOSHIFUMI , 吉田均 YOSHIDA, HITOSHI , 渥克R 佛斯 WALKER R, FORCE , 陳興捷 CHEN, XINGJIE , 高橋信明 TAKAHASHI, NOBUAKI
IPC分类号： C07K , A61K , A61P
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/74 , C07K2319/00 , C07K2319/30
摘要：本發明係有關對於CD40具有催動性(agonistic)或拮抗性(antagonistic)作用之抗體或其功能性片段。
简体摘要：本发明系有关对于CD40具有催动性(agonistic)或拮抗性(antagonistic)作用之抗体或其功能性片段。

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