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81. 发明授权

US07833699B2 Detection of tuberculosis and infection by Mycobacterium tuberculosis using HBHA 有权
标题翻译：使用HBHA检测结核分枝杆菌和结核分枝杆菌感染
公开(公告)号：US07833699B2
公开(公告)日：2010-11-16
申请号：US11646299
申请日：2006-12-28
申请人： Camille Locht , Françoise Mascart , Stéphane Temmerman , Jean-Michel Hougardy , Sammy Place , Christian Sergheraert
发明人： Camille Locht , Françoise Mascart , Stéphane Temmerman , Jean-Michel Hougardy , Sammy Place , Christian Sergheraert
IPC分类号： C12Q1/00 , A61K39/38 , A61K39/04
CPC分类号： G01N33/5695
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
摘要翻译：本发明涉及用于体外检测哺乳动物结核分枝杆菌感染的方法，以及用于体外鉴别被感染疾病的结核分枝杆菌（活性形式）和感染但无症状的结核病的哺乳动物之间体外区别的方法（潜在形式），以及用于体外区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染或呈现潜在形式的结核病的哺乳动物的体外区别的方法。本发明还涉及用于检测和区分呈现结核病症状的受感染哺乳动物和没有疾病发展的感染哺乳动物的试剂盒，以及用于区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染的哺乳动物或呈现潜伏形式的结核病。

82. 发明申请

US20100178360A1 NUTRITIVE COMPOSITION 审中-公开
标题翻译：营养成分
公开(公告)号：US20100178360A1
公开(公告)日：2010-07-15
申请号：US12633405
申请日：2009-12-08
申请人： Jacques Deviere , Nicolas Cauche , Alain Delchambre , Marianna Arvanitaki
发明人： Jacques Deviere , Nicolas Cauche , Alain Delchambre , Marianna Arvanitaki
IPC分类号： A61K33/34 , A61K31/715 , A61K33/00
CPC分类号： A61K45/06 , A23L29/30 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/715 , A61K31/77 , A61K33/00 , A61K33/06 , A61K33/42 , A61K2300/00
摘要： An energetic or nutritive composition includes at least one compound having laxative properties, mineral salts (or electrolytes) such as sodium, potassium, chlorine, calcium, magnesium, phosphor. The composition may also include carbohydrates that may be assimilated by the human digestive system such as glucose, galactose, fructose, maltose, saccharose, polysaccharides.
摘要翻译：能量或营养组合物包括至少一种具有泻药性质的化合物，矿物盐（或电解质）如钠，钾，氯，钙，镁，磷光体。组合物还可以包括可被人类消化系统如葡萄糖，半乳糖，果糖，麦芽糖，蔗糖，多糖同化的碳水化合物。

83. 发明授权

US07585511B2 Apolipoprotein L-I and/or derivated polypeptide for the treatment of and/or the prevention of diseases induced by trypanosoma 有权
标题翻译：用于治疗和/或预防由锥虫病引起的疾病的载脂蛋白L-1和/或衍生多肽
公开(公告)号：US07585511B2
公开(公告)日：2009-09-08
申请号：US10523466
申请日：2003-08-04
申请人： Etienne Pays , Luc Vanhamme , Francoise Paturiaux-Hanocq , Philippe Poelvoorde
发明人： Etienne Pays , Luc Vanhamme , Francoise Paturiaux-Hanocq , Philippe Poelvoorde
IPC分类号： A61K39/002
CPC分类号： C12Q1/6893 , A01K2227/101 , A61K38/17 , A61K38/1709 , G01N33/92 , Y02A50/415
摘要： The present invention is related to a composition comprising apolipoprotein L-l, the use of apolipoprotein L-l or a derivated polypeptide for the diagnostic, the treatment and/or the prevention of diseases induced in mammals by Trypanosoma. Another aspect is related to a transgenic non-human mammal comprising a polynucleotide expressing the apolipoprotein L-l or a derivated polypeptide and which is tolerant or resistant to the Trypanosoma infection.
摘要翻译：本发明涉及包含载脂蛋白L-1，载脂蛋白L-1或衍生多肽用于诊断，治疗和/或预防由锥虫病在哺乳动物中诱导的疾病的组合物的组合物。另一方面涉及包含表达载脂蛋白L-1或衍生多肽并且对锥虫病感染具有耐受性或抗性的多核苷酸的转基因非人哺乳动物。

84. 发明申请

US20090162333A1 PHARMACEUTICAL COMPOSITION COMPRISING APOLIPOPROTEINS FOR THE TREATMENT OF HUMAN DISEASES 审中-公开
标题翻译：包含APOLIPOPROTEIN治疗人类疾病的药物组合物
公开(公告)号：US20090162333A1
公开(公告)日：2009-06-25
申请号：US12300569
申请日：2007-05-25
申请人： Etienne Pays , Benoit Vanhollebeke
发明人： Etienne Pays , Benoit Vanhollebeke
IPC分类号： A61K48/00 , A61K38/17 , A61K31/7105 , A61P35/00 , A61P25/18 , A61P29/00 , A61K31/711 , A61K35/12
CPC分类号： A61K38/17
摘要： A pharmaceutical composition has an adequate pharmaceutical carrier or diluent and an element selected from a pharmaceutical composition having an adequate pharmaceutical carrier or diluent and an element selected from: —apolipoprotein apoL-III; —a pharmaceutically active fragment of this apolipoprotein apoL-III; —a nucleotide sequence encoding this apolipoprotein apoL-III or the fragment; —a vector having the nucleotide sequence; —a cell transformed by the nucleotide sequence or the vector; —an inhibitor or activator directed against the apolipoprotein apoL-III, its fragment or its nucleotide sequence, —an anti-inhibitor or anti-activator directed against the inhibitor or activator or its encoding nucleotide sequence.
摘要翻译：药物组合物具有足够的药物载体或稀释剂和选自具有足够的药物载体或稀释剂的药物组合物和选自以下的元素的元素：脂蛋白载体-III; - 该载脂蛋白apoL-III的药物活性片段; - 编码该载脂蛋白apoL-III或片段的核苷酸序列; 具有该核苷酸序列的载体; - 由核苷酸序列或载体转化的细胞; - 针对载脂蛋白apoL-III，其片段或其核苷酸序列的抑制剂或活化剂 - 针对抑制剂或活化剂的抗抑制剂或抗激活剂或其编码核苷酸序列。

85. 发明申请

US20080018966A1 DIGITAL HOLOGRAPHIC MICROSCOPE FOR 3D IMAGING AND PROCESS USING IT 有权
标题翻译：用于3D成像的数字全息显微镜和使用它的过程
公开(公告)号：US20080018966A1
公开(公告)日：2008-01-24
申请号：US10557240
申请日：2004-05-17
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G03H1/08
CPC分类号： G01B9/021 , G01B9/04 , G02B21/16 , G02B21/22 , G02B21/36 , G03H1/0005 , G03H1/0443 , G03H1/0493 , G03H1/0866 , G03H2001/005 , G03H2001/0454 , G03H2222/24
摘要： The present invention is related to a compact microscope able to work in digital holography for obtaining high quality 3D images of samples, including fluorescent samples and relatively thick samples such as biological samples, said microscope comprising illumination means (1,41) at least partially spatially coherent for illuminating a sample (2) to be studied and a differential interferometer (5) for generating interfering beams from said sample (2) on the sensor (33) of an electronic imaging device (7), said interferometer (5) comprising namely tilting means (17) for tilting by a defined angle one the interfering beams (28 or 29) relatively to the other, said tilting resulting into a defined shift (27) of said interfering beam on the sensor of the electronic imaging device (7), said shift (27) being smaller than spatial coherence width of each beam, said microscope being able to be quasi totally preadjusted independently from the samples so that minimum additional adjustments are required for obtaining reliable 3D images of samples.
摘要翻译：本发明涉及能够在数字全息术中工作以获得样品的高质量3D图像的紧凑型显微镜，包括荧光样品和相对较厚的样品例如生物样品，所述显微镜包括至少部分空间上的照明装置（1,41）用于照射要研究的样品（2）的相干性和用于在电子成像装置（7）的传感器（33）上产生来自所述样品（2）的干扰光束的差分干涉仪（5），所述干涉仪（5）包括倾斜装置（17），用于相对于另一个倾斜定影角度的一个干涉光束（28或29），所述倾斜导致所述干涉光束在电子成像装置（7）的传感器上的限定位移（27）），所述偏移（27）小于每个光束的空间相干宽度，所述显微镜能够独立于样品被准全部预调整，使得最小加法为了获得样品的可靠3D图像，需要进行调整。

86. 发明申请

US20070275953A1 2-Pyridinone Derivatives, Having Hiv Inhibiting Properties 审中-公开
标题翻译：具有抑制性质的2-吡啶酮衍生物
公开(公告)号：US20070275953A1
公开(公告)日：2007-11-29
申请号：US10573143
申请日：2004-09-22
申请人： Kiet Le Van , Renoit Georges , Laszlo Heyesi , Christine Cauvin , Sandra Boland , Francois Durant , Dominique Demonte , Chris Van Lint , Arthu Burny , Alex Bollen , Alain Jacquet , Stephaine De Walque
发明人： Kiet Le Van , Renoit Georges , Laszlo Heyesi , Christine Cauvin , Sandra Boland , Francois Durant , Dominique Demonte , Chris Van Lint , Arthu Burny , Alex Bollen , Alain Jacquet , Stephaine De Walque
IPC分类号： A61K31/4747 , A61P31/18 , C07D211/86 , A61K31/443 , A61K31/4439 , A61K31/4436 , A61K31/4433 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号： C07D213/69 , C07D213/80
摘要： The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of Acquired Immune Deficiency Syndrome (AIDS). The present invention further relates to the synthesis of said compounds and their use, with or without other pharmaceutical agents, in the treatment of AIDS and viral infections by HIV-1.
摘要翻译：本发明涉及抑制人免疫缺陷病毒1型（HIV-1）复制物的通式I的2-吡啶酮衍生物，更具体地说是5-乙基-6-甲基-2-吡啶酮衍生物，因此在治疗获得性免疫缺陷综合征（AIDS）。本发明还涉及所述化合物的合成及其用于或不用其它药剂用于治疗HIV-1的AIDS和病毒感染的用途。

87. 发明授权

US07176029B2 Cloning and/or sequencing vector 有权
标题翻译：克隆和/或测序载体
公开(公告)号：US07176029B2
公开(公告)日：2007-02-13
申请号：US10994208
申请日：2004-11-19
申请人： Philippe Bernard , Philippe Gabant
发明人： Philippe Bernard , Philippe Gabant
IPC分类号： C12N15/70 , C12N15/81 , C12N1/21 , C12P19/34
CPC分类号： C12N15/70
摘要： A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison.
摘要翻译：克隆和/或测序载体能够直接选择重组克隆。载体编码融合蛋白，其包含蛋白质毒素。

88. 发明授权

US4125560A Aromatic amines synthesis process and products resulting from application of this process 失效
标题翻译：芳香胺合成工艺和产品由此应用而产生
公开(公告)号：US4125560A
公开(公告)日：1978-11-14
申请号：US705577
申请日：1976-07-15
申请人： Claude L. Delaunois , Willy O. De Graeve
发明人： Claude L. Delaunois , Willy O. De Graeve
IPC分类号： C07C209/00 , C07C67/00 , C07C209/18 , C07C213/02 , C07C215/74 , C07C85/06
CPC分类号： C07C209/18
摘要： The invention pertains to an aromatic amines synthesis process, fundamentally characterized by the fact that it consists of carrying out the ammonolysis of phenols under pressure in liquid phase by ammonia in aqueous solution.
摘要翻译：本发明涉及一种芳香胺合成方法，其基本特征在于它包括在水溶液中用氨在液相中进行苯酚的氨解作用。

89. 发明公开

US20240101260A1 DEVICE AND METHOD FOR DETECTING A TRANSITION BETWEEN A LIQUID PHASE AND A SOLID PHASE OF A SUBSTANCE, SUCH AS THE FORMATION OF ICE 审中-公开
公开(公告)号：US20240101260A1
公开(公告)日：2024-03-28
申请号：US18261820
申请日：2022-01-27
申请人： UNIVERSITE LIBRE DE BRUXELLES
发明人： Carlo Saverio IORIO , Patrice Désiré DONGO , Patrick QUEECKERS , Dario FARINA , Simone FABIANO , Xavier CRISPIN , Anna HAKANSSON
IPC分类号： B64D15/20 , G01N27/12
CPC分类号： B64D15/20 , G01N27/126
摘要： A device and method for detecting a phase transition between a liquid phase and a solid phase of a substance include a pair of electrodes, a sensing layer arranged in an electrical path between the pair of electrodes, and means for measuring a first electrical characteristic of the electrical path. The sensing layer includes a mixed ion and electron conducting composite material. The composite material has an electrical property, in particular electrical resistance, which shows a peak variation as a function of time at the phase transition, such as an onset of ice formation. Computing means process the first electrical characteristic to indicate an occurrence of the phase transition.

90. 发明授权

US11918961B2 Droplet and/or bubble generator 有权
公开(公告)号：US11918961B2
公开(公告)日：2024-03-05
申请号：US16628616
申请日：2018-07-03
申请人： UNIVERSITE LIBRE DE BRUXELLES
发明人： Benoit Scheid , Adrien Dewandre , Youen Vitry
IPC分类号： B01F23/00 , B01F23/232 , B01F23/41 , B01F33/3011 , B01F35/10 , B01F35/21 , B01F35/221 , B01F35/71 , B01J4/00 , B01J13/00 , B33Y10/00 , B33Y80/00
CPC分类号： B01F23/4105 , B01F23/232 , B01F33/3011 , B01F35/10 , B01F35/2111 , B01F35/2213 , B01F35/71745 , B01J4/002 , B01J13/0004 , B33Y10/00 , B33Y80/00 , B01F2215/0431
摘要： A device for generating bubbles or droplets may include a cavity comprising a first pressurized phase, at least one input capillary of a second phase, and an output capillary coaxially aligned with the at least one input capillary. The opening of the tip of the at least one input capillary has an internal diameter of less than half the internal diameter of the output capillary. The cross section of the cavity may be selected so that, in use, the average speed field in the cavity is quasi-static.

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