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    • 86. 发明授权
    • Process for producing 2,2'-Bis(hydroxymethyl) alkanoic acid
    • 制备2,2'-双(羟甲基)链烷酸的方法
    • US6072082A
    • 2000-06-06
    • US246964
    • 1999-02-09
    • Hideshi SaitoMikio SuzukiShoji SakamotoToshiharu YokoyamaKouji Maeda
    • Hideshi SaitoMikio SuzukiShoji SakamotoToshiharu YokoyamaKouji Maeda
    • C07C51/235C07C45/75C07C51/285C07C51/43C07C51/48C07C59/105C07C51/16C07C59/10
    • C07C51/285C07C45/75C07C51/48
    • A process for producing 2,2'-bis(hydroxymethyl)alkanoic acid of the present invention, comprises:a 2,2'-bis(hydroxymethyl)alkanal production step (A1) of reacting aliphatic aldehyde having two hydrogen atoms bonded to .alpha.-carbon atom thereof, with formaldehyde in the presence of a water-soluble base;a 2,2'-bis(hydroxymethyl)alkanoic acid production step (B) of subjecting the thus obtained aqueous solution (a) containing 2,2'-bis(hydroxymethyl)alkanal and the base to oxidation treatment; andan alkanoic acid recovery step (C) of separating 2,2'-bis(hydroxymethyl)alkanoic acid from the thus obtained aqueous solution (b) containing the 2,2'-bis(hydroxymethyl)alkanoic acid and the base,in the alkanoic acid recovery step (C), a mineral acid being added to the aqueous solution (b) in an amount of not more than one equivalent based on the base in the aqueous solution (b) to convert the base into a salt thereof,water in the aqueous solution (b) being replaced with an organic solvent to form an organic solvent solution, and after removing the mineral acid salt precipitated from the organic solvent solution, 2,2'-bis(hydroxymethyl)alkanoic acid being crystallized from the organic solvent solution.
    • 制备本发明的2,2'-双(羟甲基)链烷酸的方法包括:使具有两个氢原子的脂族醛键合到α - (羟甲基)链烷酸的2,2'-双(羟甲基)链烷醛生产步骤(A1) 碳原子与甲醛在水溶性碱存在下反应; 将由此得到的含有2,2'-双(羟甲基)链烷醛和碱的水溶液(a)进行氧化处理的2,2'-双(羟甲基)链烷酸制备步骤(B) 和从这样得到的含有2,2'-双(羟甲基)链烷酸和碱的水溶液(b)中分离出2,2'-双(羟甲基)链烷酸的链烷酸回收步骤(C) 链烷酸回收步骤(C),将无机酸以水溶液(b)中的碱为基准添加到水溶液(b)中的量不超过1当量,将碱转化成其盐,将水 在水溶液(b)被有机溶剂代替以形成有机溶剂溶液后,从有机溶剂溶液中除去沉淀的无机酸盐后,从有机溶剂中结晶出2,2'-双(羟甲基)链烷酸 溶剂溶液。