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81. 发明申请

US20120214225A1 CELL INCUBATOR AND INCUBATION CONDITION MONITORING SYSTEM 审中-公开
标题翻译：细胞孵化器和孵化条件监测系统
公开(公告)号：US20120214225A1
公开(公告)日：2012-08-23
申请号：US13400107
申请日：2012-02-19
申请人： Mitsuhiro OURA , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Katsuyoshi Suzuki , Sunao Takeda
发明人： Mitsuhiro OURA , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Katsuyoshi Suzuki , Sunao Takeda
IPC分类号： C12M3/00
CPC分类号： C12M41/36 , C12M31/10 , C12M41/14 , C12M41/48
摘要： A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus.
摘要翻译：细胞培养箱包括：容纳待培养细胞的培养细胞容纳部分和培养液; 以及RFID标签，其附接到所述培养单元容纳部，并且被配置为响应于从所述通信装置无线发送的信号的接收，向所述通信装置发送预定信息。

82. 发明申请

US20120107930A1 METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS OR ARTIFICIAL PLURIPOTENT STEM CELLS 审中-公开
标题翻译：诱导胚胎干细胞或人工细胞干细胞分化的方法
公开(公告)号：US20120107930A1
公开(公告)日：2012-05-03
申请号：US13320777
申请日：2010-05-21
申请人： Daisuke Sasaki , Tatsuya Shimizu , Teruo Okano
发明人： Daisuke Sasaki , Tatsuya Shimizu , Teruo Okano
IPC分类号： C12N5/071
CPC分类号： A61L27/3834 , A61K35/12 , A61L27/16 , A61L2430/20 , C12N5/0657 , C12N2506/02 , C12N2513/00 , C12N2535/10 , C12N2539/10 , C08L33/00
摘要： Differentiation of a large number of embryonic stem cells or artificial pluripotent stem cells such as induced pluripotent stem cells can be readily induced by the following method. A substrate surface having a cell non-adhesive region on the periphery of a cell adhesive region is used, and (1) the cells are allowed to adhere to the cell adhesive region of the substrate surface in a differentiation-inducing medium; (2) the cells are subsequently allowed to grow on the cell adhesive surface to reach confluence; (3) the culture is further continued to three-dimensionally stratify the cells from the boundary with the cell non-adhesive region surrounding the cell adhesive region; and (4) a plurality of the stratified portions formed in the cell adhesive region is finally bound to one another to produce a cell agglomerate spreading over the entire cell adhesive region with a certain thickness.
摘要翻译：通过以下方法可以容易地诱导大量胚胎干细胞或人造多能干细胞如诱导多能干细胞的分化。使用在细胞粘附区域的周围具有细胞非粘合区域的基板表面，（1）允许细胞在分化诱导介质中粘附到基板表面的细胞粘附区域; （2）随后使细胞在细胞粘附剂表面上生长以达到汇合; （3）进一步将培养物与细胞粘附区域周围的细胞非粘合区域从边界三维地分层化，和（4）形成在电池粘合剂区域中的多个分层部分最终彼此结合以产生在整个电池粘合剂区域上以一定厚度铺展的电池团聚体。

83. 发明申请

US20120052524A1 CELL EVALUATION SYSTEM USING CELL SHEET AND METHOD FOR USING THE SYSTEM 审中-公开
标题翻译：使用细胞片的细胞评估系统和使用该系统的方法
公开(公告)号：US20120052524A1
公开(公告)日：2012-03-01
申请号：US13254040
申请日：2010-03-04
申请人： Masahiro Kinooka , Yasunori Takezawa , Masahito Taya , Atsuhiro Saito , Yoshiki Sawa , Tatsuya Shimizu , Teruo Okano
发明人： Masahiro Kinooka , Yasunori Takezawa , Masahito Taya , Atsuhiro Saito , Yoshiki Sawa , Tatsuya Shimizu , Teruo Okano
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/5008 , C12M41/46 , C12Q1/025 , G01N33/5026 , G01N33/5029 , G01N33/5064
摘要： Three-dimensional information on a biological parameter relating to at least one selected from viability, proliferating ability, migration, and differentiation of cultured cells can be obtained by a simple two-dimensional analytical technique by constructing a cell evaluation system including a multilayered cell sheet, target cells, and a two-dimensional analyzer.
摘要翻译：通过简单的二维分析技术，可以通过构建包括多层细胞片的细胞评估系统来获得关于选自生殖力，增殖能力，迁移和培养细胞分化中的至少一种的生物学参数的三维信息，靶细胞和二维分析仪。

84. 发明授权

US07616439B2 Electric connection box 失效
标题翻译：电接线盒
公开(公告)号：US07616439B2
公开(公告)日：2009-11-10
申请号：US11984086
申请日：2007-11-13
申请人： Tatsuya Shimizu , Manabu Hashikura , Futoshi Nishida
发明人： Tatsuya Shimizu , Manabu Hashikura , Futoshi Nishida
IPC分类号： H05K7/20
CPC分类号： H05K7/20009 , H05K5/0208 , H05K7/026
摘要： One aspect of the present invention can include an electric connection box having a circuit board, a case inside of which said circuit board is housed, a plurality of fitting depressions capable of being fitted with an external electrical component, positioned on a side wall of the case opposing a board surface of the circuit board. Further, an air path inside of said case is defined by the plurality of fitting depressions positioned as an arrayed side by side with a spacing in between, and the air path circulates the air up and down between the plurality of fitting depressions, and an inlet positioned in the case and in communication with the air path, an exhaust outlet is positioned in the case in communication with the air path and positioned above said inlet, and a heat generating component is positioned in the air path.
摘要翻译：本发明的一个方面可以包括具有电路板的电连接盒，容纳所述电路板的壳体内的多个嵌合凹部，其能够装配有外部电气部件，位于所述电路板的侧壁上壳体与电路板的板表面相对。此外，所述壳体内部的空气通道由多个嵌合凹部限定，所述多个嵌合凹部被排列成并排排列，间隔开，空气通道在多个嵌合凹部之间上下循环空气，定位在壳体中并与空气通道连通，排气出口定位在与空气路径连通并且位于所述入口上方的壳体中，并且发热部件位于空气路径中。

85. 发明申请

US20090050852A1 Metal Oxide Particle-Containing Polysiloxane Composition and Method for Producing Same 审中-公开
标题翻译：含金属氧化物颗粒的聚硅氧烷组合物及其制备方法
公开(公告)号：US20090050852A1
公开(公告)日：2009-02-26
申请号：US12295439
申请日：2007-03-27
申请人： Tarou Kanamori , Tatsuya Shimizu , Keisuke Yajima
发明人： Tarou Kanamori , Tatsuya Shimizu , Keisuke Yajima
IPC分类号： C09K11/02 , C08K3/22
CPC分类号： H01L23/295 , C08G77/16 , C08G77/18 , C08L83/04 , C09D183/04 , H01L23/296 , H01L2924/0002 , C08L83/00 , H01L2924/00
摘要： The metal oxide fine particle-containing polysiloxane composition of the present invention is obtained by mixing (A) metal oxide fine particles with (B1) polyfunctional polysiloxane obtained by allowing alkoxy-terminated polyfunctional polysiloxane (b1) represented by the following average compositional formula (1): R1aSiOb(OR2)c (1) (wherein R1 is a hydrogen atom or a monovalent hydrocarbon group having no oxyalkylene group, R2 is an alkyl group, a is more than 0 but less than 2, b is more than 0 but less than 2, c is more than 0 but less than 4, and a+b×2+c=4) and having a weight-average molecular weight of not less than 3,000 but not more than 100,000 and hydroxy-terminated hydroxy-terminated polydimethylsiloxane (b2) having a weight-average molecular weight of not less than 2,000 but not more than 100,000 to undergo dealcoholization reaction in a specific ratio, in an organic solvent in the presence of a basic compound, an acidic compound or a metal chelate compound and thereby dispersing the metal oxide fine particles (A) in the organic solvent.
摘要翻译：本发明的含金属氧化物微粒子的聚硅氧烷组合物是通过将（A）金属氧化物微粒与（B1）多官能聚硅氧烷（通过使由以下平均组成式（1）表示的烷氧基封端的多官能团聚硅氧烷（b1））：R1aSiOb（OR2）c（1）（其中R1是氢原子或不含氧化烯基的一价烃基，R2是烷基，a大于0但小于2，b大于0但少于 2以上，c大于0但小于4，a + bx2 + c = 4），重均分子量为3000以上且100,000以下，羟基封端的羟基封端的聚二甲基硅氧烷（b2 ），在碱性化合物，酸性化合物或金属螯合物的存在下，在有机溶剂中以特定比例进行脱醇反应，其重均分子量不小于2,000但不大于100,000，由此脱除使金属氧化物微粒（A）在有机溶剂中进行。

86. 发明申请

US20080119066A1 Electric connection box 失效
标题翻译：电接线盒
公开(公告)号：US20080119066A1
公开(公告)日：2008-05-22
申请号：US11984083
申请日：2007-11-13
申请人： Tatsuya Shimizu , Manabu Hashikura , Futoshi Nishida
发明人： Tatsuya Shimizu , Manabu Hashikura , Futoshi Nishida
IPC分类号： H01R12/00
CPC分类号： H01R9/226 , H05K7/026
摘要： An electric connection box according to one aspect of the present invention can include conductive members on a circuit board, a case accommodating the circuit board, a ventilation path formed in the case and through which air can flow in a vertical direction, a suction port formed in the case to be in communication with the ventilation path, an exhaust port formed in the case to be in communication with the ventilation path, the exhaust port positioned above the suction port, cooled portions positioned on the conductive members and positioned in the ventilation path so as to allow air to flow in the vertical direction between conductive members, and heat generating components connected to the cooled portions of the conductive members.
摘要翻译：根据本发明的一个方面的电连接盒可以包括电路板上的导电构件，容纳电路板的壳体，形成在壳体中的通气路径，空气可以沿垂直方向流动，形成吸入口在与通气路径连通的情况下，形成在壳体中与通气路径连通的排气口，位于吸入口上方的排气口，位于导电构件上并位于通气路径中的冷却部分使得空气在导电构件之间沿垂直方向流动，以及连接到导电构件的冷却部分的发热元件。

87. 发明授权

US07346588B2 Cost estimation method and system, and computer readable medium for the method 有权
标题翻译：成本估算方法和系统，以及该方法的计算机可读介质
公开(公告)号：US07346588B2
公开(公告)日：2008-03-18
申请号：US10212687
申请日：2002-08-07
申请人： Tatsuya Shimizu , Masayuki Ueda , Hikaru Amano , Kenichi Ishida , Masafumi Aoyama , Yohichiroh Mukunoki , Daiho Sakuragi , Manabu Ogishima , Yoichi Terashima
发明人： Tatsuya Shimizu , Masayuki Ueda , Hikaru Amano , Kenichi Ishida , Masafumi Aoyama , Yohichiroh Mukunoki , Daiho Sakuragi , Manabu Ogishima , Yoichi Terashima
IPC分类号： G06Q99/00
CPC分类号： G06Q10/06 , G06Q20/201 , G06Q30/0283
摘要： A part cost estimation system including a processing cost information storage device; a shape designating device configured to designate the shape of the part; a processing designating device configured to designate contents of processing to be performed on a material to form the part having the designated shape; a processing facility designating device configured to designate a processing facility; a processing time calculating device configured to calculate a processing time; a processing cost calculating device configured to calculate a processing cost spent on manufacturing the part based on a unit machining cost and the processing cost calculated by the processing time calculating device; and an adding device configured to add the processing cost to determine a cost of the part.
摘要翻译：一种部件成本估算系统，包括处理成本信息存储装置; 形状指定装置，被配置为指定所述部件的形状; 处理指定装置，被配置为指定要对材料进行的处理的内容以形成具有指定形状的部分; 配置为指定处理设备的处理设备指定设备; 处理时间计算装置，被配置为计算处理时间; 处理成本计算装置，被配置为基于由所述处理时间计算装置计算的单位加工成本和所述处理成本来计算用于制造所述部件的处理成本; 以及添加装置，被配置为增加处理成本以确定部件的成本。

88. 发明授权

US09956804B2 Sheet binding processing apparatus and image forming system having the same 有权
公开(公告)号：US09956804B2
公开(公告)日：2018-05-01
申请号：US14935956
申请日：2015-11-09
申请人： Eiichi Kubo , Shin Tsugane , Tatsuya Shimizu
发明人： Eiichi Kubo , Shin Tsugane , Tatsuya Shimizu
IPC分类号： B42C1/12 , B65H37/04 , B31F5/02 , B42B4/00 , B42B5/00 , B65H39/10 , G03G15/00
CPC分类号： B42C1/12 , B31F5/02 , B42B4/00 , B42B5/00 , B65H37/04 , B65H39/10 , B65H2801/27 , B65H2801/48 , G03G15/6541
摘要： A sheet binding processing apparatus includes a binding device which performs a binding process on a sheet bundle stacked on a stacking unit and a sheet bundle set at a manual setting portion, the stacking unit stacking introduced sheets, a sheet bundle being set to the manual setting portion from an outside; a moving portion which moves the binding device to a first binding position for performing the binding process on a sheet bundle stacked on the stacking unit and a second binding position for performing the binding process on a sheet bundle set at the manual setting portion; and a controller which causes the binding device, in a case that the binding process is not performed on a sheet bundle stacked on the stacking unit, to wait due to the moving portion at a position different from the first binding position.

89. 发明授权

US09289454B2 Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof 有权
标题翻译：制造多层细胞片的方法，由此获得的具有血管网的多层细胞片及其使用方法
公开(公告)号：US09289454B2
公开(公告)日：2016-03-22
申请号：US13822945
申请日：2011-09-14
申请人： Hidekazu Sekine , Tatsuya Shimizu , Teruo Okano
发明人： Hidekazu Sekine , Tatsuya Shimizu , Teruo Okano
IPC分类号： A61K35/44 , A61K35/34 , A61K35/36 , C12N5/077 , A61L27/36 , A61L27/38
CPC分类号： A61K35/44 , A61K35/34 , A61K35/36 , A61L27/3604 , A61L27/3839 , A61L27/3895 , C12N5/0657 , C12N2502/28 , C12N2513/00
摘要： A method for producing multilayered cell sheets, including producing a vascular bed which includes an artery-vein loop and in which a capillary vascular network is constructed; layering cell sheets on the vascular bed; and perfusing a culture medium in vitro to construct a vascular network in the cell sheets. The production method enables vascular networks to be constructed in cell sheets and enables thick multilayered cell sheets to foe easily produced by layering the cell sheets. Such thick multilayered cell sheets are useful as in vivo tissue-like products for regenerative medicine for various tissues and for evaluation of drugs and the like.
摘要翻译：一种生产多层细胞片的方法，包括制备包括动静脉环的血管床，其中构成毛细血管网络; 在血管床上分层细胞片; 并在体外灌注培养基以在细胞片中构建血管网络。该制造方法能够在细胞片中构建血管网络，能够通过层叠细胞片容易地制造厚层多层细胞片。这种厚的多层细胞片可用作用于各种组织的再生医学的体内组织样产品和药物等的评估。

90. 发明授权

US09253975B2 Tool for transferring membranous tissue, kit and method for transferring membranous tissue 有权
标题翻译：用于转移膜组织的工具，用于转移膜组织的试剂盒和方法
公开(公告)号：US09253975B2
公开(公告)日：2016-02-09
申请号：US13470271
申请日：2012-05-12
申请人： Ryohei Takeuchi , Tatsuya Shimizu , Katsuhisa Sakaguchi
发明人： Ryohei Takeuchi , Tatsuya Shimizu , Katsuhisa Sakaguchi
IPC分类号： A61B18/18 , A01N1/02 , A61B17/00
CPC分类号： A01N1/0236 , A61B2017/00747 , A61B2017/00969
摘要： Disclosed herein is a tool, a kit, and associated method for transferring a membranous tissue composed of cells derived from a living body. The tool can include a first sheet-like supporting member disposed on one side of the membranous tissue in a wet state, and a second sheet-like supporting member disposed on the other side of the membranous tissue in a wet state. The first supporting member and the second supporting member can be configured to entirely hold the membranous tissue, such that a frictional force between the first supporting member and the membranous tissue is larger than a frictional force between the second supporting member and the membranous tissue.
摘要翻译：本文公开了用于转移由活体衍生的细胞组成的膜组织的工具，试剂盒和相关方法。该工具可以包括设置在湿状态的膜组织的一侧上的第一片状支撑构件和在湿状态下设置在膜组织另一侧的第二片状支撑构件。第一支撑构件和第二支撑构件可以构造成完全保持膜组织，使得第一支撑构件和膜组织之间的摩擦力大于第二支撑构件和膜组织之间的摩擦力。

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