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81. 发明申请

US20140192952A1 MODULATING GANTRY ROTATION SPEED AND IMAGE ACQUISITION IN RESPIRATORY CORRELATED (4D) CONE BEAM CT IMAGES 有权
标题翻译：呼吸相关（4D）CONE BEAM CT图像中的调制旋转速度和图像采集
公开(公告)号：US20140192952A1
公开(公告)日：2014-07-10
申请号：US14131896
申请日：2012-07-27
申请人： Paul J. Keall , Ricky O'Brien , Benjamin J. Cooper , Jun Lu , Jeffrey F. Williamson
发明人： Paul J. Keall , Ricky O'Brien , Benjamin J. Cooper , Jun Lu , Jeffrey F. Williamson
IPC分类号： A61B6/00
CPC分类号： A61B6/541 , A61B6/4085 , A61B6/486 , A61B6/5205 , A61B6/5264 , A61B6/583 , A61N2005/1061
摘要： A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the CBCT forms an optimized 4DCBCT image set.
摘要翻译：提供了一种优化4D锥形束计算机断层摄影（4DCBCT）成像的方法，其包括使用扫描仪产生靶的投影，其中投影用于形成目标的锥束计算机断层摄影（CBCT）扫描，其中CBCT 包括目标的3D图像，并且使用适当编程的计算机根据所测量的患者呼吸信号实时地控制台架的转速和CBCT的投影采集，其中CBCT的实时采集形成优化的4DCBCT图像集。

82. 发明申请

US20140135497A1 SYNTHESIS OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE 审中-公开
标题翻译： 2,4-二氯-5-三氟甲基吡啶的合成
公开(公告)号：US20140135497A1
公开(公告)日：2014-05-15
申请号：US14072146
申请日：2013-11-05
申请人： Li Liu , Deniz Akalay , Weitong Dong , Jianqing Feng , Christian Wolfgang Hemp , Jun Lu , Le Xie , Jinsong Yang
发明人： Li Liu , Deniz Akalay , Weitong Dong , Jianqing Feng , Christian Wolfgang Hemp , Jun Lu , Le Xie , Jinsong Yang
IPC分类号： C07D239/30 , C07D239/54
CPC分类号： C07D239/30 , C07D239/54
摘要： This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.
摘要翻译：本发明涉及一种合成2,4-二氯-5-三氟甲基 - 嘧啶的新方法，其用作制备药物活性成分的中间体。

83. 发明授权

US08615493B2 Data mining systems and methods for heterogeneous data sources 有权
公开(公告)号：US08615493B2
公开(公告)日：2013-12-24
申请号：US13615357
申请日：2012-09-13
申请人： Anand Prahlad , Parag Gokhale , Rajiv Kottomtharayil , Jun Lu , Rahul S. Pawar
发明人： Anand Prahlad , Parag Gokhale , Rajiv Kottomtharayil , Jun Lu , Rahul S. Pawar
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： G06F11/1451 , G06F11/1448 , G06F11/1458 , G06F11/1464 , G06F11/1469 , G06F17/30283 , G06F17/3056 , H04L63/102 , H04L67/1097
摘要： Systems and methods integrate disparate backup devices with a unified interface. In certain examples, a management console manages data from various backup devices, while retaining such data in its native format. The management console can display a hierarchical view the client devices and/or their data and can further provide utilities for processing the various data formats. A data structure including fields for storing both metadata common to the client device data and value-added metadata can be used to mine or process the data of the disparate client devices. The unified single platform and interface reduces the need for multiple data management products and/or customized data utilities for each individual client device and provides a single pane of glass view into data management operations. Integrating the various types of storage formats and media allows a user to retain existing storage infrastructures and further facilitates scaling to meet long-term management needs.

84. 发明授权

US08592468B2 Bacterial thioredoxin reductase inhibitors and methods for use thereof 有权
标题翻译：细菌硫氧还蛋白还原酶抑制剂及其使用方法
公开(公告)号：US08592468B2
公开(公告)日：2013-11-26
申请号：US13070457
申请日：2011-03-23
申请人： Arne Holmgren , Jun Lu , Alexios Vlamis-Gardikas , Rong Zhao , Karuppasamy Kandasamy , Lars Engman , Lars Engstrand , Sven Hoffner
发明人： Arne Holmgren , Jun Lu , Alexios Vlamis-Gardikas , Rong Zhao , Karuppasamy Kandasamy , Lars Engman , Lars Engstrand , Sven Hoffner
IPC分类号： A61K31/425
CPC分类号： C07D421/04 , A61K31/381 , A61K31/41 , C07D293/12 , Y02A50/473
摘要： The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E. coli TrxR with Ki of 0.14 μM and 0.46 μM, respectively. E. coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.
摘要翻译： Ebselen的作用机制区分细菌和哺乳动物硫氧还蛋白还原酶（TrxR）。它显示哺乳动物Trx的快速氧化，并且通过NADPH-TrxR催化依次硒硒酚与过氧化氢的周转，因此是哺乳动物抗氧化剂。依布硒及其二硒化物是大肠杆菌TrxR的强烈竞争抑制剂，Ki分别为0.14μM和0.46μM。缺乏谷胱甘肽还原酶或谷胱甘肽的大肠杆菌突变体对依布硒林的抑制更敏感。由于谷氧还蛋白或硫氧还蛋白系统是核糖核苷酸还原酶的电子供体，依普硒靶主要是谷胱甘肽和谷氧还蛋白阴性细菌，一类包括主要病原体。因此，依布硒林和类似化合物可用作抗菌剂，即使对于多抗性菌株也是有用的。以前不知道对ebselen，结核分枝杆菌（结核分枝杆菌）和幽门螺杆菌（胃溃疡和癌症）敏感的两种主要致病菌被证明是优异的靶标。幽门螺杆菌对硫化硫也敏感。

85. 发明授权

US08589798B2 Information management systems and methods for heterogeneous data sources 有权
标题翻译：用于异构数据源的信息管理系统和方法
公开(公告)号：US08589798B2
公开(公告)日：2013-11-19
申请号：US12749862
申请日：2010-03-30
申请人： Anand Prahlad , Parag Gokhale , Rajiv Kottomtharayil , Jun Lu , Rahul S. Pawar
发明人： Anand Prahlad , Parag Gokhale , Rajiv Kottomtharayil , Jun Lu , Rahul S. Pawar
IPC分类号： G06F17/30
CPC分类号： G06F11/1451 , G06F11/1448 , G06F11/1458 , G06F11/1464 , G06F11/1469 , G06F17/30283 , G06F17/3056 , H04L63/102 , H04L67/1097
摘要： Systems and methods integrate disparate backup devices with a unified interface. In certain examples, a management console manages data from various backup devices, while retaining such data in its native format. The management console can display a hierarchical view the client devices and/or their data and can further provide utilities for processing the various data formats. A data structure including fields for storing both metadata common to the client device data and value-added metadata can be used to mine or process the data of the disparate client devices. The unified single platform and interface reduces the need for multiple data management products and/or customized data utilities for each individual client device and provides a single pane of glass view into data management operations. Integrating the various types of storage formats and media allows a user to retain existing storage infrastructures and further facilitates scaling to meet long-term management needs.
摘要翻译：系统和方法将不同的备份设备与统一的接口集成。在某些示例中，管理控制台管理来自各种备份设备的数据，同时以其本机格式保留此类数据。管理控制台可以显示客户端设备和/或其数据的分层视图，并且可以进一步提供用于处理各种数据格式的实用程序。可以使用包括用于存储客户端设备数据和增值元数据共有的元数据的字段的数据结构来挖掘或处理不同客户端设备的数据。统一的单一平台和接口减少了对每个单独的客户端设备的多个数据管理产品和/或定制数据实用程序的需求，并将单个窗格视图提供到数据管理操作中。集成各种类型的存储格式和媒体允许用户保留现有的存储基础架构，并进一步促进扩展以满足长期管理需求。

86. 发明授权

US08575006B2 Process to form semiconductor packages with external leads 有权
标题翻译：与外部引线形成半导体封装的工艺
公开(公告)号：US08575006B2
公开(公告)日：2013-11-05
申请号：US12592596
申请日：2009-11-30
申请人： Yan Xun Xue , Jun Lu
发明人： Yan Xun Xue , Jun Lu
IPC分类号： H01L31/00
CPC分类号： H01L23/49551 , H01L21/4842 , H01L21/561 , H01L23/4952 , H01L23/49562 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/97 , H01L2224/32245 , H01L2224/451 , H01L2224/48247 , H01L2224/49111 , H01L2224/73265 , H01L2224/97 , H01L2924/00014 , H01L2924/01033 , H01L2924/01082 , H01L2924/181 , H01L2224/85 , H01L2224/83 , H01L2924/00 , H01L2924/00015 , H01L2224/05599 , H01L2924/00012
摘要： This invention discloses a process for packaging semiconductor device with external leads. The process includes comprises Step 1: providing a lead frame comprising a plurality of lead frame units connected by a plurality of metal beams, each lead frame unit comprising a die pad and a plurality of leads located on opposite sides of the die pad; adhering a semiconductor chip onto each of the die pad, and providing a plurality of metal connections for electrically connecting each chip to its corresponding leads; Step 2 providing a plastic molding material to enclose the plurality of the lead frame units, the metal beams, the chips, and at least portions of the metal connections; Step 3 removing a portion of the plastic molding material above the metal beams to expose the metal beams and portions of the leads in connection with the metal beams; and Step 4 separating each lead frame unit, forming a plurality of individual semiconductor plastic package components with external leads.
摘要翻译：本发明公开了一种用外部引线封装半导体器件的方法。该方法包括步骤1：提供引线框架，该引线框架包括由多个金属梁连接的多个引线框架单元，每个引线框架单元包括管芯焊盘和位于管芯焊盘的相对侧上的多个引线; 将半导体芯片粘附到每个芯片焊盘上，并且提供多个金属连接件，用于将每个芯片电连接到其相应的引线; 步骤2提供塑料模制材料以封闭多个引线框架单元，金属梁，芯片以及金属连接件的至少部分; 步骤3，移除金属梁上方的塑料成型材料的一部分，以暴露金属梁和引线的与金属梁相关的部分; 以及步骤4分离每个引线框架单元，用外部引线形成多个单独的半导体塑料封装部件。

87. 发明授权

US08530443B2 miR-150 for the treatment of blood disorders 有权
标题翻译： miR-150用于治疗血液疾病
公开(公告)号：US08530443B2
公开(公告)日：2013-09-10
申请号：US13652672
申请日：2012-10-16
申请人： Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
发明人： Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A61K31/7105 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2330/10 , C12N2310/3521
摘要： The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively.
摘要翻译：本发明提供了治疗某些血液相关病症，特别是血小板减少症和贫血症的方法，其包括分别增加miR-150表达或在祖细胞中抑制miR-150。

88. 发明授权

US08476752B2 Package structure for DC-DC converter 有权
标题翻译： DC-DC转换器的封装结构
公开(公告)号：US08476752B2
公开(公告)日：2013-07-02
申请号：US13494219
申请日：2012-06-12
申请人： Yueh-Se Ho , Yan Xun Xue , Jun Lu
发明人： Yueh-Se Ho , Yan Xun Xue , Jun Lu
IPC分类号： H01L21/00 , H01L23/02
CPC分类号： H01L24/49 , H01L23/49524 , H01L23/49541 , H01L23/49562 , H01L23/49575 , H01L24/37 , H01L24/40 , H01L24/41 , H01L24/48 , H01L2224/371 , H01L2224/40095 , H01L2224/40137 , H01L2224/40245 , H01L2224/40247 , H01L2224/4103 , H01L2224/48091 , H01L2224/48137 , H01L2224/48247 , H01L2224/48257 , H01L2224/49111 , H01L2224/49112 , H01L2224/49113 , H01L2224/49171 , H01L2224/73221 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01067 , H01L2924/01082 , H01L2924/1306 , H01L2924/13091 , H01L2224/45099 , H01L2924/00 , H01L2224/84
摘要： A package structure for DC-DC converter disclosed herein can reduce the number of encapsulated elements as a low-side MOSFET chip can be stacked above the high-side MOSFET chip of a first die pad, through die pads of different thicknesses or interposers with joint parts of different thicknesses; moreover, it further reduces the size of the entire semiconductor package as a number of bond wires are contained in the space between the controller and the low-side MOSFET chip. Moreover, electrical connection between the top source electrode pin and the bottom source electrode pin of the low-side MOSFET chip is realized with a metal joint plate, such that when the DC-DC converter is sealed with plastic, the metal joint plate can be exposed outside to improve the thermal performance and effectively reduce the thickness of the semiconductor package.
摘要翻译：本文公开的用于DC-DC转换器的封装结构可以减少封装元件的数量，因为低侧MOSFET芯片可以堆叠在第一裸片焊盘的高侧MOSFET芯片上方，通过具有不同厚度的芯片焊盘或具有接头的插入件不同厚度的零件; 而且，由于控制器和低侧MOSFET芯片之间的空间中包含多个接合线，因此进一步减小了整个半导体封装的尺寸。此外，利用金属接合板实现了顶部源极电极引脚和低端MOSFET芯片的底部源极电极引脚之间的电连接，使得当DC-DC转换器用塑料密封时，金属接合板可以暴露在外面以改善热性能并有效地减小半导体封装的厚度。

89. 发明授权

US08457013B2 Wireless dual-function network device dynamically switching and reconfiguring from a wireless network router state of operation into a wireless network coordinator state of operation in a wireless communication network 有权
标题翻译：无线双功能网络设备从无线网络路由器动态切换和重新配置运行状态到无线网络协调器在无线通信网络中的运行状态
公开(公告)号：US08457013B2
公开(公告)日：2013-06-04
申请号：US12319905
申请日：2009-01-13
申请人： Steven Essinger , Xiaoxun Zhu , Michael Schnee , JiBin Liu , Xin Shen , LiangLiang Chen , Jun Lu
发明人： Steven Essinger , Xiaoxun Zhu , Michael Schnee , JiBin Liu , Xin Shen , LiangLiang Chen , Jun Lu
IPC分类号： H04L12/28
CPC分类号： H04W4/001 , H04W4/50 , H04W16/00 , H04W84/10 , H04W84/18 , H04W88/00
摘要： Various wireless network components that offer increased flexibility, ease of use, functionality and performance in many demanding applications in diverse fields of use, namely: a wireless multi-function network device for use on a wireless communication network, that can serve multiple functions and dynamically switch and reconfigure from a network router into a network coordinator in the event that the originally designated network coordinator is permanently or temporally disabled; a wireless mesh-type communication network, including a plurality of wireless network router devices, each capable of performing the functions of a network controller/coordinator; a wireless network router device for use on a wireless communication network, and employing an integrated phased-array antenna structure, supporting the spatial isolation of multi-regions, and utilizing beam steering principles of operation, for illuminating multiple wireless network end-devices over separate regions; a network gateway device that supports a USB-type communication interface and RF-based wireless communication interface; a network protocol translation (NPT) based gateway device for use in a wireless communication network; and wireless network coordinator device for automatically establishing a Personal Area Network (PAN) on a wireless communication network, and having a compact housing with an electrical wall plug integrated therein having electrical prongs for plugging into a standard electrical wall socket.
摘要翻译：各种无线网络组件在不同使用领域的许多苛刻应用中提供了增强的灵活性，易用性，功能性和性能，即：在无线通信网络上使用的无线多功能网络设备，可以提供多种功能和动态在原始指定的网络协调器永久或暂时禁用的情况下，从网络路由器切换和重配置到网络协调器中; 无线网状通信网络，包括多个无线网络路由器设备，每个能够执行网络控制器/协调器的功能; 用于在无线通信网络上使用的无线网络路由器设备，以及采用集成的相控阵天线结构，支持多区域的空间隔离，以及利用波束操纵原理，用于单独地照射多个无线网络终端设备区域; 支持USB型通信接口和基于RF的无线通信接口的网络网关设备; 基于网络协议转换（NPT）的网关设备，用于无线通信网络; 以及用于在无线通信网络上自动建立个人区域网络（PAN）的无线网络协调器设备，并且具有紧凑的壳体，其中集成有电壁插塞，其中具有用于插入标准电壁插座的电插脚。

90. 发明授权

US08436429B2 Stacked power semiconductor device using dual lead frame and manufacturing method 有权
标题翻译：采用双引线框架的叠层功率半导体器件及其制造方法
公开(公告)号：US08436429B2
公开(公告)日：2013-05-07
申请号：US13118445
申请日：2011-05-29
申请人： Yan Xun Xue , Yueh-Se Ho , Lei Shi , Jun Lu , Liang Zhao
发明人： Yan Xun Xue , Yueh-Se Ho , Lei Shi , Jun Lu , Liang Zhao
IPC分类号： H01L27/088
CPC分类号： H01L23/49562 , H01L23/49524 , H01L23/49575 , H01L24/48 , H01L2224/48247 , H01L2924/00014 , H01L2924/01322 , H01L2924/13091 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A stacked power semiconductor device includes vertical metal oxide semiconductor field-effect transistors and dual lead frames packaged with flip-chip technology. In the method of manufacturing the stacked power semiconductor device, a first semiconductor chip is flip chip mounted on the first lead frame. A mounting clips is connected to the electrode at back side of the first semiconductor chip. A second semiconductor chip is mounted on the second lead frame, which is then flipped and stacked on the mounting clip.
摘要翻译：叠层功率半导体器件包括垂直金属氧化物半导体场效应晶体管和采用倒装芯片技术封装的双引线框架。在制造堆叠式功率半导体器件的方法中，第一半导体芯片是安装在第一引线框上的倒装芯片。安装夹在第一半导体芯片的背面连接到电极。第二半导体芯片安装在第二引线框架上，然后翻转并堆叠在安装夹上。

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