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81. 发明授权

US07910799B2 Genetic loci associated with Fusarium solani tolerance in soybean 有权
标题翻译：与大豆镰刀菌耐药性相关的遗传基因座
公开(公告)号：US07910799B2
公开(公告)日：2011-03-22
申请号：US12512178
申请日：2009-07-30
申请人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas C. Corbin , Jeffrey Thompson
发明人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas C. Corbin , Jeffrey Thompson
IPC分类号： A01H1/00 , A01H1/02
CPC分类号： C12Q1/6895 , A01H1/04 , A01H5/10 , C12N15/8282 , C12Q2600/13 , C12Q2600/156
摘要： The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Fusarium solani infection (the causative agent of sudden death syndrome or SDS). The methods use molecular genetic markers to identify, select and/or construct disease-tolerant plants or identify and counterselect disease-susceptible plants. Soybean plants that display tolerance or improved tolerance to Fusarium solani infection that are generated by the methods of the invention are also a feature of the invention.
摘要翻译：本发明涉及用于鉴定耐受性好，具有改善的耐受性或易受镰孢镰刀菌感染（猝死综合征或SDS的致病因子）的大豆植物的方法和组合物。该方法使用分子遗传标记来鉴定，选择和/或构建耐病植物或识别并对抗疾病敏感植物。通过本发明的方法产生的显示对茄病菌感染的耐受性或改善的耐受性的大豆植物也是本发明的一个特征。

82. 发明授权

US07767882B2 Genetic loci associated with Fusarium solani tolerance in soybean 有权
标题翻译：与大豆镰刀菌耐药性相关的遗传基因座
公开(公告)号：US07767882B2
公开(公告)日：2010-08-03
申请号：US11200526
申请日：2005-08-08
申请人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas C. Corbin , Jeffrey Thompson
发明人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas C. Corbin , Jeffrey Thompson
IPC分类号： A01H1/00 , A01H1/02
CPC分类号： C12Q1/6895 , A01H1/04 , A01H5/10 , C12N15/8282 , C12Q2600/13 , C12Q2600/156
摘要： The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Fusarium solani infection (the causative agent of sudden death syndrome or SDS). The methods use molecular genetic markers to identify, select and/or construct disease-tolerant plants or identify and counterselect disease-susceptible plants. Soybean plants that display tolerance or improved tolerance to Fusarium solani infection that are generated by the methods of the invention are also a feature of the invention.
摘要翻译：本发明涉及用于鉴定耐受性好，具有改善的耐受性或易受镰孢镰刀菌感染（猝死综合征或SDS的致病因子）的大豆植物的方法和组合物。该方法使用分子遗传标记来鉴定，选择和/或构建耐病植物或识别并对抗疾病敏感植物。通过本发明的方法产生的显示对茄病菌感染的耐受性或改善的耐受性的大豆植物也是本发明的一个特征。

83. 发明申请

US20090156640A1 NOCICEPTIN ANALOGS 有权
公开(公告)号：US20090156640A1
公开(公告)日：2009-06-18
申请号：US12390683
申请日：2009-02-23
申请人： Qun SUN , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun SUN , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/454 , C07D413/04 , A61P25/00
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

84. 发明授权

US07495109B2 Nociceptin analogs 失效
标题翻译：伤害感受类似物
公开(公告)号：US07495109B2
公开(公告)日：2009-02-24
申请号：US11032955
申请日：2005-01-11
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： C07D235/00 , C07D235/20 , C07D403/02 , A61K31/40
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

85. 发明申请

US20070117830A1 Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone 有权
公开(公告)号：US20070117830A1
公开(公告)日：2007-05-24
申请号：US11653530
申请日：2007-01-16
申请人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
发明人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： C07D489/08 , A61K9/14 , A61K9/20 , A61K9/2095 , A61K9/48 , A61K9/4833 , A61K31/485 , C07D489/02 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

86. 发明申请

US20070117829A1 Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone 有权
公开(公告)号：US20070117829A1
公开(公告)日：2007-05-24
申请号：US11653529
申请日：2007-01-16
申请人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
发明人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： C07D489/08 , A61K9/14 , A61K9/20 , A61K9/2095 , A61K9/48 , A61K9/4833 , A61K31/485 , C07D489/02 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

87. 发明申请

US20060264638A1 Benzimidazole compounds having nociceptin receptor affinity 失效
标题翻译：具有伤害感受器受体亲和力的苯并咪唑化合物
公开(公告)号：US20060264638A1
公开(公告)日：2006-11-23
申请号：US11494826
申请日：2006-07-28
申请人： Donald Kyle , Richard Goehring , Bin Shao
发明人： Donald Kyle , Richard Goehring , Bin Shao
IPC分类号： C07D403/02
CPC分类号： C07D401/04
摘要： Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
摘要翻译：公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4， >和X 1'如本文所公开的。该化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。

88. 发明申请

US20060258669A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060258669A1
公开(公告)日：2006-11-16
申请号：US11344937
申请日：2006-01-31
申请人： Donald Kyle , Qun Sun
发明人： Donald Kyle , Qun Sun
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D401/04 , C07D213/74 , C07D213/85
摘要： Compounds of formulae: where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “3-substituted Pyridyl Compound”), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.
摘要翻译：式的化合物：其中X是S或O和Ar 2，R 1，R 2，R 3，本文公开了R 8，n，m和t或其药学上可接受的盐（“3-取代的吡啶基化合物”），包含有效量的3-取代的吡啶基化合物以及用于治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫症，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其包括向有需要的动物施用有效量的 3-取代的吡啶基化合物在本文中公开。

89. 发明申请

US20060235055A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060235055A1
公开(公告)日：2006-10-19
申请号：US11317832
申请日：2005-12-22
申请人： Donald Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2 2在本文中公开）或其药学上可接受的盐（“吡啶” - 炔基化合物“）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

90. 发明申请

US20060148814A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060148814A1
公开(公告)日：2006-07-06
申请号：US11368133
申请日：2006-03-02
申请人： Donald Kyle , Sun Qun
发明人： Donald Kyle , Sun Qun
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D405/12 , C07D213/74 , C07D417/12
摘要： A Compound of formula (wherein X is O or S and R1-R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (each being a “Piperazine Compound”), pharmaceutical compositions comprising a Piperazine Compound and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.
摘要翻译：式（其中X是O或S和R 1 -R 5）的化合物在此公开）或其药学上可接受的盐（各自为“哌嗪化合物”），包含哌嗪化合物的药物组合物和治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌嗪化合物被公开。

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