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81. 发明授权

US5650504A Nucleic acids encoding eck receptor ligands 失效
标题翻译：编码eck受体配体的核酸
公开(公告)号：US5650504A
公开(公告)日：1997-07-22
申请号：US448736
申请日：1995-05-24
申请人： Timothy D. Bartley , William J. Boyle , Vann P. Parker , Gary M. Fox , Andrew A. Welcher
发明人： Timothy D. Bartley , William J. Boyle , Vann P. Parker , Gary M. Fox , Andrew A. Welcher
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , C12N15/12
CPC分类号： A61K38/1709 , C07K14/47 , C07K14/52 , C07K14/705 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
摘要翻译：公开了与eck受体结合的配体。更具体地，公开了与eck受体（eck受体结合蛋白或EBP）特异性结合的多肽和编码所述多肽的DNA序列。使用eck受体配体和可溶性eck受体的治疗方法，以及包含其的药物组合物。提供了用于检测粗样品中受体结合活性的快速且灵敏的方法。

82. 发明授权

US5628754A Stent delivery guide catheter 失效
标题翻译：支架输送导管
公开(公告)号：US5628754A
公开(公告)日：1997-05-13
申请号：US510117
申请日：1995-08-01
申请人： Michael R. Shevlin , James M. Shy , William J. Boyle , Paul W. Krejol , Peter A. Lunn
发明人： Michael R. Shevlin , James M. Shy , William J. Boyle , Paul W. Krejol , Peter A. Lunn
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61F11/00
CPC分类号： A61F2/958 , A61F2002/9522 , A61M25/0045
摘要： The present invention is for a stent delivery guide catheter to be used in percutaneous transluminal coronary angioplasty (PTCA). The stent delivery guide catheter consists of a guide catheter body having proximal and distal ends with a cylindrical outer wall and a coaxial inner wall defining a inner lumen. A bladder is formed between the inner and outer walls and is in fluid communication with an inflation lumen. A radially expandable and compressible stent is located inside the guide catheter body and is removably attached to the inner wall in the area of the bladder. In use, a balloon catheter is slid inside the guide catheter with the balloon positioned under the stent. When the bladder is inflated, the stent is compressed radially inward and is deposited on the balloon catheter. The present invention can also be used without the stent to facilitate the exchange of an over-the-wire balloon catheter. The balloon catheter is pulled proximal to the inflatable bladder inside the guide catheter. The bladder is then inflated and compressed to hold the guidewire while the balloon catheter is exchanged.
摘要翻译：本发明涉及一种用于经皮腔内冠状动脉血管成形术（PTCA）的支架输送导管。支架输送导管由具有近端和远端的引导导管主体组成，其具有圆柱形外壁和限定内腔的同轴内壁。膀胱形成在内壁和外壁之间并且与膨胀腔流体连通。径向可膨胀和可压缩的支架位于引导导管主体内部并且可移除地附接到膀胱区域中的内壁。在使用中，气囊导管在引导导管内滑动，气囊位于支架下方。当膀胱膨胀时，支架被径向向内压缩并且沉积在球囊导管上。本发明也可以在没有支架的情况下使用来促进线上球囊导管的交换。气囊导管被拉近到引导导管内的可充气囊。然后在更换气囊导管的同时使膀胱充气并压缩以保持导丝。

83. 发明授权

US5591198A Multiple sinusoidal wave configuration stent 失效
标题翻译：多重正弦波配置支架
公开(公告)号：US5591198A
公开(公告)日：1997-01-07
申请号：US429975
申请日：1995-04-27
申请人： William J. Boyle , Rosalinda A. Wong , James M. Shy
发明人： William J. Boyle , Rosalinda A. Wong , James M. Shy
IPC分类号： A61F2/06 , A61F2/84 , A61M29/00
CPC分类号： A61F2/958
摘要： The present invention is accomplished by providing a method and apparatus for a radially expandable stent for implantation within a body vessel, comprising a large wire formed winding segment and 2 small wire formed winding segments. The large wire formed winding segment has a hollow cylindrical shape including a preformed pattern such as a sinusoidal wave form being wound into a continuous helix the length of the stent. The second and third wire formed winding segments have a hollow cylindrical shape including a preformed pattern such as a sinusoidal wave form wound into a continuous helix. The uniform pattern of the first, second and third wire segments permit uniform expansion of the stent. The second and third winding segments have more wire per unit surface area than the first winding segment. The second winding segment proximal end is attached to the distal end of the second winding segment to form a ring. The second winding segment is attached to the proximal end of the first winding segment. The third winding segment proximal end is attached to the distal end of the third winding segment to form a ring. The third winding segment is attached to the distal end of the first winding segment. The first, second and third winding segments may be formed of a unitary wire or may be formed from two or more wires. A member within the first, second and third winding segments to expand the first, second and third winding segments is included.
摘要翻译：本发明通过提供一种用于植入体内的可径向扩张的支架的方法和装置来实现，该方法和装置包括大线形成的绕组段和2条小线形成的绕组段。大线形成的绕线段具有中空的圆柱形形状，其包括诸如正弦波形的预成形图案，其缠绕在支架的长度上的连续螺旋中。第二和第三线形成的绕组段具有中空圆柱形状，其包括预先形成的图案，例如缠绕成连续螺旋的正弦波形。第一，第二和第三线段的均匀图案允许支架的均匀膨胀。第二和第三绕组段具有比第一绕组段更多的单位表面积的导线。第二绕组段近端附接到第二绕组段的远端以形成环。第二绕组段附接到第一绕组段的近端。第三绕组段近端附接到第三绕组段的远端以形成环。第三绕组段连接到第一绕组段的远端。第一，第二和第三绕组段可以由单一线形成，或者可以由两条或更多条线形成。包括在第一，第二和第三绕组段内的用于使第一，第二和第三绕组段膨胀的构件。

84. 外观设计

USD289687S Handpiece for occular irrigation and aspiration 失效
公开(公告)号：USD289687S
公开(公告)日：1987-05-05
申请号：US684425
申请日：1984-12-20
申请人： William J. Boyle , Thomas F. Irish
设计人： William J. Boyle , Thomas F. Irish

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