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81. 发明授权

US09095264B2 Method and system for identifying cardiac arrhythmia driver sites 有权
标题翻译：识别心律失常司机场所的方法和系统
公开(公告)号：US09095264B2
公开(公告)日：2015-08-04
申请号：US13678764
申请日：2012-11-16
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61B5/044 , A61B5/0452 , A61B5/046 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
摘要翻译：识别用于心律失常的潜在驾驶员位置的方法包括从患者心脏的至少一部分上的多个位置获取多个电描记图。使用所获取的电描记图，生成至少一个电活动图。期望的电活动图包括复杂的分级电描记图标准偏差和平均图，主要频率图，峰 - 峰电压图和激活序列图。使用这些图中的一个或多个（例如，通过分析由这些图表示的一个或多个电描记图形态特征），可以检测至少一个潜在的驾驶员位置。

82. 发明授权

US08694094B1 Adaptive single site and multi-site ventricular pacing 有权
标题翻译：自适应单位点和多位点心室起搏
公开(公告)号：US08694094B1
公开(公告)日：2014-04-08
申请号：US11749662
申请日：2007-05-16
申请人： Kyungmoo Ryu , Jong Gill
发明人： Kyungmoo Ryu , Jong Gill
IPC分类号： A61N1/362
CPC分类号： A61N1/3686 , A61N1/3684
摘要： An exemplary method includes delivering a cardiac pacing therapy using an electrode configuration for left ventricular, single site pacing or left ventricular, multi-site pacing, measuring a series of interventricular conduction delays using the left ventricular pacing and right ventricular sensing (IVCD-LR), comparing the interventricular conduction delay values to a limit and, based on the comparison, deciding whether to change the electrode configuration for the left ventricular pacing. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括使用左心室，单位起搏或左心室多局部起搏的电极配置递送心脏起搏疗法，使用左心室起搏和右心室感测（IVCD-LR）测量一系列心室间传导延迟，，将室间传导延迟值与极限进行比较，并且基于比较，决定是否改变左心室起搏的电极配置。还公开了其它示例性方法，装置，系统等。

83. 发明授权

US08442620B2 Implantable lead/electrode delivery measurement and feedback system 有权
标题翻译：可植入铅/电极传输测量和反馈系统
公开(公告)号：US08442620B2
公开(公告)日：2013-05-14
申请号：US12243674
申请日：2008-10-01
申请人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
发明人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61N1/05 , A61N1/08
摘要： A lead implantation system with an introducer, a lead configured to engage with the introducer such that the introducer can convey the lead to a desired internal target location, and at least one sensor. The sensor is adapted to generate an indicator of desired engagement of the system with the desired target tissue location prior to engagement of the lead with the target tissue. Also a method of implanting an implantable patient lead including advancing a lead implantation assembly towards a desired target location along an introduction axis and monitoring at least one indicator of lead implantation assembly position along the lead introduction axis. At least one indicator can be generated by the lead implantation assembly. Advancing of the lead introduction assembly can be halted when the monitoring indicates contact with the desired target tissue. The patient lead can then be advanced towards the target tissue and fixed to the target tissue.
摘要翻译：一种具有引导器的引线植入系统，引线被构造成与导引器接合，使得导引器可将引线传送到期望的内部目标位置，以及至少一个传感器。所述传感器适于在所述引线与所述目标组织接合之前产生具有期望的目标组织位置的所述系统期望接合的指示器。还有一种植入可植入患者导线的方法，包括沿着引入轴线将引线植入组件推向所需目标位置，并且沿导线引入轴监测铅植入组件位置的至少一个指示器。至少一个指示器可以由引线注入组件产生。当监测指示与所需目标组织接触时，引导组件的推进可以停止。然后可以将患者导线朝向目标组织推进并固定到靶组织。

84. 发明申请

US20130030314A1 DEVICES, SYSTEMS AND METHODS TO PERFORM ARRHYTHMIA DISCRIMINATION BASED ON THE ATRIAL AND VENTRICULAR ACTIVATION TIMES 有权
标题翻译：基于ATRIAL和VENTRICULAR激活时间进行ARRHYTHMIA诊断的设备，系统和方法
公开(公告)号：US20130030314A1
公开(公告)日：2013-01-31
申请号：US13194747
申请日：2011-07-29
申请人： Allen J. Keel , Kyungmoo Ryu , Stuart Rosenburg
发明人： Allen J. Keel , Kyungmoo Ryu , Stuart Rosenburg
IPC分类号： A61B5/046 , A61N1/368 , A61B5/0464 , A61B5/0452
CPC分类号： A61N1/3962 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61N1/3627 , A61N1/3684 , A61N1/3686
摘要： Described herein are implantable systems and devices, and methods for use therewith, that can be used to perform arrhythmia discrimination based on activation times. A plurality of different sensing vectors are used to obtain a plurality of IEGMs that collectively enable electrical activations to be detected in the left atrial (LA) chamber, the right atrial (RA) chamber, and at least one ventricular chamber of a patient's heart. For each of a plurality of cardiac cycles, there is a determination, based on the plurality of obtained IEGMs, of an LA activation time, an RA activation time, and a ventricular activation time. Arrhythmia discrimination is then performed based on the determined activation times.
摘要翻译：本文描述的是可植入的系统和装置及其使用的方法，其可用于基于活化时间执行心律失常鉴别。使用多个不同的感测向量来获得多个IEGM，其共同地使得能够在左心房（LA）腔室，右心房（RA）腔室和患者心脏的至少一个心室中检测电激活。对于多个心动周期中的每一个，基于多个获得的IEGM，确定LA激活时间，RA激活时间和心室激活时间。然后基于确定的活化时间进行心律失常鉴别。

85. 发明申请

US20120089038A1 Method and system for identifying cardiac arrhythmia driver sites 有权
标题翻译：识别心律失常司机场所的方法和系统
公开(公告)号：US20120089038A1
公开(公告)日：2012-04-12
申请号：US12923769
申请日：2010-10-07
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
摘要翻译：识别用于心律失常的潜在驾驶员位置的方法包括从患者心脏的至少一部分上的多个位置获取多个电描记图。使用所获取的电描记图，生成至少一个电活动图。期望的电活动图包括复杂的分级电描记图标准偏差和平均图，主要频率图，峰 - 峰电压图和激活序列图。使用这些图中的一个或多个（例如，通过分析由这些图表示的一个或多个电描记图形态特征），可以检测至少一个潜在的驾驶员位置。

86. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

87. 发明授权

US07908004B1 Considering cardiac ischemia in electrode selection 有权
标题翻译：考虑到电极选择中的心脏缺血
公开(公告)号：US07908004B1
公开(公告)日：2011-03-15
申请号：US11847878
申请日：2007-08-30
申请人： Jong Gill , Kyungmoo Ryu
发明人： Jong Gill , Kyungmoo Ryu
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/04525 , A61N1/3686
摘要： Exemplary systems, devices, and methods for considering cardiac ischemia in electrode selection are described. One method determines whether an electrode of a multiple-electrode lead is proximate a region of cardiac ischemia or infarct. The method also paces through a different electrode of the multiple-electrode lead in an instance where the electrode is determined to be proximate the region.
摘要翻译：描述了用于考虑电极选择中心脏缺血的示例性系统，装置和方法。一种方法确定多电极引线的电极是否接近心脏缺血或梗死的区域。在确定电极靠近该区域的情况下，该方法还穿过多电极引线的不同电极。

88. 发明授权

US07783352B1 Optimizing anti-tachycardia pacing for terminating atrial fibrillation 有权
标题翻译：优化抗心动过速起搏用于终止房颤
公开(公告)号：US07783352B1
公开(公告)日：2010-08-24
申请号：US11473403
申请日：2006-06-23
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

89. 发明授权

US08750993B2 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US08750993B2
公开(公告)日：2014-06-10
申请号：US13029048
申请日：2011-02-16
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

90. 发明授权

US08478405B2 Optimizing anti-tachycardia pacing for terminating atrial fibrillation 有权
标题翻译：优化抗心动过速起搏用于终止房颤
公开(公告)号：US08478405B2
公开(公告)日：2013-07-02
申请号：US12841012
申请日：2010-07-21
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

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