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81. 发明申请

US20050004664A1 Vascular graft 审中-公开
标题翻译：血管移植
公开(公告)号：US20050004664A1
公开(公告)日：2005-01-06
申请号：US10833930
申请日：2004-04-27
申请人： Paul Martakos , Joseph Ferraro , Theodore Karwoski , Ibrahim Dagher
发明人： Paul Martakos , Joseph Ferraro , Theodore Karwoski , Ibrahim Dagher
IPC分类号： A61F2/06 , A61L27/16
CPC分类号： A61F2/06 , A61F2002/065 , A61L27/16 , C08L27/18
摘要： Disclosed are vascular grafts including an expanded copolymer of tetrafluoroethylene (TFE) and perfluoropropylene vinyl ether (PPVE). In certain embodiments, the copolymer includes between about 0.01% and about 1.5% PPVE. Vascular grafts exhibit superior performance properties, e.g., radial strength, and suture strength, and manufacturing properties, e.g., sinter time. Methods of forming vascular grafts from the copolymer also are described.
摘要翻译：公开了包括四氟乙烯（TFE）和全氟丙烯乙烯基醚（PPVE）的发泡共聚物的血管移植物。在某些实施方案中，共聚物包括约0.01％至约1.5％的PPVE。血管移植物表现出优异的性能，例如径向强度和缝合强度，以及制造性质，例如烧结时间。还描述了从共聚物形成血管移植物的方法。

82. 发明申请

US20080113001A1 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US20080113001A1
公开(公告)日：2008-05-15
申请号：US11980155
申请日：2007-10-30
申请人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
发明人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

83. 发明申请

US20070202149A1 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US20070202149A1
公开(公告)日：2007-08-30
申请号：US11582135
申请日：2006-10-16
申请人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
发明人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

84. 发明申请

US20060110457A1 Heat cured gel and method of making 有权
标题翻译：热固化凝胶及其制作方法
公开(公告)号：US20060110457A1
公开(公告)日：2006-05-25
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
IPC分类号： A61K9/14 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。

85. 发明申请

US20060067983A1 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US20060067983A1
公开(公告)日：2006-03-30
申请号：US11237264
申请日：2005-09-28
申请人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K31/355 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

86. 发明授权

US10322213B2 Compositions and methods for altering the rate of hydrolysis of cured oil-based materials 有权
公开(公告)号：US10322213B2
公开(公告)日：2019-06-18
申请号：US13184512
申请日：2011-07-16
申请人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
发明人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
IPC分类号： A61L29/08 , A61L29/14 , A61L31/08 , C08L91/00 , C09D191/00
摘要： Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.

87. 发明授权

US09278161B2 Tissue-separating fatty acid adhesion barrier 有权
标题翻译：组织分离脂肪酸粘附屏障
公开(公告)号：US09278161B2
公开(公告)日：2016-03-08
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
发明人： Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
IPC分类号： A61L31/00 , A61L31/14 , A61L31/10 , A61F2/06
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译：本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。粘合屏障由脂肪酸基膜形成。脂肪酸基膜可以由脂肪酸衍生的生物材料形成。膜可以涂覆或可以包括组织固定材料以产生粘合屏障。粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。

88. 发明授权

US09427423B2 Fatty-acid based particles 有权
标题翻译：脂肪酸基颗粒
公开(公告)号：US09427423B2
公开(公告)日：2016-08-30
申请号：US12401243
申请日：2009-03-10
申请人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
发明人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号： A61K31/20 , A61K31/7028 , A61K38/13 , A61K9/10 , A61K31/4353 , A61K9/70 , A61K31/00 , A61K9/14 , A61K31/4545 , A61K31/496
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译：本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。颗粒可以与另外的治疗剂相关联。本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。该颗粒可用于各种治疗应用。

89. 发明申请

US20120016038A1 COMPOSITIONS AND METHODS FOR ALTERING THE RATE OF HYDROLYSIS OF CURED OIL-BASED MATERIALS 审中-公开
标题翻译：改善固化油基材料水解速率的组合物和方法
公开(公告)号：US20120016038A1
公开(公告)日：2012-01-19
申请号：US13184512
申请日：2011-07-16
申请人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
发明人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
IPC分类号： A61K47/44 , A61P31/00 , A61P29/00 , C09D191/02 , A61P35/00
CPC分类号： A61L31/08 , A61L29/08 , A61L29/148 , A61L2300/22 , A61L2300/604 , C09D191/00 , C08L91/00
摘要： Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
摘要翻译：本文公开了油的化学性质与所得固化油组合物的物理性质的相关性。还公开了使用富油制备的医疗器械的生物相容性材料和涂层以及通过用脂肪酸烷基酯富集这种油来增强或改变固化油的物理和化学特性的方法。还提供了调整生物相容性材料和涂层以递送一种或多种治疗剂的性质的方法。

90. 发明授权

US06616876B1 Method for treating expandable polymer materials 有权
标题翻译：处理可膨胀聚合物材料的方法
公开(公告)号：US06616876B1
公开(公告)日：2003-09-09
申请号：US09678765
申请日：2000-10-03
申请人： Roger Labrecque , Joseph Ferraro , Tom Swanick , Paul Martakos
发明人： Roger Labrecque , Joseph Ferraro , Tom Swanick , Paul Martakos
IPC分类号： B29B1110
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译：本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比。本发明还可以实现具有独特性质和处理特性的材料。这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。

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