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81. 发明授权

US06197595B1 Integrated nucleic acid diagnostic device 有权
标题翻译：集成核酸诊断装置
公开(公告)号：US06197595B1
公开(公告)日：2001-03-06
申请号：US09294700
申请日：1999-04-19
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： G01N110
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

82. 发明授权

US06043080A Integrated nucleic acid diagnostic device 有权
标题翻译：集成核酸诊断装置
公开(公告)号：US06043080A
公开(公告)日：2000-03-28
申请号：US210025
申请日：1998-12-11
申请人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
发明人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10 , C12Q1/68
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/0059 , B01F15/0238 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L7/52 , G01N35/1095 , B01F13/005 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , B01L3/502715 , B01L3/502753 , B01L9/527 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

83. 发明授权

US6040193A Combinatorial strategies for polymer synthesis 失效
标题翻译：聚合物合成的组合策略
公开(公告)号：US6040193A
公开(公告)日：2000-03-21
申请号：US129463
申请日：1998-08-04
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： C07H21/04 , B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C07K1/06 , C07K5/103 , C07K5/107 , C07K7/06 , C07K14/705 , C12M1/34 , C12N15/09 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/10 , G01N37/00 , B01L3/02
CPC分类号： B01J19/0046 , B82Y30/00 , C07H21/00 , C07K1/045 , C07K1/047 , C07K5/1008 , C07K5/1016 , G01N35/1072 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , Y02P20/55 , Y10S435/97 , Y10S435/973 , Y10T436/143333 , Y10T436/2575
摘要： An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.
摘要翻译：通过将分配器朝向固体支撑件移动来产生阵列，直到分配器的尖端接触支撑件，从表面抽出尖端并在小于1mm 2的区域中释放5纳升或更小的一滴以产生在至少100个点。

84. 发明授权

US06025601A Method and apparatus for imaging a sample on a device 失效
公开(公告)号：US06025601A
公开(公告)日：2000-02-15
申请号：US871269
申请日：1997-06-09
申请人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
发明人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , G01N2021/6417 , G01N2021/6423 , G01N2021/6441
摘要： Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by exposing selected regions of sample 1500 to radiation from a source 1100 and detecting the emission therefrom, and repeating the steps of exposition and detection until the sample is completely examined.

85. 发明授权

US5922591A Integrated nucleic acid diagnostic device 失效
公开(公告)号：US5922591A
公开(公告)日：1999-07-13
申请号：US671928
申请日：1996-06-27
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/0059 , B01F15/0238 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L7/52 , G01N35/1095 , B01F13/005 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , B01L3/502715 , B01L3/502753 , B01L9/527 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

86. 发明授权

US5547839A Sequencing of surface immobilized polymers utilizing microflourescence detection 失效
公开(公告)号：US5547839A
公开(公告)日：1996-08-20
申请号：US626730
申请日：1990-12-06
申请人： William J. Dower , Stephen P. A. Fodor
发明人： William J. Dower , Stephen P. A. Fodor
IPC分类号： G01N33/48 , B01J19/00 , B01J19/08 , B01L7/00 , B05D3/00 , C07B51/00 , C07B61/00 , C07C231/02 , C07C237/22 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K14/00 , C07K16/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/14 , C12M1/34 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N1/30 , G01N15/14 , G01N21/64 , G01N33/53 , G01N33/533 , G01N33/536 , G01N33/541 , G01N33/543 , G01N33/566 , G01N33/58 , G01N37/00 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02
CPC分类号： B01J19/0046 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6823 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C12Q2535/101 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475
摘要： Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.

87. 发明授权

US5412087A Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces 失效
标题翻译：寡核苷酸和其他生物聚合物在表面上的空间可寻址固定
公开(公告)号：US5412087A
公开(公告)日：1995-05-02
申请号：US874849
申请日：1992-04-24
申请人： Glenn H. McGall , Stephen P. A. Fodor , Edward L. Sheldon
发明人： Glenn H. McGall , Stephen P. A. Fodor , Edward L. Sheldon
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C07H17/00 , C12N11/06
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/045 , C07K1/047 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00686 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , Y02P20/55 , Y10S530/816
摘要： Substrates with surfaces comprising compounds with thiol functional groups protected with a photoremovable protecting group can be used to construct arrays of immobilized anti-ligands, such as oligonucleotide probes or other biological polymers. The arrays can be used in assays to detect the presence of complementary nucleic acids in a sample. Spatially addressed irradiation of predefined regions on the surface permits immobilization of oligonucleotides and other biological polymers at the activated regions on the surface. Cycles of irradiation on different regions of the surface and immobilization of different anti-ligands allow formation of an immobilized matrix of anti-ligands at defined sites on the surface. The immobilized matrix of anti-ligands permits simultaneous screenings of a liquid sample for ligands having high affinities for certain anti-ligands of the matrix.
摘要翻译：具有由具有可光除去保护基团保护的具有硫醇官能团的化合物的表面的底物可用于构建固定化抗配体的阵列，例如寡核苷酸探针或其它生物聚合物。阵列可以用于测定中以检测样品中互补核酸的存在。表面上预定区域的空间照射可以使寡核苷酸和其他生物聚合物固定在表面上的活化区域。在不同表面区域照射的周期和不同抗配体的固定使得能够在表面上的限定位置形成固定的抗配体基团。抗配体的固定化基质允许对基质的某些抗配体具有高亲和力的配体的液体样品的同时筛选。

88. 发明授权

US08835125B2 Methods and compositions for selective labeling of different biotinylated targets within multicolor or multilabel assays 有权
标题翻译：在多色或多标签测定中选择性标记不同生物素标靶的方法和组合物
公开(公告)号：US08835125B2
公开(公告)日：2014-09-16
申请号：US13329175
申请日：2011-12-16
申请人： Robert G. Kuimelis , Glenn H. McGall , Stephen P. A. Fodor
发明人： Robert G. Kuimelis , Glenn H. McGall , Stephen P. A. Fodor
IPC分类号： G01N1/00 , G01N33/00 , G01N33/53 , C12Q1/00 , C12N9/00
CPC分类号： C07K1/13 , G01N33/582 , Y10T436/10 , Y10T436/105831 , Y10T436/107497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within multilabel assays which employ the biotin-biotin binding protein binding relationship for each distinct label in relation to targets such as nucleic acids, polypeptides, antibodies or cells. These multilabel assays are enabled through the use of biotin with desthiobiotin, orthogonal protecting schemes for biotin, or a combination of the approaches.
摘要翻译：公开了用于标记具有不同标签的两个或更多个靶标的组合物和方法。具体地，公开了生物素的组合物和在多标记测定中保护生物素，其与针对诸如核酸，多肽，抗体或细胞的靶相对应的每个不同标记使用生物素 - 生物素结合蛋白结合关系。通过使用具有脱硫生物素的生物素，生物素的正交保护方案或这些方法的组合来实现这些多标记测定。

89. 发明授权

US08808995B2 Methods for genotyping selected polymorphism 有权
标题翻译：选择多态性基因分型的方法
公开(公告)号：US08808995B2
公开(公告)日：2014-08-19
申请号：US13348394
申请日：2012-01-11
申请人： Ketih W. Jones , Michael H. Shapero , Stephen P. A. Fodor
发明人： Ketih W. Jones , Michael H. Shapero , Stephen P. A. Fodor
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , C12Q1/6855 , C12Q2600/156
摘要： Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific primers that incorporate some degenerate positions are also disclosed. A plurality of different sequence capture probes are synthesized simultaneously using degenerate oligonucleotide synthesis. The sequence of the locus specific regions of the capture probes are related in that they have some bases that are identical in each sequence in the plurality of sequences and positions that vary from one locus specific region to another. The sequences are selected based on proximity to a polymorphism of interest and because they conform to a similar sequence pattern.
摘要翻译：描述使用与选定多态性附近的区域互补的位点特异性引物进行基因分型多态性的方法。还公开了合并含有一些退化位置的基因座特异性引物库的方法。使用简并寡核苷酸合成同时合成多个不同的序列捕获探针。捕获探针的基因座特异性区域的序列是相关的，因为它们具有在从一个基因座特异性区域到另一个基因座特异性区域变化的多个序列和位置中的每个序列中具有相同的一些碱基。基于与感兴趣的多态性的接近度并且因为它们符合类似的序列模式来选择序列。

90. 发明授权

US07459273B2 Methods for genotyping selected polymorphism 有权
标题翻译：选择多态性基因分型的方法
公开(公告)号：US07459273B2
公开(公告)日：2008-12-02
申请号：US10912445
申请日：2004-08-05
申请人： Keith W. Jones , Michael H. Shapero , Stephen P. A. Fodor
发明人： Keith W. Jones , Michael H. Shapero , Stephen P. A. Fodor
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q2600/156
摘要： Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific primers that incorporate some degenerate positions are also disclosed. A plurality of different sequence capture probes are synthesized simultaneously using degenerate oligonucleotide synthesis. The sequence of the locus specific regions of the capture probes are related in that they have some bases that are identical in each sequence in the plurality of sequences and positions that vary from one locus specific region to another. The sequences are selected based on proximity to a polymorphism of interest and because they conform to a similar sequence pattern.
摘要翻译：描述使用与选定多态性附近的区域互补的位点特异性引物进行基因分型多态性的方法。还公开了合并含有一些退化位置的基因座特异性引物库的方法。使用简并寡核苷酸合成同时合成多个不同的序列捕获探针。捕获探针的基因座特异性区域的序列是相关的，因为它们具有在从一个基因座特异性区域到另一个基因座特异性区域变化的多个序列和位置中的每个序列中具有相同的一些碱基。基于与感兴趣的多态性的接近度并且因为它们符合类似的序列模式来选择序列。

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