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81. 发明专利

SK286592B6 Epothilone derivates, pharmaceutical composition and their use 未知
公开(公告)号：SK286592B6
公开(公告)日：2009-01-07
申请号：SK181799
申请日：1998-06-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： VITE GREGORY D , BORZILLERI ROBERT M , KIM SOONG-HOON , JOHNSON JAMES A
IPC分类号： C07D313/00 , A61K20060101 , A61K31/00 , A61K31/335 , A61K31/395 , A61P35/00 , C07D20060101 , C07D225/00 , C07D417/00 , C07D491/00
摘要： Epothilone derivates of formula (V), where meaning of substituent is described in description. It is described pharmaceutical composition included epothilone derivate and pharmaceutically acceptable carrier too and use of epothilone derivates for treating cancer.

82. 发明专利

AU2007317296A1 Pyridinone compounds 未知
公开(公告)号：AU2007317296A1
公开(公告)日：2008-05-15
申请号：AU2007317296
申请日：2007-11-08
申请人： SQUIBB BRISTOL MYERS CO
发明人： SCHROEDER GRETCHEN M , CAI ZHEN-WEI , BORZILLERI ROBERT M
IPC分类号： C07D213/82 , A61K31/444 , A61P35/00
摘要： The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.

83. 发明专利

MY128370A PYRROLOTRIAZANE INHIBITORS OF KINASES 未知
公开(公告)号：MY128370A
公开(公告)日：2007-01-31
申请号：MYPI20002202
申请日：2000-05-19
申请人： SQUIBB BRISTOL MYERS CO
发明人： HUNT JOHN T , BHIDE RAJEEV S , BORZILLERI ROBERT M , QIAN LIGANG
IPC分类号： A61K31/53 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D487/04
摘要： THE PRESENT INVENTION PROVIDES COMPOUNDS OF FORMULA 1 AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THE FORMULA 1 COMPOUNDS INHIBIT THE TYROSINE KINASE ACTIVITY OF GROWTH FACTOR RECEPTORS SUCH AS VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, THEREBY MAKING THEM USEFUL AS ANTI-CANCER AGENTS. THE FORMULA 1 COMPOUNDS ARE ALSO USEFUL FOR THE TREATMENT OF OTHER DISEASES ASSOCIATED WITH SIGNAL TRANDUCTION PATHWAYS OPERATING THROUGH GROWTH FACTOR RECEPTORS.

84. 发明专利

MY124151A EPOTHILONE DERIVATIVES 未知
公开(公告)号：MY124151A
公开(公告)日：2006-06-30
申请号：MYPI9803121
申请日：1998-07-08
申请人： SQUIBB BRISTOL MYERS CO
发明人： VITE GREGORY D , BORZILLERI ROBERT M , KIM SOONG-HOON , JOHNSON JAMES A
IPC分类号： A61K31/425 , C07D491/044 , A61K31/335 , A61K31/395 , A61K31/427 , A61P19/00 , A61P35/00 , A61P43/00 , C07D225/00 , C07D273/00 , C07D277/26 , C07D313/00 , C07D417/06 , C07D417/08 , C07D491/04 , C07D493/04 , C07D498/04
摘要： THE PRESENT INVENTION RELATES TO EPOTHILONE DERIVATIVES, HAVING THE FOLLOWING FORMULA IN WHICH THE VARIABLES G, W,Q, X, Y, B₁, B₂, Z₁, Z₂, AND R₁-R7 ARE AS DEFINED HEREIN, METHODS FOR THE PREPARATION OF THE DERIVATIVES AND INTERMEDIATES THEREOF.

85. 发明专利

CA2563831A1 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS 未知
公开(公告)号：CA2563831A1
公开(公告)日：2005-12-15
申请号：CA2563831
申请日：2005-04-22
申请人： SQUIBB BRISTOL MYERS CO
发明人： SCHMIDT ROBERT J , SCHROEDER GRETCHEN M , CORNELIUS LYNDON A M , BORZILLERI ROBERT M , KIM KYOUNG S
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/506 , A61P35/00 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D239/34 , C07D239/42 , C07D239/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/02 , C07D417/02 , C07D417/12
摘要： The present invention is directed to compounds having the formula [I + II] a nd methods for using them for the treatment of cancer.

86. 发明专利

AT309236T 未知
公开(公告)号：AT309236T
公开(公告)日：2005-11-15
申请号：AT98930300
申请日：1998-06-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： VITE GREGORY D , BORZILLERI ROBERT M , KIM SOONG-HOON , JOHNSON JAMES A
IPC分类号： C07D491/044 , A61K31/335 , A61K31/395 , A61K31/427 , A61P19/00 , A61P35/00 , A61P43/00 , C07D225/00 , C07D273/00 , C07D277/26 , C07D313/00 , C07D417/06 , C07D417/08 , C07D491/04 , C07D493/04 , C07D498/04 , A61K31/425
摘要： The present invention relates to compounds of the formulaQ is selected from the group consisting ofG is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo,W is O or NR 15 ;X is O or H,H;Y is selected from the group consisting of O; H,OR 16 ; OR 17 ,OR 17 ; NOR 18 ; H,NOR 19 ; H,NR 20 R 21 ; H,H; or CHR 22 ; OR 17 OR 17 can be a cyclic ketal;Z 1 , and Z 2 are selected from the group consisting of CH 2 , O, NR 23 , S, or SO 2 , wherein only one of Z and Z 2 is a heteroatom;B 1 and B 2 are selected from the group consisting of OR 24 , or OCOR 25 , or O 2 CNR 26 R 27 ; when B 1 is H and Y is OH, H they can form a six-membered ring ketal or acetal;D is selected from the group consisting of NR 28 R 29 , NR 30 COR 31 or saturated heterocycleR 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 13 , R 14 , R 18 , R 19 , R 20 , R 21 , R 22 , R 26 , and R 27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R 1 and R 2 are alkyl can be joined to form a cycloalkyl; R 3 and R 4 are alkyl can be joined to form a cycloalkyl;R 9 , R 10 , R 16 , R 17 , R 24 , R 25 , and R 31 are selected from the group H, alkyl, or substituted alkyl;R 8 , R 11 , R 12 , R 28 , R 30 , R 32 , R 33 , and R 30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo;R 15 , R 23 and R 29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R 32 C=O, R 33 SO 2 , hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds whereinW and X are both O; andR 1 , R 2 , R 7 , are H; andR 3 , R 4 , R 6 , are methyl; andR 8 , is H or methyl; andZ 1 , and Z 2 , are CH 2 ; andG is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; andQ is as defined above are excluded.

87. 发明专利

PE05812004A1 INHIBIDORES HETEROCICLICOS DE CINASAS 未知
公开(公告)号：PE05812004A1
公开(公告)日：2004-09-08
申请号：PE0006222003
申请日：2003-06-20
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHIDE RAJEEV S , TOKARSKI JOHN S , BORZILLERI ROBERT M
IPC分类号： C07D277/20 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , A61P43/00 , C07D233/70 , C07D233/84 , C07D233/88 , C07D263/28 , C07D263/46 , C07D263/48 , C07D277/34 , C07D277/36 , C07D277/38 , C07D277/42 , C07D417/12 , C07D417/14 , C12Q1/00
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： SE REFIERE A COMPUESTOS FARMACEUTICOS DE FORMULA I DONDE A Y B SON CADA UNO ARILO, HETEROALRILO, HETEROCICLO, ENTRE OTROS; X E Y SON CADA UNO R1CR2, S, O, SO2, ENTRE OTROS; D ES S, O Y NR4; R1, R2 Y R4 SON CADA UNO H, ALQUILO, HETEROCICLO, ENTRE OTROS. SUS COMPUESTOS PREFERIDOS SON: 2,4-DIFLUORO-N-METIL-5-{[2-(PIRIDIN-2-ILAMINO)-TIAZOL-5-ILMETIL]-AMINO}-BENZAMIDA Y 4-FLUORO-N-METIL-3-{[2-(PIRIDIN-2-ILAMINO)-TIAZOL-5-ILMETIL]-AMINO}-BENZAMIDA; ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE TIROSINA CINASA Y SON UTILES EN EL TRATAMIENTO DEL CANCER

88. 发明专利

HU0301005A2 PIRROLOTRIAZINE INHIBITORS OF KINASES PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：HU0301005A2
公开(公告)日：2003-07-28
申请号：HU0301005
申请日：2000-05-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHIDE RAJEEV S , BORZILLERI ROBERT M , HUNT JOHN T , QIAN LIGANG
IPC分类号： A61K31/53 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D487/04
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

89. 发明专利

AU756544B2 2,3-olefinic epothilone derivatives 未知
公开(公告)号：AU756544B2
公开(公告)日：2003-01-16
申请号：AU3559099
申请日：1999-04-14
申请人： SQUIBB BRISTOL MYERS CO
发明人： VITE GREGORY D , BORZILLERI ROBERT M , HOFLE GERHARD , LEIBOLD THOMAS
IPC分类号： C07D491/044 , A61K31/427 , A61K31/438 , A61K31/5513 , A61K31/5517 , A61P35/00 , C07D277/30 , C07D417/06 , C07D491/04 , C07D493/04

90. 发明专利

BR0010482A 未知
公开(公告)号：BR0010482A
公开(公告)日：2002-04-23
申请号：BR0010482
申请日：2000-05-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： HUNT JOHN T , BHIDE RAJEEV S , BORZILLERI ROBERT M , QIAN LIGANG
IPC分类号： A61K31/53 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D487/04
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

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