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    • 81. 发明授权
    • Optical reflecting system
    • 光学反射系统
    • US4013353A
    • 1977-03-22
    • US647098
    • 1976-01-07
    • Robert PortnerPhillip Miller
    • Robert PortnerPhillip Miller
    • G03B21/28G02B5/10G02B17/00
    • G03B21/28
    • A reflecting system utilizing a uniquely designed external mirror of specified shape to project and reflect light beams, distortion-free to the eye, from a light source to a receiving surface. The light source is uniquely positioned in relation to the mirror and supplemental mirrors may also be utilized to afford flexibility in the positioning of the elements. A uniquely designed reflector is constructed of a plurality of points specifically determined by an iterative method of solution utilizing as critical variables the size of the viewing surface, the distance from the light source to the reflector and the distance from the reflector to the receiving surface.
    • 一种使用独特设计的指定形状的外部反射镜的反射系统将从光源到接收表面的光束投射并反射到眼睛,使其无变形。 光源相对于镜子是独特定位的,并且补充反射镜也可以用于在元件的定位中提供灵活性。 独特设计的反射器由多个点构成,多个点由迭代的解决方案确定,利用作为观察表面的尺寸,从光源到反射器的距离以及从反射器到接收表面的距离的关键变量。
    • 82. 发明授权
    • Projection screen unit
    • 投影屏单元
    • US3942869A
    • 1976-03-09
    • US488010
    • 1974-07-12
    • Robert PortnerPhillip Miller
    • Robert PortnerPhillip Miller
    • G03B21/58
    • G03B21/58
    • A screen for a projection system supported by a pair of cross members extending to the four corners of the screen where they receive a tensioning member disposed around the perimeter of the screen and held in stress by a tensioning mechanism secured to a portion of one of the cross members. The cross members may be secured in their "up" position by means of a restraining member and the screen may be tilted forward as permitted by one of several modes of support. The screen may be shaped with curvilinear edges preferably of a catenary configuration to increase tautness which is imparted thereto by the tensioning member.
    • 一种用于投影系统的屏幕,该屏幕由一对延伸到屏幕的四个角的横向构件支撑,在这些横向构件中,它们接收围绕屏幕的周边布置的张紧构件,并且被张紧机构固定在一个 交叉成员。 横向构件可以通过限制构件固定在其“向上”位置,并且屏幕可以如几种支撑模式之一所允许的那样向前倾斜。 屏幕可以被成形为具有优选为悬链构造的曲线边缘,以增加由张紧构件施加到其上的张紧度。
    • 84. 发明授权
    • Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue
    • 多模态对比和明场上下文渲染,用于增强组织中的病理学确定和多分析物检测
    • US09310302B2
    • 2016-04-12
    • US13499959
    • 2010-10-07
    • Karl GarshaGary PestanoMichael OtterAlexandra Dea NagyRay B. NaglePhillip MillerJan FroehlichWilliam Day
    • Karl GarshaGary PestanoMichael OtterAlexandra Dea NagyRay B. NaglePhillip MillerJan FroehlichWilliam Day
    • G06K9/36G01N21/64
    • G01N21/6456
    • Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
    • 可以使用多重模态对比来产生可以组合和渲染的图像,以产生类似于在透射白光照明下观察到的波长吸收染色产生的图像的图像。 使用其他补充对比模式获得的图像可以使用基于用于显示相同解剖结构和组织化学的经典对比度方法的工程配色方案来呈现,从而提供与医学培训和经验相关的图像。 将衍生自折射率和荧光DAPI复染图像的暗视野对比图像组合以产生与用于病理解释的常规H&E染色获得的图像相似的图像。 这种多模式图像数据可以流式传输用于组织学样本的实时导航,并且可以与遗传DNA探针(FISH),mRNA表达位点(mRNA-ISH)和定位于其上的免疫组织化学(IHC)探针的分子定位相结合 相同的组织切片,用于评估和绘制用于成像质谱法制备的组织切片。
    • 85. 发明授权
    • Detecting targets using mass tags and mass spectrometry
    • 使用质量标签和质谱检测目标
    • US09291597B2
    • 2016-03-22
    • US13805983
    • 2011-07-01
    • Rui HongHong WangMark LefeverJan FroehlichChristopher BieniarzBrian KellyPhillip Miller
    • Rui HongHong WangMark LefeverJan FroehlichChristopher BieniarzBrian KellyPhillip Miller
    • G01N27/62G01N33/68
    • G01N33/6848G01N27/62
    • Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
    • 本文公开的具体公开的实施方案涉及使用一种或多种各种质量标签,其可以通过直接或间接的酶催化转化特异性沉积在靶上,以提供用于鉴定组织样品中靶标的方法。 质量标签可以用稳定同位素标记,以产生具有相同化学结构但质量不同的质量标签。 使用质谱检测和/或定量通过电离质量标签产生的质量代码。 该方法可用于特定样品中多个目标的多路检测。 在一些实施例中,可以制备分成表示组织样本部分的部分的图,其中,图表部分包括对应于量化数据的数据,其中质量峰的大小被确定并与相应组织的靶的量相关联 样品部分。
    • 88. 发明申请
    • Electromagnetic drive for a ventricular assist device
    • 心室辅助装置的电磁驱动器
    • US20080045777A1
    • 2008-02-21
    • US11449973
    • 2006-08-23
    • Jal JassawallaPhillip MillerDavid LaForge
    • Jal JassawallaPhillip MillerDavid LaForge
    • A61M1/10
    • A61M1/1053A61M1/1037A61M1/1055A61M1/1087A61M1/122
    • An electromagnetic drive for use in a ventricular assist device. The electromagnetic drive provides adjustment to the device pressure according to the current through an electromagnet. The device includes a pair of U-shaped cores, each having a center section and two legs; one or more coils, each wound around a selected U-shaped core that, when electrically energized, generate a magnetic flux and define one or more pairs of magnetic poles each having a polar axis; and an armature between the U-shaped cores having two non-magnetic ends and a permanent magnet therebetween for generating a magnet force on the armature resulting from the attraction of the magnet to the U-shaped cores when the coils are not electrically energized. The drive geometry reduces lateral instability and device size and increases magnetic efficiency and linearity. Preferably, a coil is wound around each center section. Alternatively, the coils are wound around the legs.
    • 用于心室辅助装置的电磁驱动器。 电磁驱动器根据通过电磁体的电流提供对器件压力的调节。 该装置包括一对U形芯,每个具有中心部分和两条腿; 一个或多个线圈,每个绕组围绕所选择的U形磁芯缠绕,当电通电时,其产生磁通量并且限定一对或多对各具有极轴的磁极; 以及在两个非磁性端之间的U形磁芯之间的衔铁和用于在线圈未通电时由磁体吸引到U形磁芯而产生电枢上的磁力的永磁体之间。 驱动几何减少横向不稳定性和设备尺寸,并提高磁效率和线性度。 优选地,线圈围绕每个中心部分缠绕。 或者,线圈缠绕在腿上。