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81. 发明授权

US07904153B2 Method and apparatus for subcutaneous ECG vector acceptability and selection 有权
标题翻译：用于皮下ECG载体可接受性和选择的方法和装置
公开(公告)号：US07904153B2
公开(公告)日：2011-03-08
申请号：US11741231
申请日：2007-04-27
申请人： Saul E. Greenhut , Robert W. Stadler , Karen J. Kleckner
发明人： Saul E. Greenhut , Robert W. Stadler , Karen J. Kleckner
IPC分类号： A61N1/39
CPC分类号： A61N1/0504 , A61B5/042 , A61B5/0468 , A61B5/7203 , A61B5/7221 , A61N1/3621 , A61N1/3702 , A61N1/3925 , A61N1/3956
摘要： An implantable medical device system and associated method select subcutaneous sensing electrodes for use in monitoring the heart rhythm. A subset of multiple sensing vectors is selected from a number of electrodes positioned at a first subcutaneous location and one electrode positioned at a second subcutaneous location. The subset of sensing vectors includes one vector that includes the electrode positioned at the second location. A signal quality parameter corresponding to each of the sensing vectors of the subset is determined.
摘要翻译：可植入医疗装置系统和相关方法选择用于监测心律的皮下感测电极。从位于第一皮下位置的多个电极和位于第二皮下位置的一个电极中选择多个感测向量的子集。感测矢量的子集包括一个矢量，其包括位于第二位置处的电极。确定与子集的每个感测向量对应的信号质量参数。

82. 发明申请

US20100204597A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：US20100204597A1
公开(公告)日：2010-08-12
申请号：US12763499
申请日：2010-04-20
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/0452
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

83. 发明授权

US07769452B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07769452B2
公开(公告)日：2010-08-03
申请号：US11380807
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61N1/368
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining whether the first sensing vector and the second sensing vector is corrupted by noise, and determining, in response to one of the first sensing vector and the second sensing vector being corrupted by noise, whether the other of the first sensing vector and the second sensing vector is one of a first cardiac event and a second cardiac event different from the first cardiac event.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括从形成第一感测向量和第二感测向量的多个电极感测心脏信号，确定第一感测向量和第二感测向量是否被噪声破坏，以及确定响应于被噪声破坏的第一感测矢量和第二感测矢量中的一个，第一感测矢量和第二感测矢量中的另一个是否是与第一心脏不同的第一心脏事件和第二心脏事件之一事件。

84. 发明授权

US07761142B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07761142B2
公开(公告)日：2010-07-20
申请号：US11380802
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/0452
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, and determining whether the inflections are indicative of noise in response to the determined inflections and the generated pulse amplitude threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值并且确定所述变形是否响应于所确定的变形和产生的脉冲幅度阈值来指示噪声。

85. 发明授权

US07734336B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07734336B2
公开(公告)日：2010-06-08
申请号：US11380823
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/0452
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, determining whether the sensed cardiac signals are corrupted by noise in response to the determined inflections and the generated pulse amplitude threshold, and determining, in response to the sensed cardiac signals being corrupted by noise, whether the sensed cardiac signals are both corrupted by noise and shockable.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值拐点，响应于所确定的变形和所产生的脉冲幅度阈值确定所感测到的心脏信号是否被噪声破坏，以及响应于感测到的心脏信号被噪声破坏，确定所感测的心脏信号是否被噪声破坏并可震撼。

86. 发明申请

US20100030093A1 PERIODIC BEAT DETECTION TO DETECT ARTIFACTS IN A CARDIAC ELECTROGRAM 有权
标题翻译：在心脏电泳中检测人体的周期性BEAT检测
公开(公告)号：US20100030093A1
公开(公告)日：2010-02-04
申请号：US12183950
申请日：2008-07-31
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61N1/3621 , A61B5/0464 , A61B5/7221 , A61B5/7239 , A61N1/36507 , A61N1/3925 , A61N1/3962
摘要： Techniques for determining whether artifacts are present in a cardiac electrogram are described. According to one example, a medical device senses a cardiac electrogram via electrodes. The medical device determines a derivative, e.g., a second order derivative, the electrogram. The medical device detects beats within the derivative, e.g., by comparing a rectified version of the derivative to one or more thresholds determined based on a maximum of the rectified derivative. The medical device determines whether the beats are periodic, and determines whether artifacts are present in the cardiac electrogram based on the determination of whether the beats are periodic. The medical device may further determine whether tachyarrhythmia is present and/or whether the cardiac rhythm of the patient is treatable based on the determination of whether the beats are periodic. For example, the medical device may determine that an electrogram is not treatable when the beats are periodic.
摘要翻译：描述了用于确定伪像是否存在于心电图中的技术。根据一个示例，医疗装置通过电极感测心电图。医疗设备确定导数，例如二阶导数，电描记图。医疗设备检测导数内的跳动，例如通过将导数的整流版本与基于校正导数的最大值确定的一个或多个阈值进行比较。医疗器械确定节拍是否是周期性的，并且基于确定节拍是否是周期性的确定来确定心脏电图中是否存在假象。医疗装置可以基于是否是周期性的确定来进一步确定是否存在快速性心律失常和/或患者的心律是否可治疗。例如，当节拍是周期性的时，医疗装置可以确定电描记图是不可治疗的。

87. 发明申请

US20070232944A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A SUBCUTANEOUS MEDICAL DEVICE 有权
标题翻译：用于检测肾上腺髓质瘤的方法和装置
公开(公告)号：US20070232944A1
公开(公告)日：2007-10-04
申请号：US11461269
申请日：2006-07-31
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

88. 发明授权

US07181268B2 Ischemia detection 失效
标题翻译：缺血检测
公开(公告)号：US07181268B2
公开(公告)日：2007-02-20
申请号：US10304112
申请日：2002-11-25
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/0402
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36585
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart that are sensed by an accelerometer sensor. The heart acceleration signal can be obtained from an single- or multiple-axis accelerometer and/or a pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及由加速度计传感器感测到的心脏的动态机械活动的变化来检测心肌缺血的发生。心脏加速度信号可以从部署在心脏内部或附近的单轴或多轴加速度计和/或压力传感器获得。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

89. 发明授权

US07066891B2 Method and apparatus for gauging severity of myocardial ischemic episodes 失效
标题翻译：测量心肌缺血发作严重程度的方法和装置
公开(公告)号：US07066891B2
公开(公告)日：2006-06-27
申请号：US10325076
申请日：2002-12-20
申请人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
发明人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61N1/362 , G06F19/00
摘要： An implantable medical device (IMD) for gauging the severity of ischemia in a patient's heart includes a data collection module configured to receive data about the patient's heart, a data processing module configured to process the data to identify an episode of ischemia in the patient and to determine if the episode is stable or unstable, and a reporting module configured to provide an alarm to the patient if the episode is unstable. A method executable by an implantable medical device to detect ischemia in a human heart suitably includes the steps of receiving data about the heart at the implantable medical device, processing the data within the implantable medical device to determine the severity of ischemia, and providing a response from the implantable medical device to the patient if ischemia is indicated.
摘要翻译：用于测量患者心脏的严重程度的可植入医疗装置（IMD）包括：数据收集模块，被配置为接收关于患者心脏的数据;数据处理模块，被配置为处理所述数据以识别患者的局部缺血发作;以及以确定剧集是否稳定或不稳定，并且报告模块被配置为如果发作不稳定则向患者提供警报。可植入医疗装置可检测人心脏缺血的方法适当地包括以下步骤：在可植入医疗装置处接收关于心脏的数据，处理可植入医疗装置内的数据以确定局部缺血的严重性，并提供反应从可植入的医疗装置到患者，如果指示缺血。

90. 发明授权

US06937899B2 Ischemia detection 有权
标题翻译：缺血检测
公开(公告)号：US06937899B2
公开(公告)日：2005-08-30
申请号：US09945179
申请日：2001-08-30
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/11 , A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61B5/4839 , A61B5/04011 , A61B5/0452 , A61B5/1107 , A61B5/6869 , A61B5/7203 , A61B2562/028 , A61B2562/222 , A61N1/36542 , A61N1/368
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart. Dynamic mechanical activity can be represented, for example, by a heart acceleration signal or pressure signal. The electrical signal can be obtained from a set of implanted or external electrodes. The heart acceleration signal can be obtained from an accelerometer or pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及心脏的动态机械活动的变化来检测心肌缺血的发生。动态机械活动可以例如通过心脏加速度信号或压力信号来表示。电信号可以从一组植入电极或外部电极获得。可以从部署在心脏内部或附近的加速度计或压力传感器获得心脏加速度信号。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

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