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81. 发明授权

US07009032B2 Sulfide-containing polythiols 有权
公开(公告)号：US07009032B2
公开(公告)日：2006-03-07
申请号：US10725034
申请日：2003-12-02
申请人： Nina Bojkova , Robert A. Smith
发明人： Nina Bojkova , Robert A. Smith
IPC分类号： C08G75/14
CPC分类号： C08G75/10 , C07D339/06 , C07D339/08 , C08G18/12 , C08G18/3876 , C08G18/4018 , C08G18/4277 , C08G18/4837 , C08G18/5072 , C08G18/664 , C08G18/672 , C08G18/758 , C08G75/02 , C08G75/04 , C08G75/06 , C08G18/3243 , C08G18/64
摘要： The present invention relates to sulfide-containing polythiols and their methods of preparation. Sulfide-containing polythiols can have a variety of uses and applications. The sulfide-containing polythiols of the present invention can be especially useful in polyurethane compositions for the manufacture of ophthalmic lenses.

82. 发明授权

US06785747B2 Method and system for flexible channel path identifier assignment 失效
标题翻译：用于灵活通道路径标识符分配的方法和系统
公开(公告)号：US06785747B2
公开(公告)日：2004-08-31
申请号：US09727270
申请日：2000-11-30
申请人： Hans-Helge Lehmann , Charles E. Shapley , Robert A. Smith
发明人： Hans-Helge Lehmann , Charles E. Shapley , Robert A. Smith
IPC分类号： G06F300
CPC分类号： G06F13/387
摘要： A method and system for flexibly and efficiently assigning channel path identifiers (CHPIDs) used by operating system software in computer systems to identify the communication path to I/O devices via channels. To avoid wasted CHPIDs, which may be limited in number, CHPIDs are assigned only to channels which are installed on and configured to the computer system. The CHPIDs may be re-assigned concurrently with ongoing system operations via a user interface and/or an imported, pre-defined CHPID mapping.
摘要翻译：一种用于灵活有效地分配由计算机系统中的操作系统软件使用的信道路径标识符（CHPID）的方法和系统，以通过信道识别到I / O设备的通信路径。为了避免浪费的CHPID，数量可能受到限制，CHPID仅分配给安装在计算机系统上并配置到计算机系统的通道。 CHPID可以经由用户接口和/或导入的预定义CHPID映射与正在进行的系统操作同时重新分配。

83. 发明授权

US06783546B2 Implantable prosthetic or tissue expanding device 失效
标题翻译：植入假体或组织扩张装置
公开(公告)号：US06783546B2
公开(公告)日：2004-08-31
申请号：US09815387
申请日：2001-03-22
申请人： James F. Zucherman , Ken Y. Hsu , Scott Yerby , Robert A. Smith
发明人： James F. Zucherman , Ken Y. Hsu , Scott Yerby , Robert A. Smith
IPC分类号： A61F244
CPC分类号： A61F2/12 , A61F2/441 , A61F2/442 , A61F2002/2817 , A61F2002/30004 , A61F2002/30006 , A61F2002/30009 , A61F2002/30586 , A61F2002/30677 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2250/0014 , A61F2250/0015 , A61F2250/0028 , A61F2310/00365 , A61L27/227 , A61L27/306 , A61L27/34 , A61L27/52 , A61L2430/04 , A61L2430/38 , A61L27/38 , C08L83/04
摘要： A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. Another device is an implant for the intervertebral disc space. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area. One kit has a powdered, keratin hydrogel precursor disposed within the envelope interior, awaiting the addition of water, preferably after insertion of the implant into the body. In another method, the implant can include an envelope with a hydrogel or hydrogel precursor already placed in the envelope.
摘要翻译：角蛋白水凝胶填充的可植入假体装置。一种装置是用于增强或重建人乳房的乳房植入物，其包括含有角蛋白水凝胶的包膜。另一种装置是用于椎间盘空间的植入物。一种角蛋白水凝胶由固体前体形成，其在加入水时形成角蛋白水凝胶。角蛋白的一个来源是人的头发。在一种方法中，提供适于植入的包膜和固体角蛋白水凝胶前体。固体可以是纤维或粉末形式。固体前体可以插入信封内部。乳房附近有一个小切口，信封插入切口。插入后，水可以注入信封内部，优选通过切口并通过信封中的自密封端口注入。在一种方法中，植入物作为试剂盒提供，其中提供了包膜和角蛋白水凝胶。在插入乳房区域之前或之后，可以将水凝胶注入到信封中。一个试剂盒具有设置在信封内部的粉末状角蛋白水凝胶前体，等待加入水，优选在将植入物插入体内之后。在另一种方法中，植入物可以包括具有已经放置在包封中的水凝胶或水凝胶前体的封套。

84. 再颁专利

USRE38476E1 Signal processing apparatus 有权
标题翻译：信号处理装置
公开(公告)号：USRE38476E1
公开(公告)日：2004-03-30
申请号：US10185804
申请日：2002-06-27
申请人： Mohamed K. Diab , Massi E. Kiani , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
发明人： Mohamed K. Diab , Massi E. Kiani , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
IPC分类号： A61B500
CPC分类号： H04B1/123 , A61B5/021 , A61B5/02154 , A61B5/024 , A61B5/029 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/4821 , A61B5/7214 , A61B5/7253 , A61B5/7257 , A61B6/00 , A61B8/00 , A61B8/5276 , G06K9/0051
摘要： The present invention involves method and apparatus for analyzing two measured signals that are modeled as containing primary and secondary portions. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, the present invention involves utilizing a transformation which evaluates a plurality of possible signal coefficients in order to find appropriate coefficients. Alternatively, the present invention involves using statistical functions or Fourier transform and windowing techniques to determine the coefficients relating to two measured signals. Use of this invention is described in particular detail with respect to blood oximetry measurements.

85. 发明授权

US06631021B2 Polyfunctional thiirane compounds 失效
公开(公告)号：US06631021B2
公开(公告)日：2003-10-07
申请号：US09793886
申请日：2001-02-28
申请人： Robert A. Smith , Michael O. Okoroafor , Marvin J. Graham
发明人： Robert A. Smith , Michael O. Okoroafor , Marvin J. Graham
IPC分类号： C08G7532
CPC分类号： C07D331/02
摘要： Describes novel polyfunctional thiiranes. Also described are polymerizable compositions comprising such novel polyfunctional thiiranes, and polymerizates, e.g., optical lenses, prepared therefrom. The described polymerizates may have a refractive index of at least 1.6, and an Abbe number of at least 27.

86. 发明授权

US06461628B1 Non-woven keratin cell scaffold 有权
标题翻译：无纺布角蛋白细胞支架
公开(公告)号：US06461628B1
公开(公告)日：2002-10-08
申请号：US09587157
申请日：2000-06-05
申请人： Cheryl R. Blanchard , Mark E. Van Dyke , Scott F. Timmons , Arlene J. Siller-Jackson , Robert A. Smith
发明人： Cheryl R. Blanchard , Mark E. Van Dyke , Scott F. Timmons , Arlene J. Siller-Jackson , Robert A. Smith
IPC分类号： A01N2534
CPC分类号： A61K8/042 , A61F2013/530481 , A61F2013/530613 , A61K8/65 , A61K9/146 , A61K9/2063 , A61K9/7007 , A61K38/17 , A61K47/42 , A61K47/6953 , A61L15/32 , A61L27/227 , A61Q19/00
摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel may be used as biocompatible viscoelastic filler for implant applications. Both the hydrogel and nonwoven materials are also suitable for use as tissue engineering scaffolds.
摘要翻译：可以通过将毛发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水的可水合的高吸收性角蛋白固体纤维或粉末。中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。向固体中加入水产生水凝胶。粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。角蛋白材料可以并入无纺膜中。水凝胶可用作植入物应用的生物相容性粘弹性填料。水凝胶和非织造材料都适用于组织工程支架。

87. 发明授权

US06342571B1 High refractive index optical resin composition 失效
$High refractive index optical resin composition$
标题翻译：高折射率光学树脂组合物
公开(公告)号：US06342571B1
公开(公告)日：2002-01-29
申请号：US09377805
申请日：1999-08-20
申请人： Robert A. Smith , Michael O. Okoroafor , Robert D. Herold , T. Edwin Freeman
发明人： Robert A. Smith , Michael O. Okoroafor , Robert D. Herold , T. Edwin Freeman
IPC分类号： C08F22020
CPC分类号： C08F222/24
摘要： Polymerizable compositions comprising: (a) a mixture of thio(meth)acrylate functional monomers comprising, (a)(i) a first thio(meth)acrylate functional monomer, e.g., bis(thiomethacrylate)-1,2-ethylene, and (a)(ii) a second thio(meth)acrylate functional monomer, which is chain extended; (b) an aromatic monomer having at least two vinyl groups, e.g., divinyl benzene; (c) a polythiol monomer having at least two thiol groups, e.g., pentaerythritol tetrakis(3-mercaptopropionate); and (d) a comonomer selected from, (d)(i) an anhydride monomer having at least one ethylenically unsaturated group, e.g., methacrylic anhydride; (d) (ii) a monomer having at least three (meth)acryloyl groups, e.g., pentaerythritol tetrakis(acrylate); and (d)(iii) mixtures of monomers (d)(i) and (d)(ii). A polymerizate of the polymerizable composition has a refractive index of at least 1.57 and an Abbe number of at least 33.
摘要翻译：可聚合组合物包括：（a）硫代（甲基）丙烯酸酯官能单体的混合物，其包含（a）（i）第一硫代（甲基）丙烯酸酯官能单体，例如双（硫代甲基丙烯酸酯）-1,2-亚乙基和（ a）（ii）链延伸的第二硫代（甲基）丙烯酸酯官能单体; （b）具有至少两个乙烯基的芳族单体，例如二乙烯基苯; （c）具有至少两个硫醇基的多硫醇单体，例如季戊四醇四（3-巯基丙酸酯）; 和（d）选自（d）（i）具有至少一个烯属不饱和基团的酸酐单体的共聚单体，例如甲基丙烯酸酐; （d）（ii）具有至少三个（甲基）丙烯酰基的单体，例如季戊四醇四（丙烯酸酯）; 和（d）（iii）单体（d）（i）和（d）（ii）的混合物。聚合性组合物的聚合物的折射率为至少1.57，阿贝数为33以上。

88. 发明授权

US06270793B1 Absorbent keratin wound dressing 有权
标题翻译：吸收性角蛋白伤口敷料
公开(公告)号：US06270793B1
公开(公告)日：2001-08-07
申请号：US09528893
申请日：2000-03-20
申请人： Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Arlene J. Siller-Jackson , Robert A. Smith
发明人： Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Arlene J. Siller-Jackson , Robert A. Smith
IPC分类号： A61F1300
CPC分类号： A61K8/042 , A61F2013/530481 , A61F2013/530613 , A61K8/65 , A61K9/146 , A61K9/2063 , A61K9/7007 , A61K38/17 , A61K47/42 , A61K47/6953 , A61L15/32 , A61L27/227 , A61Q19/00
摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. Another use for the hydrogel is as a biocompatible viscoelastic filler for implant applications.
摘要翻译：可以通过将毛发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水分的可水合的高吸收性角蛋白固体纤维或粉末。中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。向固体中加入水产生水凝胶。粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。角蛋白材料可以并入无纺膜中。水凝胶的另一用途是用于植入物应用的生物相容性粘弹性填料。

89. 发明授权

US6165496A Keratin-based sheet material for biomedical applications and method of production 有权
标题翻译：用于生物医学应用的角蛋白片材和生产方法
公开(公告)号：US6165496A
公开(公告)日：2000-12-26
申请号：US365976
申请日：1999-08-02
申请人： Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
发明人： Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： A61K9/70 , A61K35/36 , A61K38/39 , A61L15/32 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/60 , A61L31/04 , A61L31/10 , C08H1/06 , C12N5/00 , A61K9/00 , A61K38/00 , A61F13/00 , A61L15/16
CPC分类号： C12N5/0068 , A61K9/70 , A61K35/36 , A61K38/39 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C08H1/06 , C12N2533/50 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially solubilizes the keratin by weakening hydrogen bonds. The suspension is added to base, such as ammonium hydroxide, forming a slurry. The slurry is cast directly onto a flat surface, allowing the re-formation of cross-links including hydrogen bonds and disulfide bonds. The resulting cross-linked keratin sheet can be used as a sheet wound dressing or as a scaffolding for growth of cells. The insoluble keratin can be derived from human hair which is washed, rinsed, dried, chopped and treated with peracetic acid to break some accessible disulfide linkages. The treated hair is filtered, rinsed, dried, and ground into a keratin powder. The keratin powder is suspended in a mixture of ammonium hydroxide and ammonium thioglycollate and heated sufficiently to dissolve the soluble keratin fraction, followed by cooling and centrifugation to concentrate the insoluble, largely Beta keratin fraction.
摘要翻译：由交联角蛋白形成的伤口敷料。将来自人类头发的不溶性大部分β角蛋白级分酸化至低pH，优选小于约3，通过削弱氢键来部分溶解角蛋白。将悬浮液加入到碱如氢氧化铵中，形成浆料。将浆料直接浇铸到平坦表面上，允许重新形成包括氢键和二硫键的交联。所得到的交联角蛋白片可用作片状伤口敷料或用作细胞生长的支架。不溶性角蛋白可以衍生自人毛，洗涤，漂洗，干燥，切碎并用过乙酸处理以破坏一些可接近的二硫键。将经处理的毛发过滤，漂洗，干燥并研磨成角蛋白粉末。将角蛋白粉末悬浮在氢氧化铵和巯基乙酸铵的混合物中并充分加热以溶解可溶性角蛋白级分，然后冷却并离心以浓缩不溶性的大部分β角蛋白级分。

90. 发明授权

US6157850A Signal processing apparatus 失效
公开(公告)号：US6157850A
公开(公告)日：2000-12-05
申请号：US859837
申请日：1997-05-16
申请人： Mohamed K. Diab , Massi E. Kiani , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
发明人： Mohamed K. Diab , Massi E. Kiani , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
IPC分类号： A61B5/0245 , A61B5/00 , A61B5/02 , A61B5/0215 , A61B5/145 , A61B5/1455 , A61B5/1464 , A61B6/00 , A61B8/00 , G06F17/00 , G06F19/00 , H04B1/12 , H04B3/46 , H04B17/00
CPC分类号： H04B1/123 , A61B5/14546 , A61B5/14551 , A61B5/4821 , A61B5/7214 , A61B5/7253 , A61B8/5276 , G06K9/0051 , A61B5/021 , A61B5/02154 , A61B5/024 , A61B5/029 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/14532 , A61B5/7257 , A61B6/00 , A61B8/00
摘要： The present invention involves method and apparatus for analyzing two measured signals that are modeled as containing primary and secondary portions. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, the present invention involves utilizing a transformation which evaluates a plurality of possible signal coefficients in order to find appropriate coefficients. Alternatively, the present invention involves using statistical functions or Fourier transform and windowing techniques to determine the coefficients relating to two measured signals. Use of this invention is described in particular detail with respect to blood oximetry measurements.

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