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81. 发明授权

US07357801B2 Tissue specimen isolating and damaging device and method 有权
标题翻译：组织样本分离和破坏装置及方法
公开(公告)号：US07357801B2
公开(公告)日：2008-04-15
申请号：US10756178
申请日：2004-01-13
申请人： Fred Burbank , Paul Lubock
发明人： Fred Burbank , Paul Lubock
IPC分类号： A61B18/18
CPC分类号： A61B10/0266 , A61B10/0041 , A61B10/02 , A61B10/0233 , A61B17/00234 , A61B17/00491 , A61B17/221 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/0206 , A61B18/06 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B18/20 , A61B90/37 , A61B2010/0208 , A61B2017/00287 , A61B2017/2212 , A61B2017/320733 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/144 , A61B2018/1475 , A61B2018/162 , A61B2018/1861 , A61B2090/3908 , A61N5/1007 , A61N5/1027
摘要： A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.
摘要翻译：用于处理设置在周围组织中的组织样本的装置和方法具有组织样本隔离工具和组织样本容器。组织标本分离工具将组织标本与周围组织隔离。组织标本损伤组织，可能的最终结果是坏死。切割工具可以具有切割构件，该切割构件可延伸到关于装置的向外径向弯曲的位置。通过围绕组织样本旋转切割构件来分离组织样本。切割构件可以功能地连接到切割构件射频发生源。组织样本容器可能会使用电离辐射，切割装置，热处理装置，化学处理装置或密封组织标本的外边界来损伤组织标本。

82. 发明申请

US20080064915A1 Vacuum device and method for treating tissue adjacent a body cavity 有权
标题翻译：真空装置和用于处理体腔附近的组织的方法
公开(公告)号：US20080064915A1
公开(公告)日：2008-03-13
申请号：US11981063
申请日：2007-10-31
申请人： Paul Lubock
发明人： Paul Lubock
IPC分类号： A61N5/00 , A61M1/00
CPC分类号： A61N5/1015 , A61B2017/22048 , A61B2017/22051
摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.
摘要翻译：提供了设备和方法，用于在靠近体腔的组织递送治疗装置的地方施加真空，有效地吸引靠近这种装置的邻近组织并增强对组织的治疗。体腔包括自然体腔和去除组织如癌组织后残留的空腔。装置可以包括具有充气导管的内气囊组件。具有流体可渗透护套壁的护套组件可以封闭内部气囊组件。施加到护套和内囊之间的空间的真空用于使组织与装置接触，提高治疗效果。还提供了用这种装置和系统处理组织的方法。治疗可以包括提供用于放射治疗的放射性物质，提供用于化疗的化学治疗材料，提供热治疗及其组合。系统可以包括本发明的装置和真空源。

83. 发明申请

US20080058675A1 Biopsy device with aperture orientation and improved tip 有权
标题翻译：具有孔径取向和改善尖端的活检装置
公开(公告)号：US20080058675A1
公开(公告)日：2008-03-06
申请号：US11981024
申请日：2007-10-31
申请人： Martin Shabaz , Richard Quick , Frank Louw , Paul Lubock , Jason Safabash
发明人： Martin Shabaz , Richard Quick , Frank Louw , Paul Lubock , Jason Safabash
IPC分类号： A61B10/02
CPC分类号： A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/3405
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括可释放地固定到驱动器部件的探针部件。探针部件具有细长的管状部分，穿透远侧末端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割组织标本通过对组织切割构件的内腔施加真空而通过孔被吸入装置的内部。驱动器具有用于操作探头部件的元件的驱动部件。组织穿透的远侧末端优选地具有三凹曲面形状，其具有三个弯曲的切割边缘，其导致尖锐的远端点。

84. 发明授权

US07322940B2 Breast biopsy system and methods 有权
标题翻译：乳腺活检系统及方法
公开(公告)号：US07322940B2
公开(公告)日：2008-01-29
申请号：US10790661
申请日：2004-03-01
申请人： Fred H. Burbank , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Paul Lubock
IPC分类号： A61B10/00 , A61B18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An instrument assembly and method are described for isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required. In particular, the instrument assembly has a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along a distal portion of the shaft. The cutting element is actuatable between a retracted position within an electrically insulating recess and a radially extended position and is rotatable about its axis in the radially extended position to isolate a desire tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen.
摘要翻译：描述了用于分离患者身体组织中的靶病变的器械组件和方法，导致当其被去除以用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅用单一经皮手术诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术。特别地，仪器组件具有适于进入患者身体的远端，纵向轴和沿着轴的远端部分设置的切割元件。切割元件可以在电绝缘凹槽中的缩回位置和径向延伸的位置之间致动，并且可以在其径向延伸的位置绕其轴线旋转，以通过围绕组织样本限定周边边缘来隔离期望的组织样本与周围组织。

85. 发明申请

US20080021449A1 Electrosurgical lesion location device 有权
标题翻译：电外科病变位置装置
公开(公告)号：US20080021449A1
公开(公告)日：2008-01-24
申请号：US11890329
申请日：2007-08-06
申请人： Fred Burbank , Frank Louw , Paul Lubock , Richard Quick
发明人： Fred Burbank , Frank Louw , Paul Lubock , Richard Quick
IPC分类号： A61B18/14
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device for localizing a target tissue mass in a body includes a tubular trocar portion having a distal end and a proximal end portion that is removably attachable to a handle portion. The trocar portion contains at least a first plurality of locator wires that are movable between a retracted position within the trocar and a deployed position extending radially from the trocar. The first plurality of locator wires mounted for axial movement within the trocar portion between a proximal retracted position and a deployed distal position. The second plurality of locator wires is mounted for movement between a distal retracted position and a proximal deployed position. The locator wires are electrically energized to facilitate their deployment electrosurgically.
摘要翻译：用于使身体中的目标组织块定位的装置包括管状套管针部分，其具有可拆卸地附接到手柄部分的远端和近端部分。套针针部分包含至少第一组多个定位线，其可在套管针内的缩回位置和从套管针径向延伸的展开位置之间移动。第一组多个定位线安装用于在套管针部分内在近端缩回位置和展开的远侧位置之间轴向移动。第二组多个定位线被安装用于在远端缩回位置和近端展开位置之间移动。定位器电线通电，以方便他们在电外科手术。

86. 发明授权

US07214178B2 Vacuum device and method for treating tissue adjacent a body cavity 有权
标题翻译：真空装置和用于处理体腔附近的组织的方法
公开(公告)号：US07214178B2
公开(公告)日：2007-05-08
申请号：US11105856
申请日：2005-04-14
申请人： Paul Lubock
发明人： Paul Lubock
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22048 , A61B2017/22051
摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.
摘要翻译：提供了设备和方法，用于在靠近体腔的组织递送治疗装置的地方施加真空，有效地吸引靠近这种装置的邻近组织并增强对组织的治疗。体腔包括自然体腔和去除组织如癌组织后残留的空腔。装置可以包括具有充气导管的内气囊组件。具有流体可渗透护套壁的护套组件可以封闭内部气囊组件。施加到护套和内囊之间的空间的真空用于使组织与装置接触，提高治疗效果。还提供了用这种装置和系统处理组织的方法。治疗可以包括提供用于放射治疗的放射性物质，提供用于化疗的化学治疗材料，提供热治疗及其组合。系统可以包括本发明的装置和真空源。

87. 发明申请

US20060155190A1 Imageable biopsy site marker 审中-公开
标题翻译：可成像的活检部位标记
公开(公告)号：US20060155190A1
公开(公告)日：2006-07-13
申请号：US11366956
申请日：2006-03-02
申请人： Fred Burbank , Paul Lubock , Michael Jones , Nancy Forcier
发明人： Fred Burbank , Paul Lubock , Michael Jones , Nancy Forcier
IPC分类号： A61B6/00
CPC分类号： A61B90/39 , A61B10/02 , A61B2017/00004 , A61B2090/3788 , A61B2090/3908 , A61B2090/3925 , A61B2090/3929 , A61B2090/3933 , A61B2090/395 , A61B2090/3975 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61M37/0069
摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by an delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.
摘要翻译：活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。具有不透射线物体的至少一个生物可再吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。将管的一端放入活检部位。至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像导入后的第二时间点（如5-7个月）附近的组织组织。

88. 发明申请

US20060094983A1 Methods and apparatus for securing medical instruments to desired locations in a patient's body 审中-公开
公开(公告)号：US20060094983A1
公开(公告)日：2006-05-04
申请号：US11303154
申请日：2005-12-15
申请人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
发明人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
IPC分类号： A61B10/00 , A61M5/178
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2090/3908 , A61B2090/3987 , A61B2090/3991
摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

89. 发明授权

US06958044B2 Methods and apparatus for securing medical instruments to desired locations in a patient's body 有权
公开(公告)号：US06958044B2
公开(公告)日：2005-10-25
申请号：US10004987
申请日：2001-12-04
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00 , A61F2/82
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2019/5487 , A61B2019/5491 , A61B2090/3908 , A61B2090/3991
摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

90. 发明授权

US06955641B2 Vacuum device and method for treating tissue adjacent a body cavity 有权
公开(公告)号：US06955641B2
公开(公告)日：2005-10-18
申请号：US10849410
申请日：2004-05-19
申请人： Paul Lubock
发明人： Paul Lubock
IPC分类号： A61F2/958 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22048 , A61B2017/22051
摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

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