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81. 发明申请

WO1998022606A1 RECOMBINANT BICISTRON ADENOVIRUS FOR TREATING PATHOLOGICAL CONDITIONS LINKED WITH DYSLIPOPROTEINEMIA 审中-公开
标题翻译：用于治疗与DYSLIPOPROTEINEMIA相关的病理状况的重组双歧杆菌ADENOVIRUS
公开(公告)号：WO1998022606A1
公开(公告)日：1998-05-28
申请号：PCT/FR1997002043
申请日：1997-11-13
申请人： RHONE-POULENC RORER S.A. , BENOIT, Patrick , DUVERGER, Nicolas , ROUY, Didier , SEGURET, Sandrine
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/47 , C12N9/1029 , C12N9/20 , C12N2710/10343 , C12N2830/42 , C12N2840/203
摘要： The invention concerns a defective recombinant virus and preferably an adenovirus characterised in that it comprises at least two nucleic acids coding for distinct enzymes, proteins and/or co-factors involved in the reverse transfer of cholesterol, said nucleic acids being operationally bound to a transcriptional promoter and mutually separated by a sequence coding for an internal entry site of the IRES ribosome. The invention further concerns plasmid constructs useful for preparing these adenovirus, and cells transformed by these plasmids or adenovirus and pharmaceutical compositions containing said adenovirus.
摘要翻译：本发明涉及有缺陷的重组病毒，优选腺病毒，其特征在于其包含至少两种编码参与胆固醇逆转移的不同酶，蛋白质和/或辅因子的核酸，所述核酸在操作上与转录结合启动子并通过编码IRES核糖体内部进入位点的序列相互分离。本发明还涉及可用于制备这些腺病毒的质粒构建体和由这些质粒或腺病毒转化的细胞和含有所述腺病毒的药物组合物。

82. 发明申请

WO1998011213A1 METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：治疗左心室狭窄的方法
公开(公告)号：WO1998011213A1
公开(公告)日：1998-03-19
申请号：PCT/FR1997001589
申请日：1997-09-10
申请人： RHONE-POULENC RORER S.A. , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , HAASE, Georg , KAHN, Axel , KENNEL, Philippe , MALLET, Jacques , REVAH, Frédéric
发明人： RHONE-POULENC RORER S.A. , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： C12N15/12
CPC分类号： A61K38/185 , A61K48/00
摘要： The invention concerns a novel method for treating motor neuron diseases and particularly amyotrophic lateral sclerosis. It consists more particularly in the systemic administration of expression systems of neurotrophic factors.
摘要翻译：本发明涉及治疗运动神经元疾病，特别是肌萎缩性侧索硬化症的新方法。它更特别地涉及神经营养因子的表达系统的全身给药。

83. 发明申请

WO1997047757A1 GENERATING REPLICATING MOLECULES IN VIVO 审中-公开
标题翻译：生成体检中的替代分子
公开(公告)号：WO1997047757A1
公开(公告)日：1997-12-18
申请号：PCT/FR1997000914
申请日：1997-05-23
申请人： RHONE-POULENC RORER S.A. , PERRICAUDET, Michel , YEH, Patrice , LEBLOIS-PREHAUD, Hélène
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2740/11043 , C12N2800/108 , C12N2800/30 , C12N2830/002 , C12N2830/003 , C12N2840/203
摘要： The invention discloses circular and replicating DNA molecules, useful in gene therapy, as well as a particularly efficient method for generating them in situ from a viral vector.
摘要翻译：本发明公开了可用于基因治疗的循环和复制DNA分子，以及用于从病毒载体原位产生它们的特别有效的方法。

84. 发明申请

WO1997043421A1 BIOSYNTHESIS METHOD ENABLING THE PREPARATION OF COBALAMINS 审中-公开
标题翻译：制备乙酰胺的制备方法
公开(公告)号：WO1997043421A1
公开(公告)日：1997-11-20
申请号：PCT/FR1997000793
申请日：1997-05-05
申请人： RHONE-POULENC RORER S.A. , BLANCHE, Francis , CAMERON, Béatrice , CROUZET, Joël , DEBUSSCHE, Laurent , THIBAUT, Denis , REMY, Elisabeth
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C12N15/52
CPC分类号： C12N15/52 , C12P19/42
摘要： The invention features a biosynthesis method enabling the preparation of cobalamins. More precisely it features a method of increasing cobalamin production and more particularly of the coenzyme B12 by recombinant DNA techniques and/or by the addition of a new cobalamin precursor.
摘要翻译：本发明的特征在于能够制备钴胺素的生物合成方法。更确切地说，它具有通过重组DNA技术和/或通过添加新的钴胺素前体来增加钴胺素生产的方法，更具体地说是辅酶B12的方法。

85. 发明申请

WO1997035002A1 PURIFICATION OF PHARMACEUTICAL-GRADE PLASMID DNA 审中-公开
标题翻译：药物级粒子DNA的纯化
公开(公告)号：WO1997035002A1
公开(公告)日：1997-09-25
申请号：PCT/FR1997000472
申请日：1997-03-17
申请人： RHONE-POULENC RORER S.A. , WILS, Pierre , OLLIVIER, Monique
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C12N15/10
CPC分类号： C12N15/101 , C12Q1/6806
摘要： A method for purifying pharmaceutical-grade plasmid DNA by means of at least one hydroxyapatite column chromatography step is disclosed.
摘要翻译：本发明涉及纯化双链DNA的方法，其包括使用陶瓷羟基磷灰石柱色谱法。本发明还涉及纯化的重组质粒DNA组合物，其包含小于或等于0.01％的染色体DNA含量以及包含通过前述方法制备的DNA的组合物。

86. 发明申请

WO1997032869A1 TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：紫杉醇，其制备方法及含有其的药物组合物
公开(公告)号：WO1997032869A1
公开(公告)日：1997-09-12
申请号：PCT/FR1997000386
申请日：1997-03-05
申请人： RHONE-POULENC RORER S.A. , BOUCHARD, Hervé , BOURZAT, Jean-Dominique , COMMERCON, Alain
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed. In general formula (I), Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl radical or a radical R2-O-CO-, where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or aromatic heterocyclic radical; R4 is a hydroxy radical or an alkoxy, alkenyloxy, optionally substituted alkynyloxy, alkanoyloxy, alkenoyloxy, alkynyloxy, alkoxyacetyl or alkyloxycarbonyloxy radical, or a cycloalkyloxy, cycloalkenyloxy, arylcarbonyloxy or heterocyclylcarbonyloxy radical; and R5 is an optionally substituted alkoxy radical or a cycloalkyloxy or cycloalkenyloxy radical. The novel compounds of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral and antineoplastic properties.
摘要翻译：公开了通式（I）的新型紫杉烷类，其制备方法和含有其的药物组合物。在通式（I）中，Z是氢原子或通式（II）的基团，其中R 1是任选取代的苯甲酰基或基团R 2 -O-CO-，其中R 2是烷基，烯基，炔基，环烷基，环烯基，双环烷基，任选取代的苯基或杂环基; R3是烷基，烯基，炔基，环烷基，苯基，萘基或芳族杂环基; R4是羟基或烷氧基，烯氧基，任选取代的炔氧基，烷酰氧基，烯酰氧基，炔氧基，烷氧基乙酰基或烷氧基羰基氧基，或环烷氧基，环烯基氧基，芳基羰基氧基或杂环基羰基氧基; 并且R 5是任选取代的烷氧基或环烷氧基或环烯氧基。通式（I）的新化合物，其中Z为通式（II）的基团，具有显着的抗肿瘤和抗肿瘤性质。

87. 发明申请

WO1997029196A1 VARIANTS OF THYMIDINE KINASE, RELATED NUCLEIC ACIDS SEQUENCES AND THEIR USE IN GENIC THERAPY 审中-公开
标题翻译：酪氨酸激酶的变体，相关核酸序列及其在基因治疗中的应用
公开(公告)号：WO1997029196A1
公开(公告)日：1997-08-14
申请号：PCT/FR1997000193
申请日：1997-01-31
申请人： RHONE-POULENC RORER S.A. , CROUZET, Joël , BLANCHE, Françis , COUDER, Michel , CAMERON, Béatrice
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C12N15/54
CPC分类号： C12N9/1211 , A01K2217/05 , A61K38/00
摘要： The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their uses in genic therapy.
摘要翻译：本发明涉及一种核酸序列，其特征在于其衍生自编码胸苷激酶的野生型核酸序列，所述核酸序列在对应于ATP结合位点的区域中具有至少一个突变，并且方便地具有第二突变在N-末端区域和/或C-末端区域。它还涉及野生胸苷激酶的变体及其在基因治疗中的用途。

88. 发明申请

WO1997029121A1 APPLICATION OF UREIDOACETAMIDES TO THE PREPARATION OF MEDICAMENTS INTENDED TO THE TREATMENT OF THE ABUSE OF DRUGS OR SUBSTANCES GIVING RISE TO PHARMACOMANIA OR TO AN EXCESSIVE USE 审中-公开
标题翻译：应用抗氧化剂对于制定治疗药物或物质滥用药物或过度使用的药物的准备
公开(公告)号：WO1997029121A1
公开(公告)日：1997-08-14
申请号：PCT/FR1997000208
申请日：1997-02-03
申请人： RHONE-POULENC RORER S.A. , BOHME, Andrees , DUBROEUCQ, Marie-Christine , FRATTA, Walter , GUYON, Claude , IMPERATO, Assunta
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07K05/06
CPC分类号： C07K5/06026 , A61K38/00
摘要： Application of ureidoacetamides having general formula (I), their racemic compounds and enantiomers when they comprise at least one asymmetric center and salts thereof, to the preparation of medicaments intended to the treatment of the abuse of drugs or substances giving rise to pharmacomania or to an excessive use.
摘要翻译：具有通式（I）的脲基乙酰胺，其外消旋化合物和对映异构体当其包含至少一个不对称中心及其盐时，可用于制备用于治疗滥用药物或引起药物性或药物滥用的物质的药物过度使用

89. 发明申请

WO1997020850A1 3,4-DIHYDRO[1,2,4]THIADIAZINO[3,4-b]BENZOTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME 审中-公开
标题翻译： 3,4-二氢[1,2,4]噻二唑并[3,4-b]苯并噻唑衍生物，其制备方法和含有其的药物
公开(公告)号：WO1997020850A1
公开(公告)日：1997-06-12
申请号：PCT/FR1996001868
申请日：1996-11-26
申请人： RHONE-POULENC RORER S.A. , BOIREAU, Alain , DUBROEUCQ, Marie-Christine , IMPERATO, Assunta , JIMONET, Patrick , MIGNANI, Serge , RANDLE, John
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： Compounds of formula (I), wherein R is a polyfluoroalkyl radical, R1 is an alkyl radical and Hal is a halogen atom, are disclosed. The compounds of formula (I) are useful for treating Parkinson's disease and parkinsonian syndromes.
摘要翻译：公开了式（I）化合物，其中R是多氟烷基，R 1是烷基，Hal是卤素原子。式（I）化合物可用于治疗帕金森病和帕金森综合征。

90. 发明申请

WO1997020557A1 USE OF 2-AMINOBENZOTHIAZOLES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES 审中-公开
标题翻译：用于治疗帕金森病和帕金森综合症的2-氨基苯唑胺的应用
公开(公告)号：WO1997020557A1
公开(公告)日：1997-06-12
申请号：PCT/FR1996001866
申请日：1996-11-26
申请人： RHONE-POULENC RORER S.A. , BOIREAU, Alain , DUBROEUCQ, Marie-Christine , IMPERATO, Assunta , JIMONET, Patrick , MIGNANI, Serge , RANDLE, John
发明人： RHONE-POULENC RORER S.A.
IPC分类号： A61K31/425
CPC分类号： A61K31/428
摘要： The use of 2-aminobenzothiazoles of formula (I), wherein R is a straight or branched C1-5 alkyl, trifluoromethyl, pentafluoroethyl or pentafluoroethoxy radical, and enantiomers and pharmaceutically acceptable salts thereof, for treating Parkinson's disease and parkinsonian syndromes, is disclosed.
摘要翻译：公开了用于治疗帕金森病和帕金森综合征的式（I）的2-氨基苯并噻唑，其中R是直链或支链C 1-5烷基，三氟甲基，五氟乙基或五氟乙氧基，及其对映异构体和药学上可接受的盐。

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