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81. 发明专利

CA2363153C LOAD-BEARING OSTEOIMPLANT, METHOD FOR ITS MANUFACTURE AND METHOD OF REPAIRING BONE USING SAME 未知
公开(公告)号：CA2363153C
公开(公告)日：2011-04-26
申请号：CA2363153
申请日：2000-02-22
申请人： OSTEOTECH INC
发明人： BOYCE TODD M , SHIMP LAWRENCE A , MANRIQUE ALBERT
IPC分类号： A61L27/36 , A61F2/00 , A61L31/00
摘要： A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.

82. 发明专利

DE60333179D1 VERFAHREN ZUR HERSTELLUNG VON KNOCHENTEILCHEN 未知
公开(公告)号：DE60333179D1
公开(公告)日：2010-08-12
申请号：DE60333179
申请日：2003-03-31
申请人： OSTEOTECH INC
发明人： MORRIS JOHN W , PETERSEN KENNETH C , SHIMP LAWRENCE A , DAUGHERTY MARK P
IPC分类号： A61F2/28 , A01N1/00 , A61F2/00 , A61F2/46 , A61L27/36

83. 发明专利

CA2706491A1 BONE/COLLAGEN COMPOSITES AND USES THEREOF 未知
公开(公告)号：CA2706491A1
公开(公告)日：2009-06-18
申请号：CA2706491
申请日：2008-12-12
申请人： OSTEOTECH INC
发明人： WANG SHERRY HSIU-YING , JAFFE MICHAEL , SHIMP LAWRENCE A , LAURITZEN NELS J , SCHIFF CHARLES M
IPC分类号： A61L27/24
摘要： A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.

84. 发明专利

CA2690457A1 BONE MATRIX COMPOSITIONS AND METHODS 未知
公开(公告)号：CA2690457A1
公开(公告)日：2008-12-24
申请号：CA2690457
申请日：2008-06-16
申请人： OSTEOTECH INC
发明人： BEHNAM KEYVAN , WEI GUOBAO , FORSYTH NANETTE , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61L27/36
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

85. 发明专利

ES2247113T3 IMPLANTE OSEO DESMINERALIZADO EN LA SUPERFICIE Y METODO PARA FABRICARLO. 未知
公开(公告)号：ES2247113T3
公开(公告)日：2006-03-01
申请号：ES01935499
申请日：2001-05-14
申请人： OSTEOTECH INC
发明人： EDWARDS JEAN T , SHIMP LAWRENCE A , DIEGMANN MICHELE , BOYCE TODD M , SCARBOROUGH NELSON L , RUSSELL JAMES L
IPC分类号： A61L27/36 , A61P19/00
摘要： Un método para fabricar una superficie desmineralizada de un implante óseo osteoinductivo que tiene al menos una zona desmineralizada y una zona no desmineralizada, donde el método comprende: desmineralizar al menos parte de al menos una superficie de una sección monolítica de un hueso hasta una profundidad de al menos 100 micras; y configurar la sección monolítica del hueso.

86. 发明专利

AU2002305907B2 Method for sterilizing bioactive materials 未知
公开(公告)号：AU2002305907B2
公开(公告)日：2006-02-23
申请号：AU2002305907
申请日：2002-01-04
申请人： OSTEOTECH INC
发明人： SHIMP LAWRENCE A
IPC分类号： A61L2/08 , A23L3/26 , A61L2/00 , A61L2/10 , A61L2/20 , A61L27/36 , A61L27/54 , A61L27/56 , A61M1/36 , C12N5/08
摘要： A method is provided for sterilizing and/or deactivating adventitious agent(s) on and/or within a biological material which comprises packaging the biological material, altering the original atmosphere associated with the biological material in order to reduce the level of oxygen to which the biological material is exposed and subjecting the packaged biological material with its altered atmosphere to irradiation.

87. 发明专利

CA2550431A1 TISSUE-DERIVED MESH FOR ORTHOPEDIC REGENERATION 未知
公开(公告)号：CA2550431A1
公开(公告)日：2005-07-14
申请号：CA2550431
申请日：2004-12-20
申请人： OSTEOTECH INC
发明人： GRASSO JENNIFER , KNAACK DAVID , LIN JO-WEN , GEREMAKIS PERRY A , WATERMAN ROBERT , WINTERBOTTOM JOHN M , SHIMP LAWRENCE A
IPC分类号： A61F2/28 , A61B17/00 , A61B17/06 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/36 , B29C47/36 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone- derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.

88. 发明专利

CA2494889A1 SYNTHESIS OF A BONE-POLYMER COMPOSITE MATERIAL 未知
公开(公告)号：CA2494889A1
公开(公告)日：2004-02-19
申请号：CA2494889
申请日：2003-08-12
申请人： OSTEOTECH INC
发明人： KNAACK DAVID , WINTERBOTTOM JOHN M , SHIMP LAWRENCE A , BOYCE TODD M
IPC分类号： A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48
摘要： A method of producing a bone-polymer composite. The method comprises the ste ps of providing a plurality of bone particles, combining the bone particles wit h a polymer precursor, and polymerizing the polymer precursor.

89. 发明专利

TR200200578T2 未知
公开(公告)号：TR200200578T2
公开(公告)日：2003-09-22
申请号：TR200200578
申请日：2000-06-08
申请人： OSTEOTECH INC
发明人： BOYLE JOHN W , SHIMP LAWRENCE A , KAES DAVID R , MORRIS JOHN W , MARTZ ERIK O , BOYCE TODD M , DAUGHERTY MARK
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
摘要： A ramp-shaped intervertebral implant is disclosed. The implant has a body having a first end, a second end, a top surface and a bottom surface. At least one of the top and bottom surfaces is tapered and converges towards the second end of the body. An opening extends through the body and has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

90. 发明专利

CA2438033A1 IMPLANT DERIVED FROM BONE 未知
公开(公告)号：CA2438033A1
公开(公告)日：2002-08-22
申请号：CA2438033
申请日：2002-02-12
申请人： OSTEOTECH INC
发明人： SHIMP LAWRENCE A , SYBERT DARYL R
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/44 , A61F2/46 , A61L27/36 , A61L27/40 , A61L27/54
摘要： An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bon e possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.

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