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81. 发明专利

NZ604094A Double stranded rna compounds to rhoa and use thereof 未知
公开(公告)号：NZ604094A
公开(公告)日：2014-11-28
申请号：NZ60409411
申请日：2011-06-23
申请人： QUARK PHARMACEUTICALS INC
发明人： FEINSTEIN ELENA , KALINSKI HAGAR , AVKIN-NACHUM SHARON , METT IGOR
IPC分类号： C12N15/113 , A61K31/713
摘要： Disclosed is a double-stranded nucleic acid molecule (RHOA_48) having the structure: 5’ UGUAGCAAGAUGACUUCUG -Z 3’ (antisense SEQ ID NO:113) 3’ Z’-ACAUCGUUCUACUGAAGAC -z” 5’(sense SEQ ID NO:79) wherein each of A, C, G and U is independently an unmodified ribonucleotide, a modified ribonucleotide, or an unconventional moiety; wherein on the antisense strand a mirror nucleotide or a 2’-5’ linked ribonucleotide is present in at least one of positions 5, 6, 7 or 8 (5’>3’), 2’-O-Methyl sugar-modified ribonucleotides are present at positions 1, 3, 11, 14, 15, 17 and 18 (5’>3’), and Z is a C3Pi-C3OH moiety or a C3Pi-C3Pi moiety covalently attached at the 3’ terminus of the antisense strand; wherein on the sense strand a 2’-O-Methyl sugar-modified ribonucleotide is present at position 1, 2’-5’ linked ribonucleotides are present at positions 15, 16, 17, 18 and 19 (5’>3’); and Z’ is 1-5 consecutive nucleotides or non-nucleotide or unconventional moieties or a combination thereof covalently attached at the 3’ terminus of the sense strand; wherein z” is a capping moiety covalently attached at the 5’ terminus of the sense strand; or a pharmaceutically acceptable salt of such nucleic acid molecule.

82. 发明专利

HRP20140522T1 PRIPRAVCI I METODE ZA INHIBIRANJE IZRAŽAJA PROAPOPTOTIÄŚKIH GENA 未知
公开(公告)号：HRP20140522T1
公开(公告)日：2014-08-15
申请号：HRP20140522
申请日：2014-06-05
申请人： QUARK PHARMACEUTICALS INC
发明人： KALINSKI HAGAR , METT IGOR , FEINSTEIN ELENA , ERLICH SHAI
IPC分类号： C12N15/113 , A61K31/713

83. 发明专利

SG186438A1 DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF 未知
公开(公告)号：SG186438A1
公开(公告)日：2013-01-30
申请号：SG2012094652
申请日：2011-06-23
申请人： QUARK PHARMACEUTICALS INC
发明人： AVKIN-NACHUM SHARON , FEINSTEIN ELENA , KALINSKI HAGAR , METT IGOR
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.

84. 发明专利

AU2011270896A1 Double stranded RNA compounds to RhoA and use thereof 未知
公开(公告)号：AU2011270896A1
公开(公告)日：2013-01-10
申请号：AU2011270896
申请日：2011-06-23
申请人： QUARK PHARMACEUTICALS INC
发明人： AVKIN-NACHUM SHARON , FEINSTEIN ELENA , KALINSKI HAGAR , METT IGOR
IPC分类号： C12N15/113 , A61K31/713
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.

85. 发明专利

NZ591391A Non-invasive methods for treating eye disorders using a topical oligonucleotide composition 未知
公开(公告)号：NZ591391A
公开(公告)日：2012-10-26
申请号：NZ59139109
申请日：2009-10-22
申请人： QUARK PHARMACEUTICALS INC
发明人： FEINSTEIN ELENA , ALPERT EVGENIA , METT IGOR , BAR-ILAN AMIR , SPIVAK IGOR , KALINSKI HAGAR , SLAGER NETANJA
IPC分类号： C12N15/113 , A61K31/711
摘要： Disclosed is a double strand RNA compound having the structure: 5'iB GCCAGAAUGUGGAACUCCU 3' (sense strand) 3' CGGUCUUACACCUUGAGGA 5' (antisense strand) Wherein each nucleotide is a ribonucleotide and each consecutive ribonucleotide is joined to the next ribonucleotide by a phosphodiester bond; And wherein the sense strand comprises an L-deoxycytidine at position 18, and an inverted abasic 5' cap, and the antisense strand comprises a 2'-O-Me sugar modified ribonucleotide at positions 2, 4, 6, 8, 11, 13, 15, 17 and 19. Further disclosed is the use of said compound in the preparation of a medicament for treating a patient suffering from an ocular disease, an ocular disorder, an ocular injury, a visual field loss, or for providing ocular neuroprotection.

86. 发明专利

MX2010010303A NUEVOS COMPUESTOS DE ACIDO RIBONUCLEICO DE PEQUEÑA INTERFERENCIA PARA INHIBIR RTP801. 未知
公开(公告)号：MX2010010303A
公开(公告)日：2010-10-20
申请号：MX2010010303
申请日：2009-03-17
申请人： QUARK PHARMACEUTICALS INC
发明人： FEINSTEIN ELENA , SKALITER RAMI , METT IGOR , KALINSKI HAGAR
IPC分类号： A61K48/00
摘要： La presente invención proporciona compuestos de ARNip modificados químicamente que se dirigen a RTP801 y composiciones farmacéuticas que los comprenden, útiles para tratar trastornos microvasculares, enfermedades oculares, deficiencia auditiva, enfermedades y trastornos neurodegenerativas, lesión de la médula espinal y afecciones respiratorias.

87. 发明专利

AU2013315524B2 Double-stranded oligonucleotide molecules to p53 and methods of use thereof 未知
公开(公告)号：AU2013315524B2
公开(公告)日：2019-01-31
申请号：AU2013315524
申请日：2013-09-12
申请人： QUARK PHARMACEUTICALS INC
发明人： FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR
IPC分类号： C12N15/113 , A61K31/713
摘要： The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.

88. 发明专利

DK2895608T3 DOBBELTSTRENGEDE OLIGONUKLEOTIDMOLEKYLER TIL P53 OG FREMGANGSMÅDER TIL ANVENDELSE DERAF 未知
公开(公告)号：DK2895608T3
公开(公告)日：2019-01-21
申请号：DK13776599
申请日：2013-09-12
申请人： QUARK PHARMACEUTICALS INC
发明人： FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR
IPC分类号： C12N15/113 , A61K31/713

89. 发明专利

CA2801928C DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF 未知
公开(公告)号：CA2801928C
公开(公告)日：2018-04-10
申请号：CA2801928
申请日：2011-06-23
申请人： QUARK PHARMACEUTICALS INC
发明人： AVKIN-NACHUM SHARON , FEINSTEIN ELENA , KALINSKI HAGAR , METT IGOR
IPC分类号： C12N15/113 , A61K31/713
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.

90. 发明专利

NZ712025A Oligonucleotide modulators of the toll-like receptor pathway 未知
公开(公告)号：NZ712025A
公开(公告)日：2017-03-31
申请号：NZ71202512
申请日：2012-03-01
申请人： QUARK PHARMACEUTICALS INC
发明人： AVKIN-NACHUM SHARON , FEINSTEIN ELENA , ADAMSKY SVETLANA , METT IGOR , KALINSKI HAGAR
IPC分类号： C12N15/113
摘要： Disclosed is a double stranded (ds) nucleic acid molecule comprising a sense strand and an antisense strand described as the sequence pair set forth as TLR4_14 (SEQ ID NOS:20624 and 20633, respectively),wherein the sequences are defined in the specification as: >20624 cucaaucucucuuuagaca >20633 ugucuaaagagagauugag

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