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81. 发明申请

US20090304944A1 Surface Assisted Fluid Loading and Droplet Dispensing 有权
标题翻译：表面辅助流体装载和滴液分配
公开(公告)号：US20090304944A1
公开(公告)日：2009-12-10
申请号：US12523776
申请日：2008-01-22
申请人： Arjun Sudarsan , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Arjun Sudarsan , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： B05D1/04 , B05B5/025
CPC分类号： B01L3/0241 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427
摘要： The present invention relates to surface assisted fluid loading and droplet dispensing on a droplet micro actuator. A droplet actuator is provided and includes one or more electrodes configured for conducting one or more droplet operations on a droplet operations surface of the substrate. The droplet actuator further includes a wettable surface defining a path from a fluid reservoir into a locus which is sufficiently near to one or more of the electrodes that activation of the one or more electrodes results in a droplet operation. Methods and systems are also provided.
摘要翻译：本发明涉及液滴微型致动器上的表面辅助流体加载和液滴分配。提供液滴致动器并且包括一个或多个电极，其被配置用于在基板的液滴操作表面上进行一个或多个液滴操作。液滴致动器还包括可润湿表面，其限定从流体储存器到足以接近一个或多个电极的轨迹的路径，所述一个或多个电极的激活导致液滴操作。还提供了方法和系统。

82. 发明申请

US20090263834A1 Droplet Actuator Devices and Methods for Immunoassays and Washing 有权
标题翻译：滴液致动器装置和免疫测定和洗涤方法
公开(公告)号：US20090263834A1
公开(公告)日：2009-10-22
申请号：US12393534
申请日：2009-02-26
申请人： Ramakrishna Sista , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Ramakrishna Sista , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： G01N33/542
CPC分类号： G01N33/54333
摘要： Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead with a reduced concentration of a substance is provided and includes: (a) providing a super paramagnetic bead in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets. The set of droplets includes: (i) a droplet in contact with the super paramagnetic bead having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the super paramagnetic bead.
摘要翻译：提供液滴致动器装置和免疫测定和洗涤方法。根据一个实施方案，提供了一种提供与物质浓度降低的超顺磁珠的表面接触的液滴的方法，包括：（a）提供与包含起始浓度的液滴接触的超顺磁珠并开始物质的起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合液滴以产生一组液滴。一组液滴包括：（i）与超顺磁珠接触的液滴，其物质相对于起始浓度降低; 和（ii）从超顺磁珠分离的液滴。

83. 发明申请

US20080281471A1 Droplet Actuator Analyzer with Cartridge 有权
标题翻译：带墨盒的液滴执行器分析仪
公开(公告)号：US20080281471A1
公开(公告)日：2008-11-13
申请号：US11838450
申请日：2007-08-14
申请人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
发明人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
IPC分类号： G06F17/00 , B01J19/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/148 , B01L2200/16 , B01L2300/024 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , B01L2400/0683 , G01N33/49
摘要： A droplet actuator with cartridge is provided. According to one embodiment, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a wherein the cartridge is coupled to the analyzer unit by a means which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit. According to another embodiment, a sample analyzer is provided and includes a sample analyzer comprising a cartridge coupled thereto and a means of electrical interface and/or optical interface between the cartridge and the analyzer, whereby electrical signals and/or optical signals may be transmitted from the cartridge to the analyzer.
摘要翻译：提供带墨盒的液滴致动器。根据一个实施例，提供了样本分析器，并且包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及其中所述盒通过使电子和 /或来自带有分析仪单元上的电子或光学接收装置的盒的光学输出。根据另一个实施例，提供了一个样本分析器，它包括一个样本分析器，该样本分析器包括与其相连接的盒，以及盒和分析器之间的电接口和/或光学接口的装置，由此电信号和/或光信号可以从墨盒进入分析仪。

84. 发明授权

US08524506B2 Methods for sampling a liquid flow 有权
标题翻译：液体取样方法
公开(公告)号：US08524506B2
公开(公告)日：2013-09-03
申请号：US11936289
申请日：2007-11-07
申请人： Vamsee K. Pamula , Michael G. Pollack , Richard B. Fair
发明人： Vamsee K. Pamula , Michael G. Pollack , Richard B. Fair
IPC分类号： G01N1/10
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0084 , B01J2219/00479 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G01N15/14 , G01N2035/1046 , G02B26/005 , Y10T436/11 , Y10T436/113332 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.
摘要翻译：提供了液体取样方法。该方法包括将连续的液体流从连续流体流体输入源提供到沿着第一流动路径的表面。该方法另外包括通过执行基于电场的技术对液体流的一部分分离样品液滴来对连续液体流进行采样，由此样品液滴与液体流不同，并且可独立于液体流动而控制，其中通过在表面上设置一组电极并选择性地偏置该组电极来执行基于电场的技术，由此在一组电极中形成样品液滴。

85. 发明申请

US20130146455A1 Droplet Manipulation Device 有权
标题翻译：液滴操纵装置
公开(公告)号：US20130146455A1
公开(公告)日：2013-06-13
申请号：US13759416
申请日：2013-02-05
申请人： Vamsee K. Pamula , Michael G. Pollack , Richard B. Fair
发明人： Vamsee K. Pamula , Michael G. Pollack , Richard B. Fair
IPC分类号： C25B9/00
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
摘要翻译：提供了用于操纵液滴的方法。所述方法包括在包括电极阵列和基本上共平面的参考元件阵列的表面上提供液滴，其中液滴设置在电极的第一个上，并且液滴至少部分地与第二个电极和设置在第一和第二电极之间的参考元件中的插入件之一。所述方法还包括激活第一和第二电极以将液滴的至少一部分扩散穿过第二电极，并且去激活第一电极以使液滴从第一电极移动到第二电极。

86. 发明授权

US08048628B2 Methods for nucleic acid amplification on a printed circuit board 有权
标题翻译：在印刷电路板上进行核酸扩增的方法
公开(公告)号：US08048628B2
公开(公告)日：2011-11-01
申请号：US11753318
申请日：2007-05-24
申请人： Michael G. Pollack , Vamsee K. Pamula , Richard B. Fair
发明人： Michael G. Pollack , Vamsee K. Pamula , Richard B. Fair
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N27/44769 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B81B3/0021 , B81B2201/058 , B81C1/00119 , C12Q1/6846 , G01N27/447 , G01N27/44791 , G05D7/0694 , H01L21/6715 , Y10T436/2575
摘要： Methods for amplifying nucleic acid, such as DNA or RNA, on a printed circuit board (PCB) substrate are disclosed. The amplification can be achieved through a variety of methods such as thermocycling or isothermally. The printed circuit board substrate can comprise an array of electrodes for transporting droplets and can be part of a sandwich structure including a top plate parallel to the printed circuit board substrate.
摘要翻译：公开了在印刷电路板（PCB）衬底上放大核酸如DNA或RNA的方法。扩增可以通过各种方法如热循环或等温进行。印刷电路板基板可以包括用于输送液滴的电极阵列，并且可以是包括平行于印刷电路板基板的顶板的夹层结构的一部分。

87. 发明申请

US20100236927A1 Droplet Actuator Structures 有权
标题翻译：液滴致动器结构
公开(公告)号：US20100236927A1
公开(公告)日：2010-09-23
申请号：US12681840
申请日：2008-10-17
申请人： Lavern Pope , Michael G. Pollack , Vamsee K. Pamula
发明人： Lavern Pope , Michael G. Pollack , Vamsee K. Pamula
IPC分类号： G01N27/26
CPC分类号： B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2300/161 , B01L2400/0427 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A droplet actuator comprising a substrate comprising an electrode coupled to a voltage source, wherein the droplet actuator is configured such that when voltage is applied to the electrode, an electrostatic energy gradient is established at a surface of the substrate which causes a droplet to be transported in a direction established by the energy gradient. Related methods and other embodiments are also provided.
摘要翻译：一种液滴致动器，包括包括耦合到电压源的电极的基板，其中所述液滴致动器被配置为使得当电压被施加到所述电极时，在所述基板的表面处建立静电能量梯度，这导致液滴被输送在能量梯度建立的方向上。还提供了相关方法和其它实施例。

88. 发明授权

US07759132B2 Methods for performing microfluidic sampling 有权
标题翻译：执行微流体取样的方法
公开(公告)号：US07759132B2
公开(公告)日：2010-07-20
申请号：US11585491
申请日：2006-10-23
申请人： Michael G. Pollack , Vamsee K. Pamula , Richard B. Fair
发明人： Michael G. Pollack , Vamsee K. Pamula , Richard B. Fair
IPC分类号： G01N1/10 , C25B9/00 , G01N27/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0084 , B01J2219/00479 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G01N15/14 , G01N2035/1046 , G02B26/005 , Y10T436/11 , Y10T436/113332 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Methods for performing microfluidic sampling are provided. The method includes providing a substrate including an arrangement of first, second and third electrodes, wherein the second electrode is interposed between the first and third electrodes. The method additionally includes causing a fluid input to continuously flow to the first electrode and biasing the first, second and third electrodes to a first voltage to cause a portion of the fluid input to spread across the second and third electrodes. The method further includes biasing the second electrode to a second voltage different from the first voltage to form a droplet on the third electrode, the droplet being separate from the fluid input.
摘要翻译：提供了执行微流体取样的方法。该方法包括提供包括第一，第二和第三电极的布置的基板，其中第二电极介于第一和第三电极之间。该方法还包括使流体输入连续地流动到第一电极并且将第一，第二和第三电极偏压到第一电压以使流体输入的一部分扩展穿过第二和第三电极。该方法还包括将第二电极偏压到不同于第一电压的第二电压，以在第三电极上形成液滴，液滴与流体输入分离。

89. 发明申请

US20100143963A1 Modular Droplet Actuator Drive 有权
标题翻译：模块化滴液致动器驱动
公开(公告)号：US20100143963A1
公开(公告)日：2010-06-10
申请号：US12707081
申请日：2010-02-17
申请人： Michael G. Pollack , Philip Paik
发明人： Michael G. Pollack , Philip Paik
IPC分类号： C12Q1/02 , B05C11/00
CPC分类号： B01L3/502792 , B01L2200/025 , B01L2200/04 , B01L2300/089 , B01L2400/0427 , G01N21/59 , G01N2021/035 , G01N2035/1046
摘要： The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and/or a means for coupling the droplet actuator circuitry to a processor. Systems, kits and methods of conducting assays are also provided.
摘要翻译：本发明提供一种液滴致动器驱动装置。在某些实施例中，液滴致动器驱动器可以包括用于感测液滴致动器上的液滴的特性的检测装置; 用于控制检测装置的电路，电子耦合到检测装置; 液滴致动器盒连接器; 用于控制耦合到液滴致动器连接器的液滴致动器的电路; 和/或用于将液滴致动器电路耦合到处理器的装置。还提供了进行测定的系统，试剂盒和方法。

90. 发明申请

US20090146380A1 METHODS AND APPARATUSES FOR GENERATING A SEAL BETWEEN A CONDUIT AND A RESERVOIR WELL 审中-公开
标题翻译：用于产生管道和储藏室之间的密封的方法和装置
公开(公告)号：US20090146380A1
公开(公告)日：2009-06-11
申请号：US11719522
申请日：2006-08-10
申请人： Gregory A. Votaw , Kelly Junge , Michael G. Pollack , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Kelly Junge , Michael G. Pollack , Hugh C. Crenshaw
IPC分类号： F16L21/02 , F16J15/00
CPC分类号： F04B19/006 , B01F5/0471 , B01F5/0646 , B01F5/0653 , B01F13/0059 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L2300/044 , B01L2300/0816 , B01L2300/1822 , B01L2300/1883 , B01L2300/1894 , B01L2400/0487 , B01L2400/0677
摘要： Methods and Apparatuses for Generating a Seal Between a Conduit and a Reservoir Well. According to one embodiment, an apparatus is provided for generating a seal between a conduit and a reservoir well. The apparatus can include a mount including a first and second end. The mount can also include a first aperture extending between the first and second ends. The apparatus can also include a tube including a first end engaging the first end of the mount, and operable to hold a conduit having an end such that the conduit extends through the first aperture of the mount and the end of the conduit communicates with a reservoir well. Further, the apparatus can include a nut operable to engage the mount and tube and seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount.
摘要翻译：在管道和储层之间产生密封的方法和装置。根据一个实施例，提供了用于在导管和储存器井之间产生密封的装置。该装置可以包括包括第一端和第二端的安装件。安装件还可以包括在第一和第二端之间延伸的第一孔。该装置还可以包括管，其包括接合安装件的第一端的第一端，并且可操作地保持具有端部的导管，使得导管延伸穿过安装件的第一孔，并且导管的端部与储存器好。此外，该装置可以包括可操作以接合安装件和管并且将导管密封到安装件的第一孔的螺母，使得空气不能从储存器穿过安装件的第一孔而连通。

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