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81. 发明申请

US20100035286A1 IN VITRO METHOD FOR THE DIAGNOSIS AND EARLY DIAGNOSIS OF NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于诊断和早期诊断神经损伤性疾病的体外方法
公开(公告)号：US20100035286A1
公开(公告)日：2010-02-11
申请号：US12516851
申请日：2007-11-28
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/535 , G01N33/92
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： In vitro method for the detection and early detection of, for the determination of the degree of severity of, and for the assessment of the course of and prognosis of neurodegenerative disorders, in which an immunodiagnostic determination method is used to determine the apolipoprotein C-1 (Apo C-1) immunoreactivity in a serum or plasma sample from a patient suffering from subjective or objectively verifiable cognitive disorders.
摘要翻译：用于检测和早期检测用于确定神经变性疾病的过程和预后的程度和用于评估神经变性疾病的体外方法，其中使用免疫诊断测定方法来测定载脂蛋白C-1 （Apo C-1）在患有主观或可客观验证的认知障碍的患者的血清或血浆样品中的免疫反应性。

82. 发明申请

US20090311186A1 METHOD FOR CONTROLLING THE THERAPY OF PATIENTS SUFFERING FROM CARDIAC INSUFFICIENCY BY MEANS OF IN VITRO DETERMINATION OF THRESHOLD VALUES OF VASOACTIVE PEPTIDES 有权
标题翻译：通过体外测定血管肽阈值的方法控制心脏缺血患者的治疗方法
公开(公告)号：US20090311186A1
公开(公告)日：2009-12-17
申请号：US12374757
申请日：2007-07-18
申请人： Andreas Bergmann
发明人： Andreas Bergmann
IPC分类号： A61K49/00 , A61P43/00
CPC分类号： G01N33/6893 , G01N2333/575 , G01N2333/5754 , G01N2333/5757 , G01N2333/5758 , G01N2800/32 , G01N2800/325
摘要： Disclosed is a method for controlling the therapeutic treatment of a patient suffering from cardiac insufficiency. In said method, it is determined how the concentration of at least one of the vasoactive peptides adrenomedullin (ADM), endothelin-1 (ET-1), and/or vasopressin (AVP) changes in the patient's blood after beginning the therapy, and the therapeutic measures are considered to be unsatisfactory and are modified in case said concentration does not decrease at all or not enough in relation to a threshold value for the respective vasoactive peptide.
摘要翻译：公开了一种用于控制患有心脏功能不全的患者的治疗性治疗的方法。在所述方法中，确定开始治疗后患者血液中至少一种血管活性肽肾上腺髓质素（ADM），内皮素-1（ET-1）和/或加压素（AVP））的浓度如何变化，以及治疗措施被认为是不令人满意的，并且在所述浓度根本不降低或相对于相应血管活性肽的阈值不足的情况下进行修饰。

83. 发明授权

US07572590B2 Method for the diagnosis of sepsis with determination of CA 19-9 失效
标题翻译：用于诊断脓毒症并确定CA 19-9的方法
公开(公告)号：US07572590B2
公开(公告)日：2009-08-11
申请号：US10496250
申请日：2002-11-27
申请人： Andreas Bergmann
发明人： Andreas Bergmann
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/56911 , G01N33/6893 , G01N2800/26
摘要： Method for early differential diagnosis and detection, prognosis and assessment of the severity and therapy-accompanying assessment of the course of sepsis and sepsis-like systemic infections, in which, preferably with determination of at least one further parameter suitable for sepsis diagnosis, the amount of CA 19-9 in a biological fluid of a patient who is suffering from sepsis or is suspected of having sepsis is determined and conclusions are drawn from the determined amount of CA 19-9 with regard to the presence, the expected course, the severity and/or the success of initiated measures for the treatment of the sepsis.
摘要翻译：用于早期鉴别诊断和检测，预后和评估败血症和败血症样全身感染过程的严重性和治疗伴随评估的方法，其中优选地通过确定适合于败血症诊断的至少一个其它参数，量的CA 19-9在患有败血症或怀疑患有败血症的患者的生物流体中被确定，并且从确定的CA 19-9的量中得出结论，关于存在，预期进程，严重程度和/或成功开展治疗败血症的措施。

84. 发明申请

US20090136973A1 DETERMINATION OF SHORT-CHAIN SRL ALCOHOL DEHYDROGENASE (DHRS4) AS A BIOMARKER FOR INFLAMMATIONS AND INFECTIONS 有权
标题翻译：短链烷醇脱氢酶（DHRS4）作为炎症和感染的生物标记物的测定
公开(公告)号：US20090136973A1
公开(公告)日：2009-05-28
申请号：US11908346
申请日：2006-03-06
申请人： Andreas Bergmann , Joachim Struck , Monika Uhlein
发明人： Andreas Bergmann , Joachim Struck , Monika Uhlein
IPC分类号： G01N33/569 , C12Q1/32
CPC分类号： G01N33/56911 , G01N33/6893 , G01N2800/26
摘要： The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the course, and also monitoring the course and therapy of septic inflammations and infections.
摘要翻译：本发明涉及短链SRL醇脱氢酶（DHRS4，SEQ ID NO：1）及其肽作为体液生物标志物用于诊断检测和预后的用途，并且还监测脓毒性炎症的过程和治疗，感染。

85. 发明申请

US20090012268A1 NOVEL MONOCLONAL THYROID STIMULATING OR BLOCKING ANTIBODIES, PEPTIDE SEQUENCES CORRESPONDING TO THEIR VARIABLE REGIONS, AND THEIR USES IN DIAGNOSTIC, PREVENTIVE AND THERAPEUTIC MEDICINE 有权
标题翻译：新型单克隆抗体刺激或阻断抗体，与其可变区域相关的肽段序列及其在诊断，预防和治疗药物中的用途
公开(公告)号：US20090012268A1
公开(公告)日：2009-01-08
申请号：US11570951
申请日：2005-06-16
申请人： Andreas Bergmann , Nils G. Morgenthaler , Gilbert Vassart , Sabine Costagliola
发明人： Andreas Bergmann , Nils G. Morgenthaler , Gilbert Vassart , Sabine Costagliola
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/564 , G01N33/76
摘要： Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab′)2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.
摘要翻译：具有甲状腺刺激活性（TSAb）的单克隆抗体（mAb），特别是完全或相当激动的活性或甲状腺阻断活性（TBAb），其可通过小鼠或片段（F（ab'）2，Fab或Fv ）或这种片段的单克隆抗体或单链形式（SCA; scFv）的人源化形式，该抗体或其片段与牛TSH竞争人TSHr的表位，与来自格雷夫斯病人的血清的自身抗体竞争与来自患有人TSHr表位的阻断自身抗体的患者的血清的自身抗体一样，与人TSHr的前281个氨基酸中的人TSHr的构象表位结合，并且通常还结合来自不同动物的TSFR受体（TSHr）。还描述和要求保护这些抗体或对应于这些抗体的可变区的肽的各种用途。

86. 发明申请

US20080261232A1 Use of Precursors of Enkephalins and/or Their Fragments in Medical Diagnostics 有权
标题翻译：使用脑啡肽和/或其片段的前体进行医学诊断
公开(公告)号：US20080261232A1
公开(公告)日：2008-10-23
申请号：US11569023
申请日：2005-05-11
申请人： Andreas Bergmann , Andrea Ernst
发明人： Andreas Bergmann , Andrea Ernst
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C07K16/26 , G01N2333/70
摘要： The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker peptide for detection of a number of diseases/disorders including diseases/disorders of the central nervous system, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, ischemia including myocardiac ishcemica, schizophrenia, disease/disorders of the immune system, diseases/conditions of pain, chronic pain, migraine, tension type headache, tumor diseases/cancer including lymphoblastic leukaemia, malignant brain tumors, adenomas, in particular human pituitary adenomas, disorders of the blood brain barrier, multiple sclerosis, inflammation, chronic arthritis, infectious diseases, bacterial and viral infections, in particular infections of Gram-positive bacteria, borna diseases virus infections, peritonitis, intoxication, AIDS, stress, trauma comprising head trauma, infarction, in particular cerebral infarction, heart and cardiovascular diseases including coronary heart disease, bone and skin disorders, malaria chronic/obstructive pulmonary disease and cerebral damage. The invention further provides antibodies that bind to proenkephalin and its fragments. In accordance with the invention, a kit useful for the above mentioned diagnosis is also provided.
摘要翻译：本发明涉及基于人或动物体液，组织和/或生物材料中生化成分的存在的疾病诊断。更具体地，本发明涉及使用脑啡肽和/或其体外分离体液，组织或其他生物材料的片段的前体作为用于检测多种疾病/病症的标记肽，包括中枢神经系统的疾病/病症，神经变性疾病，帕金森病，阿尔茨海默病，亨廷顿病，缺血，包括心肌异常，精神分裂症，免疫系统疾病/病症，疾病/疼痛状况，慢性疼痛，偏头痛，紧张型头痛，肿瘤疾病/癌症，包括淋巴细胞白血病，恶性肿瘤脑肿瘤，腺瘤，特别是人垂体腺瘤，血脑屏障障碍，多发性硬化，炎症，慢性关节炎，感染性疾病，细菌和病毒感染，特别是革兰氏阳性细菌感染，发生疾病病毒感染，腹膜炎，中毒，艾滋病，压力，创伤，包括头部创伤，梗死，在标准脑梗塞，心脏和心血管疾病，包括冠心病，骨骼和皮肤病，疟疾慢性/阻塞性肺病和脑损伤。本发明还提供结合前脑啡肽及其片段的抗体。根据本发明，还提供了可用于上述诊断的试剂盒。

87. 发明授权

US07405049B2 Method for diagnosing inflammatory diseases and infections by the determination of LASP-1 immunoreactivity 失效
标题翻译：通过测定LASP-1免疫反应性来诊断炎性疾病和感染的方法
公开(公告)号：US07405049B2
公开(公告)日：2008-07-29
申请号：US10511758
申请日：2003-04-15
申请人： Andreas Bergmann , Christina Fischer-Schulz , Joachim Struck
发明人： Andreas Bergmann , Christina Fischer-Schulz , Joachim Struck
IPC分类号： G01N33/53 , G01N33/535 , G01N33/68 , G01N33/96
CPC分类号： G01N33/566 , G01N33/6893 , G01N33/6896 , G01N2800/26
摘要： Method for early diagnosis and diagnosis, for prognosis and assessment of the severity and for therapy-accompanying monitoring of inflammatory diseases and infections, in particular sepsis-like systemic infections and Alzheimer's disease, in which the presence and/or amount of the protein LASP-1 (SEQ ID NO:1) or of the protein LAP-1 (SEQ ID NO:16) or of an immunoreactive fragment of one of these proteins in free and/or protein-bound form is determined, preferably as immunoreactivity, in a biological fluid, or optionally a tissue sample, of a patient, and conclusions are drawn with respect to the presence, the expected course, the severity or the success of a therapy of the inflammatory disease or of the infection from the presence and/or amount of the proteins determined.
摘要翻译：用于早期诊断和诊断的方法，用于预测和评估炎性疾病和感染，特别是脓毒症样全身感染和阿尔茨海默氏病的严重性和治疗伴随监测，其中蛋白质LASP- 1（SEQ ID NO：1）或蛋白质LAP-1（SEQ ID NO：16）或这些蛋白质之一的游离和/或蛋白结合形式的免疫反应性片段优选作为免疫反应性生物流体或任选的组织样品，并且根据存在和/或数量的炎症性疾病或感染的治疗的存在，预期进程，严重程度或成功性得出结论的蛋白质。

88. 发明申请

US20060115869A1 Uses of carbamoyl phosphate synthetas for the diagnosis of inflammatory diseases and sepsis 有权
标题翻译：氨基甲酰磷酸合成酶用于诊断炎性疾病和败血症
公开(公告)号：US20060115869A1
公开(公告)日：2006-06-01
申请号：US10511756
申请日：2003-04-15
申请人： Andreas Bergmann , Joachim Struck , Monika Uhlein
发明人： Andreas Bergmann , Joachim Struck , Monika Uhlein
IPC分类号： C12Q1/48
CPC分类号： G01N33/6893 , C12Q1/34 , C12Q1/48 , G01N2333/9015 , G01N2800/26
摘要： Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of multiorgan failure or for determinations in connection with inflammatory and other liver diseases.
摘要翻译：使用氨基甲酰磷酸合成酶1（CPS 1）和/或CPS 1的N末端部分片段从体液或身体组织中作为标志物肽用于诊断和预后以及监测炎症和感染，包括败血症，以及作为多器官衰竭或与炎性和其他肝脏疾病有关的确定的一部分的肝衰竭。

89. 发明授权

US06909342B2 Recursive saw-filter with a low chip length 有权
标题翻译：具有低芯片长度的递归锯式过滤器
公开(公告)号：US06909342B2
公开(公告)日：2005-06-21
申请号：US10296100
申请日：2001-04-30
申请人： Andreas Bergmann , Joachim Gerster
发明人： Andreas Bergmann , Joachim Gerster
IPC分类号： H03H9/00 , H03H9/02 , H03H9/145 , H03H9/25 , H03H9/64
CPC分类号： H03H9/0028 , H03H9/0042 , H03H9/14532 , H03H9/14547 , H03H9/14558 , H03H9/14564 , H03H9/14567
摘要： A recursive surface-active wave filter with directed reflection is provided that such that the desired transmission behavior is modeled by superimposing the signals of three electrically interconnected individual tracks.
摘要翻译：提供了具有定向反射的递归表面有源滤波器，使得通过叠加三个电互连单独轨道的信号来建模期望的传输行为。

90. 发明申请

US20050064409A1 Chp for use as marker for sepsis-type inflammatory diseases 失效
标题翻译： Chp用作败血症型炎症疾病的标志物
公开(公告)号：US20050064409A1
公开(公告)日：2005-03-24
申请号：US10480847
申请日：2002-06-17
申请人： Andreas Bergmann , Joachim Struck , Monika Uhlein
发明人： Andreas Bergmann , Joachim Struck , Monika Uhlein
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61K39/395 , A61P5/22 , A61P29/00 , A61P31/04 , C12N9/16 , C12Q1/42 , G01N33/569 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/6893 , A61K38/1738 , G01N33/56911 , G01N2800/26 , Y10T436/105831 , Y10T436/24
摘要： Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
摘要翻译：使用来自体液或身体组织的钙调神经磷酸酶B同源蛋白（CHP）作为诊断标准肽，用于预测和监测炎症和感染的过程，和/或作为治疗性影响炎症和/或感染过程的靶标。

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