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81. 发明申请

US20110282431A1 Endoprostheses 有权
标题翻译：内假体
公开(公告)号：US20110282431A1
公开(公告)日：2011-11-17
申请号：US13106449
申请日：2011-05-12
申请人： Rajesh Radhakrishnan , Liliana Atanasoska , Scott R. Schewe , Kenneth M. Merdan
发明人： Rajesh Radhakrishnan , Liliana Atanasoska , Scott R. Schewe , Kenneth M. Merdan
IPC分类号： A61F2/82 , B65B1/04
CPC分类号： A61F2/91 , A61F2250/0068
摘要： A medical device is provided with a porous region including a reservoir zone including a polymer and a protective zone between adjacent tissue and the reservoir zone that restricts the tissue from direct contact with the polymer.
摘要翻译：医疗装置设置有多孔区域，该多孔区域包括储存器区域，该储存器区域包括聚合物和相邻组织与储存区域之间的保护区域，其限制组织与聚合物的直接接触。

82. 发明申请

US20110251653A1 IMPLANTABLE ELECTRODES CONTAINING POLYOXOMETALATE ANIONS AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：含有聚羟基乙酸酯阴离子的可植入电极及其制造和使用方法
公开(公告)号：US20110251653A1
公开(公告)日：2011-10-13
申请号：US13166528
申请日：2011-06-22
申请人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
发明人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/372 , A61N1/05 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/37205
摘要： An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode.
摘要翻译：可植入装置包括至少一个电极，其包括设置在导电基底上或内部的导电基底和多金属氧酸盐阴离子; 以及至少一个连接到所述至少一个电极的导体，用于将电能传导到所述至少一个电极。

83. 发明申请

US20110245905A1 ENDOPROSTHESIS 有权
公开(公告)号：US20110245905A1
公开(公告)日：2011-10-06
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
IPC分类号： A61F2/82 , B05D3/00 , B44C1/22 , B23P11/00
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译：除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。

84. 发明授权

US08029554B2 Stent with embedded material 失效
标题翻译：支架与嵌入材料
公开(公告)号：US08029554B2
公开(公告)日：2011-10-04
申请号：US11934362
申请日：2007-11-02
申请人： Thomas J. Holman , Liliana Atanasoska
发明人： Thomas J. Holman , Liliana Atanasoska
IPC分类号： A61L31/12 , A61F2/02 , A61F2/82
CPC分类号： A61L31/12 , A61L31/022 , A61L31/088 , Y10T428/12104 , Y10T428/12486 , Y10T428/12993
摘要： An endoprosthesis such as a stent is composed of a metal or ceramic, such as Irox, embedded in the stent material.
摘要翻译：诸如支架的内假体由嵌入在支架材料中的金属或陶瓷（例如Irox）组成。

85. 发明授权

US08017179B2 Coatings for implantable electrodes 有权
公开(公告)号：US08017179B2
公开(公告)日：2011-09-13
申请号：US11256995
申请日：2005-10-24
申请人： Liliana Atanasoska , Ronald W. Heil , David M. Flynn
发明人： Liliana Atanasoska , Ronald W. Heil , David M. Flynn
IPC分类号： B05D5/12 , B05D3/02
CPC分类号： A61N1/0565 , A61N1/0568
摘要： A method includes sandblasting an electrode surface, applying a conductive oxide precursor solution to the electrode surface, and heating the electrode for at least 5 minutes at a temperature between 350 degrees C. and 550 degrees C. to convert the precursor solution into an oxide coating. One method includes applying a composite material including a conductive component and a non-conductive component to an electrode and curing the composite material to form a coating on the electrode. One method includes providing a metallic oxide coating on an electrode surface and applying a galvanostatic treatment to the electrode to increase the effective surface area of the metallic oxide coating.

86. 发明申请

US20110160839A1 Endoprosthesis 审中-公开
标题翻译：内假体
公开(公告)号：US20110160839A1
公开(公告)日：2011-06-30
申请号：US12649007
申请日：2009-12-29
申请人： Jan Weber , Liliana Atanasoska , Rajesh Radhakrishnan
发明人： Jan Weber , Liliana Atanasoska , Rajesh Radhakrishnan
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067
摘要： An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits.
摘要翻译：内表假体，例如生物可蚀塑的支架，其通过等离子体浸没离子注入在表面上和任选地在本体中进行处理。可释放的治疗剂，药物或药物活性化合物可以并入内用假体的经处理的表面以提供所需的医疗益处。

87. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

88. 发明申请

US20100269838A1 MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 有权
标题翻译：用于将治疗药物递送至目标位置的磁性颗粒
公开(公告)号：US20100269838A1
公开(公告)日：2010-10-28
申请号：US12765369
申请日：2010-04-22
申请人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
发明人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
IPC分类号： A61B19/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

89. 发明申请

US20100137978A1 Medical Implants Including Iridium Oxide 有权
标题翻译：医用植入物包括氧化铱
公开(公告)号：US20100137978A1
公开(公告)日：2010-06-03
申请号：US12630250
申请日：2009-12-03
申请人： Liliana Atanasoska , Pankaj Gupta , Charles Deng
发明人： Liliana Atanasoska , Pankaj Gupta , Charles Deng
IPC分类号： A61F2/06 , B05D7/00
CPC分类号： B32B9/00 , A61F2/82 , A61L31/028 , A61L31/088 , C23C14/08
摘要： A medical implant includes iridium oxide. The iridium oxide has a plurality of Ir—O σ bonds and a plurality of Ir═O σ bonds. The iridium oxide has a ratio of the Ir—O σ bonds to the Ir═O π bonds that is greater than 1.3.
摘要翻译：医疗植入物包括氧化铱。氧化铱具有多个Ir-O＆amp; 债券和多个Ir = O＆Sgr; 债券。氧化铱具有Ir-O和sgr的比例; 债券到Ir=O＆pgr; 大于1.3的债券。

90. 发明申请

US20100008970A1 Drug-Eluting Endoprosthesis 审中-公开
标题翻译：药物洗脱内假体
公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

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